Predictors of asthma control and lung function responsiveness to step 3 therapy in children with uncontrolled asthma

Journal of Allergy and Clinical Immunology

Volumn 133, Issue 2, 2014, Pages 350-356

  Rabinovitch, Nathan ^a   Mauger, David T ^b   Reisdorph, Nichole ^a   Covar, Ronina ^a   Malka, Jonathan ^a   Lemanske, Robert F ^c   Morgan, Wayne J ^d   Guilbert, Theresa W ^c   Zeiger, Robert S ^e   Bacharier, Leonard B ^f   Szefler, Stanley J ^a  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^b PENNSYLVANIA STATE UNIVERSITY   (United States)

^c UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^d UNIVERSITY OF ARIZONA   (United States)

^e UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^f WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Asthma; Best Add On Giving Effective Response; children; fraction of exhaled nitric oxide; impulse oscillometry; inhaled corticosteroids; leukotriene receptor antagonist

Indexed keywords

FLUTICASONE PROPIONATE; LEUKOTRIENE E4; MONTELUKAST; PEPTIDOLEUKOTRIENE; SALMETEROL;

ADOLESCENT; AIRWAY OBSTRUCTION; ARTICLE; ASTHMA; CHILD; CONTROLLED STUDY; CROSSOVER PROCEDURE; FORCED EXPIRATORY VOLUME; FORCED VITAL CAPACITY; HUMAN; LOW DRUG DOSE; LUNG FUNCTION; OSCILLOMETRY; PHENOTYPE; POST HOC ANALYSIS; PREDICTION; PRESCHOOL CHILD; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RESPIRATORY TRACT INFLAMMATION; SCHOOL CHILD; TREATMENT RESPONSE; URINE LEVEL;

AACD; ACD; ANNUALIZED ASTHMA CONTROL DAY; ASTHMA; ASTHMA CONTROL DAY; AX; BADGER; BEST ADD-ON GIVING EFFECTIVE RESPONSE; CHILDREN; FENO; FLUTICASONE PROPIONATE; FORCED VITAL CAPACITY; FP; FRACTION OF EXHALED NITRIC OXIDE; FVC; ICS; IMPULSE OSCILLOMETRY; INHALED CORTICOSTEROIDS; IOS; KILOPASCAL PER LITER PER SECOND; KPA/L/S; LABA; LEUKOTRIENE E(4); LEUKOTRIENE RECEPTOR ANTAGONIST; LONG-ACTING Β(2)-AGONIST; LTRA; R5; REACTANCE AREA; RESISTANCE AT 5 HZ; ULTE(4); URINARY LEUKOTRIENE E(4);

ACETATES; ADOLESCENT; ADRENERGIC BETA-AGONISTS; ALBUTEROL; ANDROSTADIENES; ANTI-ASTHMATIC AGENTS; ASTHMA; BIOLOGICAL MARKERS; BRONCHODILATOR AGENTS; CHILD; CROSS-OVER STUDIES; EOSINOPHILS; FEMALE; FORCED EXPIRATORY VOLUME; HUMANS; LEUKOCYTE COUNT; LEUKOTRIENE ANTAGONISTS; LEUKOTRIENE E4; MALE; QUINOLINES; VITAL CAPACITY;

EID: 84895056746     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2013.07.039     Document Type: Article

References (26)

1. R.F. Lemanske Jr., D.T. Mauger, C.A. Sorkness, D.J. Jackson, S.J. Boehmer, and F.D. Martinez et al. Step-up therapy for children with uncontrolled asthma receiving inhaled corticosteroids N Engl J Med 362 2010 975 985
2. R.S. Zeiger, S.J. Szefler, B.R. Phillips, M. Schatz, F.D. Martinez, and V.M. Chinchilli et al. Response profiles to fluticasone and montelukast in mild-to-moderate persistent childhood asthma J Allergy Clin Immunol 117 2006 45 52
3. J.E. Knuffman, C.A. Sorkness, R.F. Lemanske Jr., D.T. Mauger, S.J. Boehmer, and F.D. Martinez et al. Phenotypic predictors of long-term response to inhaled corticosteroid and leukotriene modifier therapies in pediatric asthma J Allergy Clin Immunol 123 2009 411 416
4. N. Rabinovitch, N.J. Graber, V.M. Chinchilli, C.A. Sorkness, R.S. Zeiger, and R.C. Strunk et al. Urinary leukotriene E4/exhaled nitric oxide ratio and montelukast response in childhood asthma [published Erratum in: J Allergy Clin Immunol 2010;126:959-61] J Allergy Clin Immunol 126 2010 545 551
5. S.J. Szefler, B.R. Phillips, F.D. Martinez, V.M. Chinchilli, R.F. Lemanske, and R.C. Strunk et al. Characterization of within-subject responses to fluticasone and montelukast in childhood asthma J Allergy Clin Immunol 115 2005 233 242
6. M. Armstrong, A.H. Liu, R. Harbeck, R. Reisdorph, N. Rabinovitch, and N. Reisdorph Leukotriene-E4 in human urine: comparison of on-line purification and liquid chromatography-tandem mass spectrometry to affinity purification followed by enzyme immunoassay J Chromatogr B Analyt Technol Biomed Life Sci 877 2009 3169 3174
7. H.W. Kelly Inhaled corticosteroid dosing: double for nothing? J Allergy Clin Immunol 128 2011 278 281
8. M.W. Radomski, R.M. Palmer, and S. Moncada Glucocorticoids inhibit the expression of an inducible, but not the constitutive, nitric oxide synthase in vascular endothelial cells Proc Natl Acad Sci U S A 87 1990 10043 10047
9. S.A. Kharitonov, D.H. Yates, and P.J. Barnes Inhaled glucocorticoids decrease nitric oxide in exhaled air of asthmatic patients Am J Respir Crit Care Med 153 1996 1454 1457
10. M.L. Bartoli, F.L. Dente, L. Bancalari, E. Bacci, S. Cianchetti, and A. Di Franco et al. Beclomethasone dipropionate blunts allergen-induced early increase in urinary LTE4 Eur J Clin Invest 6 2010 566 569
11. C. Severien, A. Artlich, S. Jonas, and G. Becher Urinary excretion of leukotriene E4 and eosinophil protein X in children with atopic asthma Eur Respir J 16 2000 588 592
12. C. Mondino, G. Ciabattoni, P. Koch, R. Pistelli, A. Trové, and P.J. Barnes et al. Effects of inhaled corticosteroids on exhaled leukotrienes and prostanoids in asthmatic children J Allergy Clin Immunol 114 2004 761 767
13. S.E. Wenzel, J.B. Trudeau, D.A. Kaminsky, J. Cohn, R.J. Martin, and J.Y. Westcott Effect of 5-lipoxygenase inhibition on bronchoconstriction and airway inflammation in nocturnal asthma Am J Respir Crit Care Med 152 1995 897 905
14. G.M. Gauvreau, K.N. Parameswaran, R.M. Watson, and P.M. O'Byrne Inhaled leukotriene E(4), but not leukotriene D(4), increased airway inflammatory cells in subjects with atopic asthma Am J Respir Crit Care Med 164 2001 1495 1500
15. N. Scichilone, S. Battaglia, D. Olivieri, and V. Bellia The role of small airways in monitoring the response to asthma treatment: what is beyond FEV1? Allergy 64 2009 1563 1569
16. A. Niimi, R. Amitani, K. Suzuki, E. Tanaka, T. Murayama, and F. Kuze Serum eosinophil cationic protein as a marker of eosinophilic inflammation in asthma Clin Exp Allergy 28 1998 233 240
17. D.W. Kaczka, R.L. Dellacá, D.W. Kaczka, E.P. Ingenito, E. Israel, and K.R. Lutchen Oscillation mechanics of the respiratory system: applications to lung disease Crit Rev Biomed Eng 39 2011 337 359
18. G.L. Larsen, W. Morgan, G.P. Heldt, D.T. Mauger, S.J. Boehmer, and V.M. Chinchilli et al. Impulse oscillometry versus spirometry in a long-term study of controller therapy for pediatric asthma J Allergy Clin Immunol 123 2009 861 867
19. H. Nakaji, G. Petrova, H. Matsumoto, T. Iwata, I. Ito, and T. Oguma et al. Effects of 24-week add-on treatment with ciclesonide and montelukast on small airways inflammation in asthma Ann Allergy Asthma Immunol 110 2013 198 203
20. L.G. Fritscher, M.T. Rodrigues, N. Zamel, and K.R. Chapman The effect of montelukast on exhaled nitric oxide of alveolar and bronchial origin in inhaled corticosteroid-treated asthma Respir Med 103 2009 296 300
21. S.J. Szefler, H. Mitchell, C.A. Sorkness, P.J. Gergen, G.T. O'Connor, and W.J. Morgan et al. Management of asthma based on exhaled nitric oxide in addition to guideline-based treatment for inner-city adolescents and young adults: a randomised controlled trial Lancet 372 2008 1065 1072
22. W.J. Calhoun, B.T. Ameredes, T.S. King, N. Icitovic, E.R. Bleecker, and M. Castro et al. Comparison of physician-, biomarker-, and symptom-based strategies for adjustment of inhaled corticosteroid therapy in adults with asthma: the BASALT randomized controlled trial JAMA 308 2012 987 997
23. E. von Mutius, and J.M. Drazen Choosing asthma step-up care N Engl J Med 362 2010 1042 1043
24. N.P. Duroudier, A.S. Tulah, and I. Sayers Leukotriene pathway genetics and pharmacogenetics in allergy Allergy 64 2009 823 839
25. K.H. In, E.S. Silverman, K. Asano, D. Beier, A.R. Fischer, and T.P. Keith et al. Mutations in the human 5-lipoxygenase gene Clin Rev Allergy Immunol 17 1999 59 69
26. J.J. Lima, S. Zhang, A. Grant, L. Shao, K.G. Tantisira, and H. Allayee et al. Influence of leukotriene pathway polymorphisms on response to montelukast in asthma Am J Respir Crit Care Med 173 2006 379 385