Structure-activity relationship studies toward the discovery of selective apelin receptor agonists

Journal of Medicinal Chemistry

Volumn 57, Issue 7, 2014, Pages 2908-2919

  Margathe, Jean François ^a   Iturrioz, Xavier ^b   Alvear Perez, Rodrigo ^b   Marsol, Claire ^a   Riché, Stéphanie ^a   Chabane, Hadjila ^b   Tounsi, Nassera ^a   Kuhry, Maxime ^a   Heissler, Denis ^a   Hibert, Marcel ^a   Llorens Cortes, Catherine ^b   Bonnet, Dominique ^a  

^a UNIVERSITÉ DE STRASBOURG   (France)

^b PSL RESEARCH UNIVERSITY   (France)

Author keywords

[No Author keywords available]

Indexed keywords

(2 IMINO 3 METHYL 2,3 DIHYDROTHIAZOL 4 YL)ACETIC ACID HYDROCHLORIDE; 2 (TERT BUTOXYCARBONYLIMINO 3 METHYL 2,3 DIHYDROTHIAZOL 4 YL)ACETIC ACID; AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS; APELIN; APELIN 17; APELIN RECEPTOR; APELIN RECEPTOR AGONIST; CYCLIC AMP; METHYL(2 IMINO 3 METHYL 2,3 DIHYDROTHIAZOL 4 YL)ACETATE HYDROIODIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CHEMICAL STRUCTURE; CHO CELL; CONTROLLED STUDY; DRUG STABILITY; DRUG SYNTHESIS; FEMALE; HUMAN; INTERNALIZATION; NONHUMAN; PLASMA; PLASMA HALF LIFE; SIGNAL TRANSDUCTION; SOLID; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ANIMALS; CHO CELLS; CRICETULUS; CYCLIC AMP; DIPEPTIDES; DRUG DISCOVERY; FLUORESCEINS; LIGANDS; MICE; MOLECULAR STRUCTURE; PLASMA; RATS; RECEPTOR, ANGIOTENSIN, TYPE 1; RECEPTORS, G-PROTEIN-COUPLED; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84898444177     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm401789v     Document Type: Article

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