Targeting Alzheimer's pathology through PPARγ signaling: Modulation of microglial function

Annals of Internal Medicine

Volumn 158, Issue 6, 2013, Pages 5083-5084

  Lourenco, Mychael V ^a   Ledo, Jose Henrique ^a  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; BEXAROTENE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA AGONIST; PIOGLITAZONE; REACTIVE OXYGEN METABOLITE; RETINOID X RECEPTOR;

ALZHEIMER DISEASE; AMYLOID PLAQUE; ARTICLE; CELL FUNCTION; COGNITIVE DEFECT; HUMAN; INFLAMMATION; INSULIN SENSITIVITY; MICROGLIA; MOLECULAR PATHOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TARGET CELL; TRANSGENE;

ALZHEIMER DISEASE; ANIMALS; BRAIN; MAZE LEARNING; MICROGLIA; PHAGOCYTOSIS; PPAR GAMMA;

EID: 84877100264     PISSN: 00034819     EISSN: 15393704     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.0172-13.2013     Document Type: Article

References (8)

1. Cramer PE, Cirrito JR, Wesson DW, Lee CY, Karlo JC, Zinn AE, Casali BT, Restivo JL, Goebel WD, James MJ, Brunden KR, Wilson DA, Landreth GE (2012) ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models. Science 335: 1503-1506. CrossRef Medline
2. Denner LA, Rodriguez-Rivera J, Haidacher SJ, Jahrling JB, Carmical JR, Hernandez CM, Zhao Y, Sadygov RG, Starkey JM, Spratt H, Luxon BA, Wood TG, Dineley KT (2012) Cognitive enhancement with rosiglitazone links the hippocampal PPARγ and ERK MAPK signaling pathways. J Neurosci 32:16725-16735a.CrossRef Medline
3. Kettenmann H, Kirchhoff F, Verkhratsky A (2013) Microglia: new roles for the synaptic stripper. Neuron 77:10-18. CrossRef Medline
4. Mandrekar-Colucci S, Karlo JC, Landreth GE (2012) Mechanisms underlying the rapid peroxisome proliferator-activated receptor- γ-mediated amyloid clearance and reversal of cognitive deficits in a murine model of Alzheimer's disease. J Neurosci 32:10117-10128.CrossRef Medline
5. Saijo K, Glass CK (2011) Microglial cell origin and phenotypes in health and disease. Nat Rev Immunol 11:775-787. CrossRef Medline
6. Sakurai T (2011) Targets of the peroxisome proliferator-activated receptor γ agonist trials for the prevention of Alzheimer disease. Arch Neurol 68:542-543. CrossRef Medline
7. Selkoe DJ (2011) Resolving controversies on the path to Alzheimer's therapeutics. Nat Med 17: 1060-1065. CrossRef Medline
8. Yamanaka M, Ishikawa T, Griep A, Axt D, Kummer MP, Heneka MT (2012) PPARγ/RXRα-induced and CD36-mediated microglial amy loid- β phagocytosis results in cognitive improvement in amyloid precursor protein/ presenilin 1 mice. J Neurosci 32:17321-17331.CrossRef Medline