Identification of Multiple Structurally Distinct, Nonpeptidic Small Molecule Inhibitors of Protein Arginine Deiminase 3 Using a Substrate-Based Fragment Method

Journal of the American Chemical Society

Volumn 137, Issue 10, 2015, Pages 3616-3621

  Jamali, Haya ^a   Khan, Hasan A ^a   Stringer, Joseph R ^a,b   Chowdhury, Somenath ^a,c   Ellman, Jonathan A ^a  

^a YALE UNIVERSITY   (United States)

^b Ra Pharmaceuticals   (United States)

^c Melinta Therapeutics Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; PROTEINS; SUBSTRATES;

ARGININE DEIMINASES; ARGININE RESIDUE; LOW MOLECULAR WEIGHT; NEURODEGENERATIVE; SELECTIVE INHIBITORS; SMALL MOLECULE INHIBITOR; SPINAL CORD INJURIES (SCI); TISSUE-SPECIFIC EXPRESSION;

AMINO ACIDS;

GUANIDINE DERIVATIVE; HYDROLASE INHIBITOR; PROTEIN ARGININE DEIMINASE; PROTEIN ARGININE DEIMINASE 3 INHIBITOR; SMALL MOLECULE TRANSPORT AGENT; UNCLASSIFIED DRUG; ENZYME INHIBITOR; HYDANTOIN DERIVATIVE; HYDROLASE; ISOENZYME; MOLECULAR LIBRARY; PROTEIN-ARGININE DEIMINASE;

ARTICLE; CONTROLLED STUDY; DRUG IDENTIFICATION; DRUG MECHANISM; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME SPECIFICITY; HIGH THROUGHPUT SCREENING; MOLECULAR LIBRARY; MOLECULAR WEIGHT; PHARMACOPHORE; STRUCTURE ACTIVITY RELATION; SUBSTRATE ACTIVITY SCREENING; SUICIDE SUBSTRATE; ANTAGONISTS AND INHIBITORS; CHEMISTRY; DRUG DEVELOPMENT; HUMAN; PHARMACOLOGY;

DRUG DISCOVERY; ENZYME INHIBITORS; HUMANS; HYDANTOINS; HYDROLASES; ISOENZYMES; SMALL MOLECULE LIBRARIES; SUBSTRATE SPECIFICITY;

EID: 84925264899     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/jacs.5b00095     Document Type: Article

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