Ursodeoxycholic acid and tauroursodeoxycholic acid suppress choroidal neovascularization in a laser-treated rat model

Journal of Ocular Pharmacology and Therapeutics

Volumn 26, Issue 3, 2010, Pages 223-229

  Woo, Se Joon ^a   Kim, Joo Hoon ^a   Yu, Hyeong Gon ^a  

^a Seoul National University College of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

FLUORESCEIN; TAUROURSODEOXYCHOLIC ACID; URSODEOXYCHOLIC ACID; VASCULOTROPIN; ANTIINFLAMMATORY AGENT; ARGON; TAUROCHENODEOXYCHOLIC ACID; VASCULOTROPIN A;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARGON LASER; ARTICLE; CHOROID; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; EYE; HISTOLOGY; LASER COAGULATION; MALE; NONHUMAN; RAT; RETINA FLUORESCEIN ANGIOGRAPHY; SUBRETINAL NEOVASCULARIZATION; ANIMAL; ANTAGONISTS AND INHIBITORS; BROWN NORWAY RAT; CHOROIDAL NEOVASCULARIZATION; COMPARATIVE STUDY; DISEASE MODEL;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ARGON; CHOROIDAL NEOVASCULARIZATION; DISEASE MODELS, ANIMAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; LASER COAGULATION; MALE; RATS; RATS, INBRED BN; TAUROCHENODEOXYCHOLIC ACID; URSODEOXYCHOLIC ACID; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 77954212243     PISSN: 10807683     EISSN: None     Source Type: Journal    
DOI: 10.1089/jop.2010.0012     Document Type: Article

References (35)

1. Pascolini, D., Mariotti, S.P., Pokharel, G.P., Pararajasegaram, R., Etya'ale, D., Negrel, A.D., and Resnikoff, S. 2002 Global update of available data on visual impairment: a compilation of population-based prevalence studies. Ophthalmic. Epidemiol. 11:67-115, 2004.
2. Congdon, N., O'Colmain, B., Klaver, C.C., Klein, R., Munoz, B., Friedman, D.S., Kempen, J., Taylor, H.R., and Mitchell, P. Causes and prevalence of visual impairment among adults in the United States. Arch. Ophthalmol. 122:477-485, 2004. (Pubitemid 38456282)
3. Jager, R.D., Mieler, W.F., and Miller, J.W. Age-related macular degeneration. N. Engl. J. Med. 358:2606-2617, 2008.
4. Ferris, F.L., 3rd, Fine, S.L., and Hyman, L. Age-related macular degeneration and blindness due to neovascular maculopathy. Arch. Ophthalmol. 102:1640-1642, 1984.
5. Haddad, W.M., Coscas, G., and Soubrane, G. [Age-related macular degeneration and apoptosis]. J. Fr. Ophtalmol. 26:307-311, 2003.
6. Xu, H., Chen, M., and Forrester, J.V. Para-inflammation in the aging retina. Prog. Retin. Eye Res. 28:348-368, 2009.
7. Rivard, A.L., Steer, C.J., Kren, B.T., Rodrigues, C.M., Castro, R.E., Bianco, R.W., and Low, W.C. Administration of tauroursodeoxycholic acid (TUDCA) reduces apoptosis following myocardial infarction in rat. Am. J. Chin. Med. 35: 279-295, 2007.
8. Paolini, M., Pozzetti, L., Montagnani, M., Potenza, G., Sabatini, L., Antelli, A., Cantelli-Forti, G., and Roda, A. Ursodeoxycholic acid (UDCA) prevents DCA effects on male mouse liver via up-regulation of CYP [correction of CXP] and preservation of BSEP activities. Hepatology 36:305-314, 2002.
9. Baiocchi, L., Tisone, G., Russo, M.A., Longhi, C., Palmieri, G., Volpe, A., Almerighi, C., Telesca, C., Carbone, M., Toti, L., De Leonardis, F., and Angelico, M. TUDCA prevents cholestasis and canalicular damage induced by ischemiareperfusion injury in the rat, modulating PKCalpha-ezrin pathway. Transpl. Int. 21:792-800, 2008.
10. Keene, C.D., Rodrigues, C.M., Eich, T., Chhabra, M.S., Steer, C.J., and Low, W.C. Tauroursodeoxycholic acid, a bile acid, is neuroprotective in a transgenic animal model of Huntington's disease. Proc. Natl. Acad. Sci. U. S. A. 99:10671-10676, 2002.
11. Sola, S., Amaral, J.D., Castro, R.E., Ramalho, R.M., Borralho, P.M., Kren, B.T., Tanaka, H., Steer, C.J., and Rodrigues, C.M. Nuclear translocation of UDCA by the glucocorticoid receptor is required to reduce TGF-beta1-induced apoptosis in rat hepatocytes. Hepatology 42:925-934, 2005.
12. Azzaroli, F., Mehal, W., Soroka, C.J., Wang, L., Lee, J., Crispe, N., and Boyer, J.L. Ursodeoxycholic acid diminishes Fas-ligand-induced apoptosis in mouse hepatocytes. Hepatology 36:49-54, 2002.
13. Boatright, J.H., Moring, A.G., McElroy, C., Phillips, M.J., Do, V.T., Chang, B., Hawes, N.L., Boyd, A.P., Sidney, S.S., Stewart, R.E., Minear, S.C., Chaudhury, R., Ciavatta, V.T., Rodrigues, C.M., Steer, C.J., Nickerson, J.M., and Pardue, M.T. Tool from ancient pharmacopoeia prevents vision loss. Mol. Vis. 12:1706-1714, 2006.
14. Phillips, M.J., Walker, T.A., Choi, H.Y., Faulkner, A.E., Kim, M.K., Sidney, S.S., Boyd, A.P., Nickerson, J.M., Boatright, J.H., and Pardue, M.T. Tauroursodeoxycholic acid preservation of photoreceptor structure and function in the rd10 mouse through postnatal day 30. Invest. Ophthalmol. Vis. Sci. 49:2148-2155, 2008.
15. Adler, R., Curcio, C., Hicks, D., Price, D., and Wong, F. Cell death in age-related macular degeneration. Mol. Vis. 5:31, 1999.
16. Rodrigues, C.M., Sola, S., Nan, Z., Castro, R.E., Ribeiro, P.S., Low, W.C., and Steer, C.J. Tauroursodeoxycholic acid reduces apoptosis and protects against neurological injury after acute hemorrhagic stroke in rats. Proc. Natl. Acad .Sci. U. S. A. 100:6087-6092, 2003.
17. Suh, H., Jung, E.J., Kim, T.H., Lee, H.Y., Park, Y.H., and Kim, K.W. Anti-angiogenic activity of ursodeoxycholic acid and its derivatives. Cancer Lett. 113:117-122, 1997.
18. Krzystolik, M.G., Afshari, M.A., Adamis, A.P., Gaudreault, J., Gragoudas, E.S., Michaud, N.A., Li, W., Connolly, E., O'Neill, C.A., and Miller, J.W. Prevention of experimental choroidal neovascularization with intravitreal anti-vascular endothelial growth factor antibody fragment. Arch. Ophthalmol. 120:338-346, 2002.
19. Lambert, V., Wielockx, B., Munaut, C., Galopin, C., Jost, M., Itoh, T., Werb, Z., Baker, A., Libert, C., Krell, H.W., Foidart, J.M., Noel, A., and Rakic, J.M. MMP-2 and MMP-9 synergize in promoting choroidal neovascularization. FASEB J. 17:2290-2292, 2003.
20. Zambarakji, H.J., Nakazawa, T., Connolly, E., Lane, A.M., Mallemadugula, S., Kaplan, M., Michaud, N., Hafezi- Moghadam, A., Gragoudas, E.S., and Miller, J.W. Dosedependent effect of pitavastatin on VEGF and angiogenesis in a mouse model of choroidal neovascularization. Invest. Ophthalmol. Vis. Sci. 47:2623-2631, 2006.
21. de Jong, P.T. Age-related macular degeneration. N. Engl. J. Med. 355:1474-1485, 2006.
22. Macario, A.J., and Conway de Macario, E. Sick chaperones, cellular stress, and disease. N. Engl. J. Med. 353:1489-1501, 2005.
23. Meriin, A.B., and Sherman, M.Y. Role of molecular chaperones in neurodegenerative disorders. Int. J. Hyperthermia 21:403-419, 2005.
24. Ethen, C.M., Reilly, C., Feng, X., Olsen, T.W., and Ferrington, D.A. The proteome of central and peripheral retina with progression of age-related macular degeneration. Invest. Ophthalmol. Vis. Sci. 47:2280-2290, 2006.
25. Tuo, J., Bojanowski, C.M., Zhou, M., Shen, D., Ross, R.J., Rosenberg, K.I., Cameron, D.J., Yin, C., Kowalak, J.A., Zhuang, Z., Zhang, K., and Chan, C.C. Murine ccl2/cx3cr1 deficiency results in retinal lesions mimicking human agerelated macular degeneration. Invest. Ophthalmol. Vis. Sci. 48:3827-3836, 2007.
26. Sauer, T., Patel, M., Chan, C.C., and Tuo, J. Unfolding the therapeutic potential of chemical chaperones for age-related macular degeneration. Expert Rev. Ophthalmol. 3:29-42, 2008.
27. Mor, F., Quintana, F.J., and Cohen, I.R. Angiogenesisinflammation cross-talk: vascular endothelial growth factor is secreted by activated T cells and induces Th1 polarization. J. Immunol. 172:4618-4623, 2004.
28. Chang, L.K., Spaide, R.F., Brue, C., Freund, K.B., Klancnik Jr., J.M., and Slakter, J.S. Bevacizumab treatment for subfoveal choroidal neovascularization from causes other than age-related macular degeneration. Arch. Ophthalmol. 126:941-945, 2008.
29. Frangie, C., Lefaucheur, C., Medioni, J., Jacquot, C., Hill, G.S., and Nochy, D. Renal thrombotic microangiopathy caused by anti-VEGF-antibody treatment for metastatic renal- cell carcinoma. Lancet Oncol. 8:177-178, 2007.
30. Zhao, J., Li, H., and Wang, M. Acute renal failure in a patient receiving anti-VEGF therapy for advanced non-small cell lung cancer. J. Thorac. Oncol. 4:1185-1187, 2009.
31. George, B.A., Zhou, X.J., and Toto, R. Nephrotic syndrome after bevacizumab: case report and literature review. Am. J. Kidney Dis. 49:e23-e29, 2007.
32. Bora, P.S., Kaliappan, S., Xu, Q., Kumar, S., Wang, Y., Kaplan, H.J., and Bora, N.S. Alcohol linked to enhanced angiogenesis in rat model of choroidal neovascularization. FEBS J. 273:1403-1414, 2006.
33. Ciulla, T.A., Criswell, M.H., Danis, R.P., and Hill, T.E. Intravitreal triamcinolone acetonide inhibits choroidal neovascularization in a laser-treated rat model. Arch. Ophthalmol. 119:399-404, 2001.
34. Ding, X., Patel, M., and Chan, C.C. Molecular pathology of age-related macular degeneration. Prog. Retin. Eye Res. 28: 1-18, 2009.
35. Lee, S.H., Woo, S.J., Park, K.H., Kim, J.H., Song, J.H., Park, K.U., Heo, J.W., Yu, H.G., Yu, Y.S., and Chung, H. Serratia marcescens endophthalmitis associated with intravitreal injections of bevacizumab. Eye (Lond). 24:226-232, 2010.