Substrate activity screening: A fragment-based method for the rapid identification of nonpeptidic protease inhibitors

Journal of the American Chemical Society

Volumn 127, Issue 44, 2005, Pages 15521-15527

  Wood, Warren J L ^a   Patterson, Andrew W ^a   Tsuruoka, Hiroyuki ^a   Jain, Rishi K ^a,b   Ellman, Jonathan A ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DISEASES; DRUG PRODUCTS; IMMUNOLOGY; MOLECULAR WEIGHT; PROTEINS;

AUTOIMMUNE DISEASES; N-ACYL AMINOCOUMARINS; NONPEPTIDE SUBSTRATE; SUBSTRATE ACTIVITY SCREENING;

ENZYME INHIBITION;

CATHEPSIN S; COUMARIN DERIVATIVE; N ACYLAMINOCOUMARIN; PROTEINASE; PROTEINASE INHIBITOR; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ARTICLE; AUTOIMMUNE DISEASE; DRUG SCREENING; ENZYME SUBSTRATE; FLUORESCENCE; PHARMACOPHORE; SYNTHESIS;

AMINOCOUMARINS; CATHEPSINS; COMBINATORIAL CHEMISTRY TECHNIQUES; DRUG EVALUATION, PRECLINICAL; PROTEASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 27644555726     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja0547230     Document Type: Article

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