메뉴 건너뛰기




Volumn 12, Issue 1, 2014, Pages

Cardiovascular risks and elevation of serum DHT vary by route of testosterone administration: A systematic review and meta-analysis

Author keywords

Cardiovascular disease trials; DHT; Meta analysis; Random effects; Testosterone

Indexed keywords

ANDROSTANOLONE; TESTOSTERONE;

EID: 84924112789     PISSN: None     EISSN: 17417015     Source Type: Journal    
DOI: 10.1186/s12916-014-0211-5     Document Type: Article
Times cited : (104)

References (95)
  • 3
    • 84907598449 scopus 로고    scopus 로고
    • Outcomes of testosterone therapy in men with testosterone deficiency (TD): Part II
    • Traish AM: Outcomes of testosterone therapy in men with testosterone deficiency (TD): Part II. Steroids 2014, 88:117-126.
    • (2014) Steroids , vol.88 , pp. 117-126
    • Traish, A.M.1
  • 4
    • 29144469309 scopus 로고    scopus 로고
    • Adverse events associated with testosterone replacement in middle-aged and older men: a meta-analysis of randomized, placebo-controlled trials
    • Calof OM, Singh AB, Lee ML, Kenny AM, Urban RJ, Tenover JL, Bhasin S: Adverse events associated with testosterone replacement in middle-aged and older men: a meta-analysis of randomized, placebo-controlled trials. J Gerontol A Biol Sci Med Sci 2005, 60:1451-1457.
    • (2005) J Gerontol A Biol Sci Med Sci , vol.60 , pp. 1451-1457
    • Calof, O.M.1    Singh, A.B.2    Lee, M.L.3    Kenny, A.M.4    Urban, R.J.5    Tenover, J.L.6    Bhasin, S.7
  • 10
    • 84876176964 scopus 로고    scopus 로고
    • Testosterone therapy and cardiovascular events among men: a systematic review and meta-analysis of placebo-controlled randomized trials
    • Xu L, Freeman G, Cowling BJ, Schooling CM: Testosterone therapy and cardiovascular events among men: a systematic review and meta-analysis of placebo-controlled randomized trials. BMC Med 2013, 11:108.
    • (2013) BMC Med , vol.11 , pp. 108
    • Xu, L.1    Freeman, G.2    Cowling, B.J.3    Schooling, C.M.4
  • 11
    • 84886748182 scopus 로고    scopus 로고
    • Meta-analysis of safety for low event-rate binomial trials
    • Shuster JJ, Guo JD, Skyler JS: Meta-analysis of safety for low event-rate binomial trials. Res Synth Meth 2012, 3:. doi:10.1002/jrsm.1039.
    • (2012) Res Synth Meth , vol.3
    • Shuster, J.J.1    Guo, J.D.2    Skyler, J.S.3
  • 13
    • 84924332045 scopus 로고    scopus 로고
    • Testosterone Products: Drug Safety Communication
    • January
    • Testosterone Products: Drug Safety Communication - FDA Investigating Risk of Cardiovascular Events. 31 January 2014. [http://www.fda.gov/safety/medwatch/safetyinformation/safetyalertsforhumanmedicalproducts/ucm384225.htm]
    • (2014) FDA Investigating Risk of Cardiovascular Events , vol.31
  • 14
    • 84924291757 scopus 로고    scopus 로고
    • Department of Veterans Affairs VHA Pharmacy Benefits Management Advisory Panel: Testosterone Products and Cardiovascular Safety. 7
    • February
    • Department of Veterans Affairs VHA Pharmacy Benefits Management Advisory Panel: Testosterone Products and Cardiovascular Safety. 7 February 2014. [http://www.pbm.va.gov/PBM/vacenterformedicationsafety/nationalpbmbulletin/Testosterone_Products_and_Cardiovascular_Safety_NATIONAL_PBM_BULLETIN_02.pdf]
    • (2014)
  • 15
    • 84924336714 scopus 로고    scopus 로고
    • Endocrine Society Statement on the Risk of Cardiovascular Events in Men Receiving Testosterone Therapy Available
    • Endocrine Society Statement on the Risk of Cardiovascular Events in Men Receiving Testosterone Therapy Available. In [https://www.endocrine.org/membership/email-newsletters/endocrine-insider/2014/february-20-2014/society-statement-risk-of-cardiovascular-events-in-men-receiving-testosterone-therapy-available]
  • 17
    • 0034680343 scopus 로고    scopus 로고
    • Low-dose transdermal testosterone therapy improves angina threshold in men with chronic stable angina: a randomized, double-blind, placebo-controlled study
    • English KM, Steeds RP, Jones TH, Diver MJ, Channer KS: Low-dose transdermal testosterone therapy improves angina threshold in men with chronic stable angina: a randomized, double-blind, placebo-controlled study. Circulation 2000, 102:1906-1911.
    • (2000) Circulation , vol.102 , pp. 1906-1911
    • English, K.M.1    Steeds, R.P.2    Jones, T.H.3    Diver, M.J.4    Channer, K.S.5
  • 20
    • 84875050350 scopus 로고    scopus 로고
    • Androgen actions on the human hair follicle: perspectives
    • Inui S, Itami S: Androgen actions on the human hair follicle: perspectives. Exp Dermatol 2013, 22:168-171.
    • (2013) Exp Dermatol , vol.22 , pp. 168-171
    • Inui, S.1    Itami, S.2
  • 25
    • 51649120428 scopus 로고    scopus 로고
    • Decline of plasma 5alpha-dihydrotestosterone (DHT) levels upon testosterone administration to elderly men with subnormal plasma testosterone and high DHT levels
    • Gooren LJ, Saad F, Haide A, Yassin A: Decline of plasma 5alpha-dihydrotestosterone (DHT) levels upon testosterone administration to elderly men with subnormal plasma testosterone and high DHT levels. Andrologia 2008, 40:298-302.
    • (2008) Andrologia , vol.40 , pp. 298-302
    • Gooren, L.J.1    Saad, F.2    Haide, A.3    Yassin, A.4
  • 26
    • 0032417075 scopus 로고    scopus 로고
    • The Delphi list: a criteria list for quality assessment of randomized clinical trials for conducting systematic reviews developed by Delphi consensus
    • Verhagen AP, de Vet HC, de Bie RA, Kessels AG, Boers M, Bouter LM, Knipschild PG: The Delphi list: a criteria list for quality assessment of randomized clinical trials for conducting systematic reviews developed by Delphi consensus. J Clin Epidemiol 1998, 51:1235-1241.
    • (1998) J Clin Epidemiol , vol.51 , pp. 1235-1241
    • Verhagen, A.P.1    Vet, H.C.2    Bie, R.A.3    Kessels, A.G.4    Boers, M.5    Bouter, L.M.6    Knipschild, P.G.7
  • 27
    • 85101510947 scopus 로고    scopus 로고
    • A basic introduction to fixed-effect and random-effects models for meta-analysis
    • Borenstein M, Hedges LV, Higgins J, Rothstein HR: A basic introduction to fixed-effect and random-effects models for meta-analysis. Res Synth Meth 2010, 1:97-111.
    • (2010) Res Synth Meth , vol.1 , pp. 97-111
    • Borenstein, M.1    Hedges, L.V.2    Higgins, J.3    Rothstein, H.R.4
  • 28
    • 63849105841 scopus 로고    scopus 로고
    • Cochrane Handbook for Systematic Reviews for Interventions
    • Version 5.1.0. Chichester, UK: Wiley Publications
    • Higgins JP, Green S (Eds): Cochrane Handbook for Systematic Reviews for Interventions, Version 5.1.0. Chichester, UK: Wiley Publications; 2011.
    • (2011)
    • Higgins, J.P.1    Green, S.2
  • 30
    • 0032271151 scopus 로고    scopus 로고
    • Fixed - and random-effects models in meta-analysis
    • Hedges LV, Vevea JL: Fixed - and random-effects models in meta-analysis. Psychol Methods 1998, 3:486-504.
    • (1998) Psychol Methods , vol.3 , pp. 486-504
    • Hedges, L.V.1    Vevea, J.L.2
  • 31
    • 77952818043 scopus 로고    scopus 로고
    • Empirical vs natural weighting in random effects meta-analysis
    • Shuster JJ: Empirical vs natural weighting in random effects meta-analysis. Stat Med 2010, 29:1259-1265.
    • (2010) Stat Med , vol.29 , pp. 1259-1265
    • Shuster, J.J.1
  • 33
    • 77957567733 scopus 로고    scopus 로고
    • Effects of testosterone undecanoate on cardiovascular risk factors and atherosclerosis in middle-aged men with late-onset hypogonadism and metabolic syndrome: results from a 24-month, randomized, double-blind, placebo-controlled study
    • Aversa A, Bruzziches R, Francomano D, Rosano G, Isidori AM, Lenzi A, Spera G: Effects of testosterone undecanoate on cardiovascular risk factors and atherosclerosis in middle-aged men with late-onset hypogonadism and metabolic syndrome: results from a 24-month, randomized, double-blind, placebo-controlled study. J Sex Med 2010, 7:3495-3503.
    • (2010) J Sex Med , vol.7 , pp. 3495-3503
    • Aversa, A.1    Bruzziches, R.2    Francomano, D.3    Rosano, G.4    Isidori, A.M.5    Lenzi, A.6    Spera, G.7
  • 35
    • 68949172537 scopus 로고    scopus 로고
    • Effect of long-acting testosterone treatment on functional exercise capacity, skeletal muscle performance, insulin resistance, and baroreflex sensitivity in elderly patients with chronic heart failure a double-blind, placebo-controlled, randomized study
    • Caminiti G, Volterrani M, Iellamo F, Marazzi G, Massaro R, Miceli M, Mammi C, Piepoli M, Fini M, Rosano GM: Effect of long-acting testosterone treatment on functional exercise capacity, skeletal muscle performance, insulin resistance, and baroreflex sensitivity in elderly patients with chronic heart failure a double-blind, placebo-controlled, randomized study. J Am Coll Cardiol 2009, 54:919-927.
    • (2009) J Am Coll Cardiol , vol.54 , pp. 919-927
    • Caminiti, G.1    Volterrani, M.2    Iellamo, F.3    Marazzi, G.4    Massaro, R.5    Miceli, M.6    Mammi, C.7    Piepoli, M.8    Fini, M.9    Rosano, G.M.10
  • 37
    • 84893638940 scopus 로고    scopus 로고
    • The response to testosterone undecanoate in men with type 2 diabetes is dependent on achieving threshold serum levels (the BLAST study)
    • Hackett G, Cole N, Bhartia M, Kennedy D, Raju J, Wilkinson P, Saghir A, Blast Study Group: The response to testosterone undecanoate in men with type 2 diabetes is dependent on achieving threshold serum levels (the BLAST study). Int J Clin Pract 2014, 68:203-215.
    • (2014) Int J Clin Pract , vol.68 , pp. 203-215
  • 38
    • 0029920229 scopus 로고    scopus 로고
    • A randomized trial of testosterone therapy in males with rheumatoid arthritis
    • Hall GM, Larbre JP, Spector TD, Perry LA, Da Silva JA: A randomized trial of testosterone therapy in males with rheumatoid arthritis. Br J Rheumatol 1996, 35:568-573.
    • (1996) Br J Rheumatol , vol.35 , pp. 568-573
    • Hall, G.M.1    Larbre, J.P.2    Spector, T.D.3    Perry, L.A.4    Silva, J.A.5
  • 39
    • 84863495003 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled trial on the effect of long-acting testosterone treatment as assessed by the Aging Male Symptoms scale
    • Ho CC, Tong SF, Low WY, Ng CJ, Khoo EM, Lee VK, Zainuddin ZM, Tan HM: A randomized, double-blind, placebo-controlled trial on the effect of long-acting testosterone treatment as assessed by the Aging Male Symptoms scale. BJU Int 2012, 110:260-265.
    • (2012) BJU Int , vol.110 , pp. 260-265
    • Ho, C.C.1    Tong, S.F.2    Low, W.Y.3    Ng, C.J.4    Khoo, E.M.5    Lee, V.K.6    Zainuddin, Z.M.7    Tan, H.M.8
  • 40
    • 84866672073 scopus 로고    scopus 로고
    • Body compositional and cardiometabolic effects of testosterone therapy in obese men with severe obstructive sleep apnoea: a randomised placebo-controlled trial
    • Hoyos CM, Yee BJ, Phillips CL, Machan EA, Grunstein RR, Liu PY: Body compositional and cardiometabolic effects of testosterone therapy in obese men with severe obstructive sleep apnoea: a randomised placebo-controlled trial. Eur J Endocrinol 2012, 167:531-541.
    • (2012) Eur J Endocrinol , vol.167 , pp. 531-541
    • Hoyos, C.M.1    Yee, B.J.2    Phillips, C.L.3    Machan, E.A.4    Grunstein, R.R.5    Liu, P.Y.6
  • 41
    • 78449294931 scopus 로고    scopus 로고
    • Effects of testosterone supplementation on markers of the metabolic syndrome and inflammation in hypogonadal men with the metabolic syndrome: the double-blinded placebo-controlled Moscow study
    • Kalinchenko SY, Tishova YA, Mskhalaya GJ, Gooren LJ, Giltay EJ, Saad F: Effects of testosterone supplementation on markers of the metabolic syndrome and inflammation in hypogonadal men with the metabolic syndrome: the double-blinded placebo-controlled Moscow study. Clin Endocrinol (Oxf) 2010, 73:602-612.
    • (2010) Clin Endocrinol (Oxf) , vol.73 , pp. 602-612
    • Kalinchenko, S.Y.1    Tishova, Y.A.2    Mskhalaya, G.J.3    Gooren, L.J.4    Giltay, E.J.5    Saad, F.6
  • 42
    • 0347723707 scopus 로고    scopus 로고
    • Effects of testosterone on behavior, depression, and cognitive function in older men with mild cognitive loss
    • Kenny AM, Fabregas G, Song C, Biskup B, Bellantonio S: Effects of testosterone on behavior, depression, and cognitive function in older men with mild cognitive loss. J Gerontol A Biol Sci Med Sci 2004, 59:75-78.
    • (2004) J Gerontol A Biol Sci Med Sci , vol.59 , pp. 75-78
    • Kenny, A.M.1    Fabregas, G.2    Song, C.3    Biskup, B.4    Bellantonio, S.5
  • 43
  • 44
    • 4043104928 scopus 로고    scopus 로고
    • Testosterone treatment improves body composition and sexual function in men with COPD, in a 6-month randomized controlled trial
    • Svartberg J, Aasebo U, Hjalmarsen A, Sundsfjord J, Jorde R: Testosterone treatment improves body composition and sexual function in men with COPD, in a 6-month randomized controlled trial. Respir Med 2004, 98:906-913.
    • (2004) Respir Med , vol.98 , pp. 906-913
    • Svartberg, J.1    Aasebo, U.2    Hjalmarsen, A.3    Sundsfjord, J.4    Jorde, R.5
  • 45
    • 48349144149 scopus 로고    scopus 로고
    • Testosterone treatment in elderly men with subnormal testosterone levels improves body composition and BMD in the hip
    • Svartberg J, Agledahl I, Figenschau Y, Sildnes T, Waterloo K, Jorde R: Testosterone treatment in elderly men with subnormal testosterone levels improves body composition and BMD in the hip. Int J Impot Res 2008, 20:378-387.
    • (2008) Int J Impot Res , vol.20 , pp. 378-387
    • Svartberg, J.1    Agledahl, I.2    Figenschau, Y.3    Sildnes, T.4    Waterloo, K.5    Jorde, R.6
  • 47
    • 84877707872 scopus 로고    scopus 로고
    • Efficacy and safety of long-acting intramuscular testosterone undecanoate in aging men: a randomised controlled study
    • Tan WS, Low WY, Ng CJ, Tan WK, Tong SF, Ho C, Khoo EM, Lee G, Lee BC, Lee V, Tan HM: Efficacy and safety of long-acting intramuscular testosterone undecanoate in aging men: a randomised controlled study. BJU Int 2013, 111:1130-1140.
    • (2013) BJU Int , vol.111 , pp. 1130-1140
    • Tan, W.S.1    Low, W.Y.2    Ng, C.J.3    Tan, W.K.4    Tong, S.F.5    Ho, C.6    Khoo, E.M.7    Lee, G.8    Lee, B.C.9    Lee, V.10    Tan, H.M.11
  • 51
    • 79956271879 scopus 로고    scopus 로고
    • Testosterone replacement in hypogonadal men with type 2 diabetes and/or metabolic syndrome (the TIMES2 study)
    • Jones TH, Arver S, Behre HM, Buvat J, Meuleman E, Moncada I, Morales AM, Volterrani M, Yellowlees A, Howell JD, Channer KS, TIMES2 Investigators: Testosterone replacement in hypogonadal men with type 2 diabetes and/or metabolic syndrome (the TIMES2 study). Diabetes Care 2011, 34:828-837.
    • (2011) Diabetes Care , vol.34 , pp. 828-837
  • 53
    • 77953100242 scopus 로고    scopus 로고
    • Effects of transdermal testosterone on bone and muscle in older men with low bioavailable testosterone levels, low bone mass, and physical frailty
    • Kenny AM, Kleppinger A, Annis K, Rathier M, Browner B, Judge JO, McGee D: Effects of transdermal testosterone on bone and muscle in older men with low bioavailable testosterone levels, low bone mass, and physical frailty. J Am Geriatr Soc 2010, 58:1134-1143.
    • (2010) J Am Geriatr Soc , vol.58 , pp. 1134-1143
    • Kenny, A.M.1    Kleppinger, A.2    Annis, K.3    Rathier, M.4    Browner, B.5    Judge, J.O.6    McGee, D.7
  • 56
    • 76149135996 scopus 로고    scopus 로고
    • Effects of testosterone on muscle strength, physical function, body composition, and quality of life in intermediate-frail and frail elderly men: a randomized, double-blind, placebo-controlled study
    • Srinivas-Shankar U, Roberts SA, Connolly MJ, O'Connell MD, Adams JE, Oldham JA, Wu FC: Effects of testosterone on muscle strength, physical function, body composition, and quality of life in intermediate-frail and frail elderly men: a randomized, double-blind, placebo-controlled study. J Clin Endocrinol Metab 2010, 95:639-650.
    • (2010) J Clin Endocrinol Metab , vol.95 , pp. 639-650
    • Srinivas-Shankar, U.1    Roberts, S.A.2    Connolly, M.J.3    O'Connell, M.D.4    Adams, J.E.5    Oldham, J.A.6    Wu, F.C.7
  • 57
    • 28944442442 scopus 로고    scopus 로고
    • Testosterone therapy in men with moderate severity heart failure: a double-blind randomized placebo controlled trial
    • Malkin CJ, Pugh PJ, West JN, van Beek EJ, Jones TH, Channer KS: Testosterone therapy in men with moderate severity heart failure: a double-blind randomized placebo controlled trial. Eur Heart J 2006, 27:57-64.
    • (2006) Eur Heart J , vol.27 , pp. 57-64
    • Malkin, C.J.1    Pugh, P.J.2    West, J.N.3    Beek, E.J.4    Jones, T.H.5    Channer, K.S.6
  • 58
    • 33646711687 scopus 로고    scopus 로고
    • Double-blind placebo-controlled study of testosterone patch therapy on bone turnover in men with borderline hypogonadism
    • Merza Z, Blumsohn A, Mah PM, Meads DM, McKenna SP, Wylie K, Eastell R, Wu F, Ross RJ: Double-blind placebo-controlled study of testosterone patch therapy on bone turnover in men with borderline hypogonadism. Int J Androl 2006, 29:381-391.
    • (2006) Int J Androl , vol.29 , pp. 381-391
    • Merza, Z.1    Blumsohn, A.2    Mah, P.M.3    Meads, D.M.4    McKenna, S.P.5    Wylie, K.6    Eastell, R.7    Wu, F.8    Ross, R.J.9
  • 62
    • 0022547424 scopus 로고
    • Testosterone treatment of men with alcoholic cirrhosis: a double-blind study: the Copenhagen Study Group for Liver Diseases
    • Testosterone treatment of men with alcoholic cirrhosis: a double-blind study: the Copenhagen Study Group for Liver Diseases. Hepatology 1986, 6:807-813.
    • (1986) Hepatology , vol.6 , pp. 807-813
  • 63
    • 38049005469 scopus 로고    scopus 로고
    • Effect of testosterone supplementation on functional mobility, cognition, and other parameters in older men: a randomized controlled trial
    • Emmelot-Vonk MH, Verhaar HJ, Nakhai Pour HR, Aleman A, Lock TM, Bosch JL, Grobbee DE, van der Schouw YT: Effect of testosterone supplementation on functional mobility, cognition, and other parameters in older men: a randomized controlled trial. JAMA 2008, 299:39-52.
    • (2008) JAMA , vol.299 , pp. 39-52
    • Emmelot-Vonk, M.H.1    Verhaar, H.J.2    Nakhai Pour, H.R.3    Aleman, A.4    Lock, T.M.5    Bosch, J.L.6    Grobbee, D.E.7    Schouw, Y.T.8
  • 64
    • 65549104191 scopus 로고    scopus 로고
    • Oral testosterone replacement in symptomatic late-onset hypogonadism: effects on rating scales and general safety in a randomized, placebo-controlled study
    • Legros JJ, Meuleman EJ, Elbers JM, Geurts TB, Kaspers MJ, Bouloux PM, 43203 Investigators: Oral testosterone replacement in symptomatic late-onset hypogonadism: effects on rating scales and general safety in a randomized, placebo-controlled study. Eur J Endocrinol 2009, 160:821-831.
    • (2009) Eur J Endocrinol , vol.160 , pp. 821-831
  • 68
    • 40849133645 scopus 로고    scopus 로고
    • Efficacy and safety of a new testosterone-in-adhesive matrix patch applied every 2 days for 1 year to hypogonadal men
    • Raynaud JP, Legros JJ, Rollet J, Auges M, Bunouf P, Sournac M, Fiet J: Efficacy and safety of a new testosterone-in-adhesive matrix patch applied every 2 days for 1 year to hypogonadal men. J Steroid Biochem Mol Biol 2008, 109:168-176.
    • (2008) J Steroid Biochem Mol Biol , vol.109 , pp. 168-176
    • Raynaud, J.P.1    Legros, J.J.2    Rollet, J.3    Auges, M.4    Bunouf, P.5    Sournac, M.6    Fiet, J.7
  • 69
    • 0038278875 scopus 로고    scopus 로고
    • Osteoporosis in male hypogonadism: responses to androgen substitution differ among men with primary and secondary hypogonadism
    • Schubert M, Bullmann C, Minnemann T, Reiners C, Krone W, Jockenhovel F: Osteoporosis in male hypogonadism: responses to androgen substitution differ among men with primary and secondary hypogonadism. Horm Res 2003, 60:21-28.
    • (2003) Horm Res , vol.60 , pp. 21-28
    • Schubert, M.1    Bullmann, C.2    Minnemann, T.3    Reiners, C.4    Krone, W.5    Jockenhovel, F.6
  • 70
    • 77957834802 scopus 로고    scopus 로고
    • Pharmacokinetics and safety of long-acting testosterone undecanoate injections in hypogonadal men: an 84-week phase III clinical trial
    • Wang C, Harnett M, Dobs AS, Swerdloff RS: Pharmacokinetics and safety of long-acting testosterone undecanoate injections in hypogonadal men: an 84-week phase III clinical trial. J Androl 2010, 31:457-465.
    • (2010) J Androl , vol.31 , pp. 457-465
    • Wang, C.1    Harnett, M.2    Dobs, A.S.3    Swerdloff, R.S.4
  • 71
    • 1642461538 scopus 로고    scopus 로고
    • Cognitive changes associated with supplementation of testosterone or dihydrotestosterone in mildly hypogonadal men: a preliminary report
    • Cherrier MM, Craft S, Matsumoto AH: Cognitive changes associated with supplementation of testosterone or dihydrotestosterone in mildly hypogonadal men: a preliminary report. J Androl 2003, 24:568-576.
    • (2003) J Androl , vol.24 , pp. 568-576
    • Cherrier, M.M.1    Craft, S.2    Matsumoto, A.H.3
  • 72
    • 34347394378 scopus 로고    scopus 로고
    • Transdermal testosterone gel increases serum testosterone levels in hypogonadal men in Taiwan with improvements in sexual function
    • Chiang HS, Hwang TI, Hsui YS, Lin YC, Chen HE, Chen GC, Liao CH: Transdermal testosterone gel increases serum testosterone levels in hypogonadal men in Taiwan with improvements in sexual function. Int J Impot Res 2007, 19:411-417.
    • (2007) Int J Impot Res , vol.19 , pp. 411-417
    • Chiang, H.S.1    Hwang, T.I.2    Hsui, Y.S.3    Lin, Y.C.4    Chen, H.E.5    Chen, G.C.6    Liao, C.H.7
  • 73
    • 18844361998 scopus 로고    scopus 로고
    • Long-term effects of testim(r) 1% testosterone gel in hypogonadal men
    • Dean JD, Carnegie C, Rodzvilla J, Smith T: Long-term effects of testim(r) 1% testosterone gel in hypogonadal men. Rev Urol 2004, 6:S22-S29.
    • (2004) Rev Urol , vol.6 , pp. S22-S29
    • Dean, J.D.1    Carnegie, C.2    Rodzvilla, J.3    Smith, T.4
  • 74
    • 84857646638 scopus 로고    scopus 로고
    • Concerns about serum androgens monitoring during testosterone replacement treatments in hypogonadal male athletes: a pilot study
    • Di Luigi L, Sgro P, Aversa A, Migliaccio S, Bianchini S, Botre F, Romanelli F, Lenzi A: Concerns about serum androgens monitoring during testosterone replacement treatments in hypogonadal male athletes: a pilot study. J Sex Med 2012, 9:873-886.
    • (2012) J Sex Med , vol.9 , pp. 873-886
    • Luigi, L.1    Sgro, P.2    Aversa, A.3    Migliaccio, S.4    Bianchini, S.5    Botre, F.6    Romanelli, F.7    Lenzi, A.8
  • 75
    • 84904975710 scopus 로고    scopus 로고
    • Testosterone with dutasteride, but not anastrazole, improves insulin sensitivity in young obese men: a randomized controlled trial
    • Juang PS, Peng S, Allehmazedeh K, Shah A, Coviello AD, Herbst KL: Testosterone with dutasteride, but not anastrazole, improves insulin sensitivity in young obese men: a randomized controlled trial. J Sex Med 2014, 11:563-573.
    • (2014) J Sex Med , vol.11 , pp. 563-573
    • Juang, P.S.1    Peng, S.2    Allehmazedeh, K.3    Shah, A.4    Coviello, A.D.5    Herbst, K.L.6
  • 76
    • 16344390576 scopus 로고    scopus 로고
    • Comparison of the steady-state pharmacokinetics, metabolism, and variability of a transdermal testosterone patch versus a transdermal testosterone gel in hypogonadal men
    • Mazer N, Bell D, Wu J, Fischer J, Cosgrove M, Eilers B, Bs RN: Comparison of the steady-state pharmacokinetics, metabolism, and variability of a transdermal testosterone patch versus a transdermal testosterone gel in hypogonadal men. J Sex Med 2005, 2:213-226.
    • (2005) J Sex Med , vol.2 , pp. 213-226
    • Mazer, N.1    Bell, D.2    Wu, J.3    Fischer, J.4    Cosgrove, M.5    Eilers, B.6    Bs, R.N.7
  • 77
    • 79958287449 scopus 로고    scopus 로고
    • Dutasteride reduces prostate size and prostate specific antigen in older hypogonadal men with benign prostatic hyperplasia undergoing testosterone replacement therapy
    • Page ST, Hirano L, Gilchriest J, Dighe M, Amory JK, Marck BT, Matsumoto AM: Dutasteride reduces prostate size and prostate specific antigen in older hypogonadal men with benign prostatic hyperplasia undergoing testosterone replacement therapy. J Urol 2011, 186:191-197.
    • (2011) J Urol , vol.186 , pp. 191-197
    • Page, S.T.1    Hirano, L.2    Gilchriest, J.3    Dighe, M.4    Amory, J.K.5    Marck, B.T.6    Matsumoto, A.M.7
  • 79
    • 0034453061 scopus 로고    scopus 로고
    • Pharmacokinetics of transdermal testosterone gel in hypogonadal men: application of gel at one site versus four sites: a General Clinical Research Center Study
    • Wang C, Berman N, Longstreth JA, Chuapoco B, Hull L, Steiner B, Faulkner S, Dudley RE, Swerdloff RS: Pharmacokinetics of transdermal testosterone gel in hypogonadal men: application of gel at one site versus four sites: a General Clinical Research Center Study. J Clin Endocrinol Metab 2000, 85:964-969.
    • (2000) J Clin Endocrinol Metab , vol.85 , pp. 964-969
    • Wang, C.1    Berman, N.2    Longstreth, J.A.3    Chuapoco, B.4    Hull, L.5    Steiner, B.6    Faulkner, S.7    Dudley, R.E.8    Swerdloff, R.S.9
  • 80
    • 80855156741 scopus 로고    scopus 로고
    • Efficacy and safety of the 2% formulation of testosterone topical solution applied to the axillae in androgen-deficient men
    • Wang C, Ilani N, Arver S, McLachlan RI, Soulis T, Watkinson A: Efficacy and safety of the 2% formulation of testosterone topical solution applied to the axillae in androgen-deficient men. Clin Endocrinol (Oxf) 2011, 75:836-843.
    • (2011) Clin Endocrinol (Oxf) , vol.75 , pp. 836-843
    • Wang, C.1    Ilani, N.2    Arver, S.3    McLachlan, R.I.4    Soulis, T.5    Watkinson, A.6
  • 82
    • 0023897972 scopus 로고
    • Substitution therapy of hypogonadal men with transdermal testosterone over one year
    • Bals-Pratsch M, Langer K, Place VA, Nieschlag E: Substitution therapy of hypogonadal men with transdermal testosterone over one year. Acta Endocrinol 1988, 118:7-13.
    • (1988) Acta Endocrinol , vol.118 , pp. 7-13
    • Bals-Pratsch, M.1    Langer, K.2    Place, V.A.3    Nieschlag, E.4
  • 83
    • 0032931818 scopus 로고    scopus 로고
    • Long-term substitution therapy of hypogonadal men with transscrotal testosterone over 7-10 years
    • Behre HM, von Eckardstein S, Kliesch S, Nieschlag E: Long-term substitution therapy of hypogonadal men with transscrotal testosterone over 7-10 years. Clin Endocrinol (Oxf) 1999, 50:629-635.
    • (1999) Clin Endocrinol (Oxf) , vol.50 , pp. 629-635
    • Behre, H.M.1    Eckardstein, S.2    Kliesch, S.3    Nieschlag, E.4
  • 84
    • 0024515141 scopus 로고
    • Testosterone replacement with transdermal therapeutic systems: physiological serum testosterone and elevated dihydrotestosterone levels
    • Cunningham GR, Cordero E, Thornby JI: Testosterone replacement with transdermal therapeutic systems: physiological serum testosterone and elevated dihydrotestosterone levels. JAMA 1989, 261:2525-2530.
    • (1989) JAMA , vol.261 , pp. 2525-2530
    • Cunningham, G.R.1    Cordero, E.2    Thornby, J.I.3
  • 85
    • 0026593680 scopus 로고
    • Enhanced transdermal delivery of testosterone across nonscrotal skin produces physiological concentrations of testosterone and its metabolites in hypogonadal men
    • Meikle AW, Mazer NA, Moellmer JF, Stringham JD, Tolman KG, Sanders SW, Odell WD: Enhanced transdermal delivery of testosterone across nonscrotal skin produces physiological concentrations of testosterone and its metabolites in hypogonadal men. J Clin Endocrinol Metab 1992, 74:623-628.
    • (1992) J Clin Endocrinol Metab , vol.74 , pp. 623-628
    • Meikle, A.W.1    Mazer, N.A.2    Moellmer, J.F.3    Stringham, J.D.4    Tolman, K.G.5    Sanders, S.W.6    Odell, W.D.7
  • 87
    • 81455131693 scopus 로고    scopus 로고
    • Steady-state pharmacokinetics of oral testosterone undecanoate with concomitant inhibition of 5alpha-reductase by finasteride
    • Roth MY, Dudley RE, Hull L, Leung A, Christenson P, Wang C, Swerdloff R, Amory JK: Steady-state pharmacokinetics of oral testosterone undecanoate with concomitant inhibition of 5alpha-reductase by finasteride. Int J Androl 2011, 34:541-547.
    • (2011) Int J Androl , vol.34 , pp. 541-547
    • Roth, M.Y.1    Dudley, R.E.2    Hull, L.3    Leung, A.4    Christenson, P.5    Wang, C.6    Swerdloff, R.7    Amory, J.K.8
  • 88
    • 0022453114 scopus 로고
    • Effect of chronic oral testosterone undecanoate administration on the pituitary-testicular axes of hemodialyzed male patients
    • van Coevorden A, Stolear JC, Dhaene M, van Herweghem JL, Mockel J: Effect of chronic oral testosterone undecanoate administration on the pituitary-testicular axes of hemodialyzed male patients. Clin Nephrol 1986, 26:48-54.
    • (1986) Clin Nephrol , vol.26 , pp. 48-54
    • Coevorden, A.1    Stolear, J.C.2    Dhaene, M.3    Herweghem, J.L.4    Mockel, J.5
  • 89
    • 84859927249 scopus 로고    scopus 로고
    • Intracrine and myotrophic roles of 5alpha-reductase and androgens: a review
    • Yarrow JF, McCoy SC, Borst SE: Intracrine and myotrophic roles of 5alpha-reductase and androgens: a review. Med Sci Sports Exerc 2012, 44:818-826.
    • (2012) Med Sci Sports Exerc , vol.44 , pp. 818-826
    • Yarrow, J.F.1    McCoy, S.C.2    Borst, S.E.3
  • 90
    • 84875313783 scopus 로고    scopus 로고
    • Effect of finasteride on serum levels of androstenedione, testosterone and their 5alpha-reduced metabolites in men at risk for prostate cancer
    • Stanczyk FZ, Azen CG, Pike MC: Effect of finasteride on serum levels of androstenedione, testosterone and their 5alpha-reduced metabolites in men at risk for prostate cancer. J Steroid Biochem Mol Biol 2013, 138:10-16.
    • (2013) J Steroid Biochem Mol Biol , vol.138 , pp. 10-16
    • Stanczyk, F.Z.1    Azen, C.G.2    Pike, M.C.3
  • 91
    • 54149103847 scopus 로고    scopus 로고
    • Validation of a testosterone and dihydrotestosterone liquid chromatography tandem mass spectrometry assay: interference and comparison with established methods
    • Wang C, Shiraishi S, Leung A, Baravarian S, Hull L, Goh V, Lee PW, Swerdloff RS: Validation of a testosterone and dihydrotestosterone liquid chromatography tandem mass spectrometry assay: interference and comparison with established methods. Steroids 2008, 73:1345-1352.
    • (2008) Steroids , vol.73 , pp. 1345-1352
    • Wang, C.1    Shiraishi, S.2    Leung, A.3    Baravarian, S.4    Hull, L.5    Goh, V.6    Lee, P.W.7    Swerdloff, R.S.8
  • 92
    • 84876969942 scopus 로고    scopus 로고
    • Medication adherence and treatment patterns for hypogonadal patients treated with topical testosterone therapy: a retrospective medical claims analysis
    • Schoenfeld MJ, Shortridge E, Cui Z, Muram D: Medication adherence and treatment patterns for hypogonadal patients treated with topical testosterone therapy: a retrospective medical claims analysis. J Sex Med 2013, 10:1401-1409.
    • (2013) J Sex Med , vol.10 , pp. 1401-1409
    • Schoenfeld, M.J.1    Shortridge, E.2    Cui, Z.3    Muram, D.4
  • 93
    • 84905058727 scopus 로고    scopus 로고
    • Long-term treatment patterns of testosterone replacement medications
    • Donatucci C, Cui Z, Fang Y, Muram D: Long-term treatment patterns of testosterone replacement medications. J Sex Med 2014, 11:2092-2099.
    • (2014) J Sex Med , vol.11 , pp. 2092-2099
    • Donatucci, C.1    Cui, Z.2    Fang, Y.3    Muram, D.4
  • 94
    • 84870297827 scopus 로고    scopus 로고
    • Testosterone therapy during exercise rehabilitation in male patients with chronic heart failure who have low testosterone status: a double-blind randomized controlled feasibility study
    • Stout M, Tew GA, Doll H, Zwierska I, Woodroofe N, Channer KS, Saxton JM: Testosterone therapy during exercise rehabilitation in male patients with chronic heart failure who have low testosterone status: a double-blind randomized controlled feasibility study. Am Heart J 2012, 164:893-901.
    • (2012) Am Heart J , vol.164 , pp. 893-901
    • Stout, M.1    Tew, G.A.2    Doll, H.3    Zwierska, I.4    Woodroofe, N.5    Channer, K.S.6    Saxton, J.M.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.