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Volumn 41, Issue 4, 2011, Pages 1132-1142

FOXP3+CD4+ Tregs lose suppressive potential but remain anergic during transient inflammation in human

Author keywords

Cellular immunology; Immune regulation; Inflammation; Treg

Indexed keywords

CD4 ANTIGEN; INTERLEUKIN 7 RECEPTOR; KI 67 ANTIGEN; TRANSCRIPTION FACTOR FOXP3;

EID: 79953059816     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201040363     Document Type: Article
Times cited : (13)

References (49)
  • 1
    • 0035004605 scopus 로고    scopus 로고
    • Tissue injury and the inflammatory response to pediatric cardiac surgery with cardiopulmonary bypass: a descriptive study
    • Chew, M. S., Brandslund, I., Brix-Christensen, V., Ravn, H. B., Hjortdal, V. E., Pedersen, J., Hjortdal, K. et al., Tissue injury and the inflammatory response to pediatric cardiac surgery with cardiopulmonary bypass: a descriptive study. Anesthesiology 2001. 94: 745-753.
    • (2001) Anesthesiology , vol.94 , pp. 745-753
    • Chew, M.S.1    Brandslund, I.2    Brix-Christensen, V.3    Ravn, H.B.4    Hjortdal, V.E.5    Pedersen, J.6    Hjortdal, K.7
  • 2
    • 0012467213 scopus 로고    scopus 로고
    • Humoral immune response during coronary artery bypass grafting: A comparison of limited approach, "off-pump" technique, and conventional cardiopulmonary bypass
    • Diegeler, A., Doll, N., Rauch, T., Haberer, D., Walther, T., Falk, V., Gummert, J. et al., Humoral immune response during coronary artery bypass grafting: A comparison of limited approach, "off-pump" technique, and conventional cardiopulmonary bypass. Circulation 2000. 102: 95-100.
    • (2000) Circulation , vol.102 , pp. 95-100
    • Diegeler, A.1    Doll, N.2    Rauch, T.3    Haberer, D.4    Walther, T.5    Falk, V.6    Gummert, J.7
  • 3
    • 27744496466 scopus 로고    scopus 로고
    • Transcriptomic and proteomic patterns of systemic inflammation in on-pump and off-pump coronary artery bypass grafting
    • Tomic, V., Russwurm, S., Moller, E., Claus, R. A., Blaess, M., Brunkhorst, F., Bruegel, M. et al., Transcriptomic and proteomic patterns of systemic inflammation in on-pump and off-pump coronary artery bypass grafting. Circulation 2005. 112: 2912-2920.
    • (2005) Circulation , vol.112 , pp. 2912-2920
    • Tomic, V.1    Russwurm, S.2    Moller, E.3    Claus, R.A.4    Blaess, M.5    Brunkhorst, F.6    Bruegel, M.7
  • 4
    • 0030818330 scopus 로고    scopus 로고
    • Inflammatory response to cardiopulmonary bypass: mechanisms involved and possible therapeutic strategies
    • Wan, S., LeClerc, J. L. and Vincent, J. L., Inflammatory response to cardiopulmonary bypass: mechanisms involved and possible therapeutic strategies. Chest 1997. 112: 676-692.
    • (1997) Chest , vol.112 , pp. 676-692
    • Wan, S.1    LeClerc, J.L.2    Vincent, J.L.3
  • 5
    • 0036250315 scopus 로고    scopus 로고
    • Congenital heart disease, cardiopulmonary bypass, systemic inflammatory response syndrome, compensatory anti-inflammatory response syndrome, and outcome: evolving understanding of critical care inflammation immunology
    • Zimmerman, J. J., Congenital heart disease, cardiopulmonary bypass, systemic inflammatory response syndrome, compensatory anti-inflammatory response syndrome, and outcome: evolving understanding of critical care inflammation immunology. Crit. Care Med. 2002. 30: 1178-1179.
    • (2002) Crit. Care Med. , vol.30 , pp. 1178-1179
    • Zimmerman, J.J.1
  • 6
    • 59749103715 scopus 로고    scopus 로고
    • Inducible reprogramming of human T cells into Treg cells by a conditionally active form of FOXP3
    • Allan, S. E., Song-Zhao, G. X., Abraham, T., McMurchy, A. N. and Levings, M. K., Inducible reprogramming of human T cells into Treg cells by a conditionally active form of FOXP3. Eur. J. Immunol. 2008. 38: 3282-3289.
    • (2008) Eur. J. Immunol. , vol.38 , pp. 3282-3289
    • Allan, S.E.1    Song-Zhao, G.X.2    Abraham, T.3    McMurchy, A.N.4    Levings, M.K.5
  • 8
    • 77951720536 scopus 로고    scopus 로고
    • Antigenic strength controls the generation of antigen-specific IL-10-secreting T regulatory cells
    • Gabrysova, L. and Wraith, D. C., Antigenic strength controls the generation of antigen-specific IL-10-secreting T regulatory cells. Eur. J. Immunol. 2010. 40: 1386-1395.
    • (2010) Eur. J. Immunol. , vol.40 , pp. 1386-1395
    • Gabrysova, L.1    Wraith, D.C.2
  • 9
    • 77749245828 scopus 로고    scopus 로고
    • c-Rel is crucial for the induction of Foxp3(+) regulatory CD4(+) T cells but not T(H)17 cells
    • Visekruna, A., Huber, M., Hellhund, A., Bothur, E., Reinhard, K., Bollig, N., Schmidt, N. et al., c-Rel is crucial for the induction of Foxp3(+) regulatory CD4(+) T cells but not T(H)17 cells. Eur. J. Immunol. 2010. 40: 671-676.
    • (2010) Eur. J. Immunol. , vol.40 , pp. 671-676
    • Visekruna, A.1    Huber, M.2    Hellhund, A.3    Bothur, E.4    Reinhard, K.5    Bollig, N.6    Schmidt, N.7
  • 10
  • 11
    • 2442618129 scopus 로고    scopus 로고
    • CD4+CD25bright regulatory T cells actively regulate inflammation in the joints of patients with the remitting form of juvenile idiopathic arthritis
    • de Kleer, I. M., Wedderburn, L. R., Taams, L. S., Patel, A., Varsani, H., Klein, M., de Jager, W. et al., CD4+CD25bright regulatory T cells actively regulate inflammation in the joints of patients with the remitting form of juvenile idiopathic arthritis. J. Immunol. 2004. 172: 6435-6443.
    • (2004) J. Immunol. , vol.172 , pp. 6435-6443
    • de Kleer, I.M.1    Wedderburn, L.R.2    Taams, L.S.3    Patel, A.4    Varsani, H.5    Klein, M.6    de Jager, W.7
  • 12
    • 51449116424 scopus 로고    scopus 로고
    • CD4+CD25high T cell numbers are enriched in the peripheral blood of patients with rheumatoid arthritis
    • Han, G. M., O'Neil-Andersen, N. J., Zurier, R. B. and Lawrence, D. A., CD4+CD25high T cell numbers are enriched in the peripheral blood of patients with rheumatoid arthritis. Cell Immunol. 2008. 253: 92-101.
    • (2008) Cell Immunol. , vol.253 , pp. 92-101
    • Han, G.M.1    O'Neil-Andersen, N.J.2    Zurier, R.B.3    Lawrence, D.A.4
  • 13
    • 54049086976 scopus 로고    scopus 로고
    • CD4+CD25+FoxP3+PD1- regulatory T cells in acute and stable relapsing-remitting multiple sclerosis and their modulation by therapy
    • Saresella, M., Marventano, I., Longhi, R., Lissoni, F., Trabattoni, D., Mendozzi, L., Caputo, D. and Clerici, M., CD4+CD25+FoxP3+PD1- regulatory T cells in acute and stable relapsing-remitting multiple sclerosis and their modulation by therapy. FASEB J. 2008. 22: 3500-3508.
    • (2008) FASEB J. , vol.22 , pp. 3500-3508
    • Saresella, M.1    Marventano, I.2    Longhi, R.3    Lissoni, F.4    Trabattoni, D.5    Mendozzi, L.6    Caputo, D.7    Clerici, M.8
  • 14
    • 33846900430 scopus 로고    scopus 로고
    • Deficient CD4+CD25high T regulatory cell function in patients with active systemic lupus erythematosus
    • Valencia, X., Yarboro, C., Illei, G. and Lipsky, P. E., Deficient CD4+CD25high T regulatory cell function in patients with active systemic lupus erythematosus. J. Immunol. 2007. 178: 2579-2588.
    • (2007) J. Immunol. , vol.178 , pp. 2579-2588
    • Valencia, X.1    Yarboro, C.2    Illei, G.3    Lipsky, P.E.4
  • 15
    • 47249099764 scopus 로고    scopus 로고
    • Local accumulation of FOXP3+ regulatory T cells: evidence for an immune evasion mechanism in patients with large condylomata acuminata
    • Cao, Y., Zhao, J., Lei, Z., Shen, S., Liu, C., Li, D., Liu, J. et al., Local accumulation of FOXP3+ regulatory T cells: evidence for an immune evasion mechanism in patients with large condylomata acuminata. J. Immunol. 2008. 180: 7681-7686.
    • (2008) J. Immunol. , vol.180 , pp. 7681-7686
    • Cao, Y.1    Zhao, J.2    Lei, Z.3    Shen, S.4    Liu, C.5    Li, D.6    Liu, J.7
  • 16
    • 43249107955 scopus 로고    scopus 로고
    • Identification and in vitro expansion of functional antigen-specific CD25+ FoxP3+ regulatory T cells in hepatitis C virus infection
    • Ebinuma, H., Nakamoto, N., Li, Y., Price, D. A., Gostick, E., Levine, B. L., Tobias, J. et al., Identification and in vitro expansion of functional antigen-specific CD25+ FoxP3+ regulatory T cells in hepatitis C virus infection. J. Virol. 2008. 82: 5043-5053.
    • (2008) J. Virol. , vol.82 , pp. 5043-5053
    • Ebinuma, H.1    Nakamoto, N.2    Li, Y.3    Price, D.A.4    Gostick, E.5    Levine, B.L.6    Tobias, J.7
  • 17
    • 38649132571 scopus 로고    scopus 로고
    • Helicobacter pylori gastritis in children is associated with a regulatory T-cell response
    • Harris, P. R., Wright, S. W., Serrano, C., Riera, F., Duarte, I., Torres, J., Pena, A. et al., Helicobacter pylori gastritis in children is associated with a regulatory T-cell response. Gastroenterology 2008. 134: 491-499.
    • (2008) Gastroenterology , vol.134 , pp. 491-499
    • Harris, P.R.1    Wright, S.W.2    Serrano, C.3    Riera, F.4    Duarte, I.5    Torres, J.6    Pena, A.7
  • 19
    • 46749100265 scopus 로고    scopus 로고
    • High frequency of CD4+FoxP3+ cells in HTLV-1 infection: inverse correlation with HTLV-1-specific CTL response
    • Toulza, F., Heaps, A., Tanaka, Y., Taylor, G. P. and Bangham, C. R., High frequency of CD4+FoxP3+ cells in HTLV-1 infection: inverse correlation with HTLV-1-specific CTL response. Blood 2008. 111: 5047-5053.
    • (2008) Blood , vol.111 , pp. 5047-5053
    • Toulza, F.1    Heaps, A.2    Tanaka, Y.3    Taylor, G.P.4    Bangham, C.R.5
  • 20
    • 53349153303 scopus 로고    scopus 로고
    • Human squamous cell carcinomas evade the immune response by down-regulation of vascular E-selectin and recruitment of regulatory T cells
    • Clark, R. A., Huang, S. J., Murphy, G. F., Mollet, I. G., Hijnen, D., Muthukuru, M., Schanbacher, C. F. et al., Human squamous cell carcinomas evade the immune response by down-regulation of vascular E-selectin and recruitment of regulatory T cells. J. Exp. Med. 2008. 205: 2221-2234.
    • (2008) J. Exp. Med. , vol.205 , pp. 2221-2234
    • Clark, R.A.1    Huang, S.J.2    Murphy, G.F.3    Mollet, I.G.4    Hijnen, D.5    Muthukuru, M.6    Schanbacher, C.F.7
  • 21
    • 49749084339 scopus 로고    scopus 로고
    • Intratumoural FOXP3-positive regulatory T cells are associated with adverse prognosis in radically resected gastric cancer
    • Perrone, G., Ruffini, P. A., Catalano, V., Spino, C., Santini, D., Muretto, P., Spoto, C. et al., Intratumoural FOXP3-positive regulatory T cells are associated with adverse prognosis in radically resected gastric cancer. Eur. J. Cancer 2008. 44: 1875-1882.
    • (2008) Eur. J. Cancer , vol.44 , pp. 1875-1882
    • Perrone, G.1    Ruffini, P.A.2    Catalano, V.3    Spino, C.4    Santini, D.5    Muretto, P.6    Spoto, C.7
  • 22
    • 47249084696 scopus 로고    scopus 로고
    • FOXP3 expression in human kidney transplant biopsies is associated with rejection and time post transplant but not with favorable outcomes
    • Bunnag, S., Allanach, K., Jhangri, G. S., Sis, B., Einecke, G., Mengel, M., Mueller, T. F. and Halloran, P. F., FOXP3 expression in human kidney transplant biopsies is associated with rejection and time post transplant but not with favorable outcomes. Am. J. Transplant. 2008. 8: 1423-1433.
    • (2008) Am. J. Transplant. , vol.8 , pp. 1423-1433
    • Bunnag, S.1    Allanach, K.2    Jhangri, G.S.3    Sis, B.4    Einecke, G.5    Mengel, M.6    Mueller, T.F.7    Halloran, P.F.8
  • 25
    • 29144516273 scopus 로고    scopus 로고
    • Global natural regulatory T cell depletion in active systemic lupus erythematosus
    • Miyara, M., Amoura, Z., Parizot, C., Badoual, C., Dorgham, K., Trad, S., Nochy, D. et al., Global natural regulatory T cell depletion in active systemic lupus erythematosus. J. Immunol. 2005. 175: 8392-8400.
    • (2005) J. Immunol. , vol.175 , pp. 8392-8400
    • Miyara, M.1    Amoura, Z.2    Parizot, C.3    Badoual, C.4    Dorgham, K.5    Trad, S.6    Nochy, D.7
  • 26
    • 33645051462 scopus 로고    scopus 로고
    • Inverse correlation between CD4+ regulatory T-cell population and autoantibody levels in paediatric patients with systemic lupus erythematosus
    • Lee, J. H., Wang, L. C., Lin, Y. T., Yang, Y. H., Lin, D. T. and Chiang, B. L., Inverse correlation between CD4+ regulatory T-cell population and autoantibody levels in paediatric patients with systemic lupus erythematosus. Immunology 2006. 117: 280-286.
    • (2006) Immunology , vol.117 , pp. 280-286
    • Lee, J.H.1    Wang, L.C.2    Lin, Y.T.3    Yang, Y.H.4    Lin, D.T.5    Chiang, B.L.6
  • 27
    • 56749160115 scopus 로고    scopus 로고
    • CD4+Foxp3+ regulatory T cells in the control of autoimmunity: in vivo veritas
    • Piccirillo, C. A., d'Hennezel, E., Sgouroudis, E. and Yurchenko, E., CD4+Foxp3+ regulatory T cells in the control of autoimmunity: in vivo veritas. Curr. Opin. Immunol. 2008. 20: 655-662.
    • (2008) Curr. Opin. Immunol. , vol.20 , pp. 655-662
    • Piccirillo, C.A.1    d'Hennezel, E.2    Sgouroudis, E.3    Yurchenko, E.4
  • 28
    • 0036245945 scopus 로고    scopus 로고
    • Early postoperative monocyte deactivation predicts systemic inflammation and prolonged stay in pediatric cardiac intensive care
    • Allen, M. L., Peters, M. J., Goldman, A., Elliott, M., James, I., Callard, R. and Klein, N. J., Early postoperative monocyte deactivation predicts systemic inflammation and prolonged stay in pediatric cardiac intensive care. Crit. Care Med. 2002. 30: 1140-1145.
    • (2002) Crit. Care Med. , vol.30 , pp. 1140-1145
    • Allen, M.L.1    Peters, M.J.2    Goldman, A.3    Elliott, M.4    James, I.5    Callard, R.6    Klein, N.J.7
  • 29
    • 0141606836 scopus 로고    scopus 로고
    • Plasma levels of interleukin-8 and expression of interleukin-8 receptors on circulating neutrophils and monocytes after cardiopulmonary bypass in children
    • Gessler, P., Pfenninger, J., Pfammatter, J. P., Carrel, T., Baenziger, O. and Dahinden, C., Plasma levels of interleukin-8 and expression of interleukin-8 receptors on circulating neutrophils and monocytes after cardiopulmonary bypass in children. J. Thorac. Cardiovasc. Surg. 2003. 126: 718-725.
    • (2003) J. Thorac. Cardiovasc. Surg. , vol.126 , pp. 718-725
    • Gessler, P.1    Pfenninger, J.2    Pfammatter, J.P.3    Carrel, T.4    Baenziger, O.5    Dahinden, C.6
  • 33
    • 1642534503 scopus 로고    scopus 로고
    • Bacterial translocation secondary to small intestinal mucosal ischemia during cardiopulmonary bypass. Measurement by diamine oxidase and peptidoglycan
    • Tsunooka, N., Maeyama, K., Hamada, Y., Imagawa, H., Takano, S., Watanabe, Y. and Kawachi, K., Bacterial translocation secondary to small intestinal mucosal ischemia during cardiopulmonary bypass. Measurement by diamine oxidase and peptidoglycan. Eur. J. Cardiothorac. Surg. 2004. 25: 275-280.
    • (2004) Eur. J. Cardiothorac. Surg. , vol.25 , pp. 275-280
    • Tsunooka, N.1    Maeyama, K.2    Hamada, Y.3    Imagawa, H.4    Takano, S.5    Watanabe, Y.6    Kawachi, K.7
  • 34
    • 64049091512 scopus 로고    scopus 로고
    • Hsp70 and cardiac surgery: molecular chaperone and inflammatory regulator with compartmentalized effects
    • de Jong, P. R., Schadenberg, A. W., Jansen, N. J. and Prakken, B. J., Hsp70 and cardiac surgery: molecular chaperone and inflammatory regulator with compartmentalized effects. Cell Stress Chaperones 2009. 14: 117-131.
    • (2009) Cell Stress Chaperones , vol.14 , pp. 117-131
    • de Jong, P.R.1    Schadenberg, A.W.2    Jansen, N.J.3    Prakken, B.J.4
  • 35
    • 0037065909 scopus 로고    scopus 로고
    • Inflammatory response after open heart surgery: release of heat-shock protein 70 and signaling through toll-like receptor-4
    • Dybdahl, B., Wahba, A., Lien, E., Flo, T. H., Waage, A., Qureshi, N., Sellevold, O. F. et al., Inflammatory response after open heart surgery: release of heat-shock protein 70 and signaling through toll-like receptor-4. Circulation 2002. 105: 685-690.
    • (2002) Circulation , vol.105 , pp. 685-690
    • Dybdahl, B.1    Wahba, A.2    Lien, E.3    Flo, T.H.4    Waage, A.5    Qureshi, N.6    Sellevold, O.F.7
  • 36
    • 0032995051 scopus 로고    scopus 로고
    • Myocardial injury leads to a release of heat shock protein (hsp) 60 and a suppression of the anti-hsp65 immune response
    • Schett, G., Metzler, B., Kleindienst, R., Amberger, A., Recheis, H., Xu, Q. and Wick, G., Myocardial injury leads to a release of heat shock protein (hsp) 60 and a suppression of the anti-hsp65 immune response. Cardiovasc. Res. 1999. 42: 685-695.
    • (1999) Cardiovasc. Res. , vol.42 , pp. 685-695
    • Schett, G.1    Metzler, B.2    Kleindienst, R.3    Amberger, A.4    Recheis, H.5    Xu, Q.6    Wick, G.7
  • 38
    • 61949334905 scopus 로고    scopus 로고
    • Regulatory T cells sequentially migrate from inflamed tissues to draining lymph nodes to suppress the alloimmune response
    • Zhang, N., Schroppel, B., Lal, G., Jakubzick, C., Mao, X., Chen, D., Yin, N. et al., Regulatory T cells sequentially migrate from inflamed tissues to draining lymph nodes to suppress the alloimmune response. Immunity 2009. 30: 458-469.
    • (2009) Immunity , vol.30 , pp. 458-469
    • Zhang, N.1    Schroppel, B.2    Lal, G.3    Jakubzick, C.4    Mao, X.5    Chen, D.6    Yin, N.7
  • 39
    • 33846375082 scopus 로고    scopus 로고
    • Transient expression of FOXP3 in human activated nonregulatory CD4+ T cells
    • Wang, J., Ioan-Facsinay, A., van, d. V., Huizinga, T. W. and Toes, R. E., Transient expression of FOXP3 in human activated nonregulatory CD4+ T cells. Eur. J. Immunol. 2007. 37: 129-138.
    • (2007) Eur. J. Immunol. , vol.37 , pp. 129-138
    • Wang, J.1    Ioan-Facsinay, A.2    van, d.V.3    Huizinga, T.W.4    Toes, R.E.5
  • 42
    • 33847237223 scopus 로고    scopus 로고
    • The dynamic co-evolution of memory and regulatory CD4+ T cells in the periphery
    • Akbar, A. N., Vukmanovic-Stejic, M., Taams, L. S. and Macallan, D. C., The dynamic co-evolution of memory and regulatory CD4+ T cells in the periphery. Nat. Rev. Immunol. 2007. 7: 231-237.
    • (2007) Nat. Rev. Immunol. , vol.7 , pp. 231-237
    • Akbar, A.N.1    Vukmanovic-Stejic, M.2    Taams, L.S.3    Macallan, D.C.4
  • 43
    • 33645506131 scopus 로고    scopus 로고
    • Drug trials. Violent reaction to monoclonal antibody therapy remains a mystery
    • Marshall, E., Drug trials. Violent reaction to monoclonal antibody therapy remains a mystery. Science 2006. 311: 1688-1689.
    • (2006) Science , vol.311 , pp. 1688-1689
    • Marshall, E.1
  • 44
    • 26444515022 scopus 로고    scopus 로고
    • TCR stimulation with modified anti-CD3 mAb expands CD8+ T cell population and induces CD8+CD25+ Tregs
    • Bisikirska, B., Colgan, J., Luban, J., Bluestone, J. A. and Herold, K. C., TCR stimulation with modified anti-CD3 mAb expands CD8+ T cell population and induces CD8+CD25+ Tregs. J. Clin. Invest. 2005. 115: 2904-2913.
    • (2005) J. Clin. Invest. , vol.115 , pp. 2904-2913
    • Bisikirska, B.1    Colgan, J.2    Luban, J.3    Bluestone, J.A.4    Herold, K.C.5
  • 46
    • 34247271308 scopus 로고    scopus 로고
    • Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3
    • Williams, L. M. and Rudensky, A. Y., Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3. Nat. Immunol. 2007. 8: 277-284.
    • (2007) Nat. Immunol. , vol.8 , pp. 277-284
    • Williams, L.M.1    Rudensky, A.Y.2
  • 47
    • 20444409138 scopus 로고    scopus 로고
    • Improved multiplex immunoassay performance in human plasma and synovial fluid following removal of interfering heterophilic antibodies
    • de Jager, W., Prakken, B. J., Bijlsma, J. W., Kuis, W. and Rijkers, G. T., Improved multiplex immunoassay performance in human plasma and synovial fluid following removal of interfering heterophilic antibodies. J. Immunol. Methods 2005. 300: 124-135.
    • (2005) J. Immunol. Methods , vol.300 , pp. 124-135
    • de Jager, W.1    Prakken, B.J.2    Bijlsma, J.W.3    Kuis, W.4    Rijkers, G.T.5
  • 48
    • 0037248879 scopus 로고    scopus 로고
    • Simultaneous detection of 15 human cytokines in a single sample of stimulated peripheral blood mononuclear cells
    • de Jager, W., te Veldhuis, H., Prakken, B. J., Kuis, W. and Rijkers, G. T., Simultaneous detection of 15 human cytokines in a single sample of stimulated peripheral blood mononuclear cells. Clin. Diagn. Lab. Immunol. 2003. 10: 133-139.
    • (2003) Clin. Diagn. Lab. Immunol. , vol.10 , pp. 133-139
    • de Jager, W.1    te Veldhuis, H.2    Prakken, B.J.3    Kuis, W.4    Rijkers, G.T.5
  • 49
    • 70349658485 scopus 로고    scopus 로고
    • Human regulatory T cell suppressive function is independent of apoptosis induction in activated effector T cells
    • Vercoulen, Y., Wehrens, E. J., van Teijlingen, N. H., de Jager, W., Beekman, J. M. and Prakken, B. J., Human regulatory T cell suppressive function is independent of apoptosis induction in activated effector T cells. PLoS One 2009. 4: e7183.
    • (2009) PLoS One , vol.4
    • Vercoulen, Y.1    Wehrens, E.J.2    van Teijlingen, N.H.3    de Jager, W.4    Beekman, J.M.5    Prakken, B.J.6


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