Hydrophilic bile acids protect human blood-brain barrier endothelial cells from disruption by unconjugated bilirubin: An in vitro study

Frontiers in Neuroscience

Volumn 9, Issue FEB, 2015, Pages

  Palmela, Inês ^a   Correia, Leonor ^a   Silva, Rui F M ^a   Sasaki, Hiroyuki ^b   Kim, Kwang S ^c   Brites, Dora ^a   Brito, Maria A ^a  

^a RESEARCH INSTITUTE FOR MEDICINES IMED ULISBOA   (Portugal)

^b JIKEI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Blood brain barrier; Glycoursodeoxycholic acid; Human brain microvascular endothelial cells; Interleukin 6; Unconjugated bilirubin; Ursodeoxycholic acid

Indexed keywords

BILE ACID; BILIRUBIN; CASPASE 3; GLYCOURSODEOXYCHOLIC ACID; INTERLEUKIN 6; MESSENGER RNA; UNCLASSIFIED DRUG; URSODEOXYCHOLIC ACID;

APOPTOSIS; ARTICLE; BLOOD BRAIN BARRIER; BRAIN CAPILLARY ENDOTHELIAL CELL; CONTROLLED STUDY; CYTOKINE RELEASE; DISEASE SEVERITY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; HYDROPHILICITY; IN VITRO STUDY; NEONATAL HYPERBILIRUBINEMIA; NEUROPROTECTION; NEWBORN; PROTEIN SECRETION; UPREGULATION;

EID: 84924347868     PISSN: 16624548     EISSN: 1662453X     Source Type: Journal    
DOI: 10.3389/fnins.2015.00080     Document Type: Article

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