Targeting antiapoptotic A1/Bfl-1 by in vivo RNAi reveals multiple roles in leukocyte development in mice

Blood

Volumn 119, Issue 25, 2012, Pages 6032-6042

  Ottina, Eleonora ^a   Grespi, Francesca ^a   Tischner, Denise ^a   Soratroi, Claudia ^a   Geley, Stephan ^a   Ploner, Andreas ^a   Reichardt, Holger M ^b,c   Villunger, Andreas ^a   Herold, Marco J ^c,d  

^a INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^b UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

^c UNIVERSITY OF WÜRZBURG   (Germany)

^d WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

B LYMPHOCYTE RECEPTOR; BCL2 RELATED PROTEIN A1; MITOGENIC AGENT;

ANIMAL EXPERIMENT; ARTICLE; CARCINOGENESIS; CELL CULTURE; CELL DEATH; CONTROLLED STUDY; FEMALE; GENE TARGETING; GRANULOCYTE; HEMATOPOIETIC SYSTEM; HOMEOSTASIS; HUMAN; HUMAN CELL; IMMUNITY; IN VIVO STUDY; LEUKOCYTE; LYMPHOCYTE DIFFERENTIATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN TARGETING; RNA INTERFERENCE;

EID: 84862734168     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2011-12-399089     Document Type: Article

References (37)

1. Ottina E, Tischner D, Herold MJ, Villunger A. A1/Bfl-1 in leukocyte development and cell death. Exp Cell Res. 2012;318(11):1291-1303.
2. Herold MJ, Zeitz J, Pelzer C, et al. The stability and anti-apoptotic function of A1 are controlled by its C terminus. J Biol Chem. 2006;281(19):13663-13671. (Pubitemid 43855282)
3. Kucharczak JF, Simmons MJ, Duckett CS, Gelinas C. Constitutive proteasome-mediated turnover of Bfl-1/A1 and its processing in response to TNF receptor activation in FL5. 12 pro-B cells convert it into a prodeath factor. Cell Death Diff. 2005;12(9):1225-1239. (Pubitemid 41195111)
4. Fan G, Simmons MJ, Ge S, et al. Defective ubiquitin-mediated degradation of antiapoptotic Bfl-1 predisposes to lymphoma. Blood. 2010;115(17):3559-3569.
5. Kuss AW, Knödel M, Berberich-Siebelt F, Lindemann D, Schimpl A, Berberich I. A1 expression is stimulated by CD40 in B cells and rescues WEHI 231 cells from anti-IgM-induced cell death. Eur J Immunol. 1999;29(10):3077-3088. (Pubitemid 29484197)
6. Brien G, Trescol-Biemont MC, Bonnefoy-Berard N. Downregulation of Bfl-1 protein expression sensitizes malignant B cells to apoptosis. Oncogene. 2007;26(39):5828-5832. (Pubitemid 47312815)
7. Gonzalez J, Orlofsky A, Prystowsky MB. A1 is a growth-permissive antiapoptotic factor mediating postactivation survival in T cells. Blood. 2003;101(7):2679-2685. (Pubitemid 36857630)
8. Chuang PI, Morefield S, Liu CY, Chen S, Harlan JM, Willerford DM. Perturbation of B-cell development in mice overexpressing the Bcl-2 homolog A1. Blood. 2002;99(9):3350-3359. (Pubitemid 34525316)
9. Campbell KJ, Bath ML, Turner ML, et al. Elevated Mcl-1 perturbs lymphopoiesis, promotes transformation of hematopoietic stem/progenitor cells and enhances drug-resistance. Blood. 2010;116(17):3197-3207.
10. Ogilvy S, Metcalf D, Print CG, Bath ML, Harris AW, Adams JM. Constitutive bcl-2 expression throughout the hematopoietic compartment affects multiple lineages and enhances progenitor cell survival. Proc Natl Acad Sci U S A. 1999;96(26):14943-14948. (Pubitemid 30019744)
11. Hamasaki A, Sendo F, Nakayama K, et al. Accelerated neutrophil apoptosis in mice lacking A1-a, a subtype of the bcl-2-related A1 gene. J Exp Med. 1998;188(11):1985-1992. (Pubitemid 28562516)
12. Xiang Z, Ahmed AA, Moller C, Nakayama K, Hatakeyama S, Nilsson G. Essential role of the prosurvival bcl-2 homologue A1 in mast cell survival after allergic activation. J Exp Med. 2001;194(11):1561-1569. (Pubitemid 33126807)
13. Hatakeyama S, Hamasaki A, Negishi I, Loh DY, Sendo F, Nakayama K. Multiple gene duplication and expression of mouse bcl-2-related genes, A1. Int Immunol. 1998;10(5):631-637. (Pubitemid 28221464)
14. Mandal M, Borowski C, Palomero T, et al. The BCL2A1 gene as a pre-T cell receptor-induced regulator of thymocyte survival. J Exp Med. 2005;201(4):603-614. (Pubitemid 40289550)
15. Oberdoerffer P, Kanellopoulou C, Heissmeyer V, et al. Efficiency of RNA interference in the mouse hematopoietic system varies between cell types and developmental stages. Mol Cell Biol. 2005;25(10):3896-3905. (Pubitemid 40617641)
16. Morales AA, Olsson A, Celsing F, Osterborg A, Jondal M, Osorio LM. High expression of bfl-1 contributes to the apoptosis resistant phenotype in B-cell chronic lymphocytic leukemia. Int J Cancer. 2005;113(5):730-737. (Pubitemid 40101253)
17. Vogler M, Butterworth M, Majid A, et al. Concurrent up-regulation of BCL-XL and BCL2A1 induces approximately 1000-fold resistance to ABT-737 in chronic lymphocytic leukemia. Blood. 2009;113(18):4403-4413.
18. Vogler M. BCL2A1: the underdog in the BCL2 family. Cell Death Diff. 2012;19(1):67-74.
19. Andre J, Cimaz R, Ranchin B, et al. Overexpression of the antiapoptotic gene Bfl-1 in B cells from patients with familial systemic lupus erythematosus. Lupus. 2007;16(2):95-100. (Pubitemid 46347931)
20. Santidrián AF, Gonzalez-Girones DM, Iglesias-Serret D, et al. AICAR induces apoptosis independently of AMPK and p53 through upregulation of the BH3-only proteins BIM and NOXA in chronic lymphocytic leukemia cells. Blood. 2010;116(16):3023-3032.
21. Dickins RA, McJunkin K, Hernando E, et al. Tissue-specific and reversible RNA interference in transgenic mice. Nat Genet. 2007;39(7):914-921. (Pubitemid 47014488)
22. Grespi F, Ottina E, Yannoutsos N, Geley S, Villunger A. Generation and evaluation of an IPTG-regulated version of Vav-gene promoter for mouse transgenesis. PLoS One. 2011;6(3):e18051.
23. Wiesner SM, Jones JM, Hasz DE, Largaespada DA. Repressible transgenic model of NRAS oncogene-driven mast cell disease in the mouse. Blood. 2005;106(3):1054-1062. (Pubitemid 41076454)
24. Ploner C, Rainer J, Niederegger H, et al. The BCL2 rheostat in glucocorticoid-induced apoptosis of acute lymphoblastic leukemia. Leukemia. 2008;22(2):370-377. (Pubitemid 351250542)
25. Ogilvy S, Elefanty AG, Visvader J, Bath ML, Harris AW, Adams JM. Transcriptional regulation of vav, a gene expressed throughout the hematopoietic compartment. Blood. 1998;91(2):419-430. (Pubitemid 28053363)
26. Chen CZ, Li L, Lodish HF, Bartel DP. MicroRNAs modulate hematopoietic lineage differentiation. Science. 2004;303(5654):83-86. (Pubitemid 38055775)
27. Wen R, Chen Y, Xue L, et al. Phospholipase Cgamma2 provides survival signals via Bcl2 and A1 in different subpopulations of B cells. J Biol Chem. 2003;278(44):43654-43662. (Pubitemid 37345992)
28. Verschelde C, Walzer T, Galia P, et al. A1/Bfl-1 expression is restricted to TCR engagement in T lymphocytes. Cell Death Differ. 2003;10(9):1059-1067. (Pubitemid 37069483)
29. Park JH, Adoro S, Guinter T, et al. Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells. Nat Immunol. 2010;11(3):257-264.
30. Opferman JT, Letai A, Beard C, Sorcinelli MD, Ong CC, Korsmeyer SJ. Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1. Nature. 2003;426(6967):671-676. (Pubitemid 38009376)
31. Tomayko MM, Cancro MP. Long-lived B cells are distinguished by elevated expression of A1. J Immunol. 1998;160(1):107-111. (Pubitemid 28116721)
32. Andrews SF, Rawlings DJ. Transitional B cells exhibit a B cell receptor-specific nuclear defect in gene transcription. J Immunol. 2009;182(5):2868-2878.
33. Trescol-Biémont MC, Verschelde C, Cottalorda A, Bonnefoy-Berard N. Regulation of A1/Bfl-1 expression in peripheral splenic B cells. Biochimie. 2004;86(4):287-294. (Pubitemid 38780834)
34. Grumont RJ, Rourke IJ, Gerondakis S. Rel-dependent induction of A1 transcription is required to protect B cells from antigen receptor ligation-induced apoptosis. Genes Dev. 1999;13(4):400-411. (Pubitemid 29108756)
35. Wensveen FM, Derks IA, van Gisbergen KP, et al. BH3-only protein Noxa regulates apoptosis in activated B cells and controls high-affinity antibody formation. Blood. 2012;119(6):1440-1449.
36. Steimer DA, Boyd K, Takeuchi O, Fisher JK, Zambetti GP, Opferman JT. Selective roles for antiapoptotic MCL-1 during granulocyte development and macrophage effector function. Blood. 2009;113(12):2805-2815.
37. Villunger A, Scott C, Bouillet P, Strasser A. Essential role for the BH3-only protein Bim but redundant roles for Bax, Bcl-2, and Bcl-w in the control of granulocyte survival. Blood. 2003;101(6):2393-2400. (Pubitemid 36302087)