Soluble T cell immunoglobulin mucin domain 3 is shed from CD8+ T cells by the Sheddase ADAM10, is increased in plasma during untreated HIV infection, and correlates with HIV disease progression

Journal of Virology

Volumn 89, Issue 7, 2015, Pages 3723-3736

  Clayton, Kiera L ^a   Douglas Vail, Matthew B ^a   Nur ur Rahman, A K M ^a   Medcalf, Karyn E ^a   Xie, Irene Y ^a   Chew, Glen M ^b   Tandon, Ravi ^b,g   Lanteri, Marion C ^d   Norris, Philip J ^c,d   Deeks, Steven G ^c   Ndhlovu, Lishomwa C ^b   Ostrowski, Mario A ^a,e,f  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF HAWAII   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d BLOOD SYSTEMS RESEARCH INSTITUTE   (United States)

^e Maple Leaf Medical   (Canada)

^f ST MICHAEL'S HOSPITAL   (Canada)

^g JAWAHARLAL NEHRU UNIVERSITY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ADAM10 ENDOPEPTIDASE; ECALECTIN; GAMMA INTERFERON; MEMBRANE PROTEIN; T CELL IMMUNOGLOBULIN MUCIN DOMAIN 3; UNCLASSIFIED DRUG; ADAM PROTEIN; ADAM10 PROTEIN, HUMAN; BIOLOGICAL MARKER; HAVCR2 PROTEIN, HUMAN; SECRETASE;

APOPTOSIS; ARTICLE; CD4 LYMPHOCYTE COUNT; CD8+ T LYMPHOCYTE; CELL SURFACE; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE COURSE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROCESSING; PROTEIN SYNTHESIS; VIRUS LOAD; BLOOD; CHEMISTRY; HIV INFECTIONS; METABOLISM; PATHOLOGY; PLASMA; PROSPECTIVE STUDY;

ADAM PROTEINS; AMYLOID PRECURSOR PROTEIN SECRETASES; BIOMARKERS; CD4 LYMPHOCYTE COUNT; CD8-POSITIVE T-LYMPHOCYTES; COHORT STUDIES; DISEASE PROGRESSION; HIV INFECTIONS; HUMANS; MEMBRANE PROTEINS; PLASMA; PROSPECTIVE STUDIES; VIRAL LOAD;

EID: 84924794956     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.00006-15     Document Type: Article

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