Substrate activity screening with kinases: Discovery of small-molecule substrate-competitive c-Src inhibitors

Angewandte Chemie - International Edition

Volumn 53, Issue 27, 2014, Pages 7010-7013

  Breen, Meghan E ^a   Steffey, Michael E ^a   Lachacz, Eric J ^a   Kwarcinski, Frank E ^a   Fox, Christel C ^a   Soellner, Matthew B ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

Author keywords

drug discovery; inhibitors; kinases; medicinal chemistry; substrate activity screening

Indexed keywords

AMINO ACIDS; CORROSION INHIBITORS; ENZYME INHIBITION; MOLECULES;

CELLULAR ASSAYS; DRUG DISCOVERY; KINASE INHIBITORS; KINASES; MEDICINAL CHEMISTRY; SMALL MOLECULES; SUBSTRATE ACTIVITY SCREENING; TYROSINE KINASE;

SUBSTRATES;

ADENOSINE TRIPHOSPHATE; CSK TYROSINE-PROTEIN KINASE; PROTEIN KINASE INHIBITOR; PROTEIN TYROSINE KINASE;

CELL SURVIVAL; CHEMISTRY; DRUG EFFECTS; ENZYME SPECIFICITY; HUMAN; KINETICS; METABOLISM; PRECLINICAL STUDY; TUMOR CELL LINE;

ADENOSINE TRIPHOSPHATE; CELL LINE, TUMOR; CELL SURVIVAL; DRUG EVALUATION, PRECLINICAL; HUMANS; KINETICS; PROTEIN KINASE INHIBITORS; SRC-FAMILY KINASES; SUBSTRATE SPECIFICITY;

EID: 84903197169     PISSN: 14337851     EISSN: 15213773     Source Type: Journal    
DOI: 10.1002/anie.201311096     Document Type: Article

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