Primary immunoglobulin repertoire development: Time and space matter

Current Opinion in Immunology

Volumn 33, Issue , 2015, Pages 126-131

  Granato, Alessandra ^a   Chen, Yuezhou ^a   Wesemann, Duane R ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B LYMPHOCYTE RECEPTOR; IMMUNOGLOBULIN; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOGLOBULIN LIGHT CHAIN; IMMUNOGLOBULIN M; RAG1 PROTEIN; RAG2 PROTEIN; ANTIGEN;

ANTIBODY PRODUCTION; ANTIBODY SPECIFICITY; B LYMPHOCYTE; CELL COUNT; CELL MATURATION; IMMUNE RESPONSE; IMMUNOGLOBULIN GENE; INTESTINE FLORA; LYMPHOCYTE ACTIVATION; LYMPHOCYTE COUNT; LYMPHOCYTE SUBPOPULATION; MICROBIAL COLONIZATION; MICROBIAL DIVERSITY; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVIEW; SOMATIC MUTATION; ANIMAL; ANTIGEN MEDIATED CLONAL SELECTION; CELL DIFFERENTIATION; CYTOLOGY; GENE REARRANGEMENT; GENETICS; HUMAN; HUMORAL IMMUNITY; IMMUNOLOGY; METABOLISM; PEYER PATCH;

ANIMALS; ANTIGENS; B-LYMPHOCYTES; CELL DIFFERENTIATION; CLONAL SELECTION, ANTIGEN-MEDIATED; GENE REARRANGEMENT, B-LYMPHOCYTE; HUMANS; IMMUNITY, HUMORAL; IMMUNOGLOBULINS; LYMPHOCYTE ACTIVATION; PEYER'S PATCHES;

EID: 84924977699     PISSN: 09527915     EISSN: 18790372     Source Type: Journal    
DOI: 10.1016/j.coi.2015.02.011     Document Type: Review

References (69)

1. Early P., Huang H., Davis M., Calame K., Hood L. An immunoglobulin heavy chain variable region gene is generated from three segments of DNA: VH, D and JH. Cell 1980, 19:981-992.
2. Maki R., Kearney J., Paige C., Tonegawa S. Immunoglobulin gene rearrangement in immature B cells. Science 1980, 209:1366-1369.
3. Alt F.W., Yancopoulos G.D., Blackwell T.K., Wood C., Thomas E., Boss M., Coffman R., Rosenberg N., Tonegawa S., Baltimore D. Ordered rearrangement of immunoglobulin heavy chain variable region segments. EMBO J 1984, 3:1209-1219.
4. Nemazee D.A., Burki K. Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genes. Nature 1989, 337:562-566.
5. Radic M.Z., Erikson J., Litwin S., Weigert M. B lymphocytes may escape tolerance by revising their antigen receptors. J Exp Med 1993, 177:1165-1173.
6. Koralov S.B., Novobrantseva T.I., Konigsmann J., Ehlich A., Rajewsky K. Antibody repertoires generated by VH replacement and direct VH to JH joining. Immunity 2006, 25:43-53.
7. Retter M.W., Nemazee D. Receptor editing occurs frequently during normal B cell development. J Exp Med 1998, 188:1231-1238.
8. Casellas R., Shih T.A., Kleinewietfeld M., Rakonjac J., Nemazee D., Rajewsky K., Nussenzweig MC: Contribution of receptor editing to the antibody repertoire. Science 2001, 291:1541-1544.
9. Wardemann H., Yurasov S., Schaefer A., Young J.W., Meffre E., Nussenzweig MC: Predominant autoantibody production by early human B cell precursors. Science 2003, 301:1374-1377.
10. Halverson R., Torres R.M., Pelanda R. Receptor editing is the main mechanism of B cell tolerance toward membrane antigens. Nat Immunol 2004, 5:645-650.
11. Wesemann D.R., Portuguese A.J., Meyers R.M., Gallagher M.P., Cluff-Jones K., Magee J.M., Panchakshari R.A., Rodig S.J., Kepler T.B., Alt F.W. Microbial colonization influences early B-lineage development in the gut lamina propria. Nature 2013, 501:112-115.
12. Jung D., Giallourakis C., Mostoslavsky R., Alt F.W. Mechanism and control of V(D)J recombination at the immunoglobulin heavy chain locus. Annu Rev Immunol 2006, 24:541-570.
13. Yu W., Nagaoka H., Jankovic M., Misulovin Z., Suh H., Rolink A., Melchers F., Meffre E., Nussenzweig M.C. Continued RAG expression in late stages of B cell development and no apparent re-induction after immunization. Nature 1999, 400:682-687.
14. Tiegs S.L., Russell D.M., Nemazee D. Receptor editing in self-reactive bone marrow B cells. J Exp Med 1993, 177:1009-1020.
15. Gay D., Saunders T., Camper S., Weigert M. Receptor editing: an approach by autoreactive B cells to escape tolerance. J Exp Med 1993, 177:999-1008.
16. Pelanda R., Schwers S., Sonoda E., Torres R.M., Nemazee D., Rajewsky K. Receptor editing in a transgenic mouse model: site, efficiency, and role in B cell tolerance and antibody diversification. Immunity 1997, 7:765-775.
17. Goodnow C.C., Crosbie J., Adelstein S., Lavoie T.B., Smith-Gill S.J., Brink R.A., Pritchard-Briscoe H., Wotherspoon J.S., Loblay R.H., Raphael K., et al. Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice. Nature 1988, 334:676-682.
18. Coutinho A. Beyond clonal selection and network. Immunol Rev 1989, 110:63-87.
19. Vale A.M., Nobrega H.W., Schroeder A. Chapter 7-development and function of B cell subsets. Andreas Radbruch 2015, 99-119. Academic Press, Michael Reth. W. Frederick, T.H. Alt (Eds.).
20. Chaudhuri J., Basu U., Zarrin A., Yan C., Franco S., Perlot T., Vuong B., Wang J., Phan R.T., Datta A., et al. Evolution of the immunoglobulin heavy chain class switch recombination mechanism. Adv Immunol 2007, 94:157-214.
21. Baumgarth N. The double life of a B-1 cell: self-reactivity selects for protective effector functions. Nat Rev Immunol 2011, 11:34-46.
22. Schroeder H.W., Zemlin M., Khass M., Nguyen H.H., Schelonka RL: Genetic control of DH reading frame and its effect on B-cell development and antigen-specifc antibody production. Crit Rev Immunol 2010, 30:327-344.
23. Schroeder H.W., Ippolito G.C., Shiokawa S. Regulation of the antibody repertoire through control of HCDR3 diversity. Vaccine 1998, 16:1383-1390.
24. Desiderio S.V., Yancopoulos G.D., Paskind M., Thomas E., Boss M.A., Landau N., Alt F.W., Baltimore D. Insertion of N regions into heavy-chain genes is correlated with expression of terminal deoxytransferase in B cells. Nature 1984, 311:752-755.
25. Xu J.L., Davis M.M. Diversity in the CDR3 region of V(H) is sufficient for most antibody specificities. Immunity 2000, 13:37-45.
26. Ippolito G.C., Schelonka R.L., Zemlin M., Ivanov I.I., Kobayashi R., Zemlin C., Gartland G.L., Nitschke L., Pelkonen J., Fujihashi K., et al. Forced usage of positively charged amino acids in immunoglobulin CDR-H3 impairs B cell development and antibody production. J Exp Med 2006, 203:1567-1578.
27. Osmond D.G. The turnover of B-cell populations. Immunol Today 1993, 14:34-37.
28. Forster I., Rajewsky K. The bulk of the peripheral B-cell pool in mice is stable and not rapidly renewed from the bone marrow. Proc Natl Acad Sci U S A 1990, 87:4781-4784.
29. Thomas-Vaslin V., Freitas A.A. Lymphocyte population kinetics during the development of the immune system. B cell persistence and life-span can be determined by the host environment. Int Immunol 1989, 1:237-246.
30. Williams G.T., Jolly C.J., Kohler J., Neuberger M.S. The contribution of somatic hypermutation to the diversity of serum immunoglobulin: dramatic increase with age. Immunity 2000, 13:409-417.
31. Gaudin E., Rosado M., Agenes F., McLean A., Freitas A.A. B-cell homeostasis, competition, resources, and positive selection by self-antigens. Immunol Rev 2004, 197:102-115.
32. Crowley J.E., Treml L.S., Stadanlick J.E., Carpenter E., Cancro M.P. Homeostatic niche specification among naive and activated B cells: a growing role for the BLyS family of receptors and ligands. Semin Immunol 2005, 17:193-199.
33. Lam K.P., Kuhn R., Rajewsky K. In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death. Cell 1997, 90:1073-1083.
34. Hayakawa K., Asano M., Shinton S.A., Gui M., Allman D., Stewart C.L., Silver J., Hardy R.R. Positive selection of natural autoreactive B cells. Science 1999, 285:113-116.
35. Martin F., Kearney J.F. Positive selection from newly formed to marginal zone B cells depends on the rate of clonal production, CD19, and btk. Immunity 2000, 12:39-49.
36. Clayton E., Bardi G., Bell S.E., Chantry D., Downes C.P., Gray A., Humphries L.A., Rawlings D., Reynolds H., Vigorito E., et al. A crucial role for the p110delta subunit of phosphatidylinositol 3-kinase in B cell development and activation. J Exp Med 2002, 196:753-763.
37. Kraus M., Alimzhanov M.B., Rajewsky N., Rajewsky K. Survival of resting mature B lymphocytes depends on BCR signaling via the Igalpha/beta heterodimer. Cell 2004, 117:787-800.
38. Casola S., Otipoby K.L., Alimzhanov M., Humme S., Uyttersprot N., Kutok J.L., Carroll M.C., Rajewsky K. B cell receptor signal strength determines B cell fate. Nat Immunol 2004, 5:317-327.
39. Hardy R.R. Chapter 7: B lymphocyte development and biology. Fundamental Immunology 2008, 237-269. Williams & Wilkins, Lippincott. edn 6. W. Paul (Ed.).
40. Werner M. Chapter 6-proliferation and differentiation programs of developing B cells. Molecular Biology of B Cells 2015, 75-97. Academic Press. edn 2. W. Frederick, T.H. Alt, A. Radbruch, M. Reth (Eds.).
41. Kitamura D., Roes J., Kuhn R., Rajewsky K. A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin mu chain gene. Nature 1991, 350:423-426.
42. Monroe J.G. ITAM-mediated tonic signalling through pre-BCR and BCR complexes. Nat Rev Immunol 2006, 6:283-294.
43. Srinivasan L., Sasaki Y., Calado D.P., Zhang B., Paik J.H., DePinho R.A., Kutok J.L., Kearney J.F., Otipoby K.L., Rajewsky K. PI3 kinase signals BCR-dependent mature B cell survival. Cell 2009, 139:573-586.
44. Yang J., Reth M. Oligomeric organization of the B-cell antigen receptor on resting cells. Nature 2010, 467:465-469.
45. Stadanlick J.E., Kaileh M., Karnell F.G., Scholz J.L., Miller J.P., Quinn W.J., Brezski R.J., Treml L.S., Jordan K.A., Monroe J.G., et al. Tonic B cell antigen receptor signals supply an NF-kappaB substrate for prosurvival BLyS signaling. Nat Immunol 2008, 9:1379-1380.
46. Edry E., Melamed D. Receptor editing in positive and negative selection of B lymphopoiesis. J Immunol 2004, 173:4265-4271.
47. Cancro M.P. Peripheral B-cell maturation: the intersection of selection and homeostasis. Immunol Rev 2004, 197:89-101.
48. Aoki-Ota M., Torkamani A., Ota T., Schork N., Nemazee D. Skewed primary Igkappa repertoire and V-J joining in C57BL/6 mice: implications for recombination accessibility and receptor editing. J Immunol 2012, 188:2305-2315.
49. Glick G., Chang T.S., Jaap R.G. The bursa of Fabricius and antibody production. Poult Sci 1956, vol. 35:224.
50. Reynaud C.A., Anquez V., Grimal H., Weill J.C. A hyperconversion mechanism generates the chicken light chain preimmune repertoire. Cell 1987, 48:379-388.
51. Ratcliffe M.J. Generation of immunoglobulin heavy chain diversity subsequent to cell surface immunoglobulin expression in the avian bursa of Fabricius. J Exp Med 1989, 170:1165-1173.
52. Vajdy M., Sethupathi P., Knight K.L. Dependence of antibody somatic diversification on gut-associated lymphoid tissue in rabbits. J Immunol 1998, 160:2725-2729.
53. Lanning D., Zhu X., Zhai S.K., Knight K.L. Development of the antibody repertoire in rabbit: gut-associated lymphoid tissue, microbes, and selection. Immunol Rev 2000, 175:214-228.
54. Rhee K.J., Jasper P.J., Sethupathi P., Shanmugam M., Lanning D., Knight K.L. Positive selection of the peripheral B cell repertoire in gut-associated lymphoid tissues. J Exp Med 2005, 201:55-62.
55. Butler J.E., Sinkora M. The enigma of the lower gut-associated lymphoid tissue (GALT). J Leukoc Biol 2013, 94:259-270.
56. Ratcliffe M.J. Antibodies, immunoglobulin genes and the bursa of Fabricius in chicken B cell development. Dev Comp Immunol 2006, 30:101-118.
57. Shrestha A. Chapter 17-gut microbiota and their regulation. Molecular Biology of B Cells 2015, 293-304. Academic Press, Andreas Radbruch, Michael Reth. edn 2. W. Frederick, T.H. Alt (Eds.).
58. Mackie R.I., Sghir A., Gaskins H.R. Developmental microbial ecology of the neonatal gastrointestinal tract. Am J Clin Nutr 1999, 69:1035S-1045S.
59. Wesemann D.R. Microbes and B cell development. Adv Immunol 2015.
60. Vossenkamper A., Blair P.A., Safinia N., Fraser L.D., Das L., Sanders T.J., Stagg A.J., Sanderson J.D., Taylor K., Chang F., et al. A role for gut-associated lymphoid tissue in shaping the human B cell repertoire. J Exp Med 2013, 210:1665-1674.
61. Cahenzli J., Koller Y., Wyss M., Geuking M.B., McCoy K.D. Intestinal microbial diversity during early-life colonization shapes long-term IgE levels. Cell Host Microbe 2013, 14:559-570.
62. Olszak T., An D., Zeissig S., Vera M.P., Richter J., Franke A., Glickman J.N., Siebert R., Baron R.M., Kasper D.L., et al. Microbial exposure during early life has persistent effects on natural killer T cell function. Science 2012, 336:489-493.
63. McDaniel L.S., Scott G., Kearney J.F., Briles D.E. Monoclonal antibodies against protease-sensitive pneumococcal antigens can protect mice from fatal infection with Streptococcus pneumoniae. J Exp Med 1984, 160:386-397.
64. Binder C.J., Horkko S., Dewan A., Chang M.K., Kieu E.P., Goodyear C.S., Shaw P.X., Palinski W., Witztum J.L., Silverman G.J. Pneumococcal vaccination decreases atherosclerotic lesion formation: molecular mimicry between Streptococcus pneumoniae and oxidized LDL. Nat Med 2003, 9:736-743.
65. Pappas L., Foglierini M., Piccoli L., Kallewaard N.L., Turrini F., Silacci C., Fernandez-Rodriguez B., Agatic G., Giacchetto-Sasselli I., Pellicciotta G., et al. Rapid development of broadly influenza neutralizing antibodies through redundant mutations. Nature 2014.
66. Yang G., Holl T.M., Liu Y., Li Y., Lu X., Nicely N.I., Kepler T.B., Alam S.M., Liao H.X., Cain D.W., et al. Identification of autoantigens recognized by the 2F5 and 4E10 broadly neutralizing HIV-1 antibodies. J Exp Med 2013, 210:241-256.
67. Klein F., Mouquet H., Dosenovic P., Scheid J.F., Scharf L., Nussenzweig M.C. Antibodies in HIV-1 vaccine development and therapy. Science 2013, 341:1199-1204.
68. Voreades N., Kozil A., Weir T.L. Diet and the development of the human intestinal microbiome. Front Microbiol 2014, 5:494.
69. Kogut I., Scholz J.L., Cancro M.P., Cambier J.C. B cell maintenance and function in aging. Semin Immunol 2012, 24:342-349.