Tim-3 regulates pro- and anti-inflammatory cytokine expression in human CD14 + monocytes

Journal of Leukocyte Biology

Volumn 91, Issue 2, 2012, Pages 189-196

  Zhang, Ying ^b,c   Ma, Cheng J ^b   Wang, Jia M ^b   Ji, Xiao J ^b   Wu, Xiao Y ^b   Moorman, Jonathan P ^a   Yao, Zhi Q ^a,c  

^a Veterans Administration   (United States)

^b East Tennessee State University   (United States)

^c FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

IL 12; Innate immune regulation; Macrophages; PD 1

Indexed keywords

CD14 ANTIGEN; INTERLEUKIN 10; INTERLEUKIN 12; MEMBRANE PROTEIN; TIM 3 PROTEIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ADAPTIVE IMMUNITY; ARTICLE; CYTOKINE RELEASE; GENE SILENCING; IMMUNE RESPONSE; INNATE IMMUNITY; MONOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; UPREGULATION;

ANTIBODIES; ANTIGENS, CD14; CYTOKINES; DOWN-REGULATION; GENE EXPRESSION REGULATION; HUMANS; IMMUNITY, INNATE; INTERLEUKIN-10; INTERLEUKIN-12; MACROPHAGES; MEMBRANE PROTEINS; MONOCYTES; PROGRAMMED CELL DEATH 1 RECEPTOR; RNA, SMALL INTERFERING; TOLL-LIKE RECEPTORS; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION;

EID: 84863012850     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.1010591     Document Type: Article

References (14)

1. Hafler, D. A., Kuchroo, V. (2008) TIMs: central regulators of immune responses. J. Exp. Med. 205, 2699-2701.
2. Nishimura, H., Honjo, T. (2001) PD-1: an inhibitory immunoreceptor involved in peripheral tolerance. Trends Immunol. 22, 265-268.
3. Anderson, A. C., Anderson, D. E., Bregoli, L., Hastings, W. D., Kassam, N., Lei, C., Chandwaskar, R., Karman, J., Su, E. W., Hirashima, M., Bruce J. N., Kane, L. P., Kuchroo, V. K., Hafler, D. A. (2007) Promotion of tissue inflammation by the immune receptor Tim-3 expressed on innate immune cells. Science 318, 1141-1143.
4. Dai, S. Y., Nakagawa, R., Itoh, A., Murakami, H., Kashio, Y., Abe, H., Ka-toh, S., Kontani, K., Kihara, M., Zhang, S. L., Hata, T., Nakamura, T., Yamauchi, A., Hirashima, M. (2005) Galectin-9 induces maturation of human monocyte-derived dendritic cells. J. Immunol. 175, 2974-2981.
5. Frisancho-Kiss, S., Coronado, M. J., Frisancho, J. A., Lau, V. M., Rose, N. R., Klein, S. L., Fairweather, D. (2009) Gonadectomy of male BALB/c mice increases Tim-3(+) alternatively activated M2 macrophages, Tim-3(+) T cells, Th2 cells and Treg in the heart during acute coxsackievirus-induced myocarditis. Brain Behav. Immun. 23, 649-657.
6. Frisancho-Kiss, S., Nyland, J. F., Davis, S. E., Barrett, M. A., Gatewood, S. J., Njoku, D. B., Cihakova, D., Silbergeld, E. K, Rose, N. R, Fair-weather, D. (2006) Cutting edge: T cell Ig mucin-3 reduces inflammatory heart disease by increasing CTLA-4 during innate immunity. J. Immunol. 176, 6411-6415.
7. Ju, Y., Hou, N., Meng, J., Wang, X., Zhang, X., Zhao, D., Liu, Y., Zhu, F., Zhang, L., Sun, W., Liang, X., Gao, L., Ma, C. (2010) T cell immunoglobulin- and mucin-domain-containing molecule-3 (Tim-3) mediates natural killer cell suppression in chronic hepatitis B. J. Hepatol. 52, 322-329.
8. Monney, L., Sabatos, C. A, Gaglia, J. L., Ryu, A, Waldner, H., Chernova, T., Manning, S., Greenfield, E. A, Coyle, A. J., Sobel, R A, Freeman, G. J., Kuchroo, V. K. (2002) Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease. Nature 415, 536-541.
9. Nakayama, M., Akiba, H., Takeda, K, Kojima, Y., Hashiguchi, M., Azuma, M., Yagita, H., Okumura, K (2009) Tim-3 mediates phagocytosis of apo- ptotic cells and cross-presentation. Blood 113, 3821-3830.
10. Seki, M., Oomizu, S., Sakata, K M., Sakata, A, Arikawa, T., Watanabe, K, Ito, K., Takeshita, K, Niki, T., Saita, N., Nishi, N., Yamauchi, A, Katoh, S., Matsukawa, A, Kuchroo, V., Hirashima, M. (2008) Galectin-9 suppresses the generation of Th17, promotes the induction of regulatory T cells, and regulates experimental autoimmune arthritis. Clin. Immunol. 127, 78-88.
11. Ma, C. J., Ni, L., Zhang, Y, Zhang, C. L., Wu, X. Y, Atia, A. N., Thayer, P., Moorman, J. P, Yao, Z. Q. (2011) PD-1 negatively regulates IL-12 expression by limiting STAT-1 phosphorylation in monocytes/macrophages during chronic hepatitis C infection. Immunology 132, 421-431.
12. Breckpot, K, Aerts-Toegaert, C, Heirman, C, Peeters, U., Beyaert, R, Aerts, J. L., Thielemans, K. (2009) Attenuated expression of A20 markedly increases the efficacy of double-stranded RNA-activated dendritic cells as an anti-cancer vaccine. J. Immunol. 182, 860-870.
13. Su, E. W., Bi, S., Kane, L. P. (2010) Galectin-9 regulates T helper cell function independently of Tim-3. Glycobiology, Epub ahead of print.
14. Matsuura, A, Tsukada, J., Mizobe, T., Higashi, T., Mouri, F., Tanikawa, R, Yamauchi, A, Hirashima, M., Tanaka, Y (2009) Intracellular galec-tin-9 activates inflammatory cytokines in monocytes. Genes Cells 14, 511-521.