Limited proliferation and telomere dysfunction following telomerase inhibition in immortal murine fibroblasts

Cancer Research

Volumn 62, Issue 7, 2002, Pages 2104-2114

  Boklan, Jessica ^a   Nanjangud, Gouri ^a   MacKenzie, Karen L ^a   May, Chad ^a   Sadelain, Michel ^a   Moore, Malcolm A S ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; GREEN FLUORESCENT PROTEIN; RETROVIRUS VECTOR; RIBONUCLEOPROTEIN; RNA DIRECTED DNA POLYMERASE; TELOMERASE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CANCER THERAPY; CELL CYCLE; CELL IMMORTALIZATION; CELL PROLIFERATION; CELL STRAIN 3T3; CELL STRUCTURE; CHROMOSOME ANALYSIS; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; FETUS; FIBROBLAST; GENETIC TRANSDUCTION; HUMAN; HUMAN CELL; LUNG FIBROBLAST; MOUSE; NONHUMAN; PRIORITY JOURNAL; TELOMERE;

3T3 CELLS; ADENOVIRIDAE; ANIMALS; APOPTOSIS; CELL CYCLE; CELL DIVISION; DNA-BINDING PROTEINS; FIBROBLASTS; HUMANS; MICE; TELOMERASE; TELOMERE; TRANSDUCTION, GENETIC;

EID: 0036532161     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (54)

1. Telomerases
2. Telomerase extends the lifespan of virus-transformed human cells without net telomere lengthening
3. Mammalian telomeres end in a large duplex loop
4. Telomeres do d-loop-t-loop
5. Telomere states and cell fates
6. The serial cultivation of human diploid cell strains
7. Telomeres shorten during aging of human fibroblasts
8. Telomerase activity in hematopoietic cells is associated with self-renewal potential
9. Telomerase regulation, cell cycle, and telomere stability in primitive hematopoietic cells
10. A survey of telomerase activity in human cancer
11. Telomerase catalytic subunit homologs from fission yeast and human
12. hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization
13. Expression of mouse telomerase catalytic subunit in embryos and adult tissues
14. Expression of mouse telomerase reverse transcriptase during development, differentiation and proliferation
15. Extension of life-span by introduction of telomerase into normal human cells
16. Absence of cancer-associated changes in human fibroblasts immortalized with telomerase
17. Human endothelial cell life extension by telomerase expression
18. Mass cultured human fibroblasts overexpressing hTERT encounter a growth crisis following an extended period of proliferation
19. Defining the molecular mechanisms of human cell immortalization
20. CIPI/WAFIgene in normal diploid human fibroblasts
21. Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity
22. Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization
23. Creation of human tumour cells with defined genetic elements
24. Effect of reverse transcriptase inhibitors on telomere length and telomerase activity in two immortalized human cell lines
25. Inhibition of human telomerase in immortal human cells leads to progressive telomere shortening and cell death
26. Inhibition of telomerase limits the growth of human cancer cells
27. Telomere shortening and apoptosis in telomerase-inhibited human tumor cells
28. Immortalized cells with no detectable telomerase activity. A review
29. Hypervariable ultra-long telomeres in mice
30. Telomeres in the mouse have large inter-chromosomal variations in the number of T2AG3 repeats
31. Functional characterization and developmental regulation of mouse telomerase RNA
32. Developmental and tissue-specific regulation of mouse telomerase and telomere length
33. Telomerase, activity in normal and malignant murine tissues
34. Differential regulation of telomerase activity and telomerase RNA during multi-stage tumorigenesis
35. Essential role of mouse telomerase in highly proliferative organs
36. Effects of retroviral vector design on expression of human adenosine deaminase in murine bone marrow transplant recipients engrafted with genetically modified cells
37. A stable human derived packaging cell line for production of high titer retrovirus/vesicular stomatitis G pseudotypes
38. A safe packaging line for gene transfer: Separating viral genes on two different plasmids
39. Advances in quantification and characterization of telomerase activity by the telomere repeat amplification protocol TRAP
40. Measurement of telomeric DNA content in human tissues
41. Nucleotide sequence of mouse satellite DNA
42. Mouse major γ satellite DNA is highly conserved and organized into extremely long tandem arrays: Implications for recombination between nonhomologous chromosomes
43. Nonisotopical labelling of murine heterochromatin in si tu by hybridization with in vitro-synthesized biotinylated γ major satellite DNA
44. 2/M-phase, subpopulations in mammalian cell nuclei using side scatter and DNA content measurements
45. Light scatter of isolated cell nuclei as a parameter discriminating the cell-cycle subcompartments
46. A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled annexin V
47. Reconstitution of human telomerase activity and identification of a minimal functional region of human telomerase RNA
48. Reconstitution of human telomerase activity in vitro
49. Telomere length dynamics in human lymphocyte subpopulations measured by flow cytometry
50. Telomere length dynamics and chromosomal instability in cells derived from telomerase null mice
51. Longevity, stress response, and cancer in aging telomerase-deficient mice
52. Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice
53. Wild-derived inbred mouse strains have short telomeres
54. Telomere shortening and tumor formation by mouse cells lacking telomerase RNA