-
1
-
-
77957768653
-
A tale of two hormones
-
Friedman JM. A tale of two hormones. Nat Med 2010; 16 (10): 1100-6
-
(2010)
Nat Med
, vol.16
, Issue.10
, pp. 1100-1106
-
-
Friedman, J.M.1
-
2
-
-
0000736325
-
Obese, a new mutation in the house mouse
-
Ingalls AM, Dickie MM, Snell GD. Obese, a new mutation in the house mouse. J Hered 1950; 41 (12): 317-8
-
(1950)
J Hered
, vol.41
, Issue.12
, pp. 317-318
-
-
Ingalls, A.M.1
Dickie, M.M.2
Snell, G.D.3
-
3
-
-
0028139089
-
Positional cloning of the mouse obese gene and its human homologue
-
Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. Positional cloning of the mouse obese gene and its human homologue. Nature 1994; 372 (6505): 425-32
-
(1994)
Nature
, vol.372
, Issue.6505
, pp. 425-432
-
-
Zhang, Y.1
Proenca, R.2
Maffei, M.3
Barone, M.4
Leopold, L.5
Friedman, J.M.6
-
4
-
-
0030878110
-
Congenital leptin deficiency is associated with severe early-onset obesity in humans
-
Montague CT, Farooqi IS, Whitehead JP, Soos MA, Rau H, Wareham NJ, et al. Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature 1997; 387 (6636): 903-8
-
(1997)
Nature
, vol.387
, Issue.6636
, pp. 903-908
-
-
Montague, C.T.1
Farooqi, I.S.2
Whitehead, J.P.3
Soos, M.A.4
Rau, H.5
Wareham, N.J.6
-
5
-
-
0033575993
-
Effects of recombinant leptin therapy in a child with congenital leptin deficiency
-
Farooqi IS, Jebb SA, Langmack G, Lawrence E, Cheetham CH, Prentice AM, et al. Effects of recombinant leptin therapy in a child with congenital leptin deficiency. N Engl J Med 1999; 341 (12): 879-84
-
(1999)
N Engl J Med
, vol.341
, Issue.12
, pp. 879-884
-
-
Farooqi, I.S.1
Jebb, S.A.2
Langmack, G.3
Lawrence, E.4
Cheetham, C.H.5
Prentice, A.M.6
-
6
-
-
0037148928
-
Leptin-replacement therapy for lipodystrophy
-
Oral EA, Simha V, Ruiz E, Andewelt A, Premkumar A, Snell P, et al. Leptin-replacement therapy for lipodystrophy. N Engl J Med 2002; 346 (8): 570-8
-
(2002)
N Engl J Med
, vol.346
, Issue.8
, pp. 570-578
-
-
Oral, E.A.1
Simha, V.2
Ruiz, E.3
Andewelt, A.4
Premkumar, A.5
Snell, P.6
-
7
-
-
0029066265
-
Effects of the obese gene product on body weight regulation in ob/ob mice
-
Pelleymounter MA, Cullen MJ, Baker MB, Hecht R, Winters D, Boone T, et al. Effects of the obese gene product on body weight regulation in ob/ob mice. Science 1995; 269 (5223): 540-3
-
(1995)
Science
, vol.269
, Issue.5223
, pp. 540-543
-
-
Pelleymounter, M.A.1
Cullen, M.J.2
Baker, M.B.3
Hecht, R.4
Winters, D.5
Boone, T.6
-
8
-
-
0032747280
-
Recombinant leptin for weight loss in obese and lean adults: A randomized, controlled, dose-escalation trial
-
Heymsfield SB, Greenberg AS, Fujioka K, Dixon RM, Kushner R, Hunt T, et al. Recombinant leptin for weight loss in obese and lean adults: a randomized, controlled, dose-escalation trial. JAMA 1999; 282 (16): 1568-75
-
(1999)
JAMA
, vol.282
, Issue.16
, pp. 1568-1575
-
-
Heymsfield, S.B.1
Greenberg, A.S.2
Fujioka, K.3
Dixon, R.M.4
Kushner, R.5
Hunt, T.6
-
9
-
-
69749086148
-
Enhanced weight loss with pramlintide/metreleptin: An integrated neurohormonal approach to obesity pharmacotherapy
-
Ravussin E, Smith SR, Mitchell JA, Shringarpure R, Shan K, Maier H, et al. Enhanced weight loss with pramlintide/metreleptin: an integrated neurohormonal approach to obesity pharmacotherapy. Obesity (Silver Spring) 2009; 17 (9): 1736-43
-
(2009)
Obesity (Silver Spring)
, vol.17
, Issue.9
, pp. 1736-1743
-
-
Ravussin, E.1
Smith, S.R.2
Mitchell, J.A.3
Shringarpure, R.4
Shan, K.5
Maier, H.6
-
10
-
-
0034522997
-
Weekly subcutaneous pegylated recombinant native human leptin (PEG-OB) administration in obese men
-
Hukshorn CJ, Saris WH, Westerterp-Plantenga MS, Farid AR, Smith FJ, Campfield LA. Weekly subcutaneous pegylated recombinant native human leptin (PEG-OB) administration in obese men. J Clin Endocrinol Metab 2000; 85 (11): 4003-9
-
(2000)
J Clin Endocrinol Metab
, vol.85
, Issue.11
, pp. 4003-4009
-
-
Hukshorn, C.J.1
Saris, W.H.2
Westerterp-Plantenga, M.S.3
Farid, A.R.4
Smith, F.J.5
Campfield, L.A.6
-
11
-
-
78049311283
-
Obesity and leptin resistance: Distinguishing cause from effect
-
Myers MG Jr, Leibel RL, Seeley RJ, Schwartz MW. Obesity and leptin resistance: distinguishing cause from effect. Trends Endocrinol Metab 2010; 21(11): 643-51
-
(2010)
Trends Endocrinol Metab
, vol.21
, Issue.11
, pp. 643-651
-
-
Myers, M.G.1
Leibel, R.L.2
Seeley, R.J.3
Schwartz, M.W.4
-
12
-
-
70450183813
-
Leptin-melanocortin system, body weight regulation and obesity
-
Santos MJ. [Leptin-melanocortin system, body weight regulation and obesity]. Rev Med Chile 2009; 137 (9): 1225-34
-
(2009)
Rev Med Chile
, vol.137
, Issue.9
, pp. 1225-1234
-
-
Santos, M.J.1
-
13
-
-
0032558725
-
Leptin and the regulation of body weight in mammals
-
Friedman JM, Halaas JL. Leptin and the regulation of body weight in mammals. Nature 1998; 395 (6704): 763-70
-
(1998)
Nature
, vol.395
, Issue.6704
, pp. 763-770
-
-
Friedman, J.M.1
Halaas, J.L.2
-
14
-
-
0029086473
-
Threading analysis suggests that the obese gene product may be a helical cytokine
-
Madej T, Boguski MS, Bryant SH. Threading analysis suggests that the obese gene product may be a helical cytokine. FEBS Lett 1995; 373 (1): 13-8
-
(1995)
FEBS Lett
, vol.373
, Issue.1
, pp. 13-18
-
-
Madej, T.1
Boguski, M.S.2
Bryant, S.H.3
-
15
-
-
2442654859
-
Identification and expression cloning of a leptin receptor, OB-R
-
Tartaglia LA, Dembski M, Weng X, Deng N, Culpepper J, Devos R, et al. Identification and expression cloning of a leptin receptor, OB-R. Cell 1995; 83 (7): 1263-71
-
(1995)
Cell
, vol.83
, Issue.7
, pp. 1263-1271
-
-
Tartaglia, L.A.1
Dembski, M.2
Weng, X.3
Deng, N.4
Culpepper, J.5
Devos, R.6
-
16
-
-
0030866843
-
Nonadipose tissue production of leptin: Leptin as a novel placenta-derived hormone in humans
-
Masuzaki H, Ogawa Y, Sagawa N, Hosoda K, Matsumoto T, Mise H, et al. Nonadipose tissue production of leptin: leptin as a novel placenta-derived hormone in humans. Nat Med 1997; 3 (9): 1029-33
-
(1997)
Nat Med
, vol.3
, Issue.9
, pp. 1029-1033
-
-
Masuzaki, H.1
Ogawa, Y.2
Sagawa, N.3
Hosoda, K.4
Matsumoto, T.5
Mise, H.6
-
17
-
-
0032552112
-
The stomach is a source of leptin
-
Bado A, Levasseur S, Attoub S, Kermorgant S, Laigneau JP, Bortoluzzi MN, et al. The stomach is a source of leptin. Nature 1998; 394 (6695): 790-3
-
(1998)
Nature
, vol.394
, Issue.6695
, pp. 790-793
-
-
Bado, A.1
Levasseur, S.2
Attoub, S.3
Kermorgant, S.4
Laigneau, J.P.5
Bortoluzzi, M.N.6
-
18
-
-
0030039272
-
Abnormal splicing of the leptin receptor in diabetic mice
-
Lee GH, Proenca R, Montez JM, Carroll KM, Darvishzadeh JG, Lee JI, et al. Abnormal splicing of the leptin receptor in diabetic mice. Nature 1996; 379 (6566): 632-5
-
(1996)
Nature
, vol.379
, Issue.6566
, pp. 632-635
-
-
Lee, G.H.1
Proenca, R.2
Montez, J.M.3
Carroll, K.M.4
Darvishzadeh, J.G.5
Lee, J.I.6
-
19
-
-
0030942844
-
The leptin receptor
-
Tartaglia LA. The leptin receptor. J Biol Chem 1997; 272 (10): 6093-6
-
(1997)
J Biol Chem
, vol.272
, Issue.10
, pp. 6093-6096
-
-
Tartaglia, L.A.1
-
20
-
-
30044434035
-
Intracellular signalling pathways activated by leptin
-
Fruhbeck G. Intracellular signalling pathways activated by leptin. Biochem J 2006; 393 (Pt 1): 7-20
-
(2006)
Biochem J
, vol.393
, pp. 7-20
-
-
Fruhbeck, G.1
-
21
-
-
13344259300
-
Evidence that the diabetes gene encodes the leptin receptor: Identification of a mutation in the leptin receptor gene in db/db mice
-
Chen H, Charlat O, Tartaglia LA, Woolf EA, Weng X, Ellis SJ, et al. Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice. Cell 1996; 84 (3): 491-5
-
(1996)
Cell
, vol.84
, Issue.3
, pp. 491-495
-
-
Chen, H.1
Charlat, O.2
Tartaglia, L.A.3
Woolf, E.A.4
Weng, X.5
Ellis, S.J.6
-
22
-
-
0032527071
-
Distributions of leptin receptor mRNA isoforms in the rat brain
-
Elmquist JK, Bjorbaek C, Ahima RS, Flier JS, Saper CB. Distributions of leptin receptor mRNA isoforms in the rat brain. J Comp Neurol 1998; 395 (4): 535-47
-
(1998)
J Comp Neurol
, vol.395
, Issue.4
, pp. 535-547
-
-
Elmquist, J.K.1
Bjorbaek, C.2
Ahima, R.S.3
Flier, J.S.4
Saper, C.B.5
-
23
-
-
0034776770
-
Selective deletion of leptin receptor in neurons leads to obesity
-
Cohen P, Zhao C, Cai X, Montez JM, Rohani SC, Feinstein P, et al. Selective deletion of leptin receptor in neurons leads to obesity. J Clin Invest 2001; 108 (8): 1113-21
-
(2001)
J Clin Invest
, vol.108
, Issue.8
, pp. 1113-1121
-
-
Cohen, P.1
Zhao, C.2
Cai, X.3
Montez, J.M.4
Rohani, S.C.5
Feinstein, P.6
-
24
-
-
0036168190
-
Characterizaton of short isoforms of the leptin receptor in rat cerebral microvessels and of brain uptake of leptin in mouse models of obesity
-
Hileman SM, Pierroz DD, Masuzaki H, Bjorbaek C, El-Haschimi K, Banks WA, et al. Characterizaton of short isoforms of the leptin receptor in rat cerebral microvessels and of brain uptake of leptin in mouse models of obesity. Endocrinology 2002; 143 (3): 775-83
-
(2002)
Endocrinology
, vol.143
, Issue.3
, pp. 775-783
-
-
Hileman, S.M.1
Pierroz, D.D.2
Masuzaki, H.3
Bjorbaek, C.4
El-Haschimi, K.5
Banks, W.A.6
-
25
-
-
85047698415
-
Obesity is associated with decreasing levels of the circulating soluble leptin receptor in humans
-
Ogier V, Ziegler O, Mejean L, Nicolas JP, Stricker-Krongrad A. Obesity is associated with decreasing levels of the circulating soluble leptin receptor in humans. Int J Obes Relat Metab Disord 2002; 26 (4): 496-503
-
(2002)
Int J Obes Relat Metab Disord
, vol.26
, Issue.4
, pp. 496-503
-
-
Ogier, V.1
Ziegler, O.2
Mejean, L.3
Nicolas, J.P.4
Stricker-Krongrad, A.5
-
26
-
-
77950359650
-
Leptin and soluble leptin receptor levels in plasma and risk of type 2 diabetes in U.S. Women: A prospective study
-
Sun Q, van Dam RM, Meigs JB, Franco OH, Mantzoros CS, Hu FB. Leptin and soluble leptin receptor levels in plasma and risk of type 2 diabetes in U.S. women: a prospective study. Diabetes 2010; 59 (3): 611-8
-
(2010)
Diabetes
, vol.59
, Issue.3
, pp. 611-618
-
-
Sun, Q.1
Van Dam, R.M.2
Meigs, J.B.3
Franco, O.H.4
Mantzoros, C.S.5
Hu, F.B.6
-
27
-
-
0035292465
-
Leptin: Physiological and clinical role
-
Botella Carretero JI, Lledin Barbancho MD, Valero González MA, Varela Dacosta C. [Leptin: physiological and clinical role]. An Med Interna 2001; 18 (3): 152-60
-
(2001)
An Med Interna
, vol.18
, Issue.3
, pp. 152-160
-
-
Botella Carretero, J.I.1
Lledin Barbancho, M.D.2
Valero GonzáLez, M.A.3
Varela Dacosta, C.4
-
28
-
-
0034703229
-
Role of brain insulin receptor in control of body weight and reproduction
-
Bruning JC, Gautam D, Burks DJ, Gillette J, Schubert M, Orban PC, et al. Role of brain insulin receptor in control of body weight and reproduction. Science 2000; 289 (5487): 2122-5
-
(2000)
Science
, vol.289
, Issue.5487
, pp. 2122-2125
-
-
Bruning, J.C.1
Gautam, D.2
Burks, D.J.3
Gillette, J.4
Schubert, M.5
Orban, P.C.6
-
29
-
-
0033304576
-
Human leptin deficiency caused by a missense mutation: Multiple endocrine defects, decreased sympathetic tone, and immune system dysfunction indicate new targets for leptin action, greater central than peripheral resistance to the effects of leptin, and spontaneous correction of leptin-mediated defects
-
Ozata M, Ozdemir IC, Licinio J. Human leptin deficiency caused by a missense mutation: multiple endocrine defects, decreased sympathetic tone, and immune system dysfunction indicate new targets for leptin action, greater central than peripheral resistance to the effects of leptin, and spontaneous correction of leptin-mediated defects. J Clin Endocrinol Metab 1999; 84 (10): 3686-95
-
(1999)
J Clin Endocrinol Metab
, vol.84
, Issue.10
, pp. 3686-3695
-
-
Ozata, M.1
Ozdemir, I.C.2
Licinio, J.3
-
30
-
-
17744384711
-
Increased leptin levels in serum and peritoneal fluid of patients with pelvic endometriosis
-
Matarese G, Alviggi C, Sanna V, Howard JK, Lord GM, Carravetta C, et al. Increased leptin levels in serum and peritoneal fluid of patients with pelvic endometriosis. J Clin Endocrinol Metab 2000; 85 (7): 2483-7
-
(2000)
J Clin Endocrinol Metab
, vol.85
, Issue.7
, pp. 2483-2487
-
-
Matarese, G.1
Alviggi, C.2
Sanna, V.3
Howard, J.K.4
Lord, G.M.5
Carravetta, C.6
-
32
-
-
0030959788
-
Interleukin 1 alpha increases serum leptin concentrations in humans
-
Janik JE, Curti BD, Considine RV, Rager HC, Powers GC, Alvord WG, et al. Interleukin 1 alpha increases serum leptin concentrations in humans. J Clin Endocrinol Metab 1997; 82 (9): 3084-6
-
(1997)
J Clin Endocrinol Metab
, vol.82
, Issue.9
, pp. 3084-3086
-
-
Janik, J.E.1
Curti, B.D.2
Considine, R.V.3
Rager, H.C.4
Powers, G.C.5
Alvord, W.G.6
-
34
-
-
0035887941
-
High-dose leptin activates human leukocytes via receptor expression on monocytes
-
Zarkesh-Esfahani H, Pockley G, Metcalfe RA, Bidlingmaier M, Wu Z, Ajami A, et al. High-dose leptin activates human leukocytes via receptor expression on monocytes. J Immunol 2001; 167 (8): 4593-9
-
(2001)
J Immunol
, vol.167
, Issue.8
, pp. 4593-4599
-
-
Zarkesh-Esfahani, H.1
Pockley, G.2
Metcalfe, R.A.3
Bidlingmaier, M.4
Wu, Z.5
Ajami, A.6
-
35
-
-
0035195887
-
Leptin regulation of the immune response and the immunodeficiency of malnutrition
-
Faggioni R, Feingold KR, Grunfeld C. Leptin regulation of the immune response and the immunodeficiency of malnutrition. FASEB J 2001; 15 (14): 2565-71
-
(2001)
FASEB J
, vol.15
, Issue.14
, pp. 2565-2571
-
-
Faggioni, R.1
Feingold, K.R.2
Grunfeld, C.3
-
36
-
-
0043198155
-
Leptin regulates functional capacities of polymorphonuclear neutrophils
-
Caldefie-Chezet F, Poulin A, Vasson MP. Leptin regulates functional capacities of polymorphonuclear neutrophils. Free Radic Res 2003; 37 (8): 809-14
-
(2003)
Free Radic Res
, vol.37
, Issue.8
, pp. 809-814
-
-
Caldefie-Chezet, F.1
Poulin, A.2
Vasson, M.P.3
-
37
-
-
0032572722
-
Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression
-
Lord GM, Matarese G, Howard JK, Baker RJ, Bloom SR, Lechler RI. Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression. Nature 1998; 394 (6696): 897-901
-
(1998)
Nature
, vol.394
, Issue.6696
, pp. 897-901
-
-
Lord, G.M.1
Matarese, G.2
Howard, J.K.3
Baker, R.J.4
Bloom, S.R.5
Lechler, R.I.6
-
38
-
-
0036431034
-
Impaired natural killer (NK) cell activity in leptin receptor deficient mice: Leptin as a critical regulator in NK cell development and activation
-
Tian Z, Sun R, Wei H, Gao B. Impaired natural killer (NK) cell activity in leptin receptor deficient mice: leptin as a critical regulator in NK cell development and activation. Biochem Biophys Res Commun 2002; 298 (3): 297-302
-
(2002)
Biochem Biophys Res Commun
, vol.298
, Issue.3
, pp. 297-302
-
-
Tian, Z.1
Sun, R.2
Wei, H.3
Gao, B.4
-
39
-
-
0032741972
-
Leptin protects mice from starvation-induced lymphoid atrophy and increases thymic cellularity in ob/ob mice
-
Howard JK, Lord GM, Matarese G, Vendetti S, Ghatei MA, Ritter MA, et al. Leptin protects mice from starvation-induced lymphoid atrophy and increases thymic cellularity in ob/ob mice. J Clin Invest 1999; 104 (8): 1051-9
-
(1999)
J Clin Invest
, vol.104
, Issue.8
, pp. 1051-1059
-
-
Howard, J.K.1
Lord, G.M.2
Matarese, G.3
Vendetti, S.4
Ghatei, M.A.5
Ritter, M.A.6
-
40
-
-
2442618838
-
The weight of leptin in immunity
-
La Cava A, Matarese G. The weight of leptin in immunity. Nat Rev Immunol 2004; 4 (5): 371-9
-
(2004)
Nat Rev Immunol
, vol.4
, Issue.5
, pp. 371-379
-
-
La Cava, A.1
Matarese, G.2
-
41
-
-
0031721269
-
Lowered leptin slims immune response
-
Flier JS. Lowered leptin slims immune response. Nat Med 1998; 4 (10): 1124-5
-
(1998)
Nat Med
, vol.4
, Issue.10
, pp. 1124-1125
-
-
Flier, J.S.1
-
42
-
-
0036800760
-
Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency
-
Farooqi IS, Matarese G, Lord GM, Keogh JM, Lawrence E, Agwu C, et al. Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency. J Clin Invest 2002; 110 (8): 1093-103
-
(2002)
J Clin Invest
, vol.110
, Issue.8
, pp. 1093-1103
-
-
Farooqi, I.S.1
Matarese, G.2
Lord, G.M.3
Keogh, J.M.4
Lawrence, E.5
Agwu, C.6
-
43
-
-
0036036625
-
Serum leptin levels in women with systemic lupus erythematosus
-
García-González A, González-López L, Valera-González IC, Cardona-Muñoz EG, Salazar-Paramo M, González-Ortiz M, et al. Serum leptin levels in women with systemic lupus erythematosus. Rheumatol Int 2002; 22 (4): 138-41
-
(2002)
Rheumatol Int
, vol.22
, Issue.4
, pp. 138-141
-
-
García-González, A.1
González-López, L.2
Valera-González, I.C.3
Cardona-Muñoz, E.G.4
Salazar-Paramo, M.5
González-Ortiz, M.6
-
44
-
-
0038797814
-
Leptin as a marker of multiple sclerosis activity in patients treated with interferon-beta
-
Batocchi AP, Rotondi M, Caggiula M, Frisullo G, Odoardi F, Nociti V, et al. Leptin as a marker of multiple sclerosis activity in patients treated with interferon-beta. J Neuroimmunol 2003; 139 (1-2): 150-4
-
(2003)
J Neuroimmunol
, vol.139
, Issue.1-2
, pp. 150-154
-
-
Batocchi, A.P.1
Rotondi, M.2
Caggiula, M.3
Frisullo, G.4
Odoardi, F.5
Nociti, V.6
-
45
-
-
1042276557
-
High leptin levels in women developing postpartum thyroiditis
-
Mazziotti G, Parkes AB, Lage M, Premawardhana LD, Casanueva FF, Lazarus JH. High leptin levels in women developing postpartum thyroiditis. Clin Endocrinol (Oxf) 2004; 60 (2): 208-13
-
(2004)
Clin Endocrinol (Oxf)
, vol.60
, Issue.2
, pp. 208-213
-
-
Mazziotti, G.1
Parkes, A.B.2
Lage, M.3
Premawardhana, L.D.4
Casanueva, F.F.5
Lazarus, J.H.6
-
46
-
-
0036379507
-
Serum leptin concentration is increased in patients with Behcet’s syndrome and is correlated with disease activity
-
Evereklioglu C, Inaloz HS, Kirtak N, Doganay S, Bulbul M, Ozerol E, et al. Serum leptin concentration is increased in patients with Behcet’s syndrome and is correlated with disease activity. Br J Dermatol 2002; 147 (2): 331-6
-
(2002)
Br J Dermatol
, vol.147
, Issue.2
, pp. 331-336
-
-
Evereklioglu, C.1
Inaloz, H.S.2
Kirtak, N.3
Doganay, S.4
Bulbul, M.5
Ozerol, E.6
-
47
-
-
0018861450
-
Cell-mediated immunity in genetically obese C57BL/6J ob/ob mice
-
Chandra RK. Cell-mediated immunity in genetically obese C57BL/6J ob/ob mice. Am J Clin Nutr 1980; 33 (1): 13-6
-
(1980)
Am J Clin Nutr
, vol.33
, Issue.1
, pp. 13-16
-
-
Chandra, R.K.1
-
48
-
-
0018148843
-
Impairment of cell-mediated immunity in mutation diabetic mice (db/db)
-
Mandel MA, Mahmoud AA. Impairment of cell-mediated immunity in mutation diabetic mice (db/db). J Immunol 1978; 120 (4): 1375-7
-
(1978)
J Immunol
, vol.120
, Issue.4
, pp. 1375-1377
-
-
Mandel, M.A.1
Mahmoud, A.A.2
-
49
-
-
9144223683
-
Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
-
Xu H, Barnes GT, Yang Q, Tan G, Yang D, Chou CJ, et al. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest 2003; 112 (12): 1821-30
-
(2003)
J Clin Invest
, vol.112
, Issue.12
, pp. 1821-1830
-
-
Xu, H.1
Barnes, G.T.2
Yang, Q.3
Tan, G.4
Yang, D.5
Chou, C.J.6
-
50
-
-
84857827167
-
Haematopoietic leptin receptor deficiency does not affect macrophage accumulation in adipose tissue or systemic insulin sensitivity
-
Gutiérrez DA, Hasty AH. Haematopoietic leptin receptor deficiency does not affect macrophage accumulation in adipose tissue or systemic insulin sensitivity. J Endocrinol 2012; 212 (3): 343-51
-
(2012)
J Endocrinol
, vol.212
, Issue.3
, pp. 343-351
-
-
Gutiérrez, D.A.1
Hasty, A.H.2
-
51
-
-
0036204924
-
Leptin in hepatic fibrosis: Evidence for increased collagen production in stellate cells and lean littermates of ob/ob mice
-
Saxena NK, Ikeda K, Rockey DC, Friedman SL, Anania FA. Leptin in hepatic fibrosis: evidence for increased collagen production in stellate cells and lean littermates of ob/ob mice. Hepatology 2002; 35 (4): 762-71
-
(2002)
Hepatology
, vol.35
, Issue.4
, pp. 762-771
-
-
Saxena, N.K.1
Ikeda, K.2
Rockey, D.C.3
Friedman, S.L.4
Anania, F.A.5
-
52
-
-
0036234147
-
Leptin receptor-mediated signaling regulates hepatic fibrogenesis and remodeling of extracellular matrix in the rat
-
Ikejima K, Takei Y, Honda H, Hirose M, Yoshikawa M, Zhang YJ, et al. Leptin receptor-mediated signaling regulates hepatic fibrogenesis and remodeling of extracellular matrix in the rat. Gastroenterology 2002; 122 (5): 1399-410
-
(2002)
Gastroenterology
, vol.122
, Issue.5
, pp. 1399-1410
-
-
Ikejima, K.1
Takei, Y.2
Honda, H.3
Hirose, M.4
Yoshikawa, M.5
Zhang, Y.J.6
-
53
-
-
0036022846
-
Leptin is essential for the hepatic fibrogenic response to chronic liver injury
-
Leclercq IA, Farrell GC, Schriemer R, Robertson GR. Leptin is essential for the hepatic fibrogenic response to chronic liver injury. J Hepatol 2002; 37 (2): 206-13
-
(2002)
J Hepatol
, vol.37
, Issue.2
, pp. 206-213
-
-
Leclercq, I.A.1
Farrell, G.C.2
Schriemer, R.3
Robertson, G.R.4
-
54
-
-
0034927064
-
Leptin augments inflammatory and profibrogenic responses in the murine liver induced by hepatotoxic chemicals
-
Ikejima K, Honda H, Yoshikawa M, Hirose M, Kitamura T, Takei Y, et al. Leptin augments inflammatory and profibrogenic responses in the murine liver induced by hepatotoxic chemicals. Hepatology 2001; 34 (2): 288-97
-
(2001)
Hepatology
, vol.34
, Issue.2
, pp. 288-297
-
-
Ikejima, K.1
Honda, H.2
Yoshikawa, M.3
Hirose, M.4
Kitamura, T.5
Takei, Y.6
-
55
-
-
70449730945
-
Serum adipokine levels predictive of liver injury in non-alcoholic fatty liver disease
-
Lemoine M, Ratziu V, Kim M, Maachi M, Wendum D, Paye F, et al. Serum adipokine levels predictive of liver injury in non-alcoholic fatty liver disease. Liver International 2009; 29 (9): 1431-8
-
(2009)
Liver International
, vol.29
, Issue.9
, pp. 1431-1438
-
-
Lemoine, M.1
Ratziu, V.2
Kim, M.3
Maachi, M.4
Wendum, D.5
Paye, F.6
-
56
-
-
0034723290
-
Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury
-
Friedman SL. Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury. J Biol Chem 2000; 275 (4): 2247-50
-
(2000)
J Biol Chem
, vol.275
, Issue.4
, pp. 2247-2250
-
-
Friedman, S.L.1
-
57
-
-
67650963803
-
Kupffer cells mediate leptin-induced liver fibrosis
-
Wang J, Leclercq I, Brymora JM, Xu N, Ramezani-Moghadam M, London RM, et al. Kupffer cells mediate leptin-induced liver fibrosis. Gastroenterology 2009; 137 (2): 713-23
-
(2009)
Gastroenterology
, vol.137
, Issue.2
, pp. 713-723
-
-
Wang, J.1
Leclercq, I.2
Brymora, J.M.3
Xu, N.4
Ramezani-Moghadam, M.5
London, R.M.6
-
58
-
-
0141737573
-
Leptin inhibits bone formation through a hypothalamic relay: A central control of bone mass
-
Ducy P, Amling M, Takeda S, Priemel M, Schilling AF, Beil FT, et al. Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass. Cell 2000; 100 (2): 197-207
-
(2000)
Cell
, vol.100
, Issue.2
, pp. 197-207
-
-
Ducy, P.1
Amling, M.2
Takeda, S.3
Priemel, M.4
Schilling, A.F.5
Beil, F.T.6
-
59
-
-
69449083603
-
A serotonin-dependent mechanism explains the leptin regulation of bone mass, appetite, and energy expenditure
-
Yadav VK, Oury F, Suda N, Liu ZW, Gao XB, Confavreux C, et al. A serotonin-dependent mechanism explains the leptin regulation of bone mass, appetite, and energy expenditure. Cell 2009; 138 (5): 976-89
-
(2009)
Cell
, vol.138
, Issue.5
, pp. 976-989
-
-
Yadav, V.K.1
Oury, F.2
Suda, N.3
Liu, Z.W.4
Gao, X.B.5
Confavreux, C.6
-
60
-
-
0036847619
-
Leptin regulates bone formation via the sympathetic nervous system
-
Takeda S, Elefteriou F, Levasseur R, Liu X, Zhao L, Parker KL, et al. Leptin regulates bone formation via the sympathetic nervous system. Cell 2002; 111 (3): 305-17
-
(2002)
Cell
, vol.111
, Issue.3
, pp. 305-317
-
-
Takeda, S.1
Elefteriou, F.2
Levasseur, R.3
Liu, X.4
Zhao, L.5
Parker, K.L.6
-
61
-
-
33846440508
-
Effect of selective serotonin reuptake inhibitors on the risk of fracture
-
Richards JB, Papaioannou A, Adachi JD, Joseph L, Whitson HE, Prior JC, et al. Effect of selective serotonin reuptake inhibitors on the risk of fracture. Arch Intern Med 2007; 167 (2): 188-94
-
(2007)
Arch Intern Med
, vol.167
, Issue.2
, pp. 188-194
-
-
Richards, J.B.1
Papaioannou, A.2
Adachi, J.D.3
Joseph, L.4
Whitson, H.E.5
Prior, J.C.6
-
62
-
-
0033304909
-
Severity of osteopenia in estrogen-deficient women with anorexia nervosa and hypothalamic amenorrhea
-
Grinspoon S, Miller K, Coyle C, Krempin J, Armstrong C, Pitts S, et al. Severity of osteopenia in estrogen-deficient women with anorexia nervosa and hypothalamic amenorrhea. J Clin Endocrinol Metab 1999; 84 (6): 2049-55
-
(1999)
J Clin Endocrinol Metab
, vol.84
, Issue.6
, pp. 2049-2055
-
-
Grinspoon, S.1
Miller, K.2
Coyle, C.3
Krempin, J.4
Armstrong, C.5
Pitts, S.6
-
63
-
-
0031128355
-
Serum immunoreactive leptin concentrations in patients with anorexia nervosa before and after partial weight recovery
-
Casanueva FF, Dieguez C, Popovic V, Peino R, Considine RV, Caro JF. Serum immunoreactive leptin concentrations in patients with anorexia nervosa before and after partial weight recovery. Biochem Mol Med 1997; 60 (2): 116-20
-
(1997)
Biochem Mol Med
, vol.60
, Issue.2
, pp. 116-120
-
-
Casanueva, F.F.1
Dieguez, C.2
Popovic, V.3
Peino, R.4
Considine, R.V.5
Caro, J.F.6
-
64
-
-
0036321622
-
Menstrual status and serum leptin levels in anorectic and in menstruating women with low body mass indexes
-
Di Carlo C, Tommaselli GA, De Filippo E, Pisano G, Nasti A, Bifulco G, et al. Menstrual status and serum leptin levels in anorectic and in menstruating women with low body mass indexes. Fertil Steril 2002; 78 (2): 376-82
-
(2002)
Fertil Steril
, vol.78
, Issue.2
, pp. 376-382
-
-
Di Carlo, C.1
Tommaselli, G.A.2
De Filippo, E.3
Pisano, G.4
Nasti, A.5
Bifulco, G.6
-
65
-
-
0030010388
-
Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin
-
Chehab FF, Lim ME, Lu R. Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin. Nat Genet 1996; 12 (3): 318-20
-
(1996)
Nat Genet
, vol.12
, Issue.3
, pp. 318-320
-
-
Chehab, F.F.1
Lim, M.E.2
Lu, R.3
-
66
-
-
0017164596
-
Reproductive hormonal function in the genetically obese (ob/ob) mouse
-
Swerdloff RS, Batt RA, Bray GA. Reproductive hormonal function in the genetically obese (ob/ob) mouse. Endocrinology 1976; 98 (6): 1359-64
-
(1976)
Endocrinology
, vol.98
, Issue.6
, pp. 1359-1364
-
-
Swerdloff, R.S.1
Batt, R.A.2
Bray, G.A.3
-
67
-
-
84856768737
-
Insulin resistance is a sufficient basis for hyperandrogenism in lipodystrophic women with polycystic ovarian syndrome
-
Lungu AO, Zadeh ES, Goodling A, Cochran E, Gorden P. Insulin resistance is a sufficient basis for hyperandrogenism in lipodystrophic women with polycystic ovarian syndrome. J Clin Endocrinol Metab 2012; 97 (2): 563-7
-
(2012)
J Clin Endocrinol Metab
, vol.97
, Issue.2
, pp. 563-567
-
-
Lungu, A.O.1
Zadeh, E.S.2
Goodling, A.3
Cochran, E.4
Gorden, P.5
-
68
-
-
0029098589
-
The role of neuropeptide Y in the antiobesity action of the obese gene product
-
Stephens TW, Basinski M, Bristow PK, Bue-Valleskey JM, Burgett SG, Craft L, et al. The role of neuropeptide Y in the antiobesity action of the obese gene product. Nature 1995; 377 (6549): 530-2
-
(1995)
Nature
, vol.377
, Issue.6549
, pp. 530-532
-
-
Stephens, T.W.1
Basinski, M.2
Bristow, P.K.3
Bue-Valleskey, J.M.4
Burgett, S.G.5
Craft, L.6
-
69
-
-
33644524098
-
Influence of a Leptin Deficiency on Testicular Morphology, Germ Cell Apoptosis, and Expression Levels of Apoptosis-Related Genes in the Mouse
-
Bhat GK, Sea TL, Olatinwo MO, Simorangkir D, Ford GD, Ford BD, et al. Influence of a Leptin Deficiency on Testicular Morphology, Germ Cell Apoptosis, and Expression Levels of Apoptosis-Related Genes in the Mouse. J Androl 2006; 27 (2): 302-10
-
(2006)
J Androl
, vol.27
, Issue.2
, pp. 302-310
-
-
Bhat, G.K.1
Sea, T.L.2
Olatinwo, M.O.3
Simorangkir, D.4
Ford, G.D.5
Ford, B.D.6
-
70
-
-
0030007116
-
Novel B219/OB receptor isoforms: Possible role of leptin in hematopoiesis and reproduction
-
Cioffi JA, Shafer AW, Zupancic TJ, Smith-Gbur J, Mikhail A, Platika D, et al. Novel B219/OB receptor isoforms: possible role of leptin in hematopoiesis and reproduction. Nat Med 1996; 2 (5): 585-9
-
(1996)
Nat Med
, vol.2
, Issue.5
, pp. 585-589
-
-
Cioffi, J.A.1
Shafer, A.W.2
Zupancic, T.J.3
Smith-Gbur, J.4
Mikhail, A.5
Platika, D.6
-
71
-
-
33846001719
-
Expression of leptin and leptin receptor in the testis of fertile and infertile patients
-
Ishikawa T, Fujioka H, Ishimura T, Takenaka A, Fujisawa M. Expression of leptin and leptin receptor in the testis of fertile and infertile patients. Andrologia 2007; 39 (1): 22-7
-
(2007)
Andrologia
, vol.39
, Issue.1
, pp. 22-27
-
-
Ishikawa, T.1
Fujioka, H.2
Ishimura, T.3
Takenaka, A.4
Fujisawa, M.5
-
72
-
-
0031051499
-
Leptin Treatment Rescues the Sterility of Genetically Obese ob/ob Males
-
Mounzih K, Lu R, Chehab FF. Leptin Treatment Rescues the Sterility of Genetically Obese ob/ob Males. Endocrinology 1997; 138 (3): 1190-3
-
(1997)
Endocrinology
, vol.138
, Issue.3
, pp. 1190-1193
-
-
Mounzih, K.1
Lu, R.2
Chehab, F.F.3
-
73
-
-
84855459920
-
Glucagonocentric restructuring of diabetes: A pathophysiologic and therapeutic makeover
-
Unger RH, Cherrington AD. Glucagonocentric restructuring of diabetes: a pathophysiologic and therapeutic makeover. J Clin Invest 2012; 122 (1): 4-12
-
(2012)
J Clin Invest
, vol.122
, Issue.1
, pp. 4-12
-
-
Unger, R.H.1
Cherrington, A.D.2
-
74
-
-
45749158925
-
Central insulin action regulates peripheral glucose and fat metabolism in mice
-
Koch L, Wunderlich FT, Seibler J, Konner AC, Hampel B, Irlenbusch S, et al. Central insulin action regulates peripheral glucose and fat metabolism in mice. J Clin Invest 2008; 118 (6): 2132-47
-
(2008)
J Clin Invest
, vol.118
, Issue.6
, pp. 2132-2147
-
-
Koch, L.1
Wunderlich, F.T.2
Seibler, J.3
Konner, A.C.4
Hampel, B.5
Irlenbusch, S.6
-
75
-
-
52949140814
-
Making insulin-deficient type 1 diabetic rodents thrive without insulin
-
Yu X, Park BH, Wang MY, Wang ZV, Unger RH. Making insulin-deficient type 1 diabetic rodents thrive without insulin. Proc Natl Acad Sci U S A 2008; 105 (37): 14070-5
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, Issue.37
, pp. 14070-14075
-
-
Yu, X.1
Park, B.H.2
Wang, M.Y.3
Wang, Z.V.4
Unger, R.H.5
-
76
-
-
0033037727
-
Leptin restores euglycemia and normalizes glucose turnover in insulin- deficient diabetes in the rat
-
Chinookoswong N, Wang JL, Shi ZQ. Leptin restores euglycemia and normalizes glucose turnover in insulin- deficient diabetes in the rat. Diabetes 1999; 48 (7): 1487-92
-
(1999)
Diabetes
, vol.48
, Issue.7
, pp. 1487-1492
-
-
Chinookoswong, N.1
Wang, J.L.2
Shi, Z.Q.3
-
77
-
-
77950373635
-
Leptin therapy in insulin-deficient type I diabetes
-
Wang MY, Chen L, Clark GO, Lee Y, Stevens RD, Ilkayeva OR, et al. Leptin therapy in insulin-deficient type I diabetes. Proc Natl Acad Sci U S A 2010; 107 (11): 4813-9
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, Issue.11
, pp. 4813-4819
-
-
Wang, M.Y.1
Chen, L.2
Clark, G.O.3
Lee, Y.4
Stevens, R.D.5
Ilkayeva, O.R.6
-
78
-
-
78049271280
-
Leptin therapy improves insulin-deficient type 1 diabetes by CNS-dependent mechanisms in mice
-
Fujikawa T, Chuang JC, Sakata I, Ramadori G, Coppari R. Leptin therapy improves insulin-deficient type 1 diabetes by CNS-dependent mechanisms in mice. Proc Natl Acad Sci U S A 2010; 107 (40): 17391-6
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, Issue.40
, pp. 17391-17396
-
-
Fujikawa, T.1
Chuang, J.C.2
Sakata, I.3
Ramadori, G.4
Coppari, R.5
-
79
-
-
79551600048
-
Glucagon receptor knockout prevents insulin-deficient type 1 diabetes in mice
-
Lee Y, Wang MY, Du XQ, Charron MJ, Unger RH. Glucagon receptor knockout prevents insulin-deficient type 1 diabetes in mice. Diabetes 2011; 60 (2): 391-7
-
(2011)
Diabetes
, vol.60
, Issue.2
, pp. 391-397
-
-
Lee, Y.1
Wang, M.Y.2
Du, X.Q.3
Charron, M.J.4
Unger, R.H.5
-
80
-
-
84866299596
-
Metabolic manifestations of insulin deficiency do not occur without glucagon action
-
Lee Y, Berglund ED, Wang MY, Fu X, Yu X, Charron MJ, et al. Metabolic manifestations of insulin deficiency do not occur without glucagon action. Proc Natl Acad Sci U S A 2012; 109 (37): 14972-6
-
(2012)
Proc Natl Acad Sci U S A
, vol.109
, Issue.37
, pp. 14972-14976
-
-
Lee, Y.1
Berglund, E.D.2
Wang, M.Y.3
Fu, X.4
Yu, X.5
Charron, M.J.6
-
81
-
-
80052297054
-
Subcutaneous administration of leptin normalizes fasting plasma glucose in obese type 2 diabetic UCD-T2DM rats
-
Cummings BP, Bettaieb A, Graham JL, Stanhope KL, Dill R, Morton GJ, et al. Subcutaneous administration of leptin normalizes fasting plasma glucose in obese type 2 diabetic UCD-T2DM rats. Proc Natl Acad Sci U S A 2011; 108 (35): 14670-5
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, Issue.35
, pp. 14670-14675
-
-
Cummings, B.P.1
Bettaieb, A.2
Graham, J.L.3
Stanhope, K.L.4
Dill, R.5
Morton, G.J.6
|