New structural insights into the apelin receptor: Identification of key residues for apelin binding

FASEB Journal

Volumn 29, Issue 1, 2015, Pages 314-322

  Gerbier, Romain ^a,b,c   Leroux, Vincent ^a,b,c   Couvineau, Pierre ^a,b,c   Alvear Perez, Rodrigo ^a,b,c   Maigret, Bernard ^a,b,c   Llorens Cortes, Catherine ^a,b,c   Iturrioz, Xavier ^a,b,c  

^a PSL RESEARCH UNIVERSITY   (France)

^b CNRS   (France)

^c INSERM   (France)

Author keywords

APJ; G protein coupled receptor; Homology models; Molecular modeling; Site directed mutagenesis

Indexed keywords

APELIN; APELIN RECEPTOR; CHEMOKINE RECEPTOR CXCR4; CHOLECYSTOKININ RECEPTOR; RADIOLIGAND; APLN PROTEIN, HUMAN; APLNR PROTEIN, HUMAN; APLNR PROTEIN, RAT; CYCLIC AMP; G PROTEIN COUPLED RECEPTOR; HYBRID PROTEIN; MULTIPROTEIN COMPLEX; SIGNAL PEPTIDE;

APPARENT DISSOCIATION CONSTANT; ARTICLE; BINDING SITE; CAMP ASSAY; GENETIC TRANSFECTION; HOMEOSTASIS; HUMAN; INTERNALIZATION; MOLECULAR DYNAMICS; MOLECULAR MODEL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN STRUCTURE; RAT MUTANT; SITE DIRECTED MUTAGENESIS; WILD TYPE; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMAL; BIOSYNTHESIS; CHEMICAL STRUCTURE; CHEMISTRY; GENETICS; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PROTEIN CONFORMATION; RAT; SEQUENCE HOMOLOGY; STRUCTURAL HOMOLOGY;

RATTUS;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; BINDING SITES; CONSERVED SEQUENCE; CYCLIC AMP; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MULTIPROTEIN COMPLEXES; MUTAGENESIS, SITE-DIRECTED; PROTEIN CONFORMATION; RATS; RECEPTORS, G-PROTEIN-COUPLED; RECOMBINANT FUSION PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; STRUCTURAL HOMOLOGY, PROTEIN;

EID: 84924661032     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.14-256339     Document Type: Article

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