Haloacetamidine-based inactivators of protein arginine deiminase 4 (PAD4): Evidence that general acid catalysis promotes efficient inactivation

ChemBioChem

Volumn 11, Issue 2, 2010, Pages 161-165

  Knuckley, Bryan ^a   Causey, Corey P ^a   Pellechia, Perry J ^a   Cook, Paul F ^b   Thompson, Paul R ^a  

^a UNIVERSITY OF SOUTH CAROLINA   (United States)

^b UNIVERSITY OF OKLAHOMA   (United States)

Author keywords

Amidines; Deiminases; Inactivators; Reaction mechanisms; Rheumatoid arthritis

Indexed keywords

ACETAMIDINE DERIVATIVE; CYSTEINE; PROTEIN ARGININE DEIMINASE; PROTEIN ARGININE DEIMINASE 4; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTEIN STRUCTURE; PROTON TRANSPORT; RHEUMATOID ARTHRITIS; SYNTHESIS;

ACIDS; AMIDINES; ARTHRITIS, RHEUMATOID; CATALYSIS; CATALYTIC DOMAIN; CYSTEINE; HUMANS; HYDROGEN-ION CONCENTRATION; HYDROLASES; KINETICS;

EID: 76649086666     PISSN: 14394227     EISSN: 14397633     Source Type: Journal    
DOI: 10.1002/cbic.200900698     Document Type: Article

References (15)

1. P. R. Thompson, W. Fast, ACS Chem. Biol. 2006, 1, 433.
2. E. R. Vossenaar, A. J. Zendman, W. J. van Venrooij, G. J. Pruijn, Bioessays 2003, 25, 1106.
3. J. E. Jones, C. P. Causey, B. Knuckley, J. L. Slack-Noyes, P. R. Thompson, Curr. Opin. Drug Discovery Dev. 2009, 12, 616.
4. P. L. Kearney, M. Bhatia, N. G. Jones, Y. Luo, M. C. Glascock, K. L. Catchings, M. Yamada, P. R. Thompson, Biochemistry 2005, 44, 10570.
5. B. Knuckley, M. Bhatia, P. R. Thompson, Biochemistry 2007, 46, 6578.
6. E. R. Vossenaar, W. J. Van Venrooij, Arthritis Res. Ther. 2004, 6, 107.
7. Y. Luo, K. Arita, M. Bhatia, B. Knuckley, Y. H. Lee, M. R. Stallcup, P. R. Thompson, Biochemistry 2006, 45, 11727.
8. Y. Luo, B. Knuckley, Y. H. Lee, M. R. Stallcup, P. R. Thompson, J. Am. Chem. Soc. 2006, 128, 1092.
9. E. M. Stone, T. H. Schaller, H. Bianchi, M. D. Person, W. Fast, Biochemistry 2005, 44, 13744.
10. J. C. Powers, J. L. Asgian, O. D. Ekici, K. E. James, Chem. Rev. 2002, 102, 4639.
11. K. Kreutter, A. C. Steinmetz, T. C. Liang, M. Prorok, R. H. Abeles, D. Ringe, Biochemistry 1994, 33, 13792.
12. J. Drenth, K. H. Kalk, H. M. Swen, Biochemistry 1976, 15, 3731.
13. K. Arita, H. Hashimoto, T. Shimizu, K. Nakashima, M. Yamada, M. Sato, Nat. Struct. Mol. Biol. 2004, 11, 777.
14. E. M. Stone, A. L. Costello, D. L. Tierney, W. Fast, Biochemistry 2006, 45, 5618.
15. R. J. Leatherbarrow, Erathicus Software, Staines, UK, 2004.