메뉴 건너뛰기




Volumn 299, Issue 1, 2008, Pages 39-52

Effect of testosterone supplementation on functional mobility, cognition, and other parameters in older men: A randomized controlled trial

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CREATININE; GAMMA GLUTAMYLTRANSFERASE; GLUCOSE; HEMOGLOBIN; INSULIN; LIPID; PLACEBO; PROSTATE SPECIFIC ANTIGEN; TESTOSTERONE; TESTOSTERONE UNDECANOATE;

EID: 38049005469     PISSN: 00987484     EISSN: 15383598     Source Type: Journal    
DOI: 10.1001/jama.2007.51     Document Type: Article
Times cited : (459)

References (77)
  • 1
    • 0035097033 scopus 로고    scopus 로고
    • Longitudinal effects of aging on serum total and free testosterone levels in healthy men: Baltimore Longitudinal Study of Aging
    • Harman SM, Metter EJ, Tobin JD, Pearson J, Blackman MR. Longitudinal effects of aging on serum total and free testosterone levels in healthy men: Baltimore Longitudinal Study of Aging. J Clin Endocrinol Metab. 2001;86(2):724-731.
    • (2001) J Clin Endocrinol Metab , vol.86 , Issue.2 , pp. 724-731
    • Harman, S.M.1    Metter, E.J.2    Tobin, J.D.3    Pearson, J.4    Blackman, M.R.5
  • 3
    • 0033307232 scopus 로고    scopus 로고
    • Effect of testosterone treatment on body composition and muscle strength in men over 65 years of age
    • Snyder PJ, Peachey H, Hannoush P, et al. Effect of testosterone treatment on body composition and muscle strength in men over 65 years of age. J Clin Endocrinol Metab. 1999;84(8):2647-2653.
    • (1999) J Clin Endocrinol Metab , vol.84 , Issue.8 , pp. 2647-2653
    • Snyder, P.J.1    Peachey, H.2    Hannoush, P.3
  • 4
    • 0026742650 scopus 로고
    • Effects of testosterone supplementation in the aging male
    • Tenover JS. Effects of testosterone supplementation in the aging male. J Clin Endocrinol Metab. 1992;75(4):1092-1098.
    • (1992) J Clin Endocrinol Metab , vol.75 , Issue.4 , pp. 1092-1098
    • Tenover, J.S.1
  • 5
    • 0035028887 scopus 로고    scopus 로고
    • Effects of transdermal testosterone on bone and muscle in older men with low bioavailable testosterone levels
    • Kenny AM, Prestwood KM, Gruman CA, Marcello KM, Raisz LG. Effects of transdermal testosterone on bone and muscle in older men with low bioavailable testosterone levels. J Gerontol A Biol Sci Med Sci. 2001;56(5):M266-M272.
    • (2001) J Gerontol A Biol Sci Med Sci , vol.56 , Issue.5
    • Kenny, A.M.1    Prestwood, K.M.2    Gruman, C.A.3    Marcello, K.M.4    Raisz, L.G.5
  • 6
    • 38049017502 scopus 로고    scopus 로고
    • Concluding remarks
    • Committee on Assessing the Need for Clinical Trials of Testosterone, Liverman CT, Blazer DG, eds, Washington, DC: National Academies Press;
    • Committee on Assessing the Need for Clinical Trials of Testosterone. Concluding remarks. In: Liverman CT, Blazer DG, eds. Replacement Therapy: Testosterone and Aging: Clinical Research Directions. Washington, DC: National Academies Press; 2004.
    • (2004) Replacement Therapy: Testosterone and Aging: Clinical Research Directions
  • 7
    • 33748761138 scopus 로고    scopus 로고
    • Double blind randomized placebo-controlled trial on the effects of testosterone supplementation in elderly men with moderate-to-low testosterone levels: Design and baseline characteristics [ISRCTN23688581]
    • Nakhai Pour HR, Emmelot-Vonk MH, Sukel-Helleman M, Verhaar HJ, Grobbee DE, van der Schouw YT. Double blind randomized placebo-controlled trial on the effects of testosterone supplementation in elderly men with moderate-to-low testosterone levels: design and baseline characteristics [ISRCTN23688581]. Trials. 2006;7:24.
    • (2006) Trials , vol.7 , pp. 24
    • Nakhai Pour, H.R.1    Emmelot-Vonk, M.H.2    Sukel-Helleman, M.3    Verhaar, H.J.4    Grobbee, D.E.5    van der Schouw, Y.T.6
  • 8
    • 0026031194 scopus 로고
    • The timed "up & go": A test of basic functional mobility for frail elderly persons
    • Podsiadlo D, Richardson S. The timed "up & go": a test of basic functional mobility for frail elderly persons. J Am Geriatr Soc. 1991;39(2):142-148.
    • (1991) J Am Geriatr Soc , vol.39 , Issue.2 , pp. 142-148
    • Podsiadlo, D.1    Richardson, S.2
  • 9
  • 10
    • 0028469113 scopus 로고
    • Grip strength testing reliability
    • Hamilton A, Balnave R, Adams R. Grip strength testing reliability. J Hand Ther. 1994;7(3):163-170.
    • (1994) J Hand Ther , vol.7 , Issue.3 , pp. 163-170
    • Hamilton, A.1    Balnave, R.2    Adams, R.3
  • 11
    • 0034066312 scopus 로고    scopus 로고
    • Relationships between physical performance measures, age, height and body weight in healthy adults
    • Samson MM, Meeuwsen IB, Crowe A, Dessens JA, Duursma SA, Verhaar HJ. Relationships between physical performance measures, age, height and body weight in healthy adults. Age Ageing. 2000;29(3):235-242.
    • (2000) Age Ageing , vol.29 , Issue.3 , pp. 235-242
    • Samson, M.M.1    Meeuwsen, I.B.2    Crowe, A.3    Dessens, J.A.4    Duursma, S.A.5    Verhaar, H.J.6
  • 13
    • 84946642987 scopus 로고
    • A standardized memory scale for clinical use
    • Wechsler D. A standardized memory scale for clinical use. J Psychol. 1945;19:27-95.
    • (1945) J Psychol , vol.19 , pp. 27-95
    • Wechsler, D.1
  • 16
    • 0018180305 scopus 로고
    • Mental rotations, a group test of three-dimensional spatial visualization
    • Vandenberg SG, Kuse AR. Mental rotations, a group test of three-dimensional spatial visualization. Percept Mot Skills. 1978;47(2):599-604.
    • (1978) Percept Mot Skills , vol.47 , Issue.2 , pp. 599-604
    • Vandenberg, S.G.1    Kuse, A.R.2
  • 18
    • 0033305020 scopus 로고    scopus 로고
    • A critical evaluation of simple methods for the estimation of free testosterone in serum
    • Vermeulen A, Verdonck L, Kaufman JM. A critical evaluation of simple methods for the estimation of free testosterone in serum. J Clin Endocrinol Metab. 1999;84(10):3666-3672.
    • (1999) J Clin Endocrinol Metab , vol.84 , Issue.10 , pp. 3666-3672
    • Vermeulen, A.1    Verdonck, L.2    Kaufman, J.M.3
  • 19
    • 4344594835 scopus 로고    scopus 로고
    • Validation of the Friedewald formula for the determination of low-density lipoprotein cholesterol compared with beta-quantification in a large population
    • Tremblay AJ, Morrissette H, Gagne JM, Bergeron J, Gagne C, Couture P. Validation of the Friedewald formula for the determination of low-density lipoprotein cholesterol compared with beta-quantification in a large population. Clin Biochem. 2004;37(9):785-790.
    • (2004) Clin Biochem , vol.37 , Issue.9 , pp. 785-790
    • Tremblay, A.J.1    Morrissette, H.2    Gagne, J.M.3    Bergeron, J.4    Gagne, C.5    Couture, P.6
  • 20
    • 0036148469 scopus 로고    scopus 로고
    • Detection of insulin resistance by simple quantitative insulin sensitivity check index QUICKI for epidemiological assessment and prevention
    • Hrebícek J, Janout V, Malincikova J, Horakova D, Cizek L. Detection of insulin resistance by simple quantitative insulin sensitivity check index QUICKI for epidemiological assessment and prevention. J Clin Endocrinol Metab. 2002;87(1):144-147.
    • (2002) J Clin Endocrinol Metab , vol.87 , Issue.1 , pp. 144-147
    • Hrebícek, J.1    Janout, V.2    Malincikova, J.3    Horakova, D.4    Cizek, L.5
  • 21
    • 0034456568 scopus 로고    scopus 로고
    • Quantitative insulin sensitivity check index: A simple, accurate method for assessing insulin sensitivity in humans
    • Katz A, Nambi SS, Mather K, et al. Quantitative insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans. J Clin Endocrinol Metab. 2000;85(7):2402-2410.
    • (2000) J Clin Endocrinol Metab , vol.85 , Issue.7 , pp. 2402-2410
    • Katz, A.1    Nambi, S.S.2    Mather, K.3
  • 22
    • 0033961701 scopus 로고    scopus 로고
    • Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity: Studies in subjects with various degrees of glucose tolerance and insulin sensitivity
    • Bonora E, Targher G, Alberiche M, et al. Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity: studies in subjects with various degrees of glucose tolerance and insulin sensitivity. Diabetes Care. 2000;23(1):57-63.
    • (2000) Diabetes Care , vol.23 , Issue.1 , pp. 57-63
    • Bonora, E.1    Targher, G.2    Alberiche, M.3
  • 23
    • 0035897696 scopus 로고    scopus 로고
    • Expert Panel on Detection. Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III)
    • Executive Summary of the Third Report of The National Cholesterol Education Program NCEP
    • Executive Summary of the Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection. Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III). JAMA. 2001;285(19):2486-2497.
    • (2001) JAMA , vol.285 , Issue.19 , pp. 2486-2497
  • 24
    • 0026877917 scopus 로고
    • The MOS 36-item Short-Form Health Survey (SF-36), I: Conceptual framework and item selection
    • Ware JE Jr, Sherbourne CD. The MOS 36-item Short-Form Health Survey (SF-36), I: conceptual framework and item selection. Med Care. 1992;30(6):473-483.
    • (1992) Med Care , vol.30 , Issue.6 , pp. 473-483
    • Ware Jr, J.E.1    Sherbourne, C.D.2
  • 25
    • 0024232299 scopus 로고
    • Measuring the quality of life: A comparison between physically and mentally chronically ill patients and healthy persons
    • Huber D, Henrich G, Herschbach P. Measuring the quality of life: a comparison between physically and mentally chronically ill patients and healthy persons. Pharmacopsychiatry. 1988;21(6):453-455.
    • (1988) Pharmacopsychiatry , vol.21 , Issue.6 , pp. 453-455
    • Huber, D.1    Henrich, G.2    Herschbach, P.3
  • 26
    • 0034845959 scopus 로고    scopus 로고
    • Development and psychometric properties of a disease-specific quality of life questionnaire for adult patients with growth hormone deficiency
    • Herschbach P, Henrich G, Strasburger CJ, et al. Development and psychometric properties of a disease-specific quality of life questionnaire for adult patients with growth hormone deficiency. Eur J Endocrinol. 2001;145(3):255-265.
    • (2001) Eur J Endocrinol , vol.145 , Issue.3 , pp. 255-265
    • Herschbach, P.1    Henrich, G.2    Strasburger, C.J.3
  • 27
    • 0032882360 scopus 로고    scopus 로고
    • Longitudinal prostate growth rates during 5 years in randomly selected community men 40 to 79 years old
    • Rhodes T, Girman CJ, Jacobsen SJ, Roberts RO, Guess HA, Lieber MM. Longitudinal prostate growth rates during 5 years in randomly selected community men 40 to 79 years old. J Urol. 1999;161(4):1174-1179.
    • (1999) J Urol , vol.161 , Issue.4 , pp. 1174-1179
    • Rhodes, T.1    Girman, C.J.2    Jacobsen, S.J.3    Roberts, R.O.4    Guess, H.A.5    Lieber, M.M.6
  • 28
    • 0022405921 scopus 로고
    • Transrectal ultrasound in the diagnosis of prostate cancer: Location, echogenicity, histopathology, and staging
    • Lee F, Gray JM, McLeary RD, et al. Transrectal ultrasound in the diagnosis of prostate cancer: location, echogenicity, histopathology, and staging. Prostate. 1985;7(2):117-129.
    • (1985) Prostate , vol.7 , Issue.2 , pp. 117-129
    • Lee, F.1    Gray, J.M.2    McLeary, R.D.3
  • 29
    • 0031054573 scopus 로고    scopus 로고
    • Ten-language translation and harmonization of the International Prostate Symptom Score: Developing a methodology for multinational clinical trials
    • Badía X, Garcia-Losa M, Dal Re R. Ten-language translation and harmonization of the International Prostate Symptom Score: developing a methodology for multinational clinical trials. Eur Urol. 1997;31(2):129-140.
    • (1997) Eur Urol , vol.31 , Issue.2 , pp. 129-140
    • Badía, X.1    Garcia-Losa, M.2    Dal, R.R.3
  • 30
    • 33644509850 scopus 로고    scopus 로고
    • Investigation, treatment, and monitoring of late-onset hypogonadism in males: ISA, ISSAM, and EAU recommendations
    • Nieschlag E, Swerdloff R, Behre HM, et al. Investigation, treatment, and monitoring of late-onset hypogonadism in males: ISA, ISSAM, and EAU recommendations. J Androl. 2006;27(2):135-137.
    • (2006) J Androl , vol.27 , Issue.2 , pp. 135-137
    • Nieschlag, E.1    Swerdloff, R.2    Behre, H.M.3
  • 31
    • 0035838329 scopus 로고    scopus 로고
    • Testosterone supplementation improves spatial and verbal memory in healthy older men
    • Cherrier MM, Asthana S, Plymate S, et al. Testosterone supplementation improves spatial and verbal memory in healthy older men. Neurology. 2001;57(1):80-88.
    • (2001) Neurology , vol.57 , Issue.1 , pp. 80-88
    • Cherrier, M.M.1    Asthana, S.2    Plymate, S.3
  • 32
    • 0036081614 scopus 로고    scopus 로고
    • Testosterone administration to older men improves muscle function: Molecular and physiological mechanisms
    • Ferrando AA, Sheffield-Moore M, Yeckel CW, et al. Testosterone administration to older men improves muscle function: molecular and physiological mechanisms. Am J Physiol Endocrinol Metab. 2002;282(3):E601-E607.
    • (2002) Am J Physiol Endocrinol Metab , vol.282 , Issue.3
    • Ferrando, A.A.1    Sheffield-Moore, M.2    Yeckel, C.W.3
  • 33
    • 0028293411 scopus 로고
    • Testosterone influences spatial cognition in older men
    • Janowsky JS, Oviatt SK, Orwoll ES. Testosterone influences spatial cognition in older men. Behav Neurosci. 1994;108(2):325-332.
    • (1994) Behav Neurosci , vol.108 , Issue.2 , pp. 325-332
    • Janowsky, J.S.1    Oviatt, S.K.2    Orwoll, E.S.3
  • 34
    • 21144442262 scopus 로고    scopus 로고
    • Testosterone improves spatial memory in men with Alzheimer disease and mild cognitive impairment
    • Cherrier MM, Matsumoto AM, Amory JK, et al. Testosterone improves spatial memory in men with Alzheimer disease and mild cognitive impairment. Neurology. 2005;64(12):2063-2068.
    • (2005) Neurology , vol.64 , Issue.12 , pp. 2063-2068
    • Cherrier, M.M.1    Matsumoto, A.M.2    Amory, J.K.3
  • 35
    • 0042463626 scopus 로고    scopus 로고
    • Oral testosterone supplementation increases muscle and decreases fat mass in healthy elderly males with low-normal gonadal status
    • Wittert GA, Chapman IM, Haren MT, Mackintosh S, Coates P, Morley JE. Oral testosterone supplementation increases muscle and decreases fat mass in healthy elderly males with low-normal gonadal status. J Gerontol A Biol Sci Med Sci. 2003;58(7):618-625.
    • (2003) J Gerontol A Biol Sci Med Sci , vol.58 , Issue.7 , pp. 618-625
    • Wittert, G.A.1    Chapman, I.M.2    Haren, M.T.3    Mackintosh, S.4    Coates, P.5    Morley, J.E.6
  • 36
    • 0042203618 scopus 로고    scopus 로고
    • Oral testosterone undecanoate (Andriol) supplement therapy improves the quality of life for men with testosterone deficiency
    • Park NC, Yan BQ, Chung JM, Lee KM. Oral testosterone undecanoate (Andriol) supplement therapy improves the quality of life for men with testosterone deficiency. Aging Male. 2003;6(2):86-93.
    • (2003) Aging Male , vol.6 , Issue.2 , pp. 86-93
    • Park, N.C.1    Yan, B.Q.2    Chung, J.M.3    Lee, K.M.4
  • 37
    • 33947216862 scopus 로고    scopus 로고
    • The effect of food composition on serum testosterone levels after oral administration of Andriol Testocaps
    • Schnabel PG, Bagchus W, Lass H, Thomsen T, Geurts TB. The effect of food composition on serum testosterone levels after oral administration of Andriol Testocaps. Clin Endocrinol (Oxf ). 2007;66(4):579-585.
    • (2007) Clin Endocrinol (Oxf ) , vol.66 , Issue.4 , pp. 579-585
    • Schnabel, P.G.1    Bagchus, W.2    Lass, H.3    Thomsen, T.4    Geurts, T.B.5
  • 38
    • 0141865633 scopus 로고    scopus 로고
    • Pharmacokinetic study in women of three different doses of a new formulation of oral testosterone undecanoate, Andriol Testocaps
    • Houwing NS, Maris F, Schnabel PG, Bagchus WM. Pharmacokinetic study in women of three different doses of a new formulation of oral testosterone undecanoate, Andriol Testocaps. Pharmacotherapy. 2003; 23(10):1257-1265.
    • (2003) Pharmacotherapy , vol.23 , Issue.10 , pp. 1257-1265
    • Houwing, N.S.1    Maris, F.2    Schnabel, P.G.3    Bagchus, W.M.4
  • 39
    • 24144489427 scopus 로고    scopus 로고
    • Effects of testosterone on body composition, bone metabolism and serum lipid profile in middle-aged men: A meta-analysis
    • Isidori AM, Giannetta E, Greco EA, et al. Effects of testosterone on body composition, bone metabolism and serum lipid profile in middle-aged men: a meta-analysis. Clin Endocrinol (Oxf ). 2005;63(3):280-293.
    • (2005) Clin Endocrinol (Oxf ) , vol.63 , Issue.3 , pp. 280-293
    • Isidori, A.M.1    Giannetta, E.2    Greco, E.A.3
  • 41
    • 0031157240 scopus 로고    scopus 로고
    • Age-associated sarcopenia - issues in the use of testosterone as an anabolic agent in older men
    • Bhasin S, Tenover JS. Age-associated sarcopenia - issues in the use of testosterone as an anabolic agent in older men. J Clin Endocrinol Metab. 1997;82(6):1659-1660.
    • (1997) J Clin Endocrinol Metab , vol.82 , Issue.6 , pp. 1659-1660
    • Bhasin, S.1    Tenover, J.S.2
  • 42
    • 33750324635 scopus 로고    scopus 로고
    • Endogenous testosterone levels, physical performance, and fall risk in older men
    • Orwoll E, Lambert LC, Marshall LM, et al. Endogenous testosterone levels, physical performance, and fall risk in older men. Arch Intern Med. 2006;166(19):2124-2131.
    • (2006) Arch Intern Med , vol.166 , Issue.19 , pp. 2124-2131
    • Orwoll, E.1    Lambert, L.C.2    Marshall, L.M.3
  • 43
    • 23244433166 scopus 로고    scopus 로고
    • The association of sex hormone levels with poor mobility, low muscle strength and incidence of falls among older men and women
    • Schaap LA, Pluijm SM, Smit JH, et al. The association of sex hormone levels with poor mobility, low muscle strength and incidence of falls among older men and women. Clin Endocrinol (Oxf ). 2005;63(2):152-160.
    • (2005) Clin Endocrinol (Oxf ) , vol.63 , Issue.2 , pp. 152-160
    • Schaap, L.A.1    Pluijm, S.M.2    Smit, J.H.3
  • 45
    • 0034847204 scopus 로고    scopus 로고
    • A double-blind, placebo-controlled, randomized clinical trial of transdermal dihydrotestosterone gel on muscular strength, mobility, and quality of life in older men with partial androgen deficiency
    • Ly LP, Jimenez M, Zhuang TN, Celermajer DS, Conway AJ, Handelsman DJ. A double-blind, placebo-controlled, randomized clinical trial of transdermal dihydrotestosterone gel on muscular strength, mobility, and quality of life in older men with partial androgen deficiency. J Clin Endocrinol Metab. 2001;86(9):4078-4088.
    • (2001) J Clin Endocrinol Metab , vol.86 , Issue.9 , pp. 4078-4088
    • Ly, L.P.1    Jimenez, M.2    Zhuang, T.N.3    Celermajer, D.S.4    Conway, A.J.5    Handelsman, D.J.6
  • 46
    • 0038823605 scopus 로고    scopus 로고
    • Testosterone supplementation in men with type 2 diabetes, visceral obesity and partial androgen deficiency
    • Boyanov MA, Boneva Z, Christov VG. Testosterone supplementation in men with type 2 diabetes, visceral obesity and partial androgen deficiency. Aging Male. 2003;6(1):1-7.
    • (2003) Aging Male , vol.6 , Issue.1 , pp. 1-7
    • Boyanov, M.A.1    Boneva, Z.2    Christov, V.G.3
  • 47
    • 33745684473 scopus 로고    scopus 로고
    • Testosterone replacement therapy improves insulin resistance, glycaemic control, visceral adiposity and hypercholesterolaemia in hypogonadal men with type 2 diabetes
    • Kapoor D, Goodwin E, Channer KS, Jones TH. Testosterone replacement therapy improves insulin resistance, glycaemic control, visceral adiposity and hypercholesterolaemia in hypogonadal men with type 2 diabetes. Eur J Endocrinol. 2006;154(6):899-906.
    • (2006) Eur J Endocrinol , vol.154 , Issue.6 , pp. 899-906
    • Kapoor, D.1    Goodwin, E.2    Channer, K.S.3    Jones, T.H.4
  • 48
    • 0027456868 scopus 로고
    • The effect of testosterone aromatization on high-density lipoprotein cholesterol level and postheparin lipolytic activity
    • Zmuda JM, Fahrenbach MC, Younkin BT, et al. The effect of testosterone aromatization on high-density lipoprotein cholesterol level and postheparin lipolytic activity. Metabolism. 1993;42(4):446-450.
    • (1993) Metabolism , vol.42 , Issue.4 , pp. 446-450
    • Zmuda, J.M.1    Fahrenbach, M.C.2    Younkin, B.T.3
  • 49
    • 0034819462 scopus 로고    scopus 로고
    • Intramuscular testosterone esters and plasma lipids in hypogonadal men: A meta-analysis
    • Whitsel EA, Boyko EJ, Matsumoto AM, Anawalt BD, Siscovick DS. Intramuscular testosterone esters and plasma lipids in hypogonadal men: a meta-analysis. Am J Med. 2001;111(4):261-269.
    • (2001) Am J Med , vol.111 , Issue.4 , pp. 261-269
    • Whitsel, E.A.1    Boyko, E.J.2    Matsumoto, A.M.3    Anawalt, B.D.4    Siscovick, D.S.5
  • 50
    • 15944411404 scopus 로고    scopus 로고
    • The metabolic syndrome in older individuals: Prevalence and prediction of cardiovascular events: the Cardiovascular Health Study
    • Scuteri A, Najjar SS, Morrell CH, Lakatta EG. The metabolic syndrome in older individuals: prevalence and prediction of cardiovascular events: the Cardiovascular Health Study. Diabetes Care. 2005;28(4):882-887.
    • (2005) Diabetes Care , vol.28 , Issue.4 , pp. 882-887
    • Scuteri, A.1    Najjar, S.S.2    Morrell, C.H.3    Lakatta, E.G.4
  • 51
    • 0037021505 scopus 로고    scopus 로고
    • The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men
    • Lakka HM, Laaksonen DE, Lakka TA, et al. The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men. JAMA. 2002;288(21):2709-2716.
    • (2002) JAMA , vol.288 , Issue.21 , pp. 2709-2716
    • Lakka, H.M.1    Laaksonen, D.E.2    Lakka, T.A.3
  • 52
    • 2342644814 scopus 로고    scopus 로고
    • Testosterone and sex hormone-binding globulin predict the metabolic syndrome and diabetes in middle-aged men
    • Laaksonen DE, Niskanen L, Punnonen K, et al. Testosterone and sex hormone-binding globulin predict the metabolic syndrome and diabetes in middle-aged men. Diabetes Care. 2004;27(5):1036-1041.
    • (2004) Diabetes Care , vol.27 , Issue.5 , pp. 1036-1041
    • Laaksonen, D.E.1    Niskanen, L.2    Punnonen, K.3
  • 53
    • 0035313592 scopus 로고    scopus 로고
    • High-grade prostate cancer is associated with low serum testosterone levels
    • Schatzl G, Madersbacher S, Thurridl T, et al. High-grade prostate cancer is associated with low serum testosterone levels. Prostate. 2001;47(1):52-58.
    • (2001) Prostate , vol.47 , Issue.1 , pp. 52-58
    • Schatzl, G.1    Madersbacher, S.2    Thurridl, T.3
  • 54
    • 33644828241 scopus 로고    scopus 로고
    • Low sex hormonebinding globulin, total testosterone, and symptomatic androgen deficiency are associated with development of the metabolic syndrome in nonobese men
    • Kupelian V, Page ST, Araujo AB, Travison TG, Bremner WJ, McKinlay JB. Low sex hormonebinding globulin, total testosterone, and symptomatic androgen deficiency are associated with development of the metabolic syndrome in nonobese men. J Clin Endocrinol Metab. 2006;91(3):843-850.
    • (2006) J Clin Endocrinol Metab , vol.91 , Issue.3 , pp. 843-850
    • Kupelian, V.1    Page, S.T.2    Araujo, A.B.3    Travison, T.G.4    Bremner, W.J.5    McKinlay, J.B.6
  • 56
    • 0026342804 scopus 로고
    • Does hypogonadism contribute to the occurrence of a minimal trauma hip fracture in elderly men?
    • Stanley HL, Schmitt BP, Poses RM, Deiss WP. Does hypogonadism contribute to the occurrence of a minimal trauma hip fracture in elderly men? J Am Geriatr Soc. 1991;39(8):766-771.
    • (1991) J Am Geriatr Soc , vol.39 , Issue.8 , pp. 766-771
    • Stanley, H.L.1    Schmitt, B.P.2    Poses, R.M.3    Deiss, W.P.4
  • 57
    • 33744962693 scopus 로고    scopus 로고
    • Testosterone use in men and its effects on bone health: A systematic review and meta-analysis of randomized placebo-controlled trials
    • Tracz MJ, Sideras K, Bolona ER, et al. Testosterone use in men and its effects on bone health: a systematic review and meta-analysis of randomized placebo-controlled trials. J Clin Endocrinol Metab. 2006;91(6):2011-2016.
    • (2006) J Clin Endocrinol Metab , vol.91 , Issue.6 , pp. 2011-2016
    • Tracz, M.J.1    Sideras, K.2    Bolona, E.R.3
  • 58
    • 0029881686 scopus 로고    scopus 로고
    • Prevalence of ageing-associated cognitive decline in an elderly population
    • Hanninen T, Koivisto K, Reinikainen KJ, et al. Prevalence of ageing-associated cognitive decline in an elderly population. Age Ageing. 1996;25(3):201-205.
    • (1996) Age Ageing , vol.25 , Issue.3 , pp. 201-205
    • Hanninen, T.1    Koivisto, K.2    Reinikainen, K.J.3
  • 59
  • 60
    • 14644430928 scopus 로고    scopus 로고
    • Endogenous sex hormone levels and cognitive function in aging men: Is there an optimal level?
    • Muller M, Aleman A, Grobbee DE, de Haan EH, van der Schouw YT. Endogenous sex hormone levels and cognitive function in aging men: is there an optimal level? Neurology. 2005;64(5):866-871.
    • (2005) Neurology , vol.64 , Issue.5 , pp. 866-871
    • Muller, M.1    Aleman, A.2    Grobbee, D.E.3    de Haan, E.H.4    van der Schouw, Y.T.5
  • 61
    • 0036845350 scopus 로고    scopus 로고
    • Longitudinal assessment of serum free testosterone concentration predicts memory performance and cognitive status in elderly men
    • Moffat SD, Zonderman AB, Metter EJ, Blackman MR, Harman SM, Resnick SM. Longitudinal assessment of serum free testosterone concentration predicts memory performance and cognitive status in elderly men. J Clin Endocrinol Metab. 2002;87(11):5001-5007.
    • (2002) J Clin Endocrinol Metab , vol.87 , Issue.11 , pp. 5001-5007
    • Moffat, S.D.1    Zonderman, A.B.2    Metter, E.J.3    Blackman, M.R.4    Harman, S.M.5    Resnick, S.M.6
  • 62
    • 0036218209 scopus 로고    scopus 로고
    • Sex hormones and cognitive function in older men
    • Yaffe K, Lui LY, Zmuda J, Cauley J. Sex hormones and cognitive function in older men. J Am Geriatr Soc. 2002;50(4):707-712.
    • (2002) J Am Geriatr Soc , vol.50 , Issue.4 , pp. 707-712
    • Yaffe, K.1    Lui, L.Y.2    Zmuda, J.3    Cauley, J.4
  • 63
    • 33644558050 scopus 로고    scopus 로고
    • The role of androgens in cognition and brain aging in men
    • Janowsky JS. The role of androgens in cognition and brain aging in men. Neuroscience. 2006;138 (3):1015-1020.
    • (2006) Neuroscience , vol.138 , Issue.3 , pp. 1015-1020
    • Janowsky, J.S.1
  • 64
    • 0842347346 scopus 로고    scopus 로고
    • Free testosterone and risk for Alzheimer disease in older men
    • Moffat SD, Zonderman AB, Metter EJ, et al. Free testosterone and risk for Alzheimer disease in older men. Neurology. 2004;62(2):188-193.
    • (2004) Neurology , vol.62 , Issue.2 , pp. 188-193
    • Moffat, S.D.1    Zonderman, A.B.2    Metter, E.J.3
  • 65
    • 0037022255 scopus 로고    scopus 로고
    • Testosterone prevents the heat shock-induced overactivation of glycogen synthase kinase-3 beta but not of cyclin-dependent kinase 5 and c-Jun NH2-terminal kinase and concomitantly abolishes hyperphosphorylation of tau: Implications for Alzheimer's disease
    • Papasozomenos SC, Shanavas A. Testosterone prevents the heat shock-induced overactivation of glycogen synthase kinase-3 beta but not of cyclin-dependent kinase 5 and c-Jun NH2-terminal kinase and concomitantly abolishes hyperphosphorylation of tau: implications for Alzheimer's disease. Proc Natl Acad Sci U S A. 2002;99(3):1140-1145.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , Issue.3 , pp. 1140-1145
    • Papasozomenos, S.C.1    Shanavas, A.2
  • 66
    • 0031035332 scopus 로고    scopus 로고
    • High-dose anabolic androgenic steroids modulate concentrations of nerve growth factor and expression of its low affinity receptor (p75-NGFr) in male rat brain
    • Tirassa P, Thiblin I, Agren G, Vigneti E, Aloe L, Stenfors C. High-dose anabolic androgenic steroids modulate concentrations of nerve growth factor and expression of its low affinity receptor (p75-NGFr) in male rat brain. J Neurosci Res. 1997;47 (2):198-207.
    • (1997) J Neurosci Res , vol.47 , Issue.2 , pp. 198-207
    • Tirassa, P.1    Thiblin, I.2    Agren, G.3    Vigneti, E.4    Aloe, L.5    Stenfors, C.6
  • 67
    • 0033950794 scopus 로고    scopus 로고
    • Testosterone reduces neuronal secretion of Alzheimer's beta-amyloid peptides
    • Gouras GK, Xu H, Gross RS, et al. Testosterone reduces neuronal secretion of Alzheimer's beta-amyloid peptides. Proc Natl Acad Sci U S A. 2000;97(3):1202-1205.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , Issue.3 , pp. 1202-1205
    • Gouras, G.K.1    Xu, H.2    Gross, R.S.3
  • 68
    • 11844302936 scopus 로고    scopus 로고
    • Effect of oral testosterone undecanoate on visuospatial cognition, mood and quality of life in elderly men with low-normal gonadal status
    • Haren MT, Wittert GA, Chapman IM, Coates P, Morley JE. Effect of oral testosterone undecanoate on visuospatial cognition, mood and quality of life in elderly men with low-normal gonadal status. Maturitas. 2005;50(2):124-133.
    • (2005) Maturitas , vol.50 , Issue.2 , pp. 124-133
    • Haren, M.T.1    Wittert, G.A.2    Chapman, I.M.3    Coates, P.4    Morley, J.E.5
  • 69
    • 0347723707 scopus 로고    scopus 로고
    • Effects of testosterone on behavior, depression, and cognitive function in older men with mild cognitive loss
    • Kenny AM, Fabregas G, Song C, Biskup B, Bellantonio S. Effects of testosterone on behavior, depression, and cognitive function in older men with mild cognitive loss. J Gerontol A Biol Sci Med Sci. 2004;59(1):75-78.
    • (2004) J Gerontol A Biol Sci Med Sci , vol.59 , Issue.1 , pp. 75-78
    • Kenny, A.M.1    Fabregas, G.2    Song, C.3    Biskup, B.4    Bellantonio, S.5
  • 70
    • 32944467155 scopus 로고    scopus 로고
    • Effects of testosterone on cognition and mood in male patients with mild Alzheimer disease and healthy elderly men
    • Lu PH, Masterman DA, Mulnard R, et al. Effects of testosterone on cognition and mood in male patients with mild Alzheimer disease and healthy elderly men. Arch Neurol. 2006;63(2):177-185.
    • (2006) Arch Neurol , vol.63 , Issue.2 , pp. 177-185
    • Lu, P.H.1    Masterman, D.A.2    Mulnard, R.3
  • 71
    • 33845762711 scopus 로고    scopus 로고
    • Testosterone and men's quality of life
    • Moncada I. Testosterone and men's quality of life. Aging Male. 2006;99(4):189-193.
    • (2006) Aging Male , vol.99 , Issue.4 , pp. 189-193
    • Moncada, I.1
  • 72
    • 0036235104 scopus 로고    scopus 로고
    • Effects of transdermal testosterone on cognitive function and health perception in older men with low bioavailable testosterone levels
    • Kenny AM, Bellantonio S, Gruman CA, Acosta RD, Prestwood KM. Effects of transdermal testosterone on cognitive function and health perception in older men with low bioavailable testosterone levels. J Gerontol A Biol Sci Med Sci. 2002;57(5):M321-M325.
    • (2002) J Gerontol A Biol Sci Med Sci , vol.57 , Issue.5
    • Kenny, A.M.1    Bellantonio, S.2    Gruman, C.A.3    Acosta, R.D.4    Prestwood, K.M.5
  • 73
    • 1642458222 scopus 로고    scopus 로고
    • Risks of testosterone-replacement therapy and recommendations for monitoring
    • Rhoden EL, Morgentaler A. Risks of testosterone-replacement therapy and recommendations for monitoring. N Engl J Med. 2004;350(5):482-492.
    • (2004) N Engl J Med , vol.350 , Issue.5 , pp. 482-492
    • Rhoden, E.L.1    Morgentaler, A.2
  • 74
    • 33750978404 scopus 로고    scopus 로고
    • Effect of testosterone replacement therapy on prostate tissue in men with late-onset hypogonadism: A randomized controlled trial
    • Marks LS, Mazer NA, Mostaghel E, et al. Effect of testosterone replacement therapy on prostate tissue in men with late-onset hypogonadism: a randomized controlled trial. JAMA. 2006;296(19):2351-2361.
    • (2006) JAMA , vol.296 , Issue.19 , pp. 2351-2361
    • Marks, L.S.1    Mazer, N.A.2    Mostaghel, E.3
  • 75
    • 0032943937 scopus 로고    scopus 로고
    • Dramatic rise in prostate-specific antigen after androgen replacement in a hypogonadal man with occult adenocarcinoma of the prostate
    • Curran MJ, Bihrle W III. Dramatic rise in prostate-specific antigen after androgen replacement in a hypogonadal man with occult adenocarcinoma of the prostate. Urology. 1999;53(2):423-424.
    • (1999) Urology , vol.53 , Issue.2 , pp. 423-424
    • Curran, M.J.1    Bihrle III, W.2
  • 77
    • 0242390083 scopus 로고    scopus 로고
    • Managing the risks of prostate disease during testosterone replacement therapy in older men: Recommendations for a standardized monitoring plan
    • Bhasin S, Singh AB, Mac RP, Carter B, Lee MI, Cunningham GR. Managing the risks of prostate disease during testosterone replacement therapy in older men: recommendations for a standardized monitoring plan. J Androl. 2003;24(3):299-311.
    • (2003) J Androl , vol.24 , Issue.3 , pp. 299-311
    • Bhasin, S.1    Singh, A.B.2    Mac, R.P.3    Carter, B.4    Lee, M.I.5    Cunningham, G.R.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.