메뉴 건너뛰기




Volumn 40, Issue 5, 2008, Pages 298-302

Decline of plasma 5α-dihydrotestosterone (DHT) levels upon testosterone administration to elderly men with subnormal plasma testosterone and high DHT levels

Author keywords

5 dihydrotestosterone; 5 reductase; Late onset hypogonadism; Testosterone treatment

Indexed keywords

ANDROSTANOLONE; SEX HORMONE; TESTOSTERONE; CHOLESTENONE 5ALPHA REDUCTASE; DRUG DERIVATIVE; TESTOSTERONE UNDECANOATE;

EID: 51649120428     PISSN: 03034569     EISSN: 14390272     Source Type: Journal    
DOI: 10.1111/j.1439-0272.2008.00857.x     Document Type: Article
Times cited : (9)

References (26)
  • 1
    • 0033054622 scopus 로고    scopus 로고
    • Bioavailable testosterone and depressed mood in older men: The Rancho Bernardo Study
    • Barrett-Connor E, Von Muhlen DG, Kritz-Silverstein D (1999) Bioavailable testosterone and depressed mood in older men: the Rancho Bernardo Study. J Clin Endocrinol Metab 84 : 573 577.
    • (1999) J Clin Endocrinol Metab , vol.84 , pp. 573-577
    • Barrett-Connor, E.1    Von Dg, M.2    Kritz-Silverstein, D.3
  • 2
    • 2442545242 scopus 로고    scopus 로고
    • Marked suppression of dihydrotestosterone in men with benign prostatic hyperplasia by dutasteride, a dual 5alpha-reductase inhibitor
    • Clark RV, Hermann DJ, Cunningham GR, Wilson TH, Morrill BB, Hobbs S (2004) Marked suppression of dihydrotestosterone in men with benign prostatic hyperplasia by dutasteride, a dual 5alpha-reductase inhibitor. J Clin Endocrinol Metab 89 : 2179 2184.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 2179-2184
    • Clark, R.V.1    Hermann, D.J.2    Cunningham, G.R.3    Wilson, T.H.4    Morrill, B.B.5    Hobbs, S.6
  • 3
    • 0034452998 scopus 로고    scopus 로고
    • Contribution of body fatness and adipose tissue distribution to the age variation in plasma steroid hormone concentrations in men: The HERITAGE Family Study
    • Couillard C, Gagnon J, Bergeron J, Leon AS, Rao DC, Skinner JS, Wilmore JH, Despres JP, Bouchard C (2000) Contribution of body fatness and adipose tissue distribution to the age variation in plasma steroid hormone concentrations in men: the HERITAGE Family Study. J Clin Endocrinol Metab 85 : 1026 1031.
    • (2000) J Clin Endocrinol Metab , vol.85 , pp. 1026-1031
    • Couillard, C.1    Gagnon, J.2    Bergeron, J.3    Leon, A.S.4    Rao, D.C.5    Skinner, J.S.6    Wilmore, J.H.7    Despres, J.P.8    Bouchard, C.9
  • 4
    • 0033304555 scopus 로고    scopus 로고
    • Pharmacokinetics, efficacy, and safety of a permeation-enhanced testosterone transdermal system in comparison with bi-weekly injections of testosterone enanthate for the treatment of hypogonadal men
    • Dobs AS, Meikle AW, Arver S, Sanders SW, Caramelli KE, Mazer NA (1999) Pharmacokinetics, efficacy, and safety of a permeation-enhanced testosterone transdermal system in comparison with bi-weekly injections of testosterone enanthate for the treatment of hypogonadal men. J Clin Endocrinol Metab 84 : 3469 3478.
    • (1999) J Clin Endocrinol Metab , vol.84 , pp. 3469-3478
    • Dobs, A.S.1    Meikle, A.W.2    Arver, S.3    Sanders, S.W.4    Caramelli, K.E.5    Mazer, N.A.6
  • 5
    • 2542466641 scopus 로고    scopus 로고
    • Short-term pharmacokinetic comparison of a novel testosterone buccal system and a testosterone gel in testosterone deficient men
    • Dobs AS, Matsumoto AM, Wang C, Kipnes MS (2004) Short-term pharmacokinetic comparison of a novel testosterone buccal system and a testosterone gel in testosterone deficient men. Curr Med Res Opin 20 : 729 738.
    • (2004) Curr Med Res Opin , vol.20 , pp. 729-738
    • Dobs, A.S.1    Matsumoto, A.M.2    Wang, C.3    Kipnes, M.S.4
  • 7
    • 0025873322 scopus 로고
    • Feed-forward control of prostate growth: Dihydrotestosterone induces expression of its own biosynthetic enzyme, steroid 5 alpha-reductase
    • George FW, Russell DW, Wilson JD (1991) Feed-forward control of prostate growth: dihydrotestosterone induces expression of its own biosynthetic enzyme, steroid 5 alpha-reductase. Proc Natl Acad Sci USA 88 : 8044 8047.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 8044-8047
    • George, F.W.1    Russell, D.W.2    Wilson, J.D.3
  • 8
    • 23044480003 scopus 로고    scopus 로고
    • Combined inhibition of types I and II 5 alpha-reductase selectively augments the basal (nonpulsatile) mode of testosterone secretion in young men
    • Iranmanesh A, Veldhuis JD (2005) Combined inhibition of types I and II 5 alpha-reductase selectively augments the basal (nonpulsatile) mode of testosterone secretion in young men. J Clin Endocrinol Metab 90 : 4232 4237.
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 4232-4237
    • Iranmanesh, A.1    Veldhuis, J.D.2
  • 9
    • 26444515048 scopus 로고    scopus 로고
    • The decline of androgen levels in elderly men and its clinical and therapeutic implications
    • Kaufman JM, Vermeulen A (2005) The decline of androgen levels in elderly men and its clinical and therapeutic implications. Endocr Rev 26 : 833 876.
    • (2005) Endocr Rev , vol.26 , pp. 833-876
    • Kaufman, J.M.1    Vermeulen, A.2
  • 10
    • 0036280902 scopus 로고    scopus 로고
    • The effects of transdermal dihydrotestosterone in the aging male: A prospective, randomized, double blind study
    • Kunelius P, Lukkarinen O, Hannuksela ML, Itkonen O, Tapanainen JS (2002) The effects of transdermal dihydrotestosterone in the aging male: a prospective, randomized, double blind study. Clin Metab Endocrinol J 87 : 1467 1472.
    • (2002) Clin Metab Endocrinol J , vol.87 , pp. 1467-1472
    • Kunelius, P.1    Lukkarinen, O.2    Hannuksela, M.L.3    Itkonen, O.4    Tapanainen, J.S.5
  • 11
    • 33644828241 scopus 로고    scopus 로고
    • Low sex hormone-binding globulin, total testosterone, and symptomatic androgen deficiency are associated with development of the metabolic syndrome in nonobese men
    • Kupelian V, Page ST, Araujo AB, Travison TG, Bremner WJ, McKinlay JB (2006) Low sex hormone-binding globulin, total testosterone, and symptomatic androgen deficiency are associated with development of the metabolic syndrome in nonobese men. J Clin Endocrinol Metab 91 : 843 850.
    • (2006) J Clin Endocrinol Metab , vol.91 , pp. 843-850
    • Kupelian, V.1    Page, S.T.2    Araujo, A.B.3    Travison, T.G.4    Bremner, W.J.5    McKinlay, J.B.6
  • 12
    • 0034847204 scopus 로고    scopus 로고
    • A double-blind, placebo-controlled, randomized clinical trial of transdermal dihydrotestosterone gel on muscular strength, mobility, and quality of life in older men with partial androgen deficiency
    • Ly LP, Jimenez M, Zhuang TN, Celermajer DS, Conway AJ, Handelsman DJ (2001) A double-blind, placebo-controlled, randomized clinical trial of transdermal dihydrotestosterone gel on muscular strength, mobility, and quality of life in older men with partial androgen deficiency. J Clin Endocrinol Metab 86 : 4078 4088.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 4078-4088
    • Ly, L.P.1    Jimenez, M.2    Zhuang, T.N.3    Celermajer, D.S.4    Conway, A.J.5    Handelsman, D.J.6
  • 13
    • 33747356206 scopus 로고    scopus 로고
    • Testosterone treatment comes of age: New options for hypogonadal men
    • Nieschlag E (2006) Testosterone treatment comes of age: new options for hypogonadal men. Clin Endocrinol (Oxf) 65 : 275 281.
    • (2006) Clin Endocrinol (Oxf) , vol.65 , pp. 275-281
    • Nieschlag, E.1
  • 14
    • 15944404290 scopus 로고    scopus 로고
    • Exogenous testosterone (T) alone or with finasteride increases physical performance, grip strength, and lean body mass in older men with low serum T
    • Page ST, Amory JK, Bowman FD, Anawalt BD, Matsumoto AM, Bremner WJ, Tenover JL (2005) Exogenous testosterone (T) alone or with finasteride increases physical performance, grip strength, and lean body mass in older men with low serum T. J Clin Endocrinol Metab 90 : 1502 1510.
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 1502-1510
    • Page, S.T.1    Amory, J.K.2    Bowman, F.D.3    Anawalt, B.D.4    Matsumoto, A.M.5    Bremner, W.J.6    Tenover, J.L.7
  • 15
    • 0034351821 scopus 로고    scopus 로고
    • Enzyme assay for 5alpha-reductase type 2 activity in the presence of 5alpha-reductase type 1 activity in rat testis
    • Pratis K, O'Donnell L, Ooi GT, McLachlan RI, Robertson DM (2000) Enzyme assay for 5alpha-reductase type 2 activity in the presence of 5alpha-reductase type 1 activity in rat testis. J Steroid Biochem Mol Biol 75 : 75 82.
    • (2000) J Steroid Biochem Mol Biol , vol.75 , pp. 75-82
    • Pratis, K.1    O'Donnell, L.2    Ooi, G.T.3    McLachlan, R.I.4    Robertson, D.M.5
  • 16
    • 0028173882 scopus 로고
    • Steroid 5 alpha-reductase: Two genes/two enzymes
    • Russell DW, Wilson JD (1994) Steroid 5 alpha-reductase: two genes/two enzymes. Annu Rev Biochem 63 : 25 61.
    • (1994) Annu Rev Biochem , vol.63 , pp. 25-61
    • Russell, D.W.1    Wilson, J.D.2
  • 17
    • 38449106735 scopus 로고    scopus 로고
    • Safety aspects of androgen treatment with 5alpha-dihydrotestosterone
    • Sakhri S, Gooren LJ (2007) Safety aspects of androgen treatment with 5alpha-dihydrotestosterone. Andrologia 39 : 216 222.
    • (2007) Andrologia , vol.39 , pp. 216-222
    • Sakhri, S.1    Gooren, L.J.2
  • 19
    • 0018959207 scopus 로고
    • The influence of age, alcohol consumption, and body build on gonadal function in men
    • Sparrow D, Bosse R, Rowe JW (1980) The influence of age, alcohol consumption, and body build on gonadal function in men. J Clin Endocrinol Metab 51 : 508 512.
    • (1980) J Clin Endocrinol Metab , vol.51 , pp. 508-512
    • Sparrow, D.1    Bosse, R.2    Rowe, J.W.3
  • 20
    • 0035652497 scopus 로고    scopus 로고
    • 5alpha-reductase activity in the prostate
    • Steers WD (2001) 5alpha-reductase activity in the prostate. Urology 58 : 17 24.
    • (2001) Urology , vol.58 , pp. 17-24
    • Steers, W.D.1
  • 21
    • 0242635893 scopus 로고    scopus 로고
    • Three-year follow-up of androgen treatment in hypogonadal men: Preliminary report with testosterone gel
    • Swerdloff RS, Wang C (2003) Three-year follow-up of androgen treatment in hypogonadal men: preliminary report with testosterone gel. Aging Male 6 : 207 211.
    • (2003) Aging Male , vol.6 , pp. 207-211
    • Swerdloff, R.S.1    Wang, C.2
  • 24
    • 2442543161 scopus 로고    scopus 로고
    • Long-term testosterone gel (AndroGel) treatment maintains beneficial effects on sexual function and mood, lean and fat mass, and bone mineral density in hypogonadal men
    • Wang C, Cunningham G, Dobs A, Iranmanesh A, Matsumoto AM, Snyder PJ, Weber T, Berman N, Hull L, Swerdloff RS (2004) Long-term testosterone gel (AndroGel) treatment maintains beneficial effects on sexual function and mood, lean and fat mass, and bone mineral density in hypogonadal men. J Clin Endocrinol Metab 89 : 2085 2098.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 2085-2098
    • Wang, C.1    Cunningham, G.2    Dobs, A.3    Iranmanesh, A.4    Matsumoto, A.M.5    Snyder, P.J.6    Weber, T.7    Berman, N.8    Hull, L.9    Swerdloff, R.S.10
  • 25
    • 0029684528 scopus 로고    scopus 로고
    • Role of dihydrotestosterone in androgen action
    • Wilson JD (1996) Role of dihydrotestosterone in androgen action. Prostate Suppl 6 : 88 92.
    • (1996) Prostate Suppl , vol.6 , pp. 88-92
    • Wilson, J.D.1
  • 26
    • 0035528888 scopus 로고    scopus 로고
    • The role of 5alpha-reduction in steroid hormone physiology
    • Wilson JD (2001) The role of 5alpha-reduction in steroid hormone physiology. Reprod Fertil Dev 13 : 673 678.
    • (2001) Reprod Fertil Dev , vol.13 , pp. 673-678
    • Wilson, J.D.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.