Neuritic growth impairment and cell death by unconjugated bilirubin is mediated by NO and glutamate, modulated by microglia, and prevented by glycoursodeoxycholic acid and interleukin-10

Neuropharmacology

Volumn 62, Issue 7, 2012, Pages 2398-2408

  Silva, Sandra L ^a   Vaz, Ana R ^a   Diógenes, Maria J ^a,b   Van Rooijen, Nico ^c   Sebastião, Ana M ^a,b   Fernandes, Adelaide ^a   Silva, Rui F M ^a   Brites, Dora ^a  

^a UNIVERSITY OF LISBON   (Portugal)

^b INSTITUTO DE MEDICINA MOLECULAR   (Portugal)

^c VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Glycoursodeoxycholic acid; Interleukin 10; Microglia depletion; Neurite outgrowth deficits; Organotypic cultured hippocampal slices; Unconjugated bilirubin

Indexed keywords

BILIRUBIN; DIZOCILPINE; GLUTAMIC ACID; GLYCOURSODEOXYCHOLIC ACID; INTERLEUKIN 10; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; UNCLASSIFIED DRUG; URSODEOXYCHOLIC ACID DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN SLICE; CONTROLLED STUDY; DRUG MECHANISM; FEMALE; FETUS; GROWTH INHIBITION; HIPPOCAMPUS; HOMEOSTASIS; HYPERBILIRUBINEMIA; MICROGLIA; NERVE CELL NECROSIS; NERVE GROWTH; NERVE SPROUTING; NEUROPATHOLOGY; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; SYNAPTIC TRANSMISSION;

EID: 84859103402     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2012.02.002     Document Type: Article

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