메뉴 건너뛰기




Volumn 8, Issue 10, 2002, Pages 1098-1104

Epstein-Barr virus-associated Burkitt lymphomagenesis selects for downregulation of the nuclear antigen EBNA2

Author keywords

[No Author keywords available]

Indexed keywords

CELL NUCLEUS ANTIGEN; EPSTEIN BARR VIRUS ANTIGEN; EPSTEIN BARR VIRUS ANTIGEN 2; UNCLASSIFIED DRUG;

EID: 0036799565     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm758     Document Type: Article
Times cited : (184)

References (45)
  • 1
    • 0004250845 scopus 로고    scopus 로고
    • Knipe, D.M. & Howley, P.M.) 2575-2627 (Lippincott, Williams & Raven, Philadelphia
    • Rickinson, A.B. & Kieff, E. in Fields Virology 4th edn., Vol. II (eds. Knipe, D.M. & Howley, P.M.) 2575-2627 (Lippincott, Williams & Raven, Philadelphia, 2001).
    • (2001) Fields Virology 4th edn. , vol.2
    • Rickinson, A.B.1    Kieff, E.2
  • 2
    • 0023409797 scopus 로고
    • Differences in B cell growth phenotype reflect novel patterns of Epstein-Barr virus latent gene expression in Burkitt's lymphoma cells
    • Rowe, M. et al. Differences in B cell growth phenotype reflect novel patterns of Epstein-Barr virus latent gene expression in Burkitt's lymphoma cells. EMBO J. 6, 2743-2751 (1987).
    • (1987) EMBO J. , vol.6 , pp. 2743-2751
    • Rowe, M.1
  • 3
    • 0025874510 scopus 로고
    • Restricted Epstein-Barr virus protein expression in Burkitt lymphoma is due to a different Epstein-Barr nuclear antigen 1 transcriptional initiation site
    • Sample, J. et al. Restricted Epstein-Barr virus protein expression in Burkitt lymphoma is due to a different Epstein-Barr nuclear antigen 1 transcriptional initiation site. Proc. Natl. Acod. Sci. USA 88, 6343-6347 (1991).
    • (1991) Proc. Natl. Acod. Sci. USA , vol.88 , pp. 6343-6347
    • Sample, J.1
  • 4
    • 0026079847 scopus 로고
    • Exclusive expression of Epstein-Barr virus nuclear antigen 1 in Burkitt lymphoma arises from a third promoter, distinct from the promoters used in latently infected lymphocytes
    • Schaefer, B.C., Woisetschlaeger, M., Strominger, J.L. & Speck, S.H. Exclusive expression of Epstein-Barr virus nuclear antigen 1 in Burkitt lymphoma arises from a third promoter, distinct from the promoters used in latently infected lymphocytes. Proc. Natl. Acad. Sci. USA 88, 6550-6554 (1991).
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 6550-6554
    • Schaefer, B.C.1    Woisetschlaeger, M.2    Strominger, J.L.3    Speck, S.H.4
  • 5
    • 0028838781 scopus 로고
    • Redefining the Epstein-Barr virus-encoded nuclear antigen EBNA- 1 gene promoter and transcription initiation site in group I Burkitt lymphoma cell lines
    • Schaefer, B.C., Strominger, J.L. & Speck, S.H. Redefining the Epstein-Barr virus-encoded nuclear antigen EBNA-1 gene promoter and transcription initiation site in group I Burkitt lymphoma cell lines. Proc. Natl. Acod. Sci. USA 92, 10565-10569 (1995).
    • (1995) Proc. Natl. Acod. Sci. USA , vol.92 , pp. 10565-10569
    • Schaefer, B.C.1    Strominger, J.L.2    Speck, S.H.3
  • 6
    • 0029656132 scopus 로고    scopus 로고
    • Transcription start sites downstream of the Epstein-Barr virus (EBV) Fp promoter in early-passage Burkitt lymphoma cells define a fourth promoter for expression of the EBV EBNA- 1 protein
    • Nonkwelo, C. et al. Transcription start sites downstream of the Epstein-Barr virus (EBV) Fp promoter in early-passage Burkitt lymphoma cells define a fourth promoter for expression of the EBV EBNA-1 protein. J. Virol. 70, 623-627 (1996).
    • (1996) J. Virol. , vol.70 , pp. 623-627
    • Nonkwelo, C.1
  • 7
    • 0004250834 scopus 로고    scopus 로고
    • Knipe, D.M. & Howley, P.M.) 2511-2573 (Lippincott, Williams & Raven, Philadelphia
    • Kieff, E. & Rickinson, A.B. in Fields Virology 4th edn., Vol. II (eds. Knipe, D.M. & Howley, P.M.) 2511-2573 (Lippincott, Williams & Raven, Philadelphia, 2001).
    • (2001) Fields Virology 4th edn.
    • Kieff, E.1    Rickinson, A.B.2
  • 8
    • 0024469159 scopus 로고
    • Expression of Epstein-Barr virus transformation-associated genes in tissues of patients with EBV lymphoproliferative disease
    • Young, L. et al. Expression of Epstein-Barr virus transformation-associated genes in tissues of patients with EBV lymphoproliferative disease. N. Engl. J. Med. 321, 1080-1085 (1989).
    • (1989) N. Engl. J. Med. , vol.321 , pp. 1080-1085
    • Young, L.1
  • 9
    • 0025236334 scopus 로고
    • Promoter switching in Epstein-Barr virus during the initial stages of infection of B lymphocytes
    • Woisetschlaeger, M. et al. Promoter switching in Epstein-Barr virus during the initial stages of infection of B lymphocytes. Proc. Natl. Acad. Sci. USA 87, 1725-1729 (1990).
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 1725-1729
    • Woisetschlaeger, M.1
  • 10
    • 0025892705 scopus 로고
    • Role for the Epstein-Barr virus nuclear antigen 2 in viral promoter switching during initial stages of infection
    • Woisetschlaeger, M. et al. Role for the Epstein-Barr virus nuclear antigen 2 in viral promoter switching during initial stages of infection. Proc. Natl. Acad. Sci. USA 88, 3942-3946 (1991).
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 3942-3946
    • Woisetschlaeger, M.1
  • 11
    • 0025739303 scopus 로고
    • EBNA2 transactivates a lymphoid-specific enhancer in the BamHI C promoter of Epstein-Barr virus
    • Sung, N.S., Kenney, S., Gutsch, D.E. & Pagano, J.S. EBNA2 transactivates a lymphoid-specific enhancer in the BamHI C promoter of Epstein-Barr virus. J. Virol. 65, 2164-2169 (1991).
    • (1991) J. Virol. , vol.65 , pp. 2164-2169
    • Sung, N.S.1    Kenney, S.2    Gutsch, D.E.3    Pagano, J.S.4
  • 12
    • 0025274390 scopus 로고
    • Epstein-Barr virus nuclear antigen 2 induces expression of the virus-encoded latent membrane protein
    • Abbot, S.D. et al. Epstein-Barr virus nuclear antigen 2 induces expression of the virus-encoded latent membrane protein. J. Virol. 64, 2126-2134 (1990).
    • (1990) J. Virol. , vol.64 , pp. 2126-2134
    • Abbot, S.D.1
  • 13
    • 0025114515 scopus 로고
    • Epstein-Barr virus-encoded nuclear antigen 2 activates the viral latent membrane protein promoter by modulating the activity of a negative regulatory element
    • Fahraeus, R. et al. Epstein-Barr virus-encoded nuclear antigen 2 activates the viral latent membrane protein promoter by modulating the activity of a negative regulatory element. Proc. Natl. Acad. Sci. USA 87, 7390-7394 (1990).
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 7390-7394
    • Fahraeus, R.1
  • 14
    • 0025285021 scopus 로고
    • Epstein-Barr virus nuclear antigen 2 transactivates latent membrane protein LMP1
    • Wang, F. et al. Epstein-Barr virus nuclear antigen 2 transactivates latent membrane protein LMP1. J. Virol. 64, 3407-3416 (1990).
    • (1990) J. Virol. , vol.64 , pp. 3407-3416
    • Wang, F.1
  • 15
    • 0025958281 scopus 로고
    • Epstein-Barr virus nuclear antigen 2 activates transcription of the terminal protein gene
    • Zimber-Strobl, U. et al. Epstein-Barr virus nuclear antigen 2 activates transcription of the terminal protein gene. J. Virol. 65, 415-423 (1991).
    • (1991) J. Virol. , vol.65 , pp. 415-423
    • Zimber-Strobl, U.1
  • 16
    • 0032923696 scopus 로고    scopus 로고
    • The proto-oncogene c-myc is a direct target gene of Epstein-Barr virus nuclear antigen 2
    • Kaiser, C. et al. The proto-oncogene c-myc is a direct target gene of Epstein-Barr virus nuclear antigen 2. J. Virol. 73, 4481-4484 (1999).
    • (1999) J. Virol. , vol.73 , pp. 4481-4484
    • Kaiser, C.1
  • 17
    • 0023185242 scopus 로고
    • Identification of a subset of normal B cells with a Burkitt's lymphoma (BL)-like phenotype
    • Gregory, C.D. et al. Identification of a subset of normal B cells with a Burkitt's lymphoma (BL)-like phenotype. J. Immunol. 139, 313-318 (1987).
    • (1987) J. Immunol. , vol.139 , pp. 313-318
    • Gregory, C.D.1
  • 18
    • 0025081901 scopus 로고
    • The pathogenesis of Burkitt's lymphoma
    • Magrath, I. The pathogenesis of Burkitt's lymphoma. Adv. Cancer Res. 55, 133-270 (1990).
    • (1990) Adv. Cancer Res. , vol.55 , pp. 133-270
    • Magrath, I.1
  • 19
    • 0033696976 scopus 로고    scopus 로고
    • The expression pattern of Epstein-Barr virus latent genes in vivo is dependent upon the differentiation stage of the infected B cell
    • Babcock, G.J., Hochberg, D. & Thorley-Lawson, D.A. The expression pattern of Epstein-Barr virus latent genes in vivo is dependent upon the differentiation stage of the infected B cell. Immunity 13, 497-506 (2000).
    • (2000) Immunity , vol.13 , pp. 497-506
    • Babcock, G.J.1    Hochberg, D.2    Thorley-Lawson, D.A.3
  • 20
    • 0033758794 scopus 로고    scopus 로고
    • Role of cytotoxic T lymphocytes in Epstein-Barr virus-associated diseases
    • Khanna, R. & Burrows, S.R. Role of cytotoxic T lymphocytes in Epstein-Barr virus-associated diseases. Annu. Rev. Microbiol. 54, 19-4B (2000).
    • (2000) Annu. Rev. Microbiol. , vol.54
    • Khanna, R.1    Burrows, S.R.2
  • 21
    • 0035885273 scopus 로고    scopus 로고
    • Antagonistic effects of c-Myc and Epstein-Barr virus latent genes on the phenotype of human B cells
    • Pajic, A. et al. Antagonistic effects of c-Myc and Epstein-Barr virus latent genes on the phenotype of human B cells. Int. J. Cancer 93, 810-816 (2001).
    • (2001) Int. J. Cancer , vol.93 , pp. 810-816
    • Pajic, A.1
  • 22
    • 0023499869 scopus 로고
    • Monoclonal and polyclonal antibodies against Epstein-Barr virus nuclear antigen 5 (EBNA-5) detect multiple protein species in Burkitt's lymphoma and lymphoblastoid cell lines
    • Finke, J. et al. Monoclonal and polyclonal antibodies against Epstein-Barr virus nuclear antigen 5 (EBNA-5) detect multiple protein species in Burkitt's lymphoma and lymphoblastoid cell lines. J. Virol. 61, 3870-3878 (1987).
    • (1987) J. Virol. , vol.61 , pp. 3870-3878
    • Finke, J.1
  • 23
    • 0029053611 scopus 로고
    • Restoration of endogenous antigen processing in Burkitt's lymphoma cells by Epstein-Barr virus latent membrane protein-1: Coordinate up-regulation of peptide transporters and HLA-class I antigen expression
    • Rowe, M. et al. Restoration of endogenous antigen processing in Burkitt's lymphoma cells by Epstein-Barr virus latent membrane protein-1: coordinate up-regulation of peptide transporters and HLA-class I antigen expression. Eur. J. Immunol. 25, 1374-1384 (1995).
    • (1995) Eur. J. Immunol. , vol.25 , pp. 1374-1384
    • Rowe, M.1
  • 24
    • 0028265113 scopus 로고
    • Endoplasmic reticulum signal sequence facilitated transport of peptide epitopes restores immunogenicity of an antigen processing defective tumor cell line
    • Khanna, R., Burrows, S.R., Argaet, V. & Moss, D.J. Endoplasmic reticulum signal sequence facilitated transport of peptide epitopes restores immunogenicity of an antigen processing defective tumor cell line. Int. Immunol. 6, 639-645 (1994).
    • (1994) Int. Immunol. , vol.6 , pp. 639-645
    • Khanna, R.1    Burrows, S.R.2    Argaet, V.3    Moss, D.J.4
  • 25
    • 0019936186 scopus 로고
    • Deletion of the nontransforming Epstein-Barr virus strain P3HR- 1 causes fusion of the large internal repeat to the DSL region
    • Bornkamm, G.W., Hudewentz, J., Freese, U.K. & Zimber, U. Deletion of the nontransforming Epstein-Barr virus strain P3HR-1 causes fusion of the large internal repeat to the DSL region. J. Virol. 43, 952-968 (1982).
    • (1982) J. Virol. , vol.43 , pp. 952-968
    • Bornkamm, G.W.1    Hudewentz, J.2    Freese, U.K.3    Zimber, U.4
  • 26
    • 0020447692 scopus 로고
    • Non-immortalizing P3J-HR-1 Epstein-Barr virus: A deletion mutant of its transforming parent, Jijoye
    • Rabson, M., Gradoville, L., Heston, L. & Miller, G. Non-immortalizing P3J-HR-1 Epstein-Barr virus: a deletion mutant of its transforming parent, Jijoye. J. Virol. 44, 834-844 (1982).
    • (1982) J. Virol. , vol.44 , pp. 834-844
    • Rabson, M.1    Gradoville, L.2    Heston, L.3    Miller, G.4
  • 27
    • 0014139019 scopus 로고
    • Immunofluorescence and herpes-type virus particles in the P3HR- 1 Burkitt lymphoma cell line
    • Hinuma, Y. et al. Immunofluorescence and herpes-type virus particles in the P3HR-1 Burkitt lymphoma cell line. J. Virol. 1, 1045-1051 (1967).
    • (1967) J. Virol. , vol.1 , pp. 1045-1051
    • Hinuma, Y.1
  • 28
    • 0021415065 scopus 로고
    • The EB virus genome in Daudi Burkitt's lymphoma cells has a deletion similar to that observed in a non-transforming strain (P3HR-1) of the virus
    • Jones, M.D., Foster, L., Sheedy, T. & Griffin, B.E. The EB virus genome in Daudi Burkitt's lymphoma cells has a deletion similar to that observed in a non-transforming strain (P3HR-1) of the virus. EMBO J. 3, 813-821 (1984).
    • (1984) EMBO J. , vol.3 , pp. 813-821
    • Jones, M.D.1    Foster, L.2    Sheedy, T.3    Griffin, B.E.4
  • 29
    • 0025091657 scopus 로고
    • Sequence and transcription of Raji Epstein-Barr virus DNA spanning the B95- 8 deletion region
    • Parker, B.D. et al. Sequence and transcription of Raji Epstein-Barr virus DNA spanning the B95-8 deletion region. Virology 179, 339-346 (1990).
    • (1990) Virology , vol.179 , pp. 339-346
    • Parker, B.D.1
  • 30
    • 0028890144 scopus 로고
    • B-cell proliferation and induction of early G1-regulating proteins by Epstein-Barr virus mutants conditional for EBNA 2
    • Kempkes, B. et al. B-cell proliferation and induction of early G1-regulating proteins by Epstein-Barr virus mutants conditional for EBNA2. EMBO J. 14, 88-96 (1995).
    • (1995) EMBO J. , vol.14 , pp. 88-96
    • Kempkes, B.1
  • 31
    • 0030782146 scopus 로고    scopus 로고
    • B cell lines immortalised with an Epstein-Barr virus mutant lacking the Cp EBNA2 enhancer are biased toward utilisation of the oriP-proximal EBNA gene promoter Wp 1
    • Yoo, L., Mooney, M., Puglielli, M.T. & Speck, S. B cell lines immortalised with an Epstein-Barr virus mutant lacking the Cp EBNA2 enhancer are biased toward utilisation of the oriP-proximal EBNA gene promoter Wp1. J. Virol. 71, 9134-9142 (1997).
    • (1997) J. Virol. , vol.71 , pp. 9134-9142
    • Yoo, L.1    Mooney, M.2    Puglielli, M.T.3    Speck, S.4
  • 32
    • 0034467099 scopus 로고    scopus 로고
    • Determining the role of the Epstein-Barr virus Cp EBNA2-dependent enhancer during the establishment of latency by using mutant and wildtype viruses recovered from cottontop marmoset lymphoblastoid cell lines
    • Yoo, L. & Speck, S.H. Determining the role of the Epstein-Barr virus Cp EBNA2-dependent enhancer during the establishment of latency by using mutant and wildtype viruses recovered from cottontop marmoset lymphoblastoid cell lines. J. Virol. 74, 11115-11120 (2000).
    • (2000) J. Virol. , vol.74 , pp. 11115-11120
    • Yoo, L.1    Speck, S.H.2
  • 33
    • 0023666535 scopus 로고
    • Mutations in the first exon are associated with altered transcription of c-myc in Burkitt lymphoma
    • Cesarman, E., Dalla-Favera, R., Bentley, D. & Groudine, M. Mutations in the first exon are associated with altered transcription of c-myc in Burkitt lymphoma. Science 238, 1272-1275 (1987).
    • (1987) Science , vol.238 , pp. 1272-1275
    • Cesarman, E.1    Dalla-Favera, R.2    Bentley, D.3    Groudine, M.4
  • 34
    • 0027275755 scopus 로고
    • Point mutations in the c-Myc transactivation domain are common in Burkitt's lymphoma and mouse plasmacytomas
    • Bhatia, K. et al. Point mutations in the c-Myc transactivation domain are common in Burkitt's lymphoma and mouse plasmacytomas. Nature Genet. 5, 56-61 (1993).
    • (1993) Nature Genet. , vol.5 , pp. 56-61
    • Bhatia, K.1
  • 35
    • 0032478071 scopus 로고    scopus 로고
    • Frequent occurrence of deletions and duplications during somatic hypermutation: Implications for oncogene translocations and heavy chain disease
    • Goossens, T., Klein, U. & Kuppers, R. Frequent occurrence of deletions and duplications during somatic hypermutation: Implications for oncogene translocations and heavy chain disease. Proc. Natl. Acad. Sci. USA 95, 2463-2468 (1998).
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 2463-2468
    • Goossens, T.1    Klein, U.2    Kuppers, R.3
  • 36
    • 0031660978 scopus 로고    scopus 로고
    • Epstein-Barr virus contributes to the malignant phenotype and to apoptosis resistance in Burkitt's lymphoma cell line Akata
    • Komano, J., Sugiura, M. & Takada, K. Epstein-Barr virus contributes to the malignant phenotype and to apoptosis resistance in Burkitt's lymphoma cell line Akata. J. Virol. 72, 9150-9156 (1998).
    • (1998) J. Virol. , vol.72 , pp. 9150-9156
    • Komano, J.1    Sugiura, M.2    Takada, K.3
  • 37
    • 0032980719 scopus 로고    scopus 로고
    • Epstein-Barr virus regulates c-Myc, apoptosis, and tumorigenicity in Burkitt lymphoma
    • Ruf, I.K. et al. Epstein-Barr virus regulates c-Myc, apoptosis, and tumorigenicity in Burkitt lymphoma. Mol. Cell. Biol. 19, 1651-1660 (1999).
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 1651-1660
    • Ruf, I.K.1
  • 38
    • 0029814787 scopus 로고    scopus 로고
    • c-myc activation renders proliferation of Epstein-Barr virus (EBV)-transformed cells independent of EBV nuclear antigen 2 and latent membrane protein 1
    • Polack, A. et al. c-myc activation renders proliferation of Epstein-Barr virus (EBV)-transformed cells independent of EBV nuclear antigen 2 and latent membrane protein 1. Proc. Natl. Acad. Sci. USA 93, 10411-10416 (1996).
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 10411-10416
    • Polack, A.1
  • 39
    • 0035097842 scopus 로고    scopus 로고
    • c-Myc overexpression activates alternative pathways for intracellular proteolysis in lymphoma cells
    • Gavioli, R. et al. c-Myc overexpression activates alternative pathways for intracellular proteolysis in lymphoma cells. Nature Cell Biol. 3, 283-288 (2001).
    • (2001) Nature Cell Biol. , vol.3 , pp. 283-288
    • Gavioli, R.1
  • 40
    • 0037007063 scopus 로고    scopus 로고
    • Myc overexpression imposes a nonimmunogenic phenotype on Epstein-Barr virus-infected B cells
    • Staege, M.S. et al. Myc overexpression imposes a nonimmunogenic phenotype on Epstein-Barr virus-infected B cells. Proc. Natl. Acad. Sci. USA 99, 4550-4555 (2002).
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 4550-4555
    • Staege, M.S.1
  • 41
    • 0034675943 scopus 로고    scopus 로고
    • Burkitt lymphoma in the mouse
    • Kovalchuk, A.L. et al. Burkitt lymphoma in the mouse. J. Exp. Med. 192, 1183-1190 (2000).
    • (2000) J. Exp. Med. , vol.192 , pp. 1183-1190
    • Kovalchuk, A.L.1
  • 42
    • 0032949138 scopus 로고    scopus 로고
    • Epstein-Barr virus nuclear antigen 1 sequences in endemic and sporadic Burkitt's lymphoma reflect virus strains prevalent in different geographic areas
    • Habeshaw, G. et al. Epstein-Barr virus nuclear antigen 1 sequences in endemic and sporadic Burkitt's lymphoma reflect virus strains prevalent in different geographic areas. J. Virol. 73, 965-975 (1999).
    • (1999) J. Virol. , vol.73 , pp. 965-975
    • Habeshaw, G.1
  • 43
    • 0022462463 scopus 로고
    • Endemic Burkitt's lymphoma: Phenotypic analysis of tumor biopsy cells and of derived tumor cell lines
    • Rooney, C.M. et al. Endemic Burkitt's lymphoma: phenotypic analysis of tumor biopsy cells and of derived tumor cell lines. J. Natl. Cancer Inst. 77, 681-687 (1986).
    • (1986) J. Natl. Cancer Inst. , vol.77 , pp. 681-687
    • Rooney, C.M.1
  • 44
    • 0028130271 scopus 로고
    • Epstein-Barr virus latency in blood mononuclear cells-analysis of viral gene-transcription during primary infection and in the carrier state
    • Tierney, R.J., Steven, N., Young, L.S. & Rickinson, A.B. Epstein-Barr virus latency in blood mononuclear cells-analysis of viral gene-transcription during primary infection and in the carrier state. J. Virol. 68, 7374-7385 (1994).
    • (1994) J. Virol. , vol.68 , pp. 7374-7385
    • Tierney, R.J.1    Steven, N.2    Young, L.S.3    Rickinson, A.B.4
  • 45
    • 0030931689 scopus 로고    scopus 로고
    • + memory T cells
    • + memory T cells. J. Exp. Med. 186, 859-865 (1997).
    • (1997) J. Exp. Med. , vol.186 , pp. 859-865
    • Lalvani, A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.