ER stress, mitochondrial dysfunction and calpain/jnk activation are involved in oligodendrocyte precursor cell death by unconjugated bilirubin

NeuroMolecular Medicine

Volumn 14, Issue 4, 2012, Pages 285-302

  Barateiro, Andreia ^a   Vaz, Ana Rita ^a   Silva, Sandra Leitão ^a   Fernandes, Adelaide ^a   Brites, Dora ^a  

^a UNIVERSITY OF LISBON   (Portugal)

Author keywords

Cell death; ER mitochondria unit disruption; Oligodendrocyte precursor primary cultures; Unconjugated bilirubin toxicity

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 6; BILIRUBIN; CALCIUM ION; CALPAIN; CASPASE 2; CASPASE 9; CYTOKINE; GLUCOSE REGULATED PROTEIN 78; GLUTAMIC ACID; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CELL SURVIVAL; CONTROLLED STUDY; CYTOKINE RELEASE; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; ENZYME INHIBITION; MITOCHONDRIAL MEMBRANE POTENTIAL; NERVE CELL NECROSIS; NEURAL STEM CELL; NONHUMAN; OLIGODENDROGLIA; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; UPREGULATION;

AMINO ACID CHLOROMETHYL KETONES; ANIMALS; ANIMALS, NEWBORN; APOPTOSIS; BILIRUBIN; CALPAIN; CASPASES; CELLS, CULTURED; CEREBRAL CORTEX; CYTOKINES; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; GLUTAMIC ACID; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; NEURAL STEM CELLS; OLIGODENDROGLIA; PRIMARY CELL CULTURE; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION;

EID: 84870563054     PISSN: 15351084     EISSN: 15591174     Source Type: Journal    
DOI: 10.1007/s12017-012-8187-9     Document Type: Article

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