Prospecting for bioactive constituents from traditional medicinal plants through ethnobotanical approaches

Biological and Pharmaceutical Bulletin

Volumn 37, Issue 6, 2014, Pages 903-915

  Gu, Ronghui ^a   Wang, Yuehu ^b   Long, Bo ^c   Kennelly, Edward ^d   Wu, Shibiao ^d   Liu, Bo ^a   Li, Ping ^a   Long, Chunlin ^a,b  

^a MINZU UNIVERSITY OF CHINA   (China)

^b KUNMING INSTITUTE OF BOTANY   (China)

^c YUNNAN UNIVERSITY   (China)

^d CITY UNIVERSITY OF NEW YORK   (United States)

Author keywords

Antiinflammatory; Antioxidative; Bioactive constituent; Drug discovery; Modern ethnobotany; Traditional medicinal plant

Indexed keywords

1 NITROAPOCAVIDINE; 12ALPHA HYDROXYELLIPTONE; 12ALPHA HYDROXYROTENONE; 3,4 O DIMETHYLQUERCETIN; 3,7 O DIMETHYLQUERCETIN; 3,7,4' O TRIMETHYLQUERCETIN; 4 O LUTEOLIN 7 O RHAMNOGLUCOSIDE; ANGUSTILOBINE C; BERBERINE; CARBAZOLE 3 CARBOXYLATE; CAULOPHYLLINE E; CHABAMIDE; DEGUELIN; DEHYDROCAVIDINE; EKEBERGININE; FLAVANONE; FLAVONE; FLAVONOID; GAMMA MANGOSTIN; MANGOSTIN; N,2 DIMETHYL 3 HYDROXY 5 (10 PHENYLDECYL)PYRROLIDINE; N,2 DIMETHYL 3 HYDROXY 6 (9 PHENYLNONYL)PIPERIDINE; PALMATINE; PHENOL; PLANT MEDICINAL PRODUCT; QUERCETIN 3 METHYL ETHER; SANGUINARINE; TERPENOID; UNCLASSIFIED DRUG; UNINDEXED DRUG; VANESSINE; ALKALOID; PHENOL DERIVATIVE; TERPENE;

ALLERGIC DISEASE; ALSTONIA ANGUSTILOBA; ANALGESIC ACTIVITY; ANTIBACTERIAL ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; ANTIVIRAL ACTIVITY; ARISAEMA DECIPIENS; ASTHMA; BIOCHEMICAL COMPOSITION; BIOLOGICAL ACTIVITY; BLEEDING; BOESENBERGIA PANDURATA; CAULOPHYLLUM ROBUSTUM; CHRYSANTHEMUM SINENSE; COPTIS CHINENSIS; CORYDALIS SAXICOLA; DERRIS TRIFOLIATA; DIABETES MELLITUS; DIARRHEA; DIURETIC ACTIVITY; DRUG CYTOTOXICITY; DRUG ISOLATION; DRUG STRUCTURE; DYSENTERY; ENZYME INHIBITION; ETHNOBOTANY; EUPHORBIA CUNEATA; GARCINIA MANGOSTANA; HEMORRHOID; HEPATITIS; HUMAN; IC 50; INJURY; KAEMPFERIA PARVIFLORA; MALARIA; MEDICINAL PLANT; MENSTRUAL IRREGULARITY; NONHUMAN; PARALYSIS; PIPER CHABA; RESPIRATORY TRACT DISEASE; REVIEW; RHEUMATOID ARTHRITIS; SNAKEBITE; STOMACH DISEASE; STOMACH PAIN; STRUCTURE ACTIVITY RELATION; TRADITIONAL MEDICINE; URINARY TRACT DISEASE; WALTHERIA DOURADINHA; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; DRUG DEVELOPMENT; ISOLATION AND PURIFICATION; PROCEDURES;

ALKALOIDS; ANIMALS; DRUG DISCOVERY; ETHNOBOTANY; HUMANS; MEDICINE, TRADITIONAL; MOLECULAR STRUCTURE; PHENOLS; PLANTS, MEDICINAL; STRUCTURE-ACTIVITY RELATIONSHIP; TERPENES;

EID: 84901846921     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.b14-00084     Document Type: Review

References (83)

1. Chin YW, Balunas MJ, Chai HB, Kinghorn AD. Drug discovery from natural sources. AAPS J., 8, E239-E253 (2006).
2. Ncube NS, Afolayan AJ, Okoh AI. Assessment techniques of antimicrobial properties of natural compounds of plant origin: current methods and future trends. Afr. J. Biotechnol., 7, 1797-1806 (2008).
3. Nirmala MJ, Samundeeswari A, Sankar PD. Natural plant resources in anti-cancer therapy - a review. Res. Plant Biol., 1, 1-14 (2011).
4. Abad MJ, Ansuategui M, Bermejo P. Active antifungal substances from natural sources. ARKIVOC, 7, 116-145 (2007).
5. Fabricant DS, Farnsworth NR. The value of plants used in traditional medicine for drug discovery. Environ. Health Perspect., 109 (Suppl. 1), S69-S75 (2001).
6. Gurib-Fakim A. Medicinal plants: traditions of yesterday and drugs of tomorrow. Mol. Aspects Med., 27, 1-93 (2006).
7. Raskin I, Ribnicky DM, Komarnytsky S, Ilic N, Poulev A, Borisjuk N, Brinker A, Moreno DA, Ripoll C, Yakoby N, O'Neal JMQ, Cornwell T, Pastor I, Fridlender B. Plants and human health in the twenty-first century. Trends Biotechnol., 20, 522-531 (2002).
8. de Boer HJ, Lamxay V, Björk L. Comparing medicinal plant knowledge using similarity indices: A case of the Brou, Saek and Kry in Lao PDR. J. Ethnopharmacol., 141, 481-500 (2012).
9. Lin KW. Ethnobotanical study of medicinal plants used by the Jah Hut peoples in Malaysia. Indian J. Med. Sci., 59, 156-161 (2005).
10. Abe R, Ohtani K. An ethnobotanical study of medicinal plants and traditional therapies on Batan island, the Philippines. J. Ethnopharmacol., 145, 554-565 (2013).
11. Rout SP, Choudary KA, Kar DM, Das L, Jain A. Plants in traditional medicinal system - future source of new drugs. Int. J. Pharm. Pharmacol. Sci., 1, 1-23 (2009).
12. Long CL. Modern ethnobotany: an introduction. Plant Diversity Resour., 35, 438-442 (2013).
13. Gao PF, Watanabe K. Introduction of the World Health Organization project of the international classification of traditional medicine. Zhong Xi Yi Jie He Xue Bao, 9, 1161-1164 (2011).
14. Plengsuriyakarn T, Viyanant V, Eursitthichai V, Picha P, Kupradinun P, Itharat A, Na-Bangchang K. Anticancer activities against cholangiocarcinoma, toxicity and pharmacological activities of Thai medicinal plants in animal models. BMC Complement. Altern. Med., 12, 23 (2012).
15. Soares AM, Ticli FK, Marcussi S, Lourenco MV, Januario AH, Sampaio SV, Giglio JR, Lomonte B, Pereira PS. Medicinal plants with inhibitory properties against snake venoms. Curr. Med. Chem., 12, 2625-2641 (2005).
16. Namdeo AG. Plant cell elicitation for production of secondary metabolites: a review. Pharmacogn. Rev., 1, 69-79 (2007).
17. Bariş Ö, Güllüce M, Şahin F, Özer H, Kiliç H, Özkan H, Sökmen M, Özbek T. Biological activities of the essential oil and methanol extract of Achillea biebersteinii AFAN. (Asteraceae). Turk. J. Biol., 30, 65-73 (2006).
18. Julsing MK, Koulman A, Woerdenbag HJ, Quax WJ, Kayser O. Combinatorial biosynthesis of medicinal plant secondary metabolites. Biomol. Eng., 23, 265-279 (2006).
19. Gu RH, Hong LY, Long CL. The ways of producing secondary metabolites via plant cell culture. Plant Physiol. J., 9, 869-881 (2013).
20. Cai Y, Luo Q, Sun M, Corke H. Antioxidant activity and phenolic compounds of 112 traditional Chinese medicinal plants associated with anticancer. Life Sci., 74, 2157-2184 (2004).
21. Samy PR, Gopalakrishnakone P. Therapeutic potential of plants as anti-microbials for drug discovery. Evid. Based Complement. Alternat. Med., 37, 283-294 (2010).
22. Wang YH, Long CL, Yang FM, Wang X, Sun QY, Wang HS, Shi YN, Tang GH. Pyrrolidinoindoline alkaloids from Selaginella moellendorfii. J. Nat. Prod., 72, 1151-1154 (2009).
23. Zhao FW, Luo M, Wang YH, Li ML, Tang GH, Long CL. A piperidine alkaloid and limonoids from Arisaema decipiens, a traditional antitumor herb used by the Dong people. Arch. Pharm. Res., 33, 1735-1739 (2010).
24. Gressler V, Stüker CZ, Dias GDO, Dalcol II, Burrow RA, Schmidt J, Wessjohann L, Morel AF. Quinolone alkaloids from Waltheria douradinha. Phytochemistry, 69, 994-999 (2008).
25. Rao VRS, Suresh G, Babu KS, Raju SS, Vishnu vardhan MVPS, Ramakrishna S, Rao JM. Novel dimeric amide alkaloids from Piper chaba HUNTER: isolation, cytotoxic activity, and their biomimetic synthesis. Tetrahedron, 67, 1885-1892 (2011).
26. Ku WF, Tan SJ, Low YY, Komiyama K, Kam TS. Angustilobine and andranginine type indole alkaloids and an uleine-seco vallesamine bisindole alkaloid from Alstonia angustiloba. Phytochemistry, 72, 2212-2218 (2011).
27. Su Y, Xu JJ, Bi JL, Wang YH, Hu GW, Yang J, Yin GF, Long CL. Chemical constituents of Arisaema franchetianum tubers. J. Asian Nat. Prod. Res., 15, 71-77 (2013).
28. Huang QQ, Bi JL, Sun QY, Yang FM, Wang YH, Tang GH, Zhao FW, Wang H, Xu JJ, Kennelly EJ, Long CL, Yin GF. Bioactive isoquinoline alkaloids from Corydalis saxicola. Planta Med., 78, 65-70 (2012).
29. Wang XL, Liu BR, Chen CK, Wang JR, Lee SS. Four new fluorenone alkaloids and one new dihydroazafluoranthene alkaloid from Caulophyllum robustum MAXIM. Fitoterapia, 82, 793-797 (2011).
30. Gutierrez-Lugo MT, Singh MP, Maiese WM, Timmermann BN. New antimicrobial cycloartane triterpenes from Acalypha communis. J. Nat. Prod., 65, 872-875 (2002).
31. Changwichit K, Khorana N, Suwanborirux K, Waranuch N, Limpeanchob N, Wisuitiprot W, Suphrom N, Ingkaninan K. Bisindole alkaloids and secoiridoids from Alstonia macrophylla WALL, ex D. DON. Fitoterapia, 82, 798-804 (2011).
32. Suresh G, Reddy PP, Babu KS, Shaik TB, Kalivendi SV. Two new cytotoxic labdane diterpenes from the rhizomes of Hedychium coronarium. Bioorg. Bioorg. Med. Chem. Lett., 20, 7544-7548 (2010).
33. Tang GH, Sun CS, Long CL, Li ML, Wang YH, Luo M, Wang HS, Shi YN. Sesquiterpenoids from Pilea cavaleriei ssp. crenata. Bioorg. Med. Chem. Lett., 19, 5737-5740 (2009).
34. Romano B, Pagano E, Montanaro V, Fortunato AL, Milic N, Borrelli F. Novel insights into the pharmacology of flavonoids. Phytother. Res., 11, 1588-1596 (2013).
35. Havsteen BH. The biochemistry and medical significance of the flavonoids. Pharmacol. Ther., 96, 67-202 (2002).
36. Amado NG, Fonseca BF, Cerqueira DM, Neto VM, Abreu JG. Flavonoids: potential wnt/beta-catenin signaling modulators in cancer. Life Sci., 89, 545-554 (2011).
37. Dajas F. Life or death: neuroprotective and anticancer effects of quercetin. J. Ethnopharmacol., 143, 383-396 (2012).
38. Procházková D, Bouová I, Wilhelmová N. Antioxidant and prooxidant properties of flavonoids. Fitoterapia, 82, 513-523 (2011).
39. Prasad S, Phromnoi K, Yadav VR, Chaturvedi MM, Aggarwal BB. Targeting inflammatory pathways by flavonoids for prevention and treatment of cancer. Planta Med., 76, 1044-1063 (2010).
40. Rao RR, Tiwari AK, Reddy PP, Babu SK, Ali AZ, Madhusudana K, Rao MJ. New furanoflavanoids, intestinal alpha-glucosidase inhibitory and free-radical (DPPH) scavenging, activity from antihyperglycemic root extract of Derris indica (LAM.). Bioorg. Med. Chem., 17, 5170-5175 (2009).
41. Kim JY, Lim HJ, Ryu JH. In vitro anti-inflammatory activity of 3-O-methyl-flavones isolated from Siegesbeckia glabrescens. Bioorg. Med. Chem. Lett., 18, 1511-1514 (2008).
42. Tewtrakul S, Subhadhirasakul S, Karalai C, Ponglimanont C, Cheenpracha S. Anti-inflammatory effects of compounds from Kaempferia parviflora and Boesenbergia pandurata. Food Chem., 115, 534-538 (2009).
43. Awaad AS, Al Jaber NA, Moses JE, El Meligy RM, Zain ME. Antiulcerogenic activities of the extracts and isolated flavonoids of Euphorbia cuneata VAHL. Phytother. Res., 27, 126-130 (2013).
44. Maity P, Hansda D, Bandyopadhyay U, Mishra DK. Biological activities of crude extracts and chemical constituents of bael, Aegle marmelos (L.) CORR. Indian J. Exp. Biol., 47, 849-861 (2009).
45. Wang QH, Kuang HX, Su Y, Sun YP, Feng J, Guo R, Chan K. Naturally derived anti-inflammatory compounds from Chinese medicinal plants. J. Ethnopharmacol., 146, 9-39 (2013).
46. Nugraha AS, Keller PA. Revealing indigenous Indonesian traditional medicine: anti-infective agents. Nat. Prod. Common., 6, 1953-1966 (2011).
47. Chen SX, Wan M, Loh BN. Active constituents against HIV-1 protease from Garcinia mangostana. Planta Med., 62, 381-382 (1996).
48. He J, Chen L, Heber D, Shi WY, Lu QY. Antibacterial compounds from Glycyrrhiza uralensis. J. Nat. Prod., 69, 121-124 (2006).
49. Huang QQ, Bi JL, Sun QY, Yang FM, Wang YH, Tang GH, Zhao FW, Wang H, Xu JJ, Kennedy EJ, Long CL, Yin GF. Bioactive isoquinoline alkaloids from Corydalis saxicola. Planta Med., 78, 65-70 (2012).
50. Álvarez ÁL, Dalton KP, Nicieza I, Diñeiro Y, Picinelli A, Melón S, Roque A, Suárez B, Parra F. Bioactivity-guided fractionation of Phyllanthus orbicularis and identification of the principal anti HSV-2 compounds. Phytother. Res., 26, 1513-1520 (2012).
51. Rahman MM, Gray AI. A benzoisofuranone derivative and carbazole alkaloids from Murraya koenigii and their antimicrobial activity. Phytochemistry, 66, 1601-1606 (2005).
52. Favela-Hernández JMJ, García A, Garza-González E, Rivas-Galindo VM, Camacho-Corona MR. Antibacterial and antimycobacterial lignans and flavonoids from Larrea tridentata. Phytother. Res., 26, 1957-1960 (2012).
53. Verma G, Dua VK, Agarwal DD, Atul PK. Anti-malarial activity of Holarrhena antidysenterica and Viola canescens, plants traditionally used against malaria in the Garhwal region of north-west Himalaya. Malar. J., 10, 20 (2011).
54. Kirmizibekmez H, Atay I, Kaiser M, Brun R, Cartagena MM, Carballeira NM, Yesilada E, Tasdemir D. Antiprotozoal activity of Melampyrum arvense and its metabolites. Phytother. Res., 25, 142-146 (2011).
55. Poulsen HE, Prieme H, Loft S. Role of oxidative DNA damage in cancer initiation and promotion. Eur. J. Cancer Prev., 1, 9-16 (1998).
56. Awaad AS, Al-Jaber NA. Antioxidant natural plant. RPMP, 27, 1-35 (2010).
57. Nguyen MTT, Awale S, Tezuka Y, Tran QL, Watanabe H, Kadota S. Xanthine oxidase inhibitory activity of Vietnamese medicinal plants. Biol. Pharm. Bull., 27, 1414-1421 (2004).
58. Wang XL, Liu BR, Chen CK, Wang JR, Lee SS. Four new fluorenone alkaloids and one new dihydroazafluoranthene alkaloid from Caulophyllum robustum MAXIM. Fitoterapia, 82, 793-797 (2011).
59. Arung ET, Kusuma IW, Purwatiningsih S, Roh SS, Yang CH, Jeon S, Kim YU, Sukaton E, Susilo J, Astuti Y, Wicaksono BD, Sandra F, Shimizu K, Kondo R. Antioxidant activity and cytotoxicity of the traditional Indonesian medicine tahongai (Kleinhovia hospita L.) extract. J. Acupunct. Meridian Stud., 2, 306-308 (2009).
60. Alshawsh MA, Abdulla MA, Ismail S, Amin ZA, Qader SW, Hadi HA, Harmal NS. Free radical scavenging, antimicrobial and immunomodulatory activities of Orthosiphon stamineus. Molecules, 17, 5385-5395 (2012).
61. Manosroi J, Moses ZZ, Manosroi W, Manosroi A. Hypoglycemic activity of Thai medicinal plants selected from the Thai/Lanna medicinal recipe database Manosroi II. J. Ethnopharmacol., 138, 92-98 (2011).
62. Barton GM. A calculated response: control of inflammation by the innate immune system. J. Clin. Invest., 118, 413-420 (2008).
63. Sautebin L. Prostaglandins and nitric oxide as molecular targets for anti-inflammatory therapy. Fitoterapia, 71 (Suppl. 1), S48-S57 (2000).
64. Tewtrakul S, Cheenpracha S, Karalai C. Nitric oxide inhibitory principles from Derris trifoliata stems. Phytomedicine, 16, 568-572 (2009).
65. Tewtrakul S, Itharat A. Nitric oxide inhibitory substances from the rhizomes of Dioscorea membranacea. J. Ethnopharmacol., 109, 412-416 (2007).
66. Chen LG, Yang LL, Wang CC. Anti-inflammatory activity of mangostins from Garcinia mangostana. Food Chem. Toxicol., 46, 688-693 (2008).
67. 2+ ions: implications for their antioxidant properties. Biochem. J., 330, 1173-1178 (1998).
68. Teixeira S, Siquet C, Alves C, Boal I, Marques MP, Borges F, Lima JL, Reis S. Structure-property studies on the antioxidant activity of flavonoids present in diet. Free Radic. Biol. Med., 39, 1099-1108 (2005).
69. Heim KE, Tagliaferro AR, Bobilya DJ. Flavonoid antioxidants: chemistry, metabolism and structure-activity relationships. J. Nutr. Biochem., 13, 572-584 (2002).
70. López-Posadas R, Ballester I, Abadía-Molina AC, Suárez MD, Zarzuelo A, Martínez-Augustin O, Sánchez De Medina F. Effect of flavonoids on rat splenocytes, a structure-activity relationship study. Biochem. Pharmacol., 76, 495-506 (2008).
71. Middleton E Jr, Kandaswami C, Theoharides TC. The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer. Pharmacol. Rev., 52, 673-751 (2000).
72. Ito C, Katsuno S, Itoigawa M, Ruangrungsi N, Mukainaka T, Okuda M, Kitagawa Y, Tokuda H, Nishino H, Furukawa H. New carbazole alkaloids from Clausena anisata with antitumor promoting activity. J. Nat. Prod., 63, 125-128 (2000).
73. Yan D, Jin C, Xiao XH, Dong XP. Antimicrobial properties of berberines alkaloids in Coptis chinensis FRANCH. by microcalorimetry. J. Biochem. Biophys. Methods, 70, 845-849 (2008).
74. Reddy PP, Lavekar AG, Babu SK, Rao RR, Shashidhar J, Shashikiran G, Rao MJ. Synthesis, cytotoxic activity and structure-activity relationships of hedychenone analogues. Bioorg. Med. Chem. Lett., 20, 2525-2528 (2010).
75. Heinrich M. Ethnobotany and natural products: the search for new molecules, new treatments of old diseases or a better understanding of indigenous cultures? Curr. Top. Med. Chem., 3, 141-154 (2003).
76. Brusotti G, Cesari I, Dentamaro A, Caccialanza G, Massolini G. Isolation and characterization of bioactive compounds from plant resources: the role of analysis in the ethnopharmacological approach. J. Pharm. Biomed. Anal., 87, 218-228 (2014).
77. Gyllenhaal C, Kadushin MR, Southavong B, Sydara K, Bouamanivong S, Xaiveu M, Xuan LT, Hiep NT, Hung NV, Loc PK, Dac LX, Bich TQ, Cuong NM, Ly HM, Zhang HJ, Franzblau SG, Xie H, Riley MC, Elkington BG, Nguyen HT, Waller DP, Ma CY, Tamez P, Tan GT, Pezzuto JM, Soejarto DD. Ethnobotanical approach versus random approach in the search for new bioactive compounds: support of a hypothesis. Pharm. Biol., 50, 30-41 (2012).
78. Leonti M. The future is written: impact of scripts on the cognition, selection, knowledge and transmission of medicinal plant use and its implications for ethnobotany and ethnopharmacology. J. Ethnopharmacol., 134, 542-555 (2011).
79. Yang CY, Long CL, Shi YN, Wang YH, Wang HS. Ethnobotanical study on medicinal market during dragon-boat festival in Jingxi County, southwestern Guangxi Region. J. CUN (Natural Sciences Edition), 18, 16-26 (2009).
80. Soejarto DD, Gyllenhaal C, Kadushin MR, Southavong B, Sydara K, Bouamanivong S, Xaiveu M, Zhang HJ, Franzblau SG, Tan GT, Pezzuto JM, Riley MC, Elkington BG, Waller DP. An ethnobotanical survey of medicinal plants of Laos toward the discovery of bioactive compounds as potential candidates for pharmaceutical development. Pharm. Biol., 50, 42-60 (2012).
81. Samuel AJSJ, Kalusalingam A, Chellappan DK, Gopinath R, Radhamani S, Husain HA, Muruganandham V, Promwichit P. Ethnomedical survey of plants used by the Orang Asli in Kampung Bawong, Perak, West Malaysia. J. Ethnobiol. Ethnomed., 6, 5 (2010).
82. Kaewpiboon C, Lirdprapamongkol K, Srisomsap C, Winayanuwattikun P, Yongvanich T, Puwaprisirisan P, Svasti J, Assavalapsakul W. Studies of the in vitro cytotoxic, antioxidant, lipase inhibitory and antimicrobial activities of selected Thai medicinal plants. BMC Complement. Altern. Med., 12, 217 (2012).
83. Kennedy J, Marchesi JR, Dobson AD. Metagenomic approaches to exploit the biotechnological potential of the microbial consortia of marine sponges. Appl. Microbiol. Biotechnol., 75, 11-20 (2007).