Preventive effects of a fermented dairy product against Alzheimer's disease and identification of a novel oleamide with enhanced microglial phagocytosis and anti-inflammatory activity

PLoS ONE

Volumn 10, Issue 3, 2015, Pages

  Ano, Yasuhisa ^a   Ozawa, Makiko ^b   Kutsukake, Toshiko ^a   Sugiyama, Shinya ^c   Uchida, Kazuyuki ^b   Yoshida, Aruto ^a   Nakayama, Hiroyuki ^b  

^a KIRIN HOLDINGS CO LTD   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c Shizukuishi Iwate Gun   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN[1-42]; B7 ANTIGEN; BRAIN DERIVED NEUROTROPHIC FACTOR; CD68 ANTIGEN; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; OLEAMIDE; SYNAPTOPHYSIN; TUMOR NECROSIS FACTOR ALPHA; AMYLOID BETA PROTEIN; AMYLOID BETA-PROTEIN (1-42); ANTIINFLAMMATORY AGENT; OLEIC ACID; OLEYLAMIDE; PEPTIDE FRAGMENT;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN EXPRESSION; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BIOACCUMULATION; CELL PHAGOCYTOSIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; DAIRY PRODUCT; FEMALE; FERMENTED PRODUCT; IN VITRO STUDY; IN VIVO STUDY; MALE; MICROGLIA; MOUSE; NEWBORN; NONHUMAN; PENICILLIUM; PENICILLIUM CANDIDUM; PROTEIN EXPRESSION; ANIMAL; BRAIN; C57BL MOUSE; CELL CULTURE; CHEMISTRY; DRUG EFFECTS; FERMENTATION; HUMAN; IMMUNOLOGY; METABOLISM; MICROBIOLOGY; PHAGOCYTOSIS; PHYSIOLOGY; TRANSGENIC MOUSE;

PENICILLIUM CANDIDUM;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; ANTI-INFLAMMATORY AGENTS; BRAIN; CELLS, CULTURED; CULTURED MILK PRODUCTS; FEMALE; FERMENTATION; HUMANS; MALE; MICE, INBRED C57BL; MICE, TRANSGENIC; MICROGLIA; OLEIC ACIDS; PENICILLIUM; PEPTIDE FRAGMENTS; PHAGOCYTOSIS;

EID: 84924385920     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0118512     Document Type: Article

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