An Inducible Lentiviral Guide RNA Platform Enables the Identification of Tumor-Essential Genes and Tumor-Promoting Mutations InVivo

Cell Reports

Volumn 10, Issue 8, 2015, Pages 1422-1432

  Aubrey, Brandon J ^a,b,c   Kelly, Gemma L ^a,b   Kueh, Andrew J ^a,b   Brennan, Margs S ^a,b   O'Connor, Liam ^a,b   Milla, Liz ^a,b   Wilcox, Stephen ^a,b   Tai, Lin ^a   Strasser, Andreas ^a,b   Herold, Marco J ^a,b  

^a WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c ROYAL MELBOURNE HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

BIM PROTEIN; CASPASE 9; PROTEIN BCL 2; RNA; SMALL GUIDE RNA; UNCLASSIFIED DRUG; APOPTOSIS REGULATORY PROTEIN; BCL-2-LIKE PROTEIN 11; DOXYCYCLINE; GUIDE RNA; MEMBRANE PROTEIN; ONCOPROTEIN; PROTEIN MCL 1; PROTEIN P53;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; BIM GENE; BURKITT LYMPHOMA; CELL GROWTH; CELL SURVIVAL; CONTROLLED STUDY; DNA SEQUENCE; EXON; GENE DELETION; GENE EXPRESSION; GENE IDENTIFICATION; GENE MUTATION; GENE TARGETING; GROWTH INHIBITION; HEMATOPOIETIC CELL; HUMAN; HUMAN CELL; MCL 1 GENE; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; TRP53 GENE; TUMOR SUPPRESSOR GENE; ANIMAL; C57BL MOUSE; CELL LINE; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEAT; DEFICIENCY; DNA END JOINING REPAIR; DRUG EFFECTS; ESSENTIAL GENE; GENETICS; KNOCKOUT MOUSE; LENTIVIRINAE; METABOLISM; MUTATION; NEOPLASM; NUCLEOTIDE SEQUENCE; PATHOLOGY; TRANSGENIC MOUSE; TUMOR GENE; XENOGRAFT;

MURINAE; MUS;

ANIMALS; APOPTOSIS REGULATORY PROTEINS; BASE SEQUENCE; CELL LINE; CELL SURVIVAL; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEATS; DNA END-JOINING REPAIR; DOXYCYCLINE; GENES, ESSENTIAL; GENES, NEOPLASM; HUMANS; LENTIVIRUS; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; MUTATION; MYELOID CELL LEUKEMIA SEQUENCE 1 PROTEIN; NEOPLASMS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; RNA, GUIDE; TRANSPLANTATION, HETEROLOGOUS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84924621296     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2015.02.002     Document Type: Article

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