Anti-carcinogenic effects of the phenolic-rich extract from abnormal Savda Munziq in association with its cytotoxicity, apoptosis-inducing properties and telomerase activity in human cervical cancer cells (SiHa)

BMC Complementary and Alternative Medicine

Volumn 15, Issue 1, 2015, Pages

  Abliz, Guzalnur ^a   Mijit, Fatima ^a   Hua, Li ^a   Abdixkur, Guzalnur ^a   Ablimit, Tangnur ^a   Amat, Nurmuhammat ^a   Upur, Halmurat ^a  

^a XINJIANG MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Human cervical cancer; Phenolic rich extracts of ASMq; SiHa cells; Telomerase

Indexed keywords

ABNORMAL SAVDA MUNZIQ; ANTINEOPLASTIC AGENT; BETA ACTIN; FRAGILE HISTIDINE TRIAD PROTEIN; HERBACEOUS AGENT; POLYPHENOL DERIVATIVE; PROTEIN BCL 2; SURVIVIN; TELOMERASE; UNCLASSIFIED DRUG; ACID ANHYDRIDE HYDROLASE; BIRC5 PROTEIN, HUMAN; INHIBITOR OF APOPTOSIS PROTEIN; PHENOL DERIVATIVE; PLANT EXTRACT; POLYPHENOL; TUMOR PROTEIN;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CELL STRUCTURE; CELL VIABILITY; CERVICAL CANCER CELL LINE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DOWN REGULATION; DRUG EFFECT; ENZYME ACTIVITY; FLOW CYTOMETRY; GENE EXPRESSION; GROWTH INHIBITION; HUMAN; HUMAN CELL; MTT ASSAY; PHASE CONTRAST MICROSCOPY; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; CELL SURVIVAL; CHEMISTRY; DRUG EFFECTS; FEMALE; METABOLISM; PHYTOTHERAPY; TRADITIONAL MEDICINE; TUMOR CELL LINE; UTERINE CERVICAL NEOPLASMS;

ACID ANHYDRIDE HYDROLASES; ANTICARCINOGENIC AGENTS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CELL LINE, TUMOR; CELL SURVIVAL; DOWN-REGULATION; FEMALE; FLOW CYTOMETRY; HUMANS; INHIBITOR OF APOPTOSIS PROTEINS; MEDICINE, TRADITIONAL; NEOPLASM PROTEINS; PHENOLS; PHYTOTHERAPY; PLANT EXTRACTS; POLYPHENOLS; TELOMERASE; UTERINE CERVICAL NEOPLASMS;

EID: 84924295826     PISSN: None     EISSN: 14726882     Source Type: Journal    
DOI: 10.1186/s12906-015-0530-x     Document Type: Article

References (55)

1. Schoell WM, Janicek MF, Mirhashmi R. Epidemiology and biology of cervical cancer. Semin Surg Oncol. 1999;16:203-11.
2. Parkin DM, Bray F, Ferlay J, Pisani P. Estimating the world cancer burden: globocan. Int J Cancer. 2001;94:153-6.
3. Ferlay J, Bray F, Pisani P, Parkin DM. Globocan 2002: cancer incidence, mortality and prevalence worldwide. Lyon: IARC Press; 2004.
4. Holmes K, Egan B, Swan N, Morain CO. Genetic mechanisms and aberrant gene expression during the development of gastric intestinal metaplasia and adenocarcinoma. Curr Genomics. 2007;8:379-97.
5. McDonald ER, El-Deiry WS. Cell cycle control as a basis for cancer drug development. Int J Oncol. 2000;16:871-86.
6. Schultz DR, Harrington WJJ. Apoptosis: programmed cell death at a molecular level. Semin Arthritis Rheum. 2003;32:345-69.
7. Decaudin D, Marzo I, Brenner C, Kroemer G. Mitochondria in chemotherapy-induced apoptosis: a prospective novel target of cancer therapy. Inter J Oncol. 1998;12:141-52.
8. Adams JM, Cory S. Life-or-death decisions by the Bcl-2 protein family. Trends in Biochem Sci. 2001;26:61-6.
9. Deveraux QL, Reed JC. IAP family proteins-suppressors of apoptosis. Genes Dev. 1999;13:239-52.
10. Oulton R, Harrington L. Telomeres, telomerase, and cancer: life on the edge of genomic stability. Current Opin Oncol. 2000;12:74-81.
11. Hahn WC, Meyerson M. Telomerase activation, cellular immortalization and cancer. Ann Med. 2001;33:123-9.
12. Ramachandran C, Fonseca HB, Jhabvala P, Escalon EA, Melnick SJ. Curcumin inhibits telomerase activity through human telomerase reverse transcriptase in MCF-7 breast cancer cell line. Cancer Lett. 2002;184:1-6.
13. Ramirez R, Carracedo J, Jimenez R, Canela A, Herrera E, Aljama P, et al. Massive telomere loss is an early event of DNA damaged-induced apoptosis. J Biol Chem. 2003;278:836-42.
14. Mainardi T, Kapoor S, Bielory L. Complementary and alternative medicine: herbs, phytochemicals and vitamins and their immunologic effects. J Allergy and Clin Immunol. 2009;123:283-94.
15. Balunas MJ, Kinghorn AD. Drug discovery from medicinal plants. Life Sci. 2005;78:431-41.
16. da Rocha AB, Lopes RM, Schwartsmann G. Natural products in anticancer therapy. Curr Opin Pharmacol. 2001;1:364-9.
17. Gu R, Wang Y, Long B, Kennelly E, Wu S, Liu B, et al. Prospecting for bioactive constituents from traditional medicinal plants through ethnobotanical approaches. Biol Pharm Bull. 2014;37:903-15.
18. Yang CS, Landaa JM, Huang MT, Newmark HL. Inhibition of carcinogenesis by dietary polyphenolic compound. Annu Rev Nutr. 2001;21:381-406.
19. Yang CS, Lambert JD. Shengmin Sang Antioxidative and anti-carcinogenic activities of tea polyphenols. Arch Toxicol. 2009;83:11-21.
20. Ullmannova V, Popescu NC. Inhibition of cell proliferation, induction of apoptosis, reactivation of DLC1, and modulation of other gene expression by dietary flavone in breast cancer cell lines. Cancer Detec Preven. 2007;31:110-8.
21. Wenzel U, Kuntz S, Brendel MD, Daniel H. Dietary flavone is a potent apoptosis inducer in human colon carcinoma cells. Cancer Res. 2000;60:3823-31.
22. Jeong SH, Jo WS, Song S, Suh H, Seol SY, Leem SH, et al. A novel resveratrol derivative, HS1793, overcomes the resistance conferred by Bcl-2 in human leukemic U937 cells. Biochem Pharmacol. 2009;77:1337-47.
23. Upur H, Yusup A, Umar A, Moore N. Uighur traditional medicine syndrome of abnormal Savda in men is associated with oxidative stress, which can be improved by Munziq and Mushil of Abnormal Savda. Therapie. 2004;59:483-4.
24. Upur H, Yusup A, Baudrimont I, Umar A, Berke B, Yimit D. Inhibition of cell growth and cellular protein, DNA and RNA synthesis in human hepatoma (HepG2) cells by ethanol extract of abnormal Savda Munziq of traditional Uighur medicine. Evid based Complement Alternat Med. 2008; DOI: 10.1093/ecam/nen1062
25. Yusup A, Upur H, Umar A, Moore N. Protective effects of Munziq and Mushil of Abnormal Savda to mitochondrial oxidative damage. Fundam Clin Pharmacol. 2004;18:471-6.
26. Chung WT, Lee SH, Kim JD, Sung NS, Wang BH, Lee SY, et al. Effect of the extracts from Glycyrrhiza uralensis Fisch on the growth characteristics of human cell lines:Anti-tumor and immune activation activities. Cytotechnology. 2001;37:55-64.
27. Jo EH, Hong HD, Ahn NC, Jung JW, Yang SR, Park JS, et al. Modulations of the Bcl-2/Bax family were involved in the chemopreventive effects of licorice root (Glycyrrhiza uralensis Fisch) in MCF-7 human breast cancer cell. J Agric Food Chem. 2004;52:1715-9.
28. Allahverdiyev A, Duran N, Cetiner S, Ozguven M. Investigation of the anticancerogenic effect of the essential oil of Melissa officinalis L. Pharma Pharmacol Lett. 2001;11:26-9.
29. Canadanovi-Brunet J, Cetkovi G, Djilas S, Tumbas V, Bogdanovi G, Mandi A, et al. Radical scavenging, antibacterial, and antiproliferative activities of Melissa officinalis L. Extracts J Med Food. 2008;11:133-43.
30. Huang X, Kojima-Yuasa A, Norikura T, Kennedy David O, Hasuma T, Matsui-Yuasa I. Mechanism of the anti-cancer activity of Zizyphus jujuba in HepG2 cells. Am J Chin Med. 2007;35:517-32.
31. Harborne JB, Williams CA. Advances in flavonoid research since 1992. Phytochemistry. 2000;55:481-504.
32. Kizaibek M, Popescu R, Prinz S, Upur H, Singhuber J, Zehl M, et al. Towards modernization of the formulation of the traditional uighur medicine herbal preparation abnormal savda munziq. Evid Based Complement Alternat Med. doi:10.1155/2012/863101.
33. Ren W, Qiao Z, Wang H, Zhu L, Zhang L. Flavonoids: promising anticancer agents. Med Res Rev. 2003;23:519-34.
34. Wilson JW, Booth C, Potten CS. Apoptosis gene. Boston, Dordrecht/London: Kluwer Academic Publisher; 1998. p. 310.
35. Liu YL, Tang LH, Liang ZQ, You BG, Yang SL. Growth inhibitory and apoptosis inducing by effects of total flavonoids from Lysimachia clethroides Duby in human chronic myeloid leukemia K562 cells. J Ethnopharmacol. 2010;131:1-9.
36. Earnshaw WC, Martins LM, Kaufmann SH. Mammalian caspases: structure, activation, substrates, and functions during apoptosis. Annu Rev Biochem. 1998;68:383-424.
37. Czabotar PE, Lessene G, Strasser A, Adams JM. Control of apoptosis by theBCL-2 protein family: implications for physiology and therapy. Nat Rev Mol Cell Biol. 2014;15:49-63.
38. Adhami VM, Aziz MH, Mukhtar H, Ahmad N. Activation of prodeath Bcl-2 family proteins and mitochondrial apoptosis pathway by sanguinarine in immortalized human HaCaT keratinocytes. Clin Cancer Res. 2003;9:3176-82.
39. Bold RJ, Chandra J, McConkey DJ. Gemcitabine-induced programmed cell death (apoptosis) of human pancreatic carcinoma is determined by Bcl-2 content. Ann Surg Oncol. 1999;6:279-85.
40. Davis JM, Navolanic PM, Weinstein-Oppenheimer CR, Steelman LS, Hu W, Konopleva M, et al. Raf-1 and Bcl-2 induce distinct and common pathways that contribute to breast cancer drug resistance. Clin Cancer Res. 2003;9:1161-117.
41. Chiu CP, Harley CB. Replicative senescence and cell immortality: the role of telomeres and telomerase. Proc Soc Exper Biol Med. 1997;214:99-106.
42. Shay J, Wright WE. Telomerase therapeutics for cancer; challenge and the new directions. Nat Rev Drug Discover. 2006;5:577-84.
43. Kondo S, Tanaka Y, Kondo Y, Hitomi M, Barnett GH, Ishizaka Y, et al. Antisense telomerase treatment: induction of two distinct pathways, apoptosis and differentiation. FASEB J. 1998;12:801-11.
44. Hahn WC, Meyerson M. Telomerase activation, cellular immortalization and cancer. Ann Med. 2000;33:123-9.
45. Boklan J, Nanjangud G, Mackenzie KL, May C, Sadelain M, Moore MA. Limited proliferation and telomere dysfunction following telomerase inhibition in immortal murine fibriblasts. Cancer Res. 2002;62:2104-14.
46. Jaio MU, Wei XL. Telomere and telomerase in oncology. Cell Res. 2002;12:1-7.
47. Mandal M, Kumar R. Bcl-2 modulates telomerase activity. J Biol Chem. 1997;272(22):14183-7.
48. Ishii H, Mimori K, Vecchione A, Sutheesophon K, Fujiwara T, Mori M, et al. Effect of exogenous E2F-1 on the expression of common chromosome fragile site genes. FHIT and WWOX Biochem Biophys ResCommun. 2004;316:1088-93.
49. Mady HH, Melhem MF. FHIT protein expression and its relation to apoptosis, tumor histologic grade and prognosis in colorectal adenocarcinoma: an immunohistochemical and image analysis study. Clin Exper Metastasis. 2002;19:351-8.
50. Sevignani C, Calin GA, Cesari R, Sarti M, Ishii H, Yendamuri S, et al. Restoration of fragile histidine triad (FHIT) expression induces apoptosis and suppresses tumorigenicity in breast cancer cell lines. Cancer Res. 2003;63:1183-7.
51. Roz L, Gramegna M, Ishii H, Croce CM, Sozzi G. Restoration of fragile histidine triad (FHIT) expression induces apoptosis and suppresses tumorigenicity in lung and cervical cancer cell lines. Proc Nat Acad Sci USA. 2002;99:3615-20.
52. Ckim H, Yoo JS, Lee CT, Kim YW, Han SK, Shim YS, et al. FHIT protein enhances paclitaxel-induced apoptosis in lung cancer cells. Int J Cancer. 2006;118:1692-8.
53. Ceballos-Cancino G, Espinosa M, Maldonado V, Melendez-Zajgla J. Regulation of mitochondrial Smac/DIABLO-selective release by surviving. Oncogene. 2007;26:7569-75.
54. Altieri DC. The molecular basis and potential role of survivin in cancer diagnosis and therapy. Trends Mol Med. 2001;7:542-7.
55. Lanham S, Herber AT, Watt P. HPV detection and measurement of HPV-16, telomerase and survivin transcripts in colposcopy clinic patients. J Clin Pathol. 2001;54:304-8.