Retraction: β-Amyloid and α-Synuclein Cooperate To Block SNARE-Dependent Vesicle Fusion(Biochemistry (2015) 54:9 (1831-1840) DOI: 10.1021/acs.biochem.5b00087);β-Amyloid and α-synuclein cooperate to block snare-dependent vesicle fusion

Biochemistry

Volumn 54, Issue 9, 2015, Pages 1831-1840

  Choi, Bong Kyu ^a   Kim, Jae Yeol ^a   Cha, Moon Yong ^b   Mook Jung, Inhee ^b   Shin, Yeon Kyun ^c   Lee, Nam Ki ^a  

^a Pohang University of Science and Technology (POSTECH)   (South Korea)

^b Seoul National University   (South Korea)

^c IOWA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOPROTEINS; OLIGOMERS; PROTEINS;

ALZHEIMERS DISEASE; N-TERMINAL DOMAINS; NEURODEGENERATIVE DISORDERS; PARKINSONS DISEASE; PATHOGENIC PROTEINS; PATHOPHYSIOLOGICAL; SYNERGISTIC EFFECT; VESICULAR SNARES;

NEURODEGENERATIVE DISEASES;

ALPHA SYNUCLEIN; AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-42]; OLIGOMER; SNARE PROTEIN; SYNAPTOBREVIN 2; PROTEIN BINDING;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CELL FUSION; CONTROLLED STUDY; EXOCYTOSIS; GROWTH INHIBITION; IN VITRO STUDY; INCUBATION TIME; MOLECULAR DOCKING; NONHUMAN; OLIGOMERIZATION; PC12 CELL LINE; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SYNAPSE; SYNAPSE VESICLE; SYNAPTIC TRANSMISSION; ANIMAL; ANTAGONISTS AND INHIBITORS; CYTOPLASM VESICLE; GENETIC TRANSFECTION; GENETICS; HUMAN; MEMBRANE FUSION; METABOLISM; PHYSIOLOGY; PROTEIN MULTIMERIZATION; RAT;

ALPHA-SYNUCLEIN; AMYLOID BETA-PEPTIDES; ANIMALS; CYTOPLASMIC VESICLES; EXOCYTOSIS; HUMANS; MEMBRANE FUSION; PC12 CELLS; PROTEIN BINDING; PROTEIN MULTIMERIZATION; RATS; SNARE PROTEINS; SYNAPSES; TRANSFECTION;

EID: 84924386284     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/acs.biochem.7b00054     Document Type: Erratum

References (58)

1. Hardy, J. and Selkoe, D. J. (2002) The amyloid hypothesis of Alzheimers disease: progress and problems on the road to therapeutics Science 297, 353-356
2. Iwai, A., Masliah, E., Yoshimoto, M., Ge, N., Flanagan, L., de Silva, H. A., Kittel, A., and Saitoh, T. (1995) The precursor protein of non-A beta component of Alzheimers disease amyloid is a presynaptic protein of the central nervous system Neuron 14, 467-475
3. Spillantini, M. G., Schmidt, M. L., Lee, V. M., Trojanowski, J. Q., Jakes, R., and Goedert, M. (1997) Alpha-synuclein in Lewy bodies Nature 388, 839-840
4. Irwin, D. J., Lee, V. M., and Trojanowski, J. Q. (2013) Parkinsons disease dementia: convergence of alpha-synuclein, tau and amyloid-beta pathologies Nat. Rev. Neurosci. 14, 626-636
5. Armstrong, R. A., Cairns, N. J., and Lantos, P. L. (1997) beta-Amyloid (A beta) deposition in the medial temporal lobe of patients with dementia with Lewy bodies Neurosci. Lett. 227, 193-196
6. Hamilton, R. L. (2000) Lewy bodies in Alzheimers disease: a neuropathological review of 145 cases using alpha-synuclein immunohistochemistry Brain Pathol. 10, 378-384
7. Leverenz, J. B., Fishel, M. A., Peskind, E. R., Montine, T. J., Nochlin, D., Steinbart, E., Raskind, M. A., Schellenberg, G. D., Bird, T. D., and Tsuang, D. (2006) Lewy body pathology in familial Alzheimer disease: evidence for disease- and mutation-specific pathologic phenotype Arch. Neurol. 63, 370-376
8. Tsuang, D. W., Riekse, R. G., Purganan, K. M., David, A. C., Montine, T. J., Schellenberg, G. D., Steinbart, E. J., Petrie, E. C., Bird, T. D., and Leverenz, J. B. (2006) Lewy body pathology in late-onset familial Alzheimers disease: a clinicopathological case series J. Alzheimers Dis. 9, 235-242
9. Rosenberg, C. K., Pericak-Vance, M. A., Saunders, A. M., Gilbert, J. R., Gaskell, P. C., and Hulette, C. M. (2000) Lewy body and Alzheimer pathology in a family with the amyloid-beta precursor protein APP717 gene mutation Acta Neuropathol. 100, 145-152
10. Masliah, E., Rockenstein, E., Veinbergs, I., Sagara, Y., Mallory, M., Hashimoto, M., and Mucke, L. (2001) beta-amyloid peptides enhance alpha-synuclein accumulation and neuronal deficits in a transgenic mouse model linking Alzheimers disease and Parkinsons disease Proc. Natl. Acad. Sci. U.S.A. 98, 12245-12250
11. Clinton, L. K., Blurton-Jones, M., Myczek, K., Trojanowski, J. Q., and LaFerla, F. M. (2010) Synergistic Interactions between Abeta, tau, and alpha-synuclein: acceleration of neuropathology and cognitive decline J. Neurosci. 30, 7281-7289
12. Marsh, S. E. and Blurton-Jones, M. (2012) Examining the mechanisms that link beta-amyloid and alpha-synuclein pathologies Alzheimer Res. Ther. 4, 11
13. Morales, R., Moreno-Gonzalez, I., and Soto, C. (2013) Cross-seeding of misfolded proteins: implications for etiology and pathogenesis of protein misfolding diseases PLoS Pathog. 9, e1003537
14. Ono, K., Takahashi, R., Ikeda, T., and Yamada, M. (2012) Cross-seeding effects of amyloid beta-protein and alpha-synuclein J. Neurochem. 122, 883-890
15. Suzuki, N., Cheung, T. T., Cai, X. D., Odaka, A., Otvos, L., Jr., Eckman, C., Golde, T. E., and Younkin, S. G. (1994) An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants Science 264, 1336-1340
16. Mandal, P. K., Pettegrew, J. W., Masliah, E., Hamilton, R. L., and Mandal, R. (2006) Interaction between Abeta peptide and alpha synuclein: molecular mechanisms in overlapping pathology of Alzheimers and Parkinsons in dementia with Lewy body disease Neurochem. Res. 31, 1153-1162
17. Tsigelny, I. F., Crews, L., Desplats, P., Shaked, G. M., Sharikov, Y., Mizuno, H., Spencer, B., Rockenstein, E., Trejo, M., Platoshyn, O., Yuan, J. X., and Masliah, E. (2008) Mechanisms of hybrid oligomer formation in the pathogenesis of combined Alzheimers and Parkinsons diseases PloS One 3, e3135
18. LaFerla, F. M., Green, K. N., and Oddo, S. (2007) Intracellular amyloid-beta in Alzheimers disease Nat. Rev. Neurosci. 8, 499-509
19. Bucciantini, M., Giannoni, E., Chiti, F., Baroni, F., Formigli, L., Zurdo, J., Taddei, N., Ramponi, G., Dobson, C. M., and Stefani, M. (2002) Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases Nature 416, 507-511
20. Lotharius, J. and Brundin, P. (2002) Pathogenesis of Parkinsons disease: dopamine, vesicles and alpha-synuclein Nat. Rev. Neurosci. 3, 932-942
21. Chiti, F. and Dobson, C. M. (2006) Protein misfolding, functional amyloid, and human disease Annu. Rev. Biochem. 75, 333-366
22. Kim, H. Y., Cho, M. K., Kumar, A., Maier, E., Siebenhaar, C., Becker, S., Fernandez, C. O., Lashuel, H. A., Benz, R., Lange, A., and Zweckstetter, M. (2009) Structural properties of pore-forming oligomers of alpha-synuclein J. Am. Chem. Soc. 131, 17482-17489
23. Lorenzen, N., Nielsen, S. B., Buell, A. K., Kaspersen, J. D., Arosio, P., Vad, B. S., Paslawski, W., Christiansen, G., Valnickova-Hansen, Z., Andreasen, M., Enghild, J. J., Pedersen, J. S., Dobson, C. M., Knowles, T. P., and Otzen, D. E. (2014) The role of stable alpha-synuclein oligomers in the molecular events underlying amyloid formation J. Am. Chem. Soc. 136, 3859-3868
24. Larsen, K. E., Schmitz, Y., Troyer, M. D., Mosharov, E., Dietrich, P., Quazi, A. Z., Savalle, M., Nemani, V., Chaudhry, F. A., Edwards, R. H., Stefanis, L., and Sulzer, D. (2006) Alpha-synuclein overexpression in PC12 and chromaffin cells impairs catecholamine release by interfering with a late step in exocytosis J. Neurosci. 26, 11915-11922
25. Gitler, A. D., Bevis, B. J., Shorter, J., Strathearn, K. E., Hamamichi, S., Su, L. J., Caldwell, K. A., Caldwell, G. A., Rochet, J. C., McCaffery, J. M., Barlowe, C., and Lindquist, S. (2008) The Parkinsons disease protein alpha-synuclein disrupts cellular Rab homeostasis Proc. Natl. Acad. Sci. U.S.A. 105, 145-150
26. Nemani, V. M., Lu, W., Berge, V., Nakamura, K., Onoa, B., Lee, M. K., Chaudhry, F. A., Nicoll, R. A., and Edwards, R. H. (2010) Increased expression of alpha-synuclein reduces neurotransmitter release by inhibiting synaptic vesicle reclustering after endocytosis Neuron 65, 66-79
27. Murphy, D. D., Rueter, S. M., Trojanowski, J. Q., and Lee, V. M. (2000) Synucleins are developmentally expressed, and alpha-synuclein regulates the size of the presynaptic vesicular pool in primary hippocampal neurons J. Neurosci. 20, 3214-3220
28. Yavich, L., Tanila, H., Vepsalainen, S., and Jakala, P. (2004) Role of alpha-synuclein in presynaptic dopamine recruitment J. Neurosci. 24, 11165-11170
29. DeWitt, D. C. and Rhoades, E. (2013) alpha-Synuclein can inhibit SNARE-mediated vesicle fusion through direct interactions with lipid bilayers Biochemistry 52, 2385-2387
30. Burre, J., Sharma, M., Tsetsenis, T., Buchman, V., Etherton, M. R., and Sudhof, T. C. (2010) Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro Science 329, 1663-1667
31. Diao, J., Burre, J., Vivona, S., Cipriano, D. J., Sharma, M., Kyoung, M., Sudhof, T. C., and Brunger, A. T. (2013) Native alpha-synuclein induces clustering of synaptic-vesicle mimics via binding to phospholipids and synaptobrevin-2/VAMP2 eLife 2, e00592
32. Choi, B. K., Choi, M. G., Kim, J. Y., Yang, Y., Lai, Y., Kweon, D. H., Lee, N. K., and Shin, Y. K. (2013) Large alpha-synuclein oligomers inhibit neuronal SNARE-mediated vesicle docking Proc. Natl. Acad. Sci. U.S.A. 110, 4087-4092
33. Ahmed, M., Davis, J., Aucoin, D., Sato, T., Ahuja, S., Aimoto, S., Elliott, J. I., Van Nostrand, W. E., and Smith, S. O. (2010) Structural conversion of neurotoxic amyloid-beta(1-42) oligomers to fibrils Nat. Struct. Mol. Biol. 17, 561-567
34. Sudhof, T. C. and Rothman, J. E. (2009) Membrane Fusion: Grappling with SNARE and SM Proteins Science 323, 474-477
35. Jahn, R. and Scheller, R. H. (2006) SNAREs - engines for membrane fusion Nat. Rev. Mol. Cell. Biol. 7, 631-643
36. Weber, T., Zemelman, B. V., McNew, J. A., Westermann, B., Gmachl, M., Parlati, F., Sollner, T. H., and Rothman, J. E. (1998) SNAREpins: Minimal machinery for membrane fusion Cell 92, 759-772
37. Lai, Y., Kim, S., Varkey, J., Lou, X., Song, J. K., Diao, J., Langen, R., and Shin, Y. K. (2014) Nonaggregated alpha-synuclein influences SNARE-dependent vesicle docking via membrane binding Biochemistry 53, 3889-3896
38. Sudhof, T. C. (2004) The synaptic vesicle cycle Annu. Rev. Neurosci. 27, 509-547
39. 2+-triggered content mixing from lipid exchange for mechanistic studies of neurotransmitter release Proc. Natl. Acad. Sci. U.S.A. 108, E304-313
40. Davidson, W. S., Jonas, A., Clayton, D. F., and George, J. M. (1998) Stabilization of alpha-synuclein secondary structure upon binding to synthetic membranes J. Biol. Chem. 273, 9443-9449
41. Jo, E., McLaurin, J., Yip, C. M., St George-Hyslop, P., and Fraser, P. E. (2000) alpha-Synuclein membrane interactions and lipid specificity J. Biol. Chem. 275, 34328-34334
42. Eliezer, D., Kutluay, E., Bussell, R., Jr., and Browne, G. (2001) Conformational properties of alpha-synuclein in its free and lipid-associated states J. Mol. Biol. 307, 1061-1073
43. Comellas, G., Lemkau, L. R., Zhou, D. H., George, J. M., and Rienstra, C. M. (2012) Structural intermediates during alpha-synuclein fibrillogenesis on phospholipid vesicles J. Am. Chem. Soc. 134, 5090-5099
44. Volles, M. J., Lee, S. J., Rochet, J. C., Shtilerman, M. D., Ding, T. T., Kessler, J. C., and Lansbury, P. T., Jr. (2001) Vesicle permeabilization by protofibrillar alpha-synuclein: implications for the pathogenesis and treatment of Parkinsons disease Biochemistry 40, 7812-7819
45. Kim, J. Y., Choi, B. K., Choi, M. G., Kim, S. A., Lai, Y., Shin, Y. K., and Lee, N. K. (2012) Solution single-vesicle assay reveals PIP(2)-mediated sequential actions of synaptotagmin-1 on SNAREs EMBO J. 31, 2144-2155
46. Sakono, M. and Zako, T. (2010) Amyloid oligomers: formation and toxicity of Abeta oligomers FEBS J. 277, 1348-1358
47. Gouras, G. K., Tsai, J., Naslund, J., Vincent, B., Edgar, M., Checler, F., Greenfield, J. P., Haroutunian, V., Buxbaum, J. D., Xu, H., Greengard, P., and Relkin, N. R. (2000) Intraneuronal Abeta42 accumulation in human brain J. Pathol. 156, 15-20
48. Chui, D. H., Tanahashi, H., Ozawa, K., Ikeda, S., Checler, F., Ueda, O., Suzuki, H., Araki, W., Inoue, H., Shirotani, K., Takahashi, K., Gallyas, F., and Tabira, T. (1999) Transgenic mice with Alzheimer presenilin 1 mutations show accelerated neurodegeneration without amyloid plaque formation Nat. Med. 5, 560-564
49. Takahashi, R. H., Milner, T. A., Li, F., Nam, E. E., Edgar, M. A., Yamaguchi, H., Beal, M. F., Xu, H., Greengard, P., and Gouras, G. K. (2002) Intraneuronal Alzheimer abeta42 accumulates in multivesicular bodies and is associated with synaptic pathology J. Pathol. 161, 1869-1879
50. Clifford, P. M., Zarrabi, S., Siu, G., Kinsler, K. J., Kosciuk, M. C., Venkataraman, V., DAndrea, M. R., Dinsmore, S., and Nagele, R. G. (2007) Abeta peptides can enter the brain through a defective blood-brain barrier and bind selectively to neurons Brain Res. 1142, 223-236
51. Sharma, M., Burre, J., and Sudhof, T. C. (2012) Proteasome inhibition alleviates SNARE-dependent neurodegeneration Sci. Transl. Med. 4, 147ra113
52. Hirsch, E., Graybiel, A. M., and Agid, Y. A. (1988) Melanized dopaminergic neurons are differentially susceptible to degeneration in Parkinsons disease Nature 334, 345-348
53. Halliday, G. M., McRitchie, D. A., Cartwright, H., Pamphlett, R., Hely, M. A., and Morris, J. G. (1996) Midbrain neuropathology in idiopathic Parkinsons disease and diffuse Lewy body disease J. Clin. Neurosci. 3, 52-60
54. Conway, K. A., Rochet, J. C., Bieganski, R. M., and Lansbury, P. T., Jr. (2001) Kinetic stabilization of the alpha-synuclein protofibril by a dopamine-alpha-synuclein adduct Science 294, 1346-1349
55. Cappai, R., Leck, S. L., Tew, D. J., Williamson, N. A., Smith, D. P., Galatis, D., Sharples, R. A., Curtain, C. C., Ali, F. E., Cherny, R. A., Culvenor, J. G., Bottomley, S. P., Masters, C. L., Barnham, K. J., and Hill, A. F. (2005) Dopamine promotes alpha-synuclein aggregation into SDS-resistant soluble oligomers via a distinct folding pathway FASEB J. 19, 1377-1379
56. Rekas, A., Knott, R. B., Sokolova, A., Barnham, K. J., Perez, K. A., Masters, C. L., Drew, S. C., Cappai, R., Curtain, C. C., and Pham, C. L. (2010) The structure of dopamine induced alpha-synuclein oligomers Eur. Biophys. J. 39, 1407-1419
57. Uversky, V. N., Li, J., and Fink, A. L. (2001) Metal-triggered structural transformations, aggregation, and fibrillation of human alpha-synuclein. A possible molecular NK between Parkinsons disease and heavy metal exposure J. Biol. Chem. 276, 44284-44296
58. Binolfi, A., Rasia, R. M., Bertoncini, C. W., Ceolin, M., Zweckstetter, M., Griesinger, C., Jovin, T. M., and Fernandez, C. O. (2006) Interaction of alpha-synuclein with divalent metal ions reveals key differences: a link between structure, binding specificity and fibrillation enhancement J. Am. Chem. Soc. 128, 9893-9901