Short term exposure of beta cells to low concentrations of interleukin-1β improves insulin secretion through focal adhesion and actin remodeling and regulation of gene expression

Journal of Biological Chemistry

Volumn 290, Issue 10, 2015, Pages 6653-6669

  Arous, Caroline ^a   Ferreira, Pedro G ^a   Dermitzakis, Emmanouil T ^a   Halban, Philippe A ^a  

^a UNIVERSITY OF GENEVA MEDICAL SCHOOL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ADHESION; CELL DEATH; CELLS; CYTOLOGY; GENE EXPRESSION; GENES; GLUCOSE; INSULIN; PHYSIOLOGY; PROTEINS; RATS; TRANSCRIPTION;

BENEFICIAL EFFECTS; BETA CELL FUNCTIONS; DIFFERENTIAL EFFECT; FOCAL ADHESION KINASE; GLUCOSE-STIMULATED INSULIN SECRETIONS; MOLECULAR MECHANISM; SHORT-TERM EXPOSURE; UPSTREAM REGULATION;

GENE EXPRESSION REGULATION;

ACTIVATING TRANSCRIPTION FACTOR 3; ACTIVATING TRANSCRIPTION FACTOR 4; ALPHA5 INTEGRIN; BETA1 INTEGRIN; CXCL1 CHEMOKINE; CXCL2 CHEMOKINE; FOCAL ADHESION KINASE; GLUCOSE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INSULIN; INTERLEUKIN 1BETA; LEUKEMIA INHIBITORY FACTOR; MACROPHAGE INFLAMMATORY PROTEIN 3ALPHA; NEUROGENIC DIFFERENTIATION FACTOR; PAXILLIN; PROTEIN C JUN; RAB PROTEIN; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; SECRETOGRANIN II; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTOME; TUMOR NECROSIS FACTOR; ACTIN;

ACTIN REMODELING; ADAMTS15 GENE; ANIMAL CELL; APOPTOSIS; ARTICLE; ATF3 GENE; ATF4 GENE; CCL20 GENE; CDC42 GENE; CELL SURVIVAL; CONCENTRATION RESPONSE; CONTROLLED STUDY; CXCL1 GENE; CXCL2 GENE; DNAAF2 GENE; EGR4 GENE; ENZYME STRUCTURE; FOCAL ADHESION; GENE; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; INSULIN RELEASE; ITGA5 GENE; ITGB1 GENE; LIF GENE; MECOM GENE; MLLT11 GENE; NEUROD1 GENE; NONHUMAN; ONCOGENE C JUN; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL FUNCTION; PCSK6 GENE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PTK2 GENE; RAB3A GENE; RAT; RHOA GENE; RNA SEQUENCE; SCG2 GENE; SIGNAL TRANSDUCTION; SNAP25 GENE; SOX12 GENE; TIMP1 GENE; TNF GENE; ANIMAL; BIOSYNTHESIS; DRUG EFFECTS; METABOLISM; NON INSULIN DEPENDENT DIABETES MELLITUS; PATHOLOGY; PRIMARY CELL CULTURE; SECRETION (PROCESS);

RATTUS;

ACTINS; ANIMALS; DIABETES MELLITUS, TYPE 2; FOCAL ADHESION PROTEIN-TYROSINE KINASES; FOCAL ADHESIONS; GENE EXPRESSION REGULATION; GLUCOSE; HUMANS; INSULIN; INSULIN-SECRETING CELLS; INTERLEUKIN-1BETA; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MAP KINASE SIGNALING SYSTEM; PAXILLIN; PRIMARY CELL CULTURE; RATS;

EID: 84925004057     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.611111     Document Type: Article

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