FHIT protein expression and its relation to apoptosis, tumor histologic grade and prognosis in colorectal adenocarcinoma: An immunohistochemical and image analysis study

Clinical and Experimental Metastasis

Volumn 19, Issue 4, 2002, Pages 351-358

  Mady, Hussam H ^a   Melhem, Mona F ^a  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Apoptosis; Colon adenocarcinoma; FHIT; Image analysis; Immunohistochemistry

Indexed keywords

FRAGILE HISTIDINE TRIAD PROTEIN;

ADENOCARCINOMA; APOPTOSIS; ARTICLE; CELL CYCLE; COLORECTAL TUMOR; GENE OVEREXPRESSION; HUMAN; IMAGE ANALYSIS; IMMUNOHISTOCHEMISTRY; LABELING INDEX; MICROSCOPY; PROGNOSIS; TUMOR SUPPRESSOR GENE;

ACID ANHYDRIDE HYDROLASES; ADENOCARCINOMA; APOPTOSIS; CELL DIFFERENTIATION; COLORECTAL NEOPLASMS; EPITHELIAL CELLS; FOLLOW-UP STUDIES; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; IMMUNOHISTOCHEMISTRY; INTESTINAL MUCOSA; NEOPLASM METASTASIS; NEOPLASM PROTEINS; NEOPLASM STAGING; PARAFFIN EMBEDDING; PROGNOSIS; RETROSPECTIVE STUDIES; SPECIMEN HANDLING; STAINING AND LABELING; SURVIVAL ANALYSIS;

EID: 0036284297     PISSN: 02620898     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1015594702522     Document Type: Article

References (26)

1. The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal cell carcinoma-associated t(3;8) breakpoint is abnormal in digestive tract cancers
2. The FHIT gene at 3p14.2 is abnormal in lung cancer
3. FHIT gene alterations in head and neck squamous cell carcinomas
4. The FHIT gene at 3p14.2 is abnormal in breast carcinomas
5. Loss of FHIT expression in cervical carcinoma cell lines and primary tumors
6. Frequent abnormalities of the putative tumor suppressor gene FHIT at 3p14.2 in pancreatic carcinoma cell lines
7. Aberrant FHIT Transcripts in cancerous and corresponding non-cancerous lesions of the digestive tract
8. Alternative splicing of the FHIT gene in colorectal cancers
9. Prevalence and digestive biologic features of flat colorectal adenomas in a north American population
10. Loss of fragile histidine triad expression in colorectal carcinomas and premalignant lesions
11. Absence of Msh2 protein expression is associated with alteration in the FHIT locus and FHIt protein expression in colorectal carcinoma
12. Apoptosis basic biologic phenomenon with wide-ranging implications in tissue kinetics
13. Molecular regulation of apoptosis. Genetic controls on cell death
14. Increased Apoptosis accompanies neoplastic development in the human colorectum
15. Inhibition of Apoptosis during development of colorectal cancer
16. Cell death by apoptosis in epidermal biology
17. Bcl-2 and the regulation of programmed cell death
18. Bcl-2 and P53 oncoprotein expression during colorectal tumorgenesis
19. bcl-2 expression in human colorectacl adenomas and carcinomas
20. The tumor-suppressor gene FHIT is involved in the regulation of apoptosis and in cell cycle control
21. Induction of apoptosis and inhibition of tumorigenicity and tumor growth by adenovirus vector-mediated fragile histidine triad (FHIT) gene overexpression
22. Role of FHIT in human cancer
23. Allelic deletion analysis of the FHITgene predicts poor survival in non-small cell lung cancer
24. FHIT loss of function in human primary breast cancer correlates with advanced stage of the disease
25. Clinicopathological significance of FHIT protein expression in stage I non-small cell lung carcinoma