PD-1 is not required for natural or peripherally induced regulatory T cells: Severe autoimmunity despite normal production of regulatory T cells

European Journal of Immunology

Volumn 44, Issue 12, 2014, Pages 3560-3572

  Ellestad, Kristofor K ^a   Thangavelu, Govindarajan ^a   Ewen, Catherine L ^a   Boon, Louis ^b   Anderson, Colin C ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b BIOCEROS   (Netherlands)

Author keywords

Autoimmunity; Coinhibition; Costimulation; Lymphopenia; Regulatory T cells; Tolerance

Indexed keywords

ENHANCED GREEN FLUORESCENT PROTEIN; PROGRAMMED DEATH 1 RECEPTOR; TRANSCRIPTION FACTOR FOXP3; AUTOANTIGEN; CD274 PROTEIN, MOUSE; PDCD1 PROTEIN, MOUSE; PROGRAMMED DEATH 1 LIGAND 1;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL MODEL; ARTICLE; AUTOIMMUNE DISEASE; AUTOIMMUNITY; CELL COUNT; CELL EXPANSION; CELL LINE; CELL POPULATION; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; GENE EXPRESSION; IN VITRO STUDY; IN VIVO STUDY; LYMPHOCYTE PROLIFERATION; LYMPHOCYTOPENIA; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECENT THYMIC EMIGRANT; REGULATORY T LYMPHOCYTE; REPORTER GENE; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; TH17 CELL; THYMOCYTE; THYMUS; WILD TYPE; ANIMAL; CELL PROLIFERATION; CYTOLOGY; GENETICS; IMMUNOLOGY; KNOCKOUT MOUSE; LYMPHOCYTE ACTIVATION; LYMPHOCYTE COUNT; PHYSIOLOGY;

ANIMALS; ANTIGENS, CD274; AUTOANTIGENS; CELL PROLIFERATION; LYMPHOCYTE ACTIVATION; LYMPHOCYTE COUNT; LYMPHOPENIA; MICE; MICE, KNOCKOUT; PROGRAMMED CELL DEATH 1 RECEPTOR; T-LYMPHOCYTES, REGULATORY; TH17 CELLS;

EID: 84924287308     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201444688     Document Type: Article

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