-
1
-
-
84858766182
-
The blockade of immune checkpoints in cancer immunotherapy
-
Pardoll, D. M. 2012. The blockade of immune checkpoints in cancer immunotherapy. Nat. Rev. Cancer 12: 252-264.
-
(2012)
Nat. Rev. Cancer
, vol.12
, pp. 252-264
-
-
Pardoll, D.M.1
-
2
-
-
34247884612
-
The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection
-
DOI 10.1038/ni1443, PII NI1443
-
Sharpe, A. H., E. J. Wherry, R. Ahmed, and G. J. Freeman. 2007. The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection. Nat. Immunol. 8: 239-245. (Pubitemid 46745373)
-
(2007)
Nature Immunology
, vol.8
, Issue.3
, pp. 239-245
-
-
Sharpe, A.H.1
Wherry, E.J.2
Ahmed, R.3
Freeman, G.J.4
-
3
-
-
0037383592
-
Viral persistence alters CD8 T-cell immunodominance and tissue distribution and results in distinct stages of functional impairment
-
DOI 10.1128/JVI.77.8.4911-4927.2003
-
Wherry, E. J., J. N. Blattman, K. Murali-Krishna, R. van der Most, and R. Ahmed. 2003. Viral persistence alters CD8 T-cell immunodominance and tissue distribution and results in distinct stages of functional impairment. J. Virol. 77: 4911-4927. (Pubitemid 36402840)
-
(2003)
Journal of Virology
, vol.77
, Issue.8
, pp. 4911-4927
-
-
Wherry, E.J.1
Blattman, J.N.2
Murali-Krishna, K.3
Van Der Most, R.4
Ahmed, R.5
-
4
-
-
58149277359
-
Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infection
-
Jones, R. B., L. C. Ndhlovu, J. D. Barbour, P. M. Sheth, A. R. Jha, B. R. Long, J. C. Wong, M. Satkunarajah, M. Schweneker, J. M. Chapman, et al. 2008. Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infection. J. Exp. Med. 205: 2763-2779.
-
(2008)
J. Exp. Med.
, vol.205
, pp. 2763-2779
-
-
Jones, R.B.1
Ndhlovu, L.C.2
Barbour, J.D.3
Sheth, P.M.4
Jha, A.R.5
Long, B.R.6
Wong, J.C.7
Satkunarajah, M.8
Schweneker, M.9
Chapman, J.M.10
-
5
-
-
77956459371
-
HCV-specific T cells in HCV/HIV co-infection show elevated frequencies of dual Tim-3/PD-1 expression that correlate with liver disease progression
-
Vali, B., R. B. Jones, A. Sakhdari, P. M. Sheth, K. Clayton, F. Y. Yue, G. Gyenes, D. Wong, M. B. Klein, S. Saeed, et al. 2010. HCV-specific T cells in HCV/HIV co-infection show elevated frequencies of dual Tim-3/PD-1 expression that correlate with liver disease progression. Eur. J. Immunol. 40: 2493-2505.
-
(2010)
Eur. J. Immunol.
, vol.40
, pp. 2493-2505
-
-
Vali, B.1
Jones, R.B.2
Sakhdari, A.3
Sheth, P.M.4
Clayton, K.5
Yue, F.Y.6
Gyenes, G.7
Wong, D.8
Klein, M.B.9
Saeed, S.10
-
6
-
-
57849168934
-
Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection
-
Blackburn, S. D., H. Shin, W. N. Haining, T. Zou, C. J. Workman, A. Polley, M. R. Betts, G. J. Freeman, D. A. Vignali, and E. J. Wherry. 2009. Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection. Nat. Immunol. 10: 29-37.
-
(2009)
Nat. Immunol.
, vol.10
, pp. 29-37
-
-
Blackburn, S.D.1
Shin, H.2
Haining, W.N.3
Zou, T.4
Workman, C.J.5
Polley, A.6
Betts, M.R.7
Freeman, G.J.8
Vignali, D.A.9
Wherry, E.J.10
-
7
-
-
84863612769
-
Tim-3 negatively regulates cytotoxicity in exhausted CD8+ T cells in HIV infection
-
Sakhdari, A., S. Mujib, B. Vali, F. Y. Yue, S. MacParland, K. Clayton, R. B. Jones, J. Liu, E. Y. Lee, E. Benko, et al. 2012. Tim-3 negatively regulates cytotoxicity in exhausted CD8+ T cells in HIV infection. PLoS ONE 7: e40146.
-
(2012)
PLoS ONE
, vol.7
-
-
Sakhdari, A.1
Mujib, S.2
Vali, B.3
Yue, F.Y.4
MacParland, S.5
Clayton, K.6
Jones, R.B.7
Liu, J.8
Lee, E.Y.9
Benko, E.10
-
8
-
-
77951673268
-
TIM genes: A family of cell surface phosphatidylserine receptors that regulate innate and adaptive immunity
-
Freeman, G. J., J. M. Casasnovas, D. T. Umetsu, and R. H. DeKruyff. 2010. TIM genes: a family of cell surface phosphatidylserine receptors that regulate innate and adaptive immunity. Immunol. Rev. 235: 172-189.
-
(2010)
Immunol. Rev.
, vol.235
, pp. 172-189
-
-
Freeman, G.J.1
Casasnovas, J.M.2
Umetsu, D.T.3
Dekruyff, R.H.4
-
9
-
-
0037203867
-
Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease
-
DOI 10.1038/415536a
-
Monney, L., C. A. Sabatos, J. L. Gaglia, A. Ryu, H. Waldner, T. Chernova, S. Manning, E. A. Greenfield, A. J. Coyle, R. A. Sobel, et al. 2002. Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease. Nature 415: 536-541. (Pubitemid 34130609)
-
(2002)
Nature
, vol.415
, Issue.6871
, pp. 536-541
-
-
Monney, L.1
Sabatos, C.A.2
Gaglia, J.L.3
Ryu, A.4
Waldner, H.5
Chernova, T.6
Manning, S.7
Greenfield, E.A.8
Coyle, A.J.9
Sobel, R.A.10
Freeman, G.J.11
Kuchroo, V.K.12
-
10
-
-
70349248367
-
TIM-3 is expressed on activated human CD4+ T cells and regulates Th1 and Th17 cytokines
-
Hastings, W. D., D. E. Anderson, N. Kassam, K. Koguchi, E. A. Greenfield, S. C. Kent, X. X. Zheng, T. B. Strom, D. A. Hafler, and V. K. Kuchroo. 2009. TIM-3 is expressed on activated human CD4+ T cells and regulates Th1 and Th17 cytokines. Eur. J. Immunol. 39: 2492-2501.
-
(2009)
Eur. J. Immunol.
, vol.39
, pp. 2492-2501
-
-
Hastings, W.D.1
Anderson, D.E.2
Kassam, N.3
Koguchi, K.4
Greenfield, E.A.5
Kent, S.C.6
Zheng, X.X.7
Strom, T.B.8
Hafler, D.A.9
Kuchroo, V.K.10
-
11
-
-
40849120400
-
Galectin-9 suppresses the generation of Th17, promotes the induction of regulatory T cells, and regulates experimental autoimmune arthritis
-
Seki, M., S. Oomizu, K. M. Sakata, A. Sakata, T. Arikawa, K. Watanabe, K. Ito, K. Takeshita, T. Niki, N. Saita, et al. 2008. Galectin-9 suppresses the generation of Th17, promotes the induction of regulatory T cells, and regulates experimental autoimmune arthritis. Clin. Immunol. 127: 78-88.
-
(2008)
Clin. Immunol.
, vol.127
, pp. 78-88
-
-
Seki, M.1
Oomizu, S.2
Sakata, K.M.3
Sakata, A.4
Arikawa, T.5
Watanabe, K.6
Ito, K.7
Takeshita, K.8
Niki, T.9
Saita, N.10
-
12
-
-
77549086947
-
T cell immunoglobulin-and mucin-domain-containing molecule-3 (Tim-3) mediates natural killer cell suppression in chronic hepatitis B
-
Ju, Y., N. Hou, J. Meng, X. Wang, X. Zhang, D. Zhao, Y. Liu, F. Zhu, L. Zhang, W. Sun, et al. 2010. T cell immunoglobulin-and mucin-domain-containing molecule-3 (Tim-3) mediates natural killer cell suppression in chronic hepatitis B. J. Hepatol. 52: 322-329.
-
(2010)
J. Hepatol.
, vol.52
, pp. 322-329
-
-
Ju, Y.1
Hou, N.2
Meng, J.3
Wang, X.4
Zhang, X.5
Zhao, D.6
Liu, Y.7
Zhu, F.8
Zhang, L.9
Sun, W.10
-
13
-
-
36248967595
-
Promotion of tissue inflammation by the immune receptor Tim-3 expressed on innate immune cells
-
DOI 10.1126/science.1148536
-
Anderson, A. C., D. E. Anderson, L. Bregoli, W. D. Hastings, N. Kassam, C. Lei, R. Chandwaskar, J. Karman, E. W. Su, M. Hirashima, et al. 2007. Promotion of tissue inflammation by the immune receptor Tim-3 expressed on innate immune cells. Science 318: 1141-1143. (Pubitemid 350134897)
-
(2007)
Science
, vol.318
, Issue.5853
, pp. 1141-1143
-
-
Anderson, A.C.1
Anderson, D.E.2
Bregoli, L.3
Hastings, W.D.4
Kassam, N.5
Lei, C.6
Chandwaskar, R.7
Karman, J.8
Su, E.W.9
Hirashima, M.10
Bruce, J.N.11
Kane, L.P.12
Kuchroo, V.K.13
Hafler, D.A.14
-
14
-
-
84856733781
-
Extended co-expression of inhibitory receptors by human CD8 T-cells depending on differentiation, antigen-specificity and anatomical localization
-
Baitsch, L., A. Legat, L. Barba, S. A. Fuertes Marraco, J. P. Rivals, P. Baumgaertner, C. Christiansen-Jucht, H. Bouzourene, D. Rimoldi, H. Pircher, et al. 2012. Extended co-expression of inhibitory receptors by human CD8 T-cells depending on differentiation, antigen-specificity and anatomical localization. PLoS ONE 7: e30852.
-
(2012)
PLoS ONE
, vol.7
-
-
Baitsch, L.1
Legat, A.2
Barba, L.3
Fuertes Marraco, S.A.4
Rivals, J.P.5
Baumgaertner, P.6
Christiansen-Jucht, C.7
Bouzourene, H.8
Rimoldi, D.9
Pircher, H.10
-
15
-
-
84860337409
-
Tim-3 marks human natural killer cell maturation and suppresses cell-mediated cytotoxicity
-
Ndhlovu, L. C., S. Lopez-Vergès, J. D. Barbour, R. B. Jones, A. R. Jha, B. R. Long, E. C. Schoeffler, T. Fujita, D. F. Nixon, and L. L. Lanier. 2012. Tim-3 marks human natural killer cell maturation and suppresses cell-mediated cytotoxicity. Blood 119: 3734-3743.
-
(2012)
Blood
, vol.119
, pp. 3734-3743
-
-
Ndhlovu, L.C.1
Lopez-Vergès, S.2
Barbour, J.D.3
Jones, R.B.4
Jha, A.R.5
Long, B.R.6
Schoeffler, E.C.7
Fujita, T.8
Nixon, D.F.9
Lanier, L.L.10
-
16
-
-
65549168745
-
Tim-3 mediates phagocytosis of apoptotic cells and cross-presentation
-
Nakayama, M., H. Akiba, K. Takeda, Y. Kojima, M. Hashiguchi, M. Azuma, H. Yagita, and K. Okumura. 2009. Tim-3 mediates phagocytosis of apoptotic cells and cross-presentation. Blood 113: 3821-3830.
-
(2009)
Blood
, vol.113
, pp. 3821-3830
-
-
Nakayama, M.1
Akiba, H.2
Takeda, K.3
Kojima, Y.4
Hashiguchi, M.5
Azuma, M.6
Yagita, H.7
Okumura, K.8
-
17
-
-
30044434075
-
The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity
-
DOI 10.1038/ni1271, PII N1271
-
Zhu, C., A. C. Anderson, A. Schubart, H. Xiong, J. Imitola, S. J. Khoury, X. X. Zheng, T. B. Strom, and V. K. Kuchroo. 2005. The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity. Nat. Immunol. 6: 1245-1252. (Pubitemid 43045636)
-
(2005)
Nature Immunology
, vol.6
, Issue.12
, pp. 1245-1252
-
-
Zhu, C.1
Anderson, A.C.2
Schubart, A.3
Xiong, H.4
Imitola, J.5
Khoury, S.J.6
Zheng, X.X.7
Strom, T.B.8
Kuchroo, V.K.9
-
18
-
-
34447267678
-
Galectin-9 inhibits CD44-hyaluronan interaction and suppresses a murine model of allergic asthma
-
DOI 10.1164/rccm.200608-1243OC
-
Katoh, S., N. Ishii, A. Nobumoto, K. Takeshita, S. Y. Dai, R. Shinonaga, T. Niki, N. Nishi, A. Tominaga, A. Yamauchi, and M. Hirashima. 2007. Galectin-9 inhibits CD44-hyaluronan interaction and suppresses a murine model of allergic asthma. Am. J. Respir. Crit. Care Med. 176: 27-35. (Pubitemid 47048051)
-
(2007)
American Journal of Respiratory and Critical Care Medicine
, vol.176
, Issue.1
, pp. 27-35
-
-
Katoh, S.1
Ishii, N.2
Nobumoto, A.3
Takeshita, K.4
Dai, S.-Y.5
Shinonaga, R.6
Niki, T.7
Nishi, N.8
Tominaga, A.9
Yamauchi, A.10
Hirashima, M.11
-
19
-
-
79960601577
-
Galectin-9 binding to cell surface protein disulfide isomerase regulates the redox environment to enhance T-cell migration and HIV entry
-
Bi, S., P. W. Hong, B. Lee, and L. G. Baum. 2011. Galectin-9 binding to cell surface protein disulfide isomerase regulates the redox environment to enhance T-cell migration and HIV entry. Proc. Natl. Acad. Sci. USA 108: 10650-10655.
-
(2011)
Proc. Natl. Acad. Sci. USA
, vol.108
, pp. 10650-10655
-
-
Bi, S.1
Hong, P.W.2
Lee, B.3
Baum, L.G.4
-
21
-
-
78649903057
-
Tim-3 expression on PD-1+ HCV-specific human CTLs is associated with viral persistence, and its blockade restores hepatocyte-directed in vitro cytotoxicity
-
McMahan, R. H., L. Golden-Mason, M. I. Nishimura, B. J. McMahon, M. Kemper, T. M. Allen, D. R. Gretch, and H. R. Rosen. 2010. Tim-3 expression on PD-1+ HCV-specific human CTLs is associated with viral persistence, and its blockade restores hepatocyte-directed in vitro cytotoxicity. J. Clin. Invest. 120: 4546-4557.
-
(2010)
J. Clin. Invest.
, vol.120
, pp. 4546-4557
-
-
McMahan, R.H.1
Golden-Mason, L.2
Nishimura, M.I.3
McMahon, B.J.4
Kemper, M.5
Allen, T.M.6
Gretch, D.R.7
Rosen, H.R.8
-
22
-
-
77957059176
-
Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection
-
Jin, H. T., A. C. Anderson, W. G. Tan, E. E. West, S. J. Ha, K. Araki, G. J. Freeman, V. K. Kuchroo, and R. Ahmed. 2010. Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection. Proc. Natl. Acad. Sci. USA 107: 14733-14738.
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 14733-14738
-
-
Jin, H.T.1
Anderson, A.C.2
Tan, W.G.3
West, E.E.4
Ha, S.J.5
Araki, K.6
Freeman, G.J.7
Kuchroo, V.K.8
Ahmed, R.9
-
23
-
-
69449091993
-
Negative immune regulator Tim-3 is overexpressed on T cells in hepatitis C virus infection and its blockade rescues dysfunctional CD4+ and CD8+ T cells
-
Golden-Mason, L., B. E. Palmer, N. Kassam, L. Townshend-Bulson, S. Livingston, B. J. McMahon, N. Castelblanco, V. Kuchroo, D. R. Gretch, and H. R. Rosen. 2009. Negative immune regulator Tim-3 is overexpressed on T cells in hepatitis C virus infection and its blockade rescues dysfunctional CD4+ and CD8+ T cells. J. Virol. 83: 9122-9130.
-
(2009)
J. Virol.
, vol.83
, pp. 9122-9130
-
-
Golden-Mason, L.1
Palmer, B.E.2
Kassam, N.3
Townshend-Bulson, L.4
Livingston, S.5
McMahon, B.J.6
Castelblanco, N.7
Kuchroo, V.8
Gretch, D.R.9
Rosen, H.R.10
-
24
-
-
33750530833
-
A highly conserved tyrosine of Tim-3 is phosphorylated upon stimulation by its ligand galectin-9
-
DOI 10.1016/j.bbrc.2006.10.079, PII S0006291X06023369
-
van de Weyer, P. S., M. Muehlfeit, C. Klose, J. V. Bonventre, G. Walz, and E. W. Kuehn. 2006. A highly conserved tyrosine of Tim-3 is phosphorylated upon stimulation by its ligand galectin-9. Biochem. Biophys. Res. Commun. 351: 571-576. (Pubitemid 44666725)
-
(2006)
Biochemical and Biophysical Research Communications
, vol.351
, Issue.2
, pp. 571-576
-
-
Van De Weyer, P.S.1
Muehlfeit, M.2
Klose, C.3
Bonventre, J.V.4
Walz, G.5
Kuehn, E.W.6
-
25
-
-
79952756344
-
Dysregulation of TIM-3-galectin-9 pathway in the cystic fibrosis airways
-
Vega-Carrascal, I., E. P. Reeves, T. Niki, T. Arikawa, P. McNally, S. J. O'Neill, M. Hirashima, and N. G. McElvaney. 2011. Dysregulation of TIM-3-galectin-9 pathway in the cystic fibrosis airways. J. Immunol. 186: 2897-2909.
-
(2011)
J. Immunol.
, vol.186
, pp. 2897-2909
-
-
Vega-Carrascal, I.1
Reeves, E.P.2
Niki, T.3
Arikawa, T.4
McNally, P.5
O'Neill, S.J.6
Hirashima, M.7
McElvaney, N.G.8
-
26
-
-
80053608320
-
Phosphotyrosine-dependent coupling of Tim-3 to T-cell receptor signaling pathways
-
Lee, J., E. W. Su, C. Zhu, S. Hainline, J. Phuah, J. A. Moroco, T. E. Smithgall, V. K. Kuchroo, and L. P. Kane. 2011. Phosphotyrosine-dependent coupling of Tim-3 to T-cell receptor signaling pathways. Mol. Cell. Biol. 31: 3963-3974.
-
(2011)
Mol. Cell. Biol.
, vol.31
, pp. 3963-3974
-
-
Lee, J.1
Su, E.W.2
Zhu, C.3
Hainline, S.4
Phuah, J.5
Moroco, J.A.6
Smithgall, T.E.7
Kuchroo, V.K.8
Kane, L.P.9
-
27
-
-
84868669212
-
Bat3 promotes T cell responses and autoimmunity by repressing Tim-3-mediated cell death and exhaustion
-
Rangachari, M., C. Zhu, K. Sakuishi, S. Xiao, J. Karman, A. Chen, M. Angin, A. Wakeham, E. A. Greenfield, R. A. Sobel, et al. 2012. Bat3 promotes T cell responses and autoimmunity by repressing Tim-3-mediated cell death and exhaustion. Nat. Med. 18: 1394-1400.
-
(2012)
Nat. Med.
, vol.18
, pp. 1394-1400
-
-
Rangachari, M.1
Zhu, C.2
Sakuishi, K.3
Xiao, S.4
Karman, J.5
Chen, A.6
Angin, M.7
Wakeham, A.8
Greenfield, E.A.9
Sobel, R.A.10
-
28
-
-
84865389598
-
Down-regulation of interleukin-2 production by CD4(+) T cells expressing TIM-3 through suppression of NFAT dephosphorylation and AP-1 transcription
-
Lee, M. J., M. Y. Woo, Y. J. Chwae, M. H. Kwon, K. Kim, and S. Park. 2012. Down-regulation of interleukin-2 production by CD4(+) T cells expressing TIM-3 through suppression of NFAT dephosphorylation and AP-1 transcription. Immunobiology 217: 986-995.
-
(2012)
Immunobiology
, vol.217
, pp. 986-995
-
-
Lee, M.J.1
Woo, M.Y.2
Chwae, Y.J.3
Kwon, M.H.4
Kim, K.5
Park, S.6
-
29
-
-
84860330727
-
Antigen-independent induction of Tim-3 expression on human T cells by the common γ-chain cytokines IL-2, IL-7, IL-15, and IL-21 is associated with proliferation and is dependent on the phosphoinositide 3-kinase pathway
-
Mujib, S., R. B. Jones, C. Lo, N. Aidarus, K. Clayton, A. Sakhdari, E. Benko, C. Kovacs, and M. A. Ostrowski. 2012. Antigen-independent induction of Tim-3 expression on human T cells by the common γ-chain cytokines IL-2, IL-7, IL-15, and IL-21 is associated with proliferation and is dependent on the phosphoinositide 3-kinase pathway. J. Immunol. 188: 3745-3756.
-
(2012)
J. Immunol.
, vol.188
, pp. 3745-3756
-
-
Mujib, S.1
Jones, R.B.2
Lo, C.3
Aidarus, N.4
Clayton, K.5
Sakhdari, A.6
Benko, E.7
Kovacs, C.8
Ostrowski, M.A.9
-
30
-
-
46749132717
-
Chronic lymphocytic leukemia T cells show impaired immunological synapse formation that can be reversed with an immunomodulating drug
-
DOI 10.1172/JC135017
-
Ramsay, A. G., A. J. Johnson, A. M. Lee, G. Gorgün, R. Le Dieu, W. Blum, J. C. Byrd, and J. G. Gribben. 2008. Chronic lymphocytic leukemia T cells show impaired immunological synapse formation that can be reversed with an immunomodulating drug. J. Clin. Invest. 118: 2427-2437. (Pubitemid 351949771)
-
(2008)
Journal of Clinical Investigation
, vol.118
, Issue.7
, pp. 2427-2437
-
-
Ramsay, A.G.1
Johnson, A.J.2
Lee, A.M.3
Gorgun, G.4
Dieu, R.L.5
Blum, W.6
Byrd, J.C.7
Gribben, J.G.8
-
31
-
-
33645295218
-
Lipid rafts in T cell receptor signalling
-
Kabouridis, P. S. 2006. Lipid rafts in T cell receptor signalling. Mol. Membr. Biol. 23: 49-57.
-
(2006)
Mol. Membr. Biol.
, vol.23
, pp. 49-57
-
-
Kabouridis, P.S.1
-
32
-
-
77951643625
-
A new type of membrane raft-like microdomains and their possible involvement in TCR signaling
-
Otáhal, P., P. Angelisová, M. Hrdinka, T. Brdicka, P. Novák, K. Drbal, and V. Horejsí. 2010. A new type of membrane raft-like microdomains and their possible involvement in TCR signaling. J. Immunol. 184: 3689-3696.
-
(2010)
J. Immunol.
, vol.184
, pp. 3689-3696
-
-
Otáhal, P.1
Angelisová, P.2
Hrdinka, M.3
Brdicka, T.4
Novák, P.5
Drbal, K.6
Horejsí, V.7
-
33
-
-
84873088843
-
Lck, membrane microdomains, and TCR triggering machinery: Defining the new rules of engagement
-
Filipp, D., O. Ballek, and J. Manning. 2012. Lck, Membrane Microdomains, and TCR Triggering Machinery: Defining the New Rules of Engagement. Front. Immunol. 3: 155.
-
(2012)
Front. Immunol.
, vol.3
, pp. 155
-
-
Filipp, D.1
Ballek, O.2
Manning, J.3
-
34
-
-
0036669692
-
Wiskott-Aldrich syndrome protein regulates lipid raft dynamics during immunological synapse formation
-
DOI 10.1016/S1074-7613(02)00360-6
-
Dupré, L., A. Aiuti, S. Trifari, S. Martino, P. Saracco, C. Bordignon, and M. G. Roncarolo. 2002. Wiskott-Aldrich syndrome protein regulates lipid raft dynamics during immunological synapse formation. Immunity 17: 157-166. (Pubitemid 35245958)
-
(2002)
Immunity
, vol.17
, Issue.2
, pp. 157-166
-
-
Dupre, L.1
Aiuti, A.2
Trifari, S.3
Martino, S.4
Saracco, P.5
Bordignon, C.6
Roncarolo, M.-G.7
-
35
-
-
33646137152
-
Immunological synapse and microclusters: The site for recognition and activation of T cells
-
Saito, T., and T. Yokosuka. 2006. Immunological synapse and microclusters: the site for recognition and activation of T cells. Curr. Opin. Immunol. 18: 305-313.
-
(2006)
Curr. Opin. Immunol.
, vol.18
, pp. 305-313
-
-
Saito, T.1
Yokosuka, T.2
-
36
-
-
84875463042
-
Molecular mechanisms of T cell co-stimulation and co-inhibition
-
Chen, L., and D. B. Flies. 2013. Molecular mechanisms of T cell co-stimulation and co-inhibition. Nat. Rev. Immunol. 13: 227-242.
-
(2013)
Nat. Rev. Immunol.
, vol.13
, pp. 227-242
-
-
Chen, L.1
Flies, D.B.2
-
37
-
-
33947190606
-
T Cell Immunoglobulin Mucin-3 Crystal Structure Reveals a Galectin-9-Independent Ligand-Binding Surface
-
DOI 10.1016/j.immuni.2007.01.016, PII S1074761307001781
-
Cao, E., X. Zang, U. A. Ramagopal, A. Mukhopadhaya, A. Fedorov, E. Fedorov, W. D. Zencheck, J. W. Lary, J. L. Cole, H. Deng, et al. 2007. T cell immunoglobulin mucin-3 crystal structure reveals a galectin-9-independent ligandbinding surface. Immunity 26: 311-321. (Pubitemid 46413908)
-
(2007)
Immunity
, vol.26
, Issue.3
, pp. 311-321
-
-
Cao, E.1
Zang, X.2
Ramagopal, U.A.3
Mukhopadhaya, A.4
Fedorov, A.5
Fedorov, E.6
Zencheck, W.D.7
Lary, J.W.8
Cole, J.L.9
Deng, H.10
Xiao, H.11
DiLorenzo, T.P.12
Allison, J.P.13
Nathenson, S.G.14
Almo, S.C.15
-
38
-
-
84864324543
-
Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2
-
Yokosuka, T., M. Takamatsu, W. Kobayashi-Imanishi, A. Hashimoto-Tane, M. Azuma, and T. Saito. 2012. Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2. J. Exp. Med. 209: 1201-1217.
-
(2012)
J. Exp. Med.
, vol.209
, pp. 1201-1217
-
-
Yokosuka, T.1
Takamatsu, M.2
Kobayashi-Imanishi, W.3
Hashimoto-Tane, A.4
Azuma, M.5
Saito, T.6
-
39
-
-
68949085309
-
LFA-1 regulates CD8+ T cell activation via T cell receptor-mediated and LFA-1-mediated Erk1/2 signal pathways
-
Li, D., J. J. Molldrem, and Q. Ma. 2009. LFA-1 regulates CD8+ T cell activation via T cell receptor-mediated and LFA-1-mediated Erk1/2 signal pathways. J. Biol. Chem. 284: 21001-21010.
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 21001-21010
-
-
Li, D.1
Molldrem, J.J.2
Ma, Q.3
-
40
-
-
84874485209
-
Initiation of TCR phosphorylation and signal transduction
-
Gascoigne, N. R., J. Casas, J. Brzostek, and V. Rybakin. 2011. Initiation of TCR phosphorylation and signal transduction. Front. Immunol. 2: 72.
-
(2011)
Front. Immunol.
, vol.2
, pp. 72
-
-
Gascoigne, N.R.1
Casas, J.2
Brzostek, J.3
Rybakin, V.4
-
41
-
-
84864002423
-
Role of LAT in the granule-mediated cytotoxicity of CD8 T cells
-
Ou-Yang, C. W., M. Zhu, D. M. Fuller, S. A. Sullivan, M. I. Chuck, S. Ogden, Q. J. Li, and W. Zhang. 2012. Role of LAT in the granule-mediated cytotoxicity of CD8 T cells. Mol. Cell. Biol. 32: 2674-2684.
-
(2012)
Mol. Cell. Biol.
, vol.32
, pp. 2674-2684
-
-
Ou-Yang, C.W.1
Zhu, M.2
Fuller, D.M.3
Sullivan, S.A.4
Chuck, M.I.5
Ogden, S.6
Li, Q.J.7
Zhang, W.8
-
42
-
-
34548679868
-
The differential regulation of lck kinase phosphorylation sites by CD45 is critical for T cell receptor signaling responses
-
DOI 10.1016/j.immuni.2007.07.015, PII S1074761307003810
-
McNeill, L., R. J. Salmond, J. C. Cooper, C. K. Carret, R. L. Cassady-Cain, M. Roche-Molina, P. Tandon, N. Holmes, and D. R. Alexander. 2007. The differential regulation of Lck kinase phosphorylation sites by CD45 is critical for T cell receptor signaling responses. Immunity 27: 425-437. (Pubitemid 47418669)
-
(2007)
Immunity
, vol.27
, Issue.3
, pp. 425-437
-
-
McNeill, L.1
Salmond, R.J.2
Cooper, J.C.3
Carret, C.K.4
Cassady-Cain, R.L.5
Roche-Molina, M.6
Tandon, P.7
Holmes, N.8
Alexander, D.R.9
-
43
-
-
84875980266
-
TIM-3 does not act as a receptor for galectin-9
-
Leitner, J., A. Rieger, W. F. Pickl, G. Zlabinger, K. Grabmeier-Pfistershammer, and P. Steinberger. 2013. TIM-3 does not act as a receptor for galectin-9. PLoS Pathog. 9: e1003253.
-
(2013)
PLoS Pathog.
, vol.9
-
-
Leitner, J.1
Rieger, A.2
Pickl, W.F.3
Zlabinger, G.4
Grabmeier-Pfistershammer, K.5
Steinberger, P.6
-
44
-
-
0041976988
-
The tyrosine phosphatase CD148 is excluded from the immunologic synapse and down-regulates prolonged T cell signaling
-
DOI 10.1083/jcb.200303040
-
Lin, J., and A. Weiss. 2003. The tyrosine phosphatase CD148 is excluded from the immunologic synapse and down-regulates prolonged T cell signaling. J. Cell Biol. 162: 673-682. (Pubitemid 37022944)
-
(2003)
Journal of Cell Biology
, vol.162
, Issue.4
, pp. 673-682
-
-
Lin, J.1
Weiss, A.2
-
45
-
-
34547131554
-
Analysis of protein complexes using mass spectrometry
-
DOI 10.1038/nrm2208, PII NRM2208
-
Gingras, A. C., M. Gstaiger, B. Raught, and R. Aebersold. 2007. Analysis of protein complexes using mass spectrometry. Nat. Rev. Mol. Cell Biol. 8: 645-654. (Pubitemid 47106612)
-
(2007)
Nature Reviews Molecular Cell Biology
, vol.8
, Issue.8
, pp. 645-654
-
-
Gingras, A.-C.1
Gstaiger, M.2
Raught, B.3
Aebersold, R.4
-
46
-
-
77949962019
-
CD45-Csk phosphatase-kinase titration uncouples basal and inducible T cell receptor signaling during thymic development
-
Zikherman, J., C. Jenne, S. Watson, K. Doan, W. Raschke, C. C. Goodnow, and A. Weiss. 2010. CD45-Csk phosphatase-kinase titration uncouples basal and inducible T cell receptor signaling during thymic development. Immunity 32: 342-354.
-
(2010)
Immunity
, vol.32
, pp. 342-354
-
-
Zikherman, J.1
Jenne, C.2
Watson, S.3
Doan, K.4
Raschke, W.5
Goodnow, C.C.6
Weiss, A.7
-
47
-
-
61849136595
-
CD45, CD148, and Lyp/Pep: Critical phosphatases regulating Src family kinase signaling networks in immune cells
-
Hermiston, M. L., J. Zikherman, and J. W. Zhu. 2009. CD45, CD148, and Lyp/Pep: critical phosphatases regulating Src family kinase signaling networks in immune cells. Immunol. Rev. 228: 288-311.
-
(2009)
Immunol. Rev.
, vol.228
, pp. 288-311
-
-
Hermiston, M.L.1
Zikherman, J.2
Zhu, J.W.3
-
48
-
-
84884561907
-
Molecular pathways: Coexpression of immune checkpoint molecules: Signaling pathways and implications for cancer immunotherapy
-
Nirschl, C. J., and C. G. Drake. 2013. Molecular pathways: coexpression of immune checkpoint molecules: signaling pathways and implications for cancer immunotherapy. Clin. Cancer Res. 19: 4917-4924.
-
(2013)
Clin. Cancer Res.
, vol.19
, pp. 4917-4924
-
-
Nirschl, C.J.1
Drake, C.G.2
|