Low cholesterol triggers membrane microdomain-dependent CD44 shedding and suppresses tumor cell migration

Journal of Biological Chemistry

Volumn 286, Issue 3, 2011, Pages 1999-2007

  Murai, Toshiyuki ^a   Maruyama, Yuusuke ^b   Mio, Kazuhiro ^b   Nishiyama, Hidetoshi ^c   Suga, Mitsuo ^c   Sato, Chikara ^b  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY AIST   (Japan)

^c JEOL LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CELL SURFACE ADHESION; CHOLESTEROL DEPLETION; CHOLESTEROL REDUCTION; COATED SUBSTRATES; EPIDERMAL GROWTH FACTORS; HYALURONAN; LIPID RAFT; LONG TERM; MALIGNANT TUMORS; MEMBRANE LIPIDS; METALLOPROTEINASES; MICRODOMAIN; MOLECULAR MECHANISM; PROTEOLYTIC CLEAVAGE; TUMOR CELL MIGRATION; TUMOR CELLS; TUMOR INVASION; TUMOR MICROENVIRONMENT;

CELL MEMBRANES; CHOLESTEROL; CYTOLOGY; ENZYME ACTIVITY; GLYCOSYLATION; LIPIDS;

TUMORS;

ADAM10 ENDOPEPTIDASE; CHOLESTEROL; HERMES ANTIGEN; HYALURONIC ACID; MEMBRANE LIPID; METHYL BETA CYCLODEXTRIN; SIMVASTATIN;

ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CELL MEMBRANE; CELL MIGRATION; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; DEPLETION; DRUG MECHANISM; GLIOBLASTOMA; HUMAN; HUMAN CELL; LIPID RAFT; MIGRATION INHIBITION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LIPID INTERACTION; PROTEIN LOCALIZATION;

ADAM PROTEINS; AMYLOID PRECURSOR PROTEIN SECRETASES; ANTIGENS, CD44; BETA-CYCLODEXTRINS; CELL LINE, TUMOR; CELL MOVEMENT; CHOLESTEROL; EPIDERMAL GROWTH FACTOR; GLIOMA; HUMANS; HYALURONIC ACID; MEMBRANE MICRODOMAINS; MEMBRANE PROTEINS; NEOPLASM METASTASIS; NEOPLASM PROTEINS;

EID: 78751479184     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.184010     Document Type: Article

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