Advances in pediatric asthma in 2014: Moving toward a population health perspective

Journal of Allergy and Clinical Immunology

Volumn 135, Issue 3, 2015, Pages 644-652

  Szefler, Stanley J ^a,b  

^a CHILDREN S HOSPITAL COLORADO   (United States)

^b UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

Author keywords

Airway remodeling; asthma; asthma control; asthma exacerbations; biomarkers; early intervention in asthma; environment; genetics; inhaled corticosteroids; leukotriene receptor antagonists; long acting adrenergic agonists; personalized medicine; severe asthma; therapeutics

Indexed keywords

BIOLOGICAL MARKER; ANTIASTHMATIC AGENT; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; CORTICOSTEROID; IMMUNOLOGIC FACTOR; LEUKOTRIENE RECEPTOR BLOCKING AGENT;

ASTHMA; CLINICAL ASSESSMENT; DISEASE PREDISPOSITION; ENVIRONMENT; EPITHELIUM; GENETICS; HEALTH EDUCATION; HUMAN; INFECTION; INFLAMMATION; INFORMATION DISSEMINATION; OBESITY; OUTCOME ASSESSMENT; PHENOTYPE; PREDICTION; PRENATAL EXPOSURE; PRIORITY JOURNAL; PUBLIC HEALTH; REVIEW; RISK ASSESSMENT; RISK FACTOR; SCHOOL HEALTH EDUCATION; SCIENTIFIC LITERATURE; TREATMENT INDICATION; TREATMENT RESPONSE; WHEEZING; CHILD; DISEASE COURSE; DISEASE MANAGEMENT; FEMALE; HYPERSENSITIVITY; IMMUNOLOGY; PATHOLOGY; PATIENT CARE; PERSONALIZED MEDICINE; PREGNANCY;

ADRENAL CORTEX HORMONES; ADRENERGIC BETA-AGONISTS; ANTI-ASTHMATIC AGENTS; ASTHMA; CHILD; DISEASE MANAGEMENT; DISEASE PROGRESSION; FEMALE; HUMANS; HYPERSENSITIVITY; IMMUNOLOGIC FACTORS; INDIVIDUALIZED MEDICINE; LEUKOTRIENE ANTAGONISTS; PATIENT-CENTERED CARE; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS;

EID: 84924551511     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2014.12.1921     Document Type: Review

References (112)

1. S.J. Szefler Advances in pediatric asthma in 2013: coordinating asthma care J Allergy Clin Immunol 133 2014 654 661
2. A.J. Apter Advances in adult asthma diagnosis and treatment in 2013 J Allergy Clin Immunol 133 2014 49 56
3. A.J. Apter Advances in adult asthma diagnosis and treatment in 2014 J Allergy Clin Immunol 135 2015 46 53
4. X. Huong, and M.B. Rosenthal Transforming specialty practice - the patient-centered medical neighborhood N Engl J Med 370 2014 1376 1379
5. S.J. Szefler, J.F. Chmiel, A.M. Fitzpatrick, G. Giacoia, T.P. Green, and D.J. Jackson Asthma across the ages: knowledge gaps in childhood asthma J Allergy Clin Immunol 133 2014 3 13
6. E.R. Sutherland, and W.S. Busse Designing clinical trials to address the needs of childhood and adult asthma: NHLBI AsthmaNet J Allergy Clin Immunol 133 2014 34 38
7. M. Cabana, S.J. Kunselman, S. Nyenhuis, and M.E. Wechlser Researching asthma across the ages: insights from the NHLBI Asthma Network J Allergy Clin Immunol 133 2014 27 33
8. V.E. Ortega, and D.A. Meyers Pharmacogenetics: implications of race and ethnicity on defining genetic profiles for personalized medicine J Allergy Clin Immunol 133 2014 16 26
9. Global Initiative for Asthma Report. Global strategy for asthma management and prevention, 2014. Available at: www.ginasthma.org. Accessed November 10, 2014.
10. S. Manners, R. Alam, D.A. Schwartz, and M.M. Gorska A mouse model links asthma susceptibility to prenatal exposure to diesel exhaust J Allergy Clin Immunol 134 2014 63 72
11. F.D. Finkelman Diesel exhaust particle exposure during pregnancy promotes development of asthma and atopy J Allergy Clin Immunol 134 2014 73 74
12. R.M. Whyatt, A.G. Rundle, M.S. Perzanowski, A.C. Just, K.M. Donahue, and A.M. Calafat Prenatal phthalate and early childhood bisphenol A exposures increase asthma risk in inner-city children J Allergy Clin Immunol 134 2014 1195 1197
13. E. Simons, T. To, R. Moineddin, D. Stieb, and S.D. Dell Maternal second-hand smoke exposure in pregnancy is associated with childhood asthma development J Allergy Clin Immunol Pract 2 2014 201 207
14. E.M. Hollams, N.H. deKlerk, P.G. Holt, and P.D. Sly Persistent effects of maternal smoking during pregnancy on lung function and asthma in adolescents Am J Respir Crit Care Med 189 2014 401 407
15. I.R. Hartwig, P.D. Sly, L.A. Schmidt, R.J. van Lieshout, J. Bienenstock, and P.G. Holt Prenatal adverse life events increase the risk for atopic diseases in children, which is enhanced in the absence of a maternal atopic predisposition J Allergy Clin Immunol 134 2014 160 169
16. M. Guxens, A.M. Sonnenschein-van der Voort, H. Tiemeier, A. Hofman, J. Sunyer, and J.C. de Jongste Parental psychological distress during pregnancy and wheezing in preschool children: the Generation R Study J Allergy Clin Immunol 133 2014 59 67
17. K. Straubinger, S. Paul, O. Prazeres da Costa, M. Ritter, T. Buch, and D.H. Busch Maternal immune response to helminth infection during pregnancy determines offspring susceptibility to allergic airway inflammation J Allergy Clin Immunol 134 2014 1271 1279
18. H.H. Smits, and C.A. Akdis In utero priming by worms protects against respiratory allergies J Allergy Clin Immunol 134 2014 1280 1281
19. H17 differentiation capacity develops within the first 3 months of life J Allergy Clin Immunol 133 2014 891 894.e5
20. J. Madura Larsen, S. Brix, A. Hammerich Thysen, S. Birch, M. Arendt Rasmussen, and H. Bisgaard Children with asthma by school age display aberrant immune responses to pathogenic airway bacteria as infants J Allergy Clin Immunol 133 2014 1008 1013
21. M. Kerkhof, H.M. Boezen, R. Granell, A.H. Wijga, B. Brunekreef, and H.A. Smit Transient early wheeze and lung function in early childhood associated with chronic obstructive pulmonary disease genes J Allergy Clin Immunol 133 2014 68 76
22. O.E. Savenije, J.M. Mahachie John, R. Granell, M. Kerkhof, F.N. Dijk, and J.C. de Jongste Association of IL33-IL-1 receptor-like 1 (IL1RL1) pathway polymorphisms with wheezing phenotypes and asthma in childhood J Allergy Clin Immunol 134 2014 170 177
23. M.F. Linehan, U. Nurmatov, T.L. Frank, R.M. Niven, D.N. Baxter, and A. Sheikh Does BCG vaccination protect against childhood asthma? Final results from the Manchester Community Asthma Study retrospective cohort study and updated systematic review and meta-analysis J Allergy Clin Immunol 133 2014 688 695
24. A.M. Sonnenschein-van der Voort, L.R. Arends, J.C. de Jongste, I. Annesi-Maesano, S.H. Arshad, and H. Barros Preterm birth, infant weight gain, and childhood asthma risk: a meta-analysis of 147,000 European children J Allergy Clin Immunol 133 2014 1317 1329
25. C. Rosas-Salazar, S.K. Ramratnam, J.M. Brehm, Y.Y. Han, N. Boutaoui, and E. Forno Prematurity, atopy and childhood asthma in Puerto Ricans J Allergy Clin Immunol 133 2014 357 362
26. J.A. Bird, J. Wang, C.M. Visness, A. Calatroni, H.A. Sampson, and R. Gruchalla Winter birth in inner-city asthmatic children is associated with increased food allergen sensitization risk J Allergy Clin Immunol 134 2014 490 492
27. Y.H. Chiu, B.A. Coull, M.J. Sternthal, I. Kloog, J. Schwartz, and S. Cohen Effects of prenatal community violence and ambient air pollution on childhood wheeze in an urban population J Allergy Clin Immunol 133 2014 713 722
28. B.I. Nwaru, H.M. Takkinen, M. Kaila, M. Erkkola, S. Ahonen, and J. Pekkanen Food diversity in infancy and the risk of childhood asthma and allergies J Allergy Clin Immunol 133 2014 1084 1091
29. M. Lumia, P. Luukkainen, H.M. Takkinen, M. Kaila, B.I. Nwaru, and J. Nevalainen Cow's milk allergy and the association between fatty acids and childhood asthma risk J Allergy Clin Immunol 134 2014 488 490
30. B. Lapin, J. Piorkowski, D. Ownby, C. Wagner-Cassanova, S. Freels, and N. Chavez The relationship of early-life antibiotic use with asthma in at-risk children J Allergy Clin Immunol 134 2014 728 729
31. S.V. Lynch, R.A. Wood, H. Boushey, L.B. Bacharier, G.R. Bloomberg, and M. Kattan Effects of early-life exposure to allergens and bacteria on recurrent wheeze and atopy in urban children J Allergy Clin Immunol 134 2014 593 601
32. L.B. Grabenhenrich, H. Gough, A. Reich, N. Eckers, F. Zepp, and O. Nitsche Early-life determinants of asthma from birth to age 20 years: a German birth cohort study J Allergy Clin Immunol 133 2014 979 988
33. J. Bousquet, J.E. Gern, F.D. Martinez, J.M. Anto, C.C. Johnson, and P.G. Holt Birth cohorts in asthma and allergic diseases: report of a NIAID/NHLBI/MeDALL joint workshop J Allergy Clin Immunol 133 2014 1535 1546
34. D.K. Radhakrishnan, S.D. Dell, A. Guttman, S.Z. Shariff, K. Liu, and T. To Trends in the age of diagnosis of childhood asthma J Allergy Clin Immunol 134 2014 1057 1062
35. A.M. Pescatore, C.M. Dogaru, L. Duembgen, M. Silverman, E.A. Gaillard, and B.D. Spycher A simple asthma prediction tool for preschool children with wheeze or cough J Allergy Clin Immunol 133 2014 111 118
36. S. Turner Predicting the future for recurrent respiratory symptoms in young children: applying a dash of science to the art of medicine J Allergy Clin Immunol 133 2014 119 120
37. A. Tai, H. Tran, M. Roberts, N. Clarke, A.M. Gibson, and S. Vidmar Outcomes of childhood asthma to the age of 50 years J Allergy Clin Immunol 133 2014 1572 1578
38. M.B. Reddy, J. Doshi, R. Covar, and J.D. Spahn The changing face of severe childhood asthma: a comparison of two cohorts of children evaluated at National Jewish Health over the past 20 years Allergy Asthma Proc 35 2014 119 125
39. L.J. Akinbami, J.E. Moorman, A.E. Simon, and K.C. Schoendorf Trends in racial disparities for asthma outcomes among children 0-17 years, 2001-2010 J Allergy Clin Immunol 134 2014 547 553
40. N. Thakur, S.S. Oh, E.A. Nguyen, M. Martin, L.A. Roth, and J. Galanter Socioeconomic status and childhood asthma in urban minority youths. The GALA II and SAGE II studies Am J Respir Crit Care Med 188 2013 1202 1209
41. Y. Aung, C. Majaesic, A. Senthiselvan, and P.J. Mandhane Physician specialty influences important aspects of pediatric asthma management J Allergy Clin Immunol Pract 2 2014 306 312
42. W.J. Calhoun, T. Haselkorn, D.R. Mink, D.P. Miller, A. Dorenbaum, and R.S. Zeiger Clinical burden and predictors of asthma exacerbations in patients on guideline-based steps 4-6 asthma therapy in the TENOR cohort J Allergy Clin Immunol Pract 2 2014 193 200
43. S. Sharma, X. Zhou, D.M. Thibault, B.E. Himes, A. Liu, and S.J. Szefler A genome-wide survey of CD4+ lymphocyte regulatory genetic variants identifies novel asthma genes J Allergy Clin Immunol 134 2014 1153 1162
44. H17 pathway genes, childhood asthma and total serum IgE levels J Allergy Clin Immunol 133 2014 888 891
45. J.M. Biagini Myers, L.J. Martin, M. Butsch Kovacic, T.B. Mersha, H. He, and V. Pilipenko Epistasis between serine protease inhibitor Kazal-type 5 (SPINK5) and thymic stromal lymphopoietin (TSLP) genes contributes to childhood asthma J Allergy Clin Immunol 134 2014 891 899
46. R.J. Van der Valk, L. Duijts, N.J. Timpson, M.T. Salam, M. Standl, and J.A. Curtin Fraction of exhaled nitric oxide values in childhood are associated with 17q11.2-q12 and 17q12-q21 variants J Allergy Clin Immunol 134 2014 46 55
47. J.M. Galanter, C.R. Gignoux, D.G. Torgerson, L.A. Roth, C. Eng, and S.S. Oh Genome-wide association study and admixture mapping identify different asthma-associated loci in Latinos: the Genes-environments & Admixture in Latino Americans study J Allergy Clin Immunol 134 2014 295 305
48. T.F. Leung, F.W. Ko, H.Y. Sy, S.K. Tsui, and G.W. Wong Differences in asthma genetics between Chinese and other populations J Allergy Clin Immunol 133 2014 42 48
49. S.L. Rosenberg, G.E. Miller, J.M. Brehm, and J.C. Celedon Stress and asthma: novel insights on genetic, epigenetic and immunologic mechanisms J Allergy Clin Immunol 134 2014 1009 1015
50. A. Poole, C. Urbanek, C. Eng, J. Schageman, S. Jacobson, and B.P. O'Connor Dissecting childhood asthma with nasal transcriptomics distinguishes subphenotypes of disease J Allergy Clin Immunol 133 2014 670 678
51. H2-promoting cytokine receptors in patients with allergic disease J Allergy Clin Immunol 133 2014 952 960
52. I.T. Harvima, F. Levi-Schaffer, P. Draber, S. Friedman, I. Polakovicova, and B.F. Gibbs Molecular targets on mast cells and basophils for novel therapies J Allergy Clin Immunol 134 2014 530 544
53. M. Guarnieri, and J.R. Balmes Outdoor air pollution and asthma Lancet 383 2014 1581 1592
54. R.L. Miller, and D.B. Peden Environmental impacts on immune responses in atopy and asthma J Allergy Clin Immunol 134 2014 1001 1008
55. E.C. Matsui, N.N. Hansel, C. Aloe, A.M. Schlitz, R.D. Peng, and N. Rabinovitch Indoor pollution exposures modify the effect of airborne endotoxin on asthma in urban children Am J Respir Crit Care Med 188 2013 1210 1215
56. M.P. Fabian, G. Adamkiewicz, N.K. Stout, M. Sandel, and J.I. Levy A simulation model of building intervention impacts on indoor environmental quality, pediatric asthma and costs J Allergy Clin Immunol 133 2014 77 84
57. S. Brandt, L. Perez, N. Kunzil, F. Lurmann, J. Wilson, and M. Pastor Cost of near-roadway and regional air pollution-attributable childhood asthma in Los Angeles County J Allergy Clin Immunol 134 2014 1028 1035
58. S.N. Georas, and F. Rezaee Epithelial barrier function: at the front line of asthma immunology and allergic airway inflammation J Allergy Clin Immunol 134 2014 509 520
59. B.N. Lambrecht, and H. Hammad Allergens and the airway epithelium response: gateway to allergic sensitization J Allergy Clin Immunol 134 2014 499 507
60. J. Iwasaki, W.A. Smith, S.K. Khoo, J. Bizzintino, G. Zhang, and D.W. Cox Comparison of rhinovirus antibody titers in children with asthma exacerbations and species-specific rhinovirus infection J Allergy Clin Immunol 134 2014 25 32
61. K.M. Kloepfer, W.M. Lee, T.E. Pappas, T.J. Kang, R.F. Vrtis, and M.D. Evans Detection of pathogenic bacteria during rhinovirus infection is associated with increased respiratory symptoms and asthma exacerbations J Allergy Clin Immunol 133 2014 1301 1307
62. N.H. Vissing, B.L. Chawes, and H. Bisgaard Increased risk of pneumonia and bronchiolitis after bacterial colonization of the airways as neonates Am J Respir Crit Care Med 188 2013 1246 1252
63. M. Ege Microbial airway colonization: a cause of asthma and pneumonia? Am J Respir Crit Care Med 188 2013 1188 1189
64. Y.J. Juhn Risks for infection in patients with asthma (or other atopic conditions): is asthma more than a chronic airway disease? J Allergy Clin Immunol 134 2014 247 257
65. W.W. Busse, and J.E. Gern Asthma and infections: is the risk more profound than previously thought? J Allergy Clin Immunol 134 2014 260 261
66. L.B. Bacharier Early-life weight gain, prematurity and asthma development J Allergy Clin Immunol 133 2014 1330 1331
67. E. Forno, E. Acosta-Perez, J.M. Brehm, Y.Y. Han, M. Alvarez, and A. Colon-Semidey Obesity and adiposity indicators, asthma and atopy in Puerto Rican children J Allergy Clin Immunol 133 2014 1308 1314
68. E. Arteaga-Solis, and M. Kattan Obesity in asthma: location or hormonal consequences? J Allergy Clin Immunol 133 2014 1315 1316
69. M. Schatz, R.S. Zeiger, F. Zhang, W. Chen, S.J. Yang, and C.A. Camargo Overweight/obesity and risk of seasonal asthma exacerbations J Allergy Clin Immunol Pract 1 2013 618 622
70. N.W. Kuo, K.Y. Tung, C.H. Tsai, Y.C. Chen, and Y.L. Lee β3-adrenergic receptor gene modifies the association between childhood obesity and asthma J Allergy Clin Immunol 134 2014 731 733.e3
71. S. Gelhaus Wendell, C. Baffi, and F. Holguin Fatty acids, inflammation and asthma J Allergy Clin Immunol 133 2014 1255 1264
72. W. Wu, E. Bleecker, W. Moore, W.W. Busse, M. Castro, and K.F. Chung Unsupervised phenotyping of Severe Asthma Research Program participants using expanded lung data J Allergy Clin Immunol 133 2014 1280 1288
73. W.C. Moore, A.T. Hastie, X. Li, H. Li, W.W. Busse, and N.N. Jarjour Sputum neutrophil counts are associated with more severe asthma phenotypes using cluster analysis J Allergy Clin Immunol 133 2014 1557 1563
74. M. Schatz, J.W. Hsu, R.S. Zeiger, W. Chen, A. Dorenbaum, and B.E. Chipps Phenotypes determined by cluster analysis in severe or difficult-to-treat asthma J Allergy Clin Immunol 133 2014 1549 1556
75. M. Depner, O. Fuchs, J. Genuneit, A.M. Karvonen, A. Hyvarinen, and V. Kaulek Clinical and epidemiologic phenotypes of childhood asthma Am J Respir Crit Care Med 189 2014 129 138
76. D. Belgrave, and A. Simpson Challenges in interpreting wheeze phenotypes: the clinical implications of statistical learning techniques Am J Respir Crit Care Med 189 2014 121 123
77. C.J. Lodge, A.J. Lowe, K.J. Allen, S. Zaloumis, L.C. Gurrin, and M.C. Matheson Childhood wheeze phenotypes show less than expected growth in FEV1 across adolescence Am J Respir Crit Care Med 189 2014 1351 1358
78. J.M. Nguyen, J.T. Holbrook, C.Y. Wei, L.B. Gerald, W.G. Teague, and R.A. Wise Validation and psychometric properties of the Asthma Control Questionnaire among children J Allergy Clin Immunol 133 2014 91 97
79. C.A. Sorkness Validation studies of asthma patient-reported outcomes: "we want more!" J Allergy Clin Immunol 133 2014 397 398
80. S. Voorend-van Bergen, A.A. Vaessen-Verberne, A.M. Landstra, H.J. Brackel, N.J. van den Berg, and D. Caudri Monitoring childhood asthma: web-based diaries and asthma control test J Allergy Clin Immunol 133 2014 1599 1605
81. S. Pedersen Measuring childhood asthma control J Allergy Clin Immunol 133 2014 1606 1607
82. D. Van Vliet, M. van Horck, K. van de Kant, S. Vaassen, S. Gulikers, and B. Winkens Electronic monitoring of symptoms and lung function to assess asthma control in children Ann Allergy Asthma Immunol 113 2014 257 262
83. S.O. Okelo, M.N. Eakin, K.A. Riekert, A.P. Teodoro, A.L. Bilderback, and D.A. Thompson Validation of parental reports of asthma trajectory, burden and risk by using the Pediatric Asthma Control and Communication Instrument J Allergy Clin Immunol Pract 2 2014 186 192
84. C.E. Rodriguez-Martinez, G. Nino, and J.A. Castro-Rodriguez Validation of the Spanish version of the Test for Respiratory and Asthma Control in Kids (TRACK) in a population of Hispanic preschoolers J Allergy Clin Immunol Pract 2 2014 326 331
85. L. Cicutto, M. Gleason, and S.J. Szefler Establishing school-centered asthma programs J Allergy Clin Immunol 134 2014 1223 1230
86. J. Lynn, S. Oppenheimer, and L. Zimmer Using public policy to improve outcomes for children with asthma in schools J Allergy Clin Immunol 134 2014 1238 1244
87. M. Huffaker, and W. Phipatanakul Introducing an environmental assessment and intervention program in inner-city schools J Allergy Clin Immunol 134 2014 1232 1237
88. J.P. Hollenbach, and M.M. Cloutier Implementing school asthma programs: lessons learned and recommendations J Allergy Clin Immunol 134 2014 1245 1249
89. T.S. Chang, R.F. Lemanske, D.T. Mauger, A.M. Fitzpatrick, C.A. Sorkness, and S.J. Szefler Childhood asthma clusters and response to therapy in clinical trials J Allergy Clin Immunol 133 2014 363 369
90. J.A. Howrylak, A.L. Fuhlbrigge, R.C. Strunk, R.S. Zeiger, S.T. Weiss, and B.A. Raby Classification of childhood asthma phenotypes and long-term clinical responses to inhaled anti-inflammatory medications J Allergy Clin Immunol 133 2014 1289 1300
91. K.A. Drake, D.G. Torgerson, C.R. Gignoux, J.M. Galanter, L.A. Roth, and S. Huntsman A genome-wide association study of bronchodilator response in Latinos implicates rare variants J Allergy Clin Immunol 133 2014 370 378
92. H.W. Park, A. Dahlin, S. Tse, Q.L. Duan, B. Schuemann, and F.D. Martinez Genetic predictors associated with improvement of asthma symptoms in response to inhaled corticosteroids J Allergy Clin Immunol 133 2014 664 669
93. A.C. Wu, B.E. Himes, J. Lasky-Su, A. Litonjua, S.P. Peters, and J. Lima Inhaled corticosteroid treatment modulates ZNF432 gene variant's effect on bronchodilator response in asthmatics J Allergy Clin Immunol 133 2014 723 728
94. N. Rabinovitch, D.T. Mauger, N. Reisdorph, R. Covar, J. Malka, and R.F. Lemanske Predictors of asthma control and lung function responsiveness to step 3 therapy in children with uncontrolled asthma J Allergy Clin Immunol 133 2014 350 356
95. J. Malka, D.T. Mauger, R. Covar, N. Rabinovitch, R.F. Lemanske, and J.D. Spahn Eczema and race as combined determinants for differential response to step-up asthma therapy J Allergy Clin Immunol 134 2014 483 485
96. S. Montella, E. Baraldi, D. Bruzzese, V. Mirra, A. DiGiorgio, and F. Santamaria What drives prescribing of asthma medication to preschool wheezing children? A primary care study Pediatr Pulmonol 48 2013 1160 1170
97. M. Weinberger The challenge of treating preschool asthma J Allergy Clin Immunol 133 2014 1014 1015
98. A. Beigelman, R.S. Zeiger, H.W. Kelly, L.B. Bacharier for the Childhood Asthma Research and Education Network of the National Heart, Lung and Blood Institute The challenge of treating preschool wheezing episodes: the need for evidence-based approaches J Allergy Clin Immunol 133 2014 1016 1017
99. E.K. Miller, P.C. Avila, Y.W. Khan, C.R. Word, B.J. Pelz, and N.G. Papadopoulos Wheezing exacerbations in early childhood: evaluation, treatment, and recent advances relevant to the genesis of asthma J Allergy Clin Immunol Pract 2 2014 537 543
100. T.W. Guilbert, L.B. Bacharier, and A.M. Fitzpatrick Severe asthma in children J Allergy Clin Immunol Pract 2 2014 489 500
101. H. Moreno-Macias, and I. Romieu Effects of antioxidant supplements and nutrients on patients with asthma and allergies J Allergy Clin Immunol 133 2014 1237 1244
102. S. Sharma, and A. Litonjua Asthma, allergy and responses to methyl donor supplements and nutrients J Allergy Clin Immunol 133 2014 1246 1254
103. M. Humbert, W. Busse, N.A. Hanania, P.J. Lowe, J. Canvin, and V.J. Erpenbeck Omalizumab in asthma: an update on recent developments J Allergy Clin Immunol Pract 2 2014 525 536
104. A. Long, A. Rahmaoui, K.J. Rothman, E. Guinan, M. Eisner, and M.S. Bradley Incidence of malignancy in patients with moderate-to-severe asthma treated with or without omalizumab J Allergy Clin Immunol 134 2014 560 567
105. E.H. deBoever, C. Ashman, A.P. Cahn, N.W. Locantore, P. Overend, and I.J. Pouliquen Efficacy and safety of an anti-IL-13 mAb in patients with severe asthma: a randomized trial J Allergy Clin Immunol 133 2014 989 996
106. P. Haldar, C.E. Brightling, A. Singapuri, B. Hargadon, S. Gupta, and W. Monteiro Outcomes after cessation of mepolizumab therapy in severe eosinophilic asthma: a 12-month follow-up analysis J Allergy Clin Immunol 133 2014 921 923
107. M.A. Birrell, S.J. Bonvini, E. Dubuis, S.A. Maher, M.A. Wortley, and M.S. Grace Tiotropium modulates transient receptor potential V1 (TRPV1) in airway sensory nerves: a beneficial off-target effect? J Allergy Clin Immunol 133 2014 679 687
108. H. Mosbech, R. Deckelmann, F. de Blay, E.A. Pastorello, E. Trebas-Pietras, and L. Prieto Andres Standardized quality (SQ) house dust mite sublingual immunotherapy tablet (ALK) reduces inhaled corticosteroid use while maintaining asthma control: a randomized, double-blind, placebo-controlled trial J Allergy Clin Immunol 134 2014 568 575
109. C. Stockman, J.S. Ross, C.M. Sherwin, C.A. Reilly, B. McDowell, and B. Fassl Rate of asthma trial outcomes reporting on ClinicalTrials.gov and in the published literature J Allergy Clin Immunol 134 2014 1443 1446
110. R. Djukanovic, T. Harrison, S.L. Johnston, F. Gabbay, P. Wark, and N.C. Thomson The effect of inhaled IFN-β on worsening of asthma symptoms caused by viral infections Am J Respir Crit Care Med 190 2014 145 154
111. D.J. Jackson Inhaled interferon: a novel treatment for virus-induced asthma? Am J Respir Crit Care Med 190 2014 123 134
112. R. Beasley, M. Weatherall, P. Shirtcliffe, R. Hancox, and H.K. Reddel Combination corticosteroid/β agonist inhaler as reliever therapy: a solution for intermittent and mild asthma? J Allergy Clin Immunol 133 2014 39 41