Advances in adult asthma diagnosis and treatment in 2013

Journal of Allergy and Clinical Immunology

Volumn 133, Issue 1, 2014, Pages 49-56

  Apter, Andrea J ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

adults; Asthma; asthma management; inhaled corticosteroids

Indexed keywords

BECLOMETASONE; FLUTICASONE; LEBRIKIZUMAB; LEUKOTRIENE RECEPTOR BLOCKING AGENT; OMALIZUMAB; SALBUTAMOL; SALMETEROL; TIOTROPIUM BROMIDE; TOBACCO SMOKE;

ADULT; ARTICLE; ASTHMA; CHRONIC OBSTRUCTIVE LUNG DISEASE; DISEASE COURSE; DISEASE EXACERBATION; ENVIRONMENTAL EXPOSURE; EXERCISE; GENETIC ASSOCIATION; HUMAN; PHENOTYPE; PHENOTYPIC PLASTICITY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); SMOKING; SUBLINGUAL IMMUNOTHERAPY;

ACQ; ADULTS; ALVEOLAR FRACTION OF EXHALED NITRIC OXIDE; ASTHMA; ASTHMA CONTROL QUESTIONNAIRE; ASTHMA MANAGEMENT; C(ALV)NO; CHEMOATTRACTANT RECEPTOR HOMOLOGOUS MOLECULE EXPRESSED ON T(H)2 CELLS; CHRONIC OBSTRUCTIVE PULMONARY DISEASE; COPD; CRTH2; EBC; EXHALED BREATH CONDENSATE; FENO; FRACTION OF EXHALED NITRIC OXIDE; ICS; INHALED CORTICOSTEROID; INHALED CORTICOSTEROIDS; LABA; LONG-ACTING Β-AGONIST; OA; OCCUPATIONAL ASTHMA; PATIENT-REPORTED OUTCOME MEASURE; PGD(2); PROM; PROSTAGLANDIN D(2); SLIT; SUBLINGUAL IMMUNOTHERAPY; TLR; TOLL-LIKE RECEPTOR; WEA; WORK-EXACERBATED ASTHMA; WORK-RELATED ASTHMA; WRA;

ADRENAL CORTEX HORMONES; ADULT; ANDROSTADIENES; ANTI-ASTHMATIC AGENTS; ASTHMA; BRONCHODILATOR AGENTS; CLINICAL TRIALS AS TOPIC; DIAGNOSIS, DIFFERENTIAL; DRUG THERAPY, COMBINATION; HUMANS; INDIVIDUALIZED MEDICINE; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE;

EID: 84891691515     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2013.11.005     Document Type: Review

References (83)

1. A.J. Apter Advances in adult asthma diagnosis and treatment in 2012: potential therapeutics and gene-environment interactions J Allergy Clin Immunol 131 2013 47 54
2. S.J. Szefler Advances in pediatric asthma in 2012: moving toward asthma prevention J Allergy Clin Immunol 131 2013 36 46
3. B.J. Carolan, and E.R. Sutherland Clinical phenotypes of chronic obstructive pulmonary disease and asthma: recent advances J Allergy Clin Immunol 131 2013 627 635
4. J. Miyata, K. Fukunaga, R. Iwamoto, Y. Isobe, K. Niimi, and R. Takamiya et al. Dysregulated synthesis of protectin D1 in eosinophils from patients with severe asthma J Allergy Clin Immunol 131 2013 353 360 e1-2
5. C.M. Lloyd, and S. Saglani T cells in asthma: influences of genetics, environment, and T-cell plasticity J Allergy Clin Immunol 131 2013 1267 1275
6. D. Pennino, P.K. Bhavsar, R. Effner, S. Avitabile, P. Venn, and M. Quaranta et al. IL-22 suppresses IFN-gamma-mediated lung inflammation in asthmatic patients J Allergy Clin Immunol 131 2013 562 570
7. A.M. Nanzer, E.S. Chambers, K. Ryanna, D.F. Richards, C. Black, and P.M. Timms et al. Enhanced production of IL-17A in patients with severe asthma is inhibited by 1alpha,25-dihydroxyvitamin D3 in a glucocorticoid-independent fashion J Allergy Clin Immunol 132 2013 297 304.e3
8. N.S. Grotenboer, M.E. Ketelaar, G.H. Koppelman, and M.C. Nawijn Decoding asthma: translating genetic variation in IL33 and IL1RL1 into disease pathophysiology J Allergy Clin Immunol 131 2013 856 865
9. L. Gabriele, G. Schiavoni, F. Mattei, M. Sanchez, P. Sestili, and C. Butteroni et al. Novel allergic asthma model demonstrates ST2-dependent dendritic cell targeting by cypress pollen J Allergy Clin Immunol 132 2013 686 695.e7
10. J.A. Sigua, and M.H. Grayson Evidence mounts that viruses drive atopic development J Allergy Clin Immunol 131 2013 1340 1341
11. G.E. Kaiko, Z. Loh, K. Spann, J.P. Lynch, A. Lalwani, and Z. Zheng et al. Toll-like receptor 7 gene deficiency and early-life Pneumovirus infection interact to predispose toward the development of asthma-like pathology in mice J Allergy Clin Immunol 131 2013 1331 1339.e10
12. G. Campbell-Harding, H. Sawkins, N. Bedke, S.T. Holgate, D.E. Davies, and A.L. Andrews The innate antiviral response upregulates IL-13 receptor alpha2 in bronchial fibroblasts J Allergy Clin Immunol 131 2013 849 855
13. K.M. Beeh, F. Kanniess, F. Wagner, C. Schilder, I. Naudts, and A. Hammann-Haenni et al. The novel TLR-9 agonist QbG10 shows clinical efficacy in persistent allergic asthma J Allergy Clin Immunol 131 2013 866 874
14. P.J. Barnes Corticosteroid resistance in patients with asthma and chronic obstructive pulmonary disease J Allergy Clin Immunol 131 2013 636 645
15. R.H. Oakley, and J.A. Cidlowski The biology of the glucocorticoid receptor: new signaling mechanisms in health and disease J Allergy Clin Immunol 132 2013 1033 1044
16. X. Li, G.A. Hawkins, E.J. Ampleford, W.C. Moore, H. Li, and A.T. Hastie et al. Genome-wide association study identifies TH1 pathway genes associated with lung function in asthmatic patients J Allergy Clin Immunol 132 2013 313 320.e15
17. E.E. Thompson, R.A. Myers, G. Du, T.M. Aydelotte, C.J. Tisler, and D.A. Stern et al. Maternal microchimerism protects against the development of asthma J Allergy Clin Immunol 132 2013 39 44
18. S. Kyoh, N. Venkatesan, A.H. Poon, M. Nishioka, T.Y. Lin, and C.J. Baglole et al. Are leukocytes in asthmatic patients aging faster? A study of telomere length and disease severity J Allergy Clin Immunol 132 2013 480 482.e2
19. P.R. Marri, D.A. Stern, A.L. Wright, D. Billheimer, and F.D. Martinez Asthma-associated differences in microbial composition of induced sputum J Allergy Clin Immunol 131 2013 346 352 e1-3
20. C. Lemiere, L.P. Boulet, S. Chaboillez, A. Forget, S. Chiry, and H. Villeneuve et al. Work-exacerbated asthma and occupational asthma: do they really differ? J Allergy Clin Immunol 131 2013 704 710
21. S.K. Ahluwalia, R.D. Peng, P.N. Breysse, G.B. Diette, J. Curtin-Brosnan, and C. Aloe et al. Mouse allergen is the major allergen of public health relevance in Baltimore City J Allergy Clin Immunol 132 2013 830 835 e1-2
22. D.R. Ownby Will the real inner-city allergen please stand up? J Allergy Clin Immunol 132 2013 836 837
23. G.A. Mueller, L.C. Pedersen, F.B. Lih, J. Glesner, A.F. Moon, and M.D. Chapman et al. The novel structure of the cockroach allergen Bla g 1 has implications for allergenicity and exposure assessment J Allergy Clin Immunol 2013 [Epub ahead of print]
24. R.J. Wright, H. Mitchell, C.M. Visness, S. Cohen, J. Stout, and R. Evans et al. Community violence and asthma morbidity: the Inner-City Asthma Study Am J Public Health 94 2004 625 632
25. A.J. Apter, L.A. Garcia, R.C. Boyd, X. Wang, D.K. Bogen, and T. Ten Have Exposure to community violence is associated with asthma hospitalizations and emergency department visits J Allergy Clin Immunol 126 2010 552 557
26. P.F. Coogan, L.A. Wise, G.T. O'Connor, T.A. Brown, J.R. Palmer, and L. Rosenberg Abuse during childhood and adolescence and risk of adult-onset asthma in African American women J Allergy Clin Immunol 131 2013 1058 1063
27. R. Felix, C. Martorell, A. Martorell, F. Pineda, J.C. Cerda, and M.D. De Las Marinas Induced bronchospasm after handling of orange flavedo (zest) J Allergy Clin Immunol 131 2013 1423 1425
28. K.M. Donohue, E.A. Hoffman, H. Baumhauer, J. Guo, F.S. Ahmed, and G.S. Lovasi et al. Asthma and lung structure on computed tomography: the Multi-Ethnic Study of Atherosclerosis Lung Study J Allergy Clin Immunol 131 2013 361 368 e1-11
29. A. Boudier, I. Curjuric, X. Basagana, H. Hazgui, J.M. Anto, and J. Bousquet et al. Ten-year follow-up of cluster-based asthma phenotypes in adults. A pooled analysis of three cohorts Am J Respir Crit Care Med 188 2013 550 560
30. W.C. Moore The natural history of asthma phenotypes identified by cluster analysis. Looking for chutes and ladders Am J Respir Crit Care Med 188 2013 521 522
31. M. Amelink, J.C. de Groot, S.B. de Nijs, R. Lutter, A.H. Zwinderman, and P.J. Sterk et al. Severe adult-onset asthma: a distinct phenotype J Allergy Clin Immunol 132 2013 336 341
32. E. van der Wiel, N.H. ten Hacken, D.S. Postma, and M. van den Berge Small-airways dysfunction associates with respiratory symptoms and clinical features of asthma: a systematic review J Allergy Clin Immunol 131 2013 646 657
33. B.R. Thompson, J.A. Douglass, M.J. Ellis, V.J. Kelly, R.E. O'Hehir, and G.G. King et al. Peripheral lung function in patients with stable and unstable asthma J Allergy Clin Immunol 131 2013 1322 1328
34. D.A. Kaminsky Multiple breath nitrogen washout profiles in asthmatic patients: what do they mean clinically? J Allergy Clin Immunol 131 2013 1329 1330
35. N. Scichilone, S. Battaglia, S. Taormina, V. Modica, E. Pozzecco, and V. Bellia Alveolar nitric oxide and asthma control in mild untreated asthma J Allergy Clin Immunol 131 2013 1513 1517
36. N.C. Thomson, R. Chaudhuri, L.G. Heaney, C. Bucknall, R.M. Niven, and C.E. Brightling et al. Clinical outcomes and inflammatory biomarkers in current smokers and exsmokers with severe asthma J Allergy Clin Immunol 131 2013 1008 1016
37. J.L. Perret, S.C. Dharmage, M.C. Matheson, D.P. Johns, L.C. Gurrin, and J.A. Burgess et al. The interplay between the effects of lifetime asthma, smoking, and atopy on fixed airflow obstruction in middle age Am J Respir Crit Care Med 187 2013 42 48
38. S. Kalliola, A.S. Pelkonen, L.P. Malmberg, S. Sarna, M. Hamalainen, and I. Mononen et al. Maternal smoking affects lung function and airway inflammation in young children with multiple-trigger wheeze J Allergy Clin Immunol 131 2013 730 735
39. T.K. Lajunen, J.J. Jaakkola, and M.S. Jaakkola Influence of heredity on asthma continues to adulthood J Allergy Clin Immunol 131 2013 916 918
40. T.K. Lajunen, J.J. Jaakkola, and M.S. Jaakkola The synergistic effect of heredity and exposure to second-hand smoke on adult-onset asthma Am J Respir Crit Care Med 188 2013 776 782
41. K.V. Carson, M.G. Chandratilleke, J. Picot, M.P. Brinn, A.J. Esterman, and B.J. Smith Physical training for asthma Cochrane Database Syst Rev 9 2013 Sept 30 CD001116
42. J. Saito, Q. Zhang, C. Hui, P. Macedo, D. Gibeon, and A. Menzies-Gow et al. Sputum hydrogen sulfide as a novel biomarker of obstructive neutrophilic asthma J Allergy Clin Immunol 131 2013 232 234 e1-3
43. S. Kazani, A. Planaguma, E. Ono, M. Bonini, M. Zahid, and G. Marigowda et al. Exhaled breath condensate eicosanoid levels associate with asthma and its severity J Allergy Clin Immunol 132 2013 547 553
44. M. Pinkerton, V. Chinchilli, E. Banta, T. Craig, A. August, and R. Bascom et al. Differential expression of microRNAs in exhaled breath condensates of patients with asthma, patients with chronic obstructive pulmonary disease, and healthy adults J Allergy Clin Immunol 132 2013 217 219
45. Z. Diamant, G.M. Gauvreau, D.W. Cockcroft, L.P. Boulet, P.J. Sterk, and F.H. de Jongh et al. Inhaled allergen bronchoprovocation tests J Allergy Clin Immunol 132 2013 1045 1055.e6
46. W. Guan, J. Zheng, Y. Gao, C. Jiang, Y. Xie, and J. An et al. Leukotriene D4 and methacholine bronchial provocation tests for identifying leukotriene-responsiveness subtypes J Allergy Clin Immunol 131 2013 332 338 e1-4
47. J.D. Brannan, C.P. Perry, and S.D. Anderson Mannitol test results in asthmatic adults receiving inhaled corticosteroids J Allergy Clin Immunol 131 2013 906 907
48. A.T. Hastie, W.C. Moore, D.A. Meyers, P.L. Vestal, H. Li, and S.P. Peters et al. Analyses of asthma severity phenotypes and inflammatory proteins in subjects stratified by sputum granulocytes J Allergy Clin Immunol 125 2010 1028 1036.e13
49. A.T. Hastie, W.C. Moore, H. Li, B.M. Rector, V.E. Ortega, and R.M. Pascual et al. Biomarker surrogates do not accurately predict sputum eosinophil and neutrophil percentages in asthmatic subjects J Allergy Clin Immunol 132 2013 72 80
50. P. Nair What is an "eosinophilic phenotype" of asthma? J Allergy Clin Immunol 132 2013 81 83
51. A. Malinovschi, J.A. Fonseca, T. Jacinto, K. Alving, and C. Janson Exhaled nitric oxide levels and blood eosinophil counts independently associate with wheeze and asthma events in National Health and Nutrition Examination Survey subjects J Allergy Clin Immunol 132 2013 821 827 e1-5
52. I.D. Pavord, and M. Bafadhel Exhaled nitric oxide and blood eosinophilia: independent markers of preventable risk J Allergy Clin Immunol 132 2013 828 829
53. G. Jia, R.W. Erickson, D.F. Choy, S. Mosesova, L.C. Wu, and O.D. Solberg et al. Periostin is a systemic biomarker of eosinophilic airway inflammation in asthmatic patients J Allergy Clin Immunol 130 2012 647 654.e10
54. Y. Kanemitsu, H. Matsumoto, K. Izuhara, Y. Tohda, H. Kita, and T. Horiguchi et al. Increased periostin associates with greater airflow limitation in patients receiving inhaled corticosteroids J Allergy Clin Immunol 132 2013 305 312.e3
55. C.E. Jia, H.P. Zhang, Y. Lv, R. Liang, Y.Q. Jiang, and H. Powell et al. The Asthma Control Test and Asthma Control Questionnaire for assessing asthma control: systematic review and meta-analysis J Allergy Clin Immunol 131 2013 695 703
56. M.E. Wechsler, M. Laviolette, A.S. Rubin, J. Fiterman, E.S.J.R. Lapa, and P.L. Shah et al. Bronchial thermoplasty: long-term safety and effectiveness in patients with severe persistent asthma J Allergy Clin Immunol 2013 [Epub ahead of print]
57. M. Castro, A.S. Rubin, M. Laviolette, J. Fiterman, M. De Andrade Lima, and P.L. Shah et al. Effectiveness and safety of bronchial thermoplasty in the treatment of severe asthma: a multicenter, randomized, double-blind, sham-controlled clinical trial Am J Respir Crit Care Med 181 2010 116 124
58. A.J. Apter, F. Wan, S. Reisine, B. Bender, C. Rand, and D.K. Bogen et al. The association of health literacy with adherence and outcomes in moderate-severe asthma J Allergy Clin Immunol 132 2013 321 327
59. R. Fernandez-Boyanapalli, E. Goleva, C. Kolakowski, E. Min, B. Day, and D.Y. Leung et al. Obesity impairs apoptotic cell clearance in asthma J Allergy Clin Immunol 131 2013 1041 1047 e1-3
60. D. Price, T.A. Popov, L. Bjermer, S. Lu, R. Petrovic, and K. Vandormael et al. Effect of montelukast for treatment of asthma in cigarette smokers J Allergy Clin Immunol 131 2013 763 771
61. H.S. Nelson Is sublingual immunotherapy ready for use in the United States? JAMA 309 2013 1297 1298
62. A.W. Burks, M.A. Calderon, T. Casale, L. Cox, P. Demoly, and M. Jutel et al. Update on allergy immunotherapy: American Academy of Allergy, Asthma & Immunology/European Academy of Allergy and Clinical Immunology/PRACTALL consensus report J Allergy Clin Immunol 131 2013 1288 1296.e3
63. P. Potter Sublingual immunotherapy in southern Africa: lessons learned J Allergy Clin Immunol 132 2013 99 100
64. S.Y. Lin, N. Erekosima, J.M. Kim, M. Ramanathan, C. Suarez-Cuervo, and Y. Chelladurai et al. Sublingual immunotherapy for the treatment of allergic rhinoconjunctivitis and asthma: a systematic review JAMA 309 2013 1278 1288
65. M.A. Kiel, E. Roder, R. Gerth van Wijk, M.J. Al, W.C. Hop, and M.P. Rutten-van Molken Real-life compliance and persistence among users of subcutaneous and sublingual allergen immunotherapy J Allergy Clin Immunol 132 2013 353 360.e2
66. P. Gevaert, L. Calus, T. Van Zele, K. Blomme, N. De Ruyck, and W. Bauters et al. Omalizumab is effective in allergic and nonallergic patients with nasal polyps and asthma J Allergy Clin Immunol 131 2013 110 116.e1
67. R.C. Kern Biologics and the treatment of chronic rhinosinusitis J Allergy Clin Immunol 131 2013 117 118
68. M.L. Fajt, S.L. Gelhaus, B. Freeman, C.E. Uvalle, J.B. Trudeau, and F. Holguin et al. Prostaglandin D(2) pathway upregulation: relation to asthma severity, control, and TH2 inflammation J Allergy Clin Immunol 131 2013 1504 1512
69. W.W. Busse, S.E. Wenzel, E.O. Meltzer, E.M. Kerwin, M.C. Liu, and N. Zhang et al. Safety and efficacy of the prostaglandin D2 receptor antagonist AMG 853 in asthmatic patients J Allergy Clin Immunol 131 2013 339 345
70. S. Wenzel, L. Ford, D. Pearlman, S. Spector, L. Sher, and F. Skobieranda et al. Dupilumab in persistent asthma with elevated eosinophil levels N Engl J Med 368 2013 2455 2466
71. J. Corren, R.F. Lemanske, N.A. Hanania, P.E. Korenblat, M.V. Parsey, and J.R. Arron et al. Lebrikizumab treatment in adults with asthma N Engl J Med 365 2011 1088 1098
72. M. Noonan, P. Korenblat, S. Mosesova, H. Scheerens, J.R. Arron, and Y. Zheng et al. Dose-ranging study of lebrikizumab in asthmatic patients not receiving inhaled steroids J Allergy Clin Immunol 132 2013 567 574.e12
73. M. Laviolette, D.L. Gossage, G. Gauvreau, R. Leigh, R. Olivenstein, and R. Katial et al. Effects of benralizumab on airway eosinophils in asthmatic patients with sputum eosinophilia J Allergy Clin Immunol 132 2013 1086 1096.e5
74. P.A. Zetstra-van der Woude, J.S. Vroegop, H.J. Bos, and L.T. de Jong-van den Berg A population analysis of prescriptions for asthma medications during pregnancy J Allergy Clin Immunol 131 2013 711 717
75. M.A. Rank, J.B. Hagan, M.A. Park, J.C. Podjasek, S.A. Samant, and G.W. Volcheck et al. The risk of asthma exacerbation after stopping low-dose inhaled corticosteroids: a systematic review and meta-analysis of randomized controlled trials J Allergy Clin Immunol 131 2013 724 729
76. National Heart, Lung, and Blood Institute. National Asthma Education and Prevention Program. Available at: http://www.nhlbi.nih.gov/guidelines/asthma/. Accessed October 13, 2013.
77. S.P. Peters, E.R. Bleecker, S.J. Kunselman, N. Icitovic, W.C. Moore, and R. Pascual et al. Predictors of response to tiotropium versus salmeterol in asthmatic adults J Allergy Clin Immunol 132 2013 1068 1074.e1
78. G. Colice, R.J. Martin, E. Israel, N. Roche, N. Barnes, and A. Burden et al. Asthma outcomes and costs of therapy with extrafine beclomethasone and fluticasone J Allergy Clin Immunol 132 2013 45 54
79. M. Sadatsafavi, L. Lynd, C. Marra, P. Bedouch, and M. Fitzgerald Comparative outcomes of leukotriene receptor antagonists and long-acting beta-agonists as add-on therapy in asthmatic patients: a population-based study J Allergy Clin Immunol 132 2013 63 69
80. P.M. O'Byrne Asthma in the real world J Allergy Clin Immunol 132 2013 70 71
81. E. Frew, M. Hankins, and H.E. Smith Patient involvement in the development of asthma-specific patient-reported outcome measures: a systematic review J Allergy Clin Immunol 2013 [Epub ahead of print]
82. P.M. Short, P.A. Williamson, W.J. Anderson, and B.J. Lipworth Randomized placebo-controlled trial to evaluate chronic dosing effects of propranolol in asthma Am J Respir Crit Care Med 187 2013 1308 1314
83. B. Buehring, R. Viswanathan, N. Binkley, and W. Busse Glucocorticoid-induced osteoporosis: an update on effects and management J Allergy Clin Immunol 1132 2013 1019 1030