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Volumn 95, Issue 6, 2010, Pages 2560-2575

Adverse effects of testosterone therapy in adult men: A systematic review and meta-analysis

Author keywords

[No Author keywords available]

Indexed keywords

HEMOGLOBIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; TESTOSTERONE; TESTOSTERONE ENANTATE; TESTOSTERONE ESTER; TESTOSTERONE UNDECANOATE;

EID: 77954394453     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2009-2575     Document Type: Review
Times cited : (613)

References (72)
  • 1
    • 0035097033 scopus 로고    scopus 로고
    • Longitudinal effects of aging on serum total and free testosterone levels in healthy men. Baltimore Longitudinal Study of Aging
    • Harman SM, Metter EJ, Tobin JD, Pearson J, Blackman MR 2001 Longitudinal effects of aging on serum total and free testosterone levels in healthy men. Baltimore Longitudinal Study of Aging. J Clin Endocrinol Metab 86:724-731
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 724-731
    • Harman, S.M.1    Metter, E.J.2    Tobin, J.D.3    Pearson, J.4    Blackman, M.R.5
  • 8
    • 34547660521 scopus 로고    scopus 로고
    • Effect of 2 years of testosterone replacement on insulin secretion, insulin action, glucose effectiveness, hepatic insulin clearance, and postprandial glucose turnover in elderly men
    • Basu R, Dalla Man C, Campioni M, Basu A, Nair KS, Jensen MD, Khosla S, Klee G, Toffolo G, Cobelli C, Rizza RA 2007 Effect of 2 years of testosterone replacement on insulin secretion, insulin action, glucose effectiveness, hepatic insulin clearance, and postprandial glucose turnover in elderly men. Diabetes Care 30:1972-1978
    • (2007) Diabetes Care , vol.30 , pp. 1972-1978
    • Basu, R.1    Dalla Man, C.2    Campioni, M.3    Basu, A.4    Nair, K.S.5    Jensen, M.D.6    Khosla, S.7    Klee, G.8    Toffolo, G.9    Cobelli, C.10    Rizza, R.A.11
  • 9
    • 33745684473 scopus 로고    scopus 로고
    • Testosterone replacement therapy improves insulin resistance, glycaemic control, visceral adiposity and hypercholesterolaemia in hypogonadal men with type 2 diabetes
    • Kapoor D, Goodwin E, Channer KS, Jones TH 2006 Testosterone replacement therapy improves insulin resistance, glycaemic control, visceral adiposity and hypercholesterolaemia in hypogonadal men with type 2 diabetes. Eur J Endocrinol 154:899-906
    • (2006) Eur J Endocrinol , vol.154 , pp. 899-906
    • Kapoor, D.1    Goodwin, E.2    Channer, K.S.3    Jones, T.H.4
  • 12
    • 28944442442 scopus 로고    scopus 로고
    • Testosterone therapy in men with moderate severity heart failure: A double-blind randomized placebo controlled trial
    • Malkin CJ, Pugh PJ, West JN, van Beek EJ, Jones TH, Channer KS 2006 Testosterone therapy in men with moderate severity heart failure: a double-blind randomized placebo controlled trial. Eur Heart J 27:57-64
    • (2006) Eur Heart J , vol.27 , pp. 57-64
    • Malkin, C.J.1    Pugh, P.J.2    West, J.N.3    Van Beek, E.J.4    Jones, T.H.5    Channer, K.S.6
  • 13
    • 68049122102 scopus 로고    scopus 로고
    • Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement
    • Prisma Group
    • Moher D, Liberati A, Tetzlaff J, Altman DG, Prisma Group 2009 Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med 6:e1000097
    • (2009) PLoS Med , vol.6
    • Moher, D.1    Liberati, A.2    Tetzlaff, J.3    Altman, D.G.4
  • 14
    • 40849142097 scopus 로고    scopus 로고
    • A case for clarity, consistency, and helpfulness: State-of-the-art clinical practice guidelines in endocrinology using the grading of recommendations, assessment, development, and evaluation system
    • Swiglo BA, Murad MH, Schünemann HJ, Kunz R, Vigersky RA, Guyatt GH, Montori VM 2008 A case for clarity, consistency, and helpfulness: state-of-the-art clinical practice guidelines in endocrinology using the grading of recommendations, assessment, development, and evaluation system. J Clin Endocrinol Metab 93:666-673
    • (2008) J Clin Endocrinol Metab , vol.93 , pp. 666-673
    • Swiglo, B.A.1    Murad, M.H.2    Schünemann, H.J.3    Kunz, R.4    Vigersky, R.A.5    Guyatt, G.H.6    Montori, V.M.7
  • 17
    • 38149032364 scopus 로고    scopus 로고
    • Testosterone therapy prevents gain in visceral adipose tissue and loss of skeletal muscle in nonobese aging men
    • Allan CA, Strauss BJ, Burger HG, Forbes EA, McLachlan RI 2008 Testosterone therapy prevents gain in visceral adipose tissue and loss of skeletal muscle in nonobese aging men. J Clin Endocrinol Metab 93:139-146
    • (2008) J Clin Endocrinol Metab , vol.93 , pp. 139-146
    • Allan, C.A.1    Strauss, B.J.2    Burger, H.G.3    Forbes, E.A.4    McLachlan, R.I.5
  • 18
    • 34347394378 scopus 로고    scopus 로고
    • Transdermal testosterone gel increases serum testosterone levels in hypogonadal men in Taiwan with improvements in sexual function
    • Chiang HS, Hwang TI, Hsui YS, Lin YC, Chen HE, Chen GC, Liao CH 2007 Transdermal testosterone gel increases serum testosterone levels in hypogonadal men in Taiwan with improvements in sexual function. Int J Impot Res 19:411-417
    • (2007) Int J Impot Res , vol.19 , pp. 411-417
    • Chiang, H.S.1    Hwang, T.I.2    Hsui, Y.S.3    Lin, Y.C.4    Chen, H.E.5    Chen, G.C.6    Liao, C.H.7
  • 22
    • 33846862242 scopus 로고    scopus 로고
    • Association between unreported outcomes and effect size estimates in Cochrane meta-analyses
    • Furukawa TA, Watanabe N, Omori IM, Montori VM, Guyatt GH 2007 Association between unreported outcomes and effect size estimates in Cochrane meta-analyses. JAMA 297:468-470
    • (2007) JAMA , vol.297 , pp. 468-470
    • Furukawa, T.A.1    Watanabe, N.2    Omori, I.M.3    Montori, V.M.4    Guyatt, G.H.5
  • 23
    • 0036858514 scopus 로고    scopus 로고
    • American Association of Clinical Endocrinologists Medical Guidelines for clinical practice for the evaluation and treatment of hypogonadism in adult male patients-2002 update
    • Petak SM, Nankin HR, Spark RF, Swerdloff RS, Rodriguez-Rigau LJ 2002 American Association of Clinical Endocrinologists Medical Guidelines for clinical practice for the evaluation and treatment of hypogonadism in adult male patients-2002 update. Endocr Pract 8:440-456
    • (2002) Endocr Pract , vol.8 , pp. 440-456
    • Petak, S.M.1    Nankin, H.R.2    Spark, R.F.3    Swerdloff, R.S.4    Rodriguez-Rigau, L.J.5
  • 24
    • 55249111590 scopus 로고    scopus 로고
    • Impact of testosterone treatment on postprandial triglyceride metabolism in elderly men with subnormal testosterone levels
    • Agledahl I, Hansen JB, Svartberg J 2008 Impact of testosterone treatment on postprandial triglyceride metabolism in elderly men with subnormal testosterone levels. Scand J Clin Lab Invest 68:641-648
    • (2008) Scand J Clin Lab Invest , vol.68 , pp. 641-648
    • Agledahl, I.1    Hansen, J.B.2    Svartberg, J.3
  • 26
    • 15944404290 scopus 로고    scopus 로고
    • Exogenous testosterone (T) alone or with finasteride increases physical performance, grip strength, and lean body mass in older men with low serum T
    • Page ST, Amory JK, Bowman FD, Anawalt BD, Matsumoto AM, Bremner WJ, Tenover JL 2005 Exogenous testosterone (T) alone or with finasteride increases physical performance, grip strength, and lean body mass in older men with low serum T. J Clin Endocrinol Metab 90:1502-1510
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 1502-1510
    • Page, S.T.1    Amory, J.K.2    Bowman, F.D.3    Anawalt, B.D.4    Matsumoto, A.M.5    Bremner, W.J.6    Tenover, J.L.7
  • 27
    • 52949126361 scopus 로고    scopus 로고
    • Effect of testosterone therapy on lumbar spine and hip mineral density in elderly men
    • Basurto L, Zarate A, Gomez R, Vargas C, Saucedo R, Galván R 2008 Effect of testosterone therapy on lumbar spine and hip mineral density in elderly men. Aging Male 11:140-145
    • (2008) Aging Male , vol.11 , pp. 140-145
    • Basurto, L.1    Zarate, A.2    Gomez, R.3    Vargas, C.4    Saucedo, R.5    Galván, R.6
  • 28
    • 0031741594 scopus 로고    scopus 로고
    • Effects of testosterone replacement with a nongenital, transdermal system, Androderm, in human immunodeficiency virus-infected men with low testosterone levels
    • Bhasin S, Storer TW, Asbel-Sethi N, Kilbourne A, Hays R, Sinha-Hikim I, Shen R, Arver S, Beall G 1998 Effects of testosterone replacement with a nongenital, transdermal system, Androderm, in human immunodeficiency virus-infected men with low testosterone levels. J Clin Endocrinol Metab 83:3155-3162
    • (1998) J Clin Endocrinol Metab , vol.83 , pp. 3155-3162
    • Bhasin, S.1    Storer, T.W.2    Asbel-Sethi, N.3    Kilbourne, A.4    Hays, R.5    Sinha-Hikim, I.6    Shen, R.7    Arver, S.8    Beall, G.9
  • 30
    • 33947533369 scopus 로고    scopus 로고
    • Effects of testosterone supplementation on whole body and regional fat mass and distribution in human immunodeficiency virus-infected men with abdominal obesity
    • Team ACTGPAS
    • Bhasin S, Parker RA, Sattler F, Haubrich R, Alston B, Umbleja T, Shikuma CM, Team ACTGPAS 2007 Effects of testosterone supplementation on whole body and regional fat mass and distribution in human immunodeficiency virus-infected men with abdominal obesity. J Clin Endocrinol Metab 92:1049-1057
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 1049-1057
    • Bhasin, S.1    Parker, R.A.2    Sattler, F.3    Haubrich, R.4    Alston, B.5    Umbleja, T.6    Shikuma, C.M.7
  • 33
    • 0038823605 scopus 로고    scopus 로고
    • Testosterone supplementation in men with type 2 diabetes, visceral obesity and partial androgen deficiency
    • Boyanov MA, Boneva Z, Christov VG 2003 Testosterone supplementation in men with type 2 diabetes, visceral obesity and partial androgen deficiency. Aging Male 6:1-7 (Pubitemid 36606394)
    • (2003) Aging Male , vol.6 , Issue.1 , pp. 1-7
    • Boyanov, M.A.1    Boneva, Z.2    Christov, V.G.3
  • 35
    • 1842789810 scopus 로고    scopus 로고
    • Carnitine versus androgen administration in the treatment of sexual dysfunction, depressed mood, and fatigue associated with male aging
    • Cavallini G, Caracciolo S, Vitali G, Modenini F, Biagiotti G 2004 Carnitine versus androgen administration in the treatment of sexual dysfunction, depressed mood, and fatigue associated with male aging. Urology 63:641-646
    • (2004) Urology , vol.63 , pp. 641-646
    • Cavallini, G.1    Caracciolo, S.2    Vitali, G.3    Modenini, F.4    Biagiotti, G.5
  • 36
    • 0032812020 scopus 로고    scopus 로고
    • Difficulties in measuring the effect of testosterone replacement therapy on muscle function in older men
    • Clague JE, Wu FC, Horan MA 1999 Difficulties in measuring the effect of testosterone replacement therapy on muscle function in older men. Int J Androl 22:261-265
    • (1999) Int J Androl , vol.22 , pp. 261-265
    • Clague, J.E.1    Wu, F.C.2    Horan, M.A.3
  • 37
    • 0030768594 scopus 로고    scopus 로고
    • A trial of testosterone therapy for HIV-associated weight loss
    • Coodley GO, Coodley MK 1997 A trial of testosterone therapy for HIV-associated weight loss. AIDS 11:1347-1352
    • (1997) AIDS , vol.11 , pp. 1347-1352
    • Coodley, G.O.1    Coodley, M.K.2
  • 38
    • 0022547424 scopus 로고
    • Testosterone treatment of men with alcoholic cirrhosis: A double-blind study. The Copenhagen Study Group for Liver Diseases
    • 1986 Testosterone treatment of men with alcoholic cirrhosis: a double-blind study. The Copenhagen Study Group for Liver Diseases. Hepatology 6:807-813
    • (1986) Hepatology , vol.6 , pp. 807-813
  • 40
    • 0034680343 scopus 로고    scopus 로고
    • Low-dose transdermal testosterone therapy improves angina threshold in men with chronic stable angina: A randomized, doubleblind, placebo-controlled study
    • English KM, Steeds RP, Jones TH, Diver MJ, Channer KS 2000 Low-dose transdermal testosterone therapy improves angina threshold in men with chronic stable angina: a randomized, doubleblind, placebo-controlled study. Circulation 102:1906-1911
    • (2000) Circulation , vol.102 , pp. 1906-1911
    • English, K.M.1    Steeds, R.P.2    Jones, T.H.3    Diver, M.J.4    Channer, K.S.5
  • 47
    • 0034852752 scopus 로고    scopus 로고
    • Randomized placebo-controlled trial of testosterone replacement in men with mild Leydig cell insufficiency following cytotoxic chemotherapy
    • Oxf
    • Howell SJ, Radford JA, Adams JE, Smets EM, Warburton R, Shalet SM 2001 Randomized placebo-controlled trial of testosterone replacement in men with mild Leydig cell insufficiency following cytotoxic chemotherapy. Clin Endocrinol (Oxf) 55:315-324
    • (2001) Clin Endocrinol , vol.55 , pp. 315-324
    • Howell, S.J.1    Radford, J.A.2    Adams, J.E.3    Smets, E.M.4    Warburton, R.5    Shalet, S.M.6
  • 48
    • 33845968457 scopus 로고    scopus 로고
    • Effects of modest testosterone supplementation and exercise for 12 weeks on body composition and quality of life in elderly men
    • Katznelson L, Robinson MW, Coyle CL, Lee H, Farrell CE 2006 Effects of modest testosterone supplementation and exercise for 12 weeks on body composition and quality of life in elderly men. Eur J Endocrinol 155:867-875
    • (2006) Eur J Endocrinol , vol.155 , pp. 867-875
    • Katznelson, L.1    Robinson, M.W.2    Coyle, C.L.3    Lee, H.4    Farrell, C.E.5
  • 50
    • 0347723707 scopus 로고    scopus 로고
    • Effects of testosterone on behavior, depression, and cognitive function in older men with mild cognitive loss
    • Kenny AM, Fabregas G, Song C, Biskup B, Bellantonio S 2004 Effects of testosterone on behavior, depression, and cognitive function in older men with mild cognitive loss. J Gerontol A Biol Sci Med Sci 59:75-78
    • (2004) J Gerontol A Biol Sci Med Sci , vol.59 , pp. 75-78
    • Kenny, A.M.1    Fabregas, G.2    Song, C.3    Biskup, B.4    Bellantonio, S.5
  • 53
    • 33646711687 scopus 로고    scopus 로고
    • Double-blind placebo-controlled study of testosterone patch therapy on bone turnover in men with borderline hypogonadism
    • Merza Z, Blumsohn A, Mah PM, Meads DM, McKenna SP, Wylie K, Eastell R, Wu F, Ross RJ 2006 Double-blind placebo-controlled study of testosterone patch therapy on bone turnover in men with borderline hypogonadism. Int J Androl 29:381-391
    • (2006) Int J Androl , vol.29 , pp. 381-391
    • Merza, Z.1    Blumsohn, A.2    Mah, P.M.3    Meads, D.M.4    McKenna, S.P.5    Wylie, K.6    Eastell, R.7    Wu, F.8    Ross, R.J.9
  • 61
    • 4043104928 scopus 로고    scopus 로고
    • Testosterone treatment improves body composition and sexual function in men with COPD, in a 6-month randomized controlled trial
    • DOI 10.1016/j.rmed.2004.02.015, PII S0954611104000836
    • Svartberg J, Aasebø U, Hjalmarsen A, Sundsfjord J, Jorde R 2004 Testosterone treatment improves body composition and sexual function in men with COPD, in a 6-month randomized controlled trial. Respir Med 98:906-913 (Pubitemid 39069342)
    • (2004) Respiratory Medicine , vol.98 , Issue.9 , pp. 906-913
    • Svartberg, J.1    Aaseboo, U.2    Hjalmarsen, A.3    Sundsfjord, J.4    Jorde, R.5
  • 62
    • 0038146927 scopus 로고    scopus 로고
    • A pilot study on the effects of testosterone in hypogonadal aging male patients with Alzheimer's disease
    • Tan RS, Pu SJ 2003 A pilot study on the effects of testosterone in hypogonadal aging male patients with Alzheimer's disease. Aging Male 6:13-17
    • (2003) Aging Male , vol.6 , pp. 13-17
    • Tan, R.S.1    Pu, S.J.2
  • 63
  • 64
    • 0014296435 scopus 로고
    • Testosterone therapy in obliterating arterial lesions in the lower limbs
    • Dohn K, Hvidt V, Nielsen J, Palm L 1968 Testosterone therapy in obliterating arterial lesions in the lower limbs. Angiology 19:342-350
    • (1968) Angiology , vol.19 , pp. 342-350
    • Dohn, K.1    Hvidt, V.2    Nielsen, J.3    Palm, L.4
  • 65
    • 0029920229 scopus 로고    scopus 로고
    • A randomized trial of testosterone therapy in males with rheumatoid arthritis
    • Hall GM, Larbre JP, Spector TD, Perry LA, Da Silva JA 1996 A randomized trial of testosterone therapy in males with rheumatoid arthritis. Br J Rheumatol 35:568-573 (Pubitemid 126719489)
    • (1996) Rheumatology , vol.35 , Issue.6 , pp. 568-573
    • Hall, G.M.1    Larbre, J.P.2    Spector, T.D.3    Perry, L.A.4    Da Silva, J.A.P.5
  • 66
    • 0014167395 scopus 로고
    • Testosterone in the treatment of arterial insufficiency of the lower limbs
    • Hentzer E, Madsen PC 1967 Testosterone in the treatment of arterial insufficiency of the lower limbs. Scand J Clin Lab Invest Suppl 99:198-206
    • (1967) Scand J Clin Lab Invest Suppl , vol.99 , pp. 198-206
    • Hentzer, E.1    Madsen, P.C.2
  • 67
    • 1642463867 scopus 로고    scopus 로고
    • Testosterone treatment for men with chronic heart failure
    • Pugh PJ, Jones RD, West JN, Jones TH, Channer KS 2004 Testosterone treatment for men with chronic heart failure. Heart 90:446-447 (Pubitemid 38406925)
    • (2004) Heart , vol.90 , Issue.4 , pp. 446-447
    • Pugh, P.J.1    Jones, R.D.2    West, J.N.3    Jones, T.H.4    Channer, K.S.5
  • 68
    • 0041411599 scopus 로고    scopus 로고
    • The effects of growth hormone and sex steroid on lean body mass, fat mass, muscle strength, cardiovascular endurance and adverse events in healthy elderly women and men
    • Harman SM, Blackman MR 2003 The effects of growth hormone and sex steroid on lean body mass, fat mass, muscle strength, cardiovascular endurance and adverse events in healthy elderly women and men. Horm Res 60(Suppl 1):121-124
    • (2003) Horm Res , vol.60 , Issue.SUPPL. 1 , pp. 121-124
    • Harman, S.M.1    Blackman, M.R.2
  • 70
    • 0037622805 scopus 로고    scopus 로고
    • Randomized placebo-controlled trial of androgen effects on muscle and bone in men requiring long-term systemic glucocorticoid treatment
    • Crawford BA, Liu PY, Kean MT, Bleasel JF, Handelsman DJ 2003 Randomized placebo-controlled trial of androgen effects on muscle and bone in men requiring long-term systemic glucocorticoid treatment. J Clin Endocrinol Metab 88:3167-3176
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 3167-3176
    • Crawford, B.A.1    Liu, P.Y.2    Kean, M.T.3    Bleasel, J.F.4    Handelsman, D.J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.