Transdermal androgen therapy to augment EPO in the treatment of anemia of chronic renal disease

American Journal of Kidney Diseases

Volumn 47, Issue 2, 2006, Pages 251-262

  Brockenbrough, Andrew T ^a   Dittrich, Mary O ^b   Page, Stephanie T ^b   Smith, Ted ^b   Stivelman, John C ^b   Bremner, William J ^b  

^a UNIVERSITY OF WASHINGTON   (United States)

^b NONE

Author keywords

Anemia; Chronic kidney failure; Hemodialysis (HD); Hypogonadism; Randomized controlled trial

Indexed keywords

ANDROSTANOLONE; CHOLESTEROL; ESTRADIOL; HEMOGLOBIN; LUTEINIZING HORMONE; PLACEBO; RECOMBINANT ERYTHROPOIETIN; TESTOSTERONE;

ACNE; ADULT; AGED; ANDROGEN THERAPY; ANEMIA; ARTICLE; BODY MASS; BONE MINERAL; CHOLESTEROL BLOOD LEVEL; CHRONIC KIDNEY DISEASE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; FAT CONTENT; GASTROINTESTINAL DISEASE; GEL; HAIR GROWTH; HEART DISEASE; HEMODIALYSIS PATIENT; HEMOGLOBIN BLOOD LEVEL; HIP FRACTURE; HUMAN; HYPOGONADISM; INFECTION; LIBIDO; MALE; MOOD; MUSCLE ATROPHY; NEUROLOGIC DISEASE; PHASE 4 CLINICAL TRIAL; RANDOMIZED CONTROLLED TRIAL; RASH; SEXUAL FUNCTION; SIDE EFFECT; THROMBOSIS;

ADMINISTRATION, CUTANEOUS; ANDROGENS; ANEMIA; DOUBLE-BLIND METHOD; ERYTHROPOIETIN, RECOMBINANT; HUMANS; KIDNEY FAILURE, CHRONIC; MALE; MIDDLE AGED; TESTOSTERONE;

EID: 31044455043     PISSN: 02726386     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.ajkd.2005.10.022     Document Type: Article

References (33)

1. D.C. Cattran, S.S. Fenton, D.R. Wilson, D. Oreopoulos, A. Shimizu, R.M. Richardson A controlled trial of nondrolone decanoate in the treatment of uremic anemia Kidney Int 12 1977 430 437
2. A. Schustack, D. Meshiaj, Z. Waiss, L. Gotloib Intramuscular iron replenishment and replacement combined with testosterone enanthate in maintenance hemodialysis anemia A follow-up of up to 8 years on 16 patients Clin Nephrol 23 1985 303 306
3. J.W. Eschbach, J.W. Adamson Improvement in the anemia of chronic renal failure with fluoxymesterone Ann Intern Med 78 1973 527 532
4. E.D. Hendler, J.A. Goffinet, S. Ross, R.E. Longnecker, V. Bakovic Controlled study of androgen therapy in anemia of patients on maintenance hemodialysis N Engl J Med 291 1974 1046 1051
5. R.L. DeGowin, A.R. Lavender, M. Forland, D. Charleston, A. Gottschalk Erythropoiesis and erythropoietin in patients with chronic renal failure treated with hemodialysis and testosterone Ann Intern Med 72 1970 913 918
6. D. Buchwald, S. Argyres, R.E. Easterling Effect of nandrolone decanoate on the anemia of chronic hemodialysis patients Nephron 18 1977 232 238
7. M.K. Mirahmadi, N.D. Vaziri, J.T. Gorman Controlled evaluation of hemodialysis patients on nandrolone decanoate (ND) vs testosterone enanthate (TE) (androgens and dialysis patient) Trans Am Soc Artif Intern Organs 25 1979 449 454
8. R. Alexanian Erythropoietin and erythropoiesis in anemic man following androgens Blood 33 1969 564 572
9. J.L. Teruel, R. Marcen, J.F. Navarro Evolution of serum erythropoietin after androgen administration to hemodialysis patients A prospective study Nephron 70 1995 282 286
10. S.H. Ballal, D.T. Domoto, D.C. Polack, P. Marciulonis, K.J. Martin Androgens potentiate the effects of erythropoietin in the treatment of anemia of end-stage renal disease Am J Kidney Dis 17 1991 29 33
11. A.B. Singh, K. Norris, N. Modi Pharmacokinetics of a transdermal testosterone system in men with end stage renal disease receiving maintenance hemodialysis and healthy hypogonadal men J Clin Endocrinol Metab 86 2001 2437 2445
12. A. Schmidt, A. Luger, W.H. Horl Sexual hormone abnormalities in male patients with renal failure Nephrol Dial Transplant 17 2002 368 371
13. C.A. Johnson Use of androgens in patients with renal failure Semin Dial 13 2000 36 39
14. W.J. Gaughan, K.A. Liss, S.R. Dunn A 6-month study of low-dose recombinant human erythropoietin alone and in combination with androgens for the treatment of anemia in chronic hemodialysis patients Am J Kidney Dis 30 1997 495 500
15. C. Steidle, S. Schwartz, K. Jacoby, T. Sebree, T. Smith, R. Bachand AA2500 testosterone gel normalizes androgen levels in aging males with improvements in body composition and sexual function J Clin Endocrinol Metab 88 2003 2673 2681
16. T.A. McNicholas, J.D. Dean, H. Mulder, C. Carnegie, N.A. Jones A novel testosterone gel formulation normalizes androgen levels in hypogonadal men, with improvements in body composition and sexual function BJU Int 91 2003 69 74
17. C. Wang, G. Alexander, N. Berman Testosterone replacement therapy improves mood in hypogonadal men - A clinical research center study J Clin Endocrinol Metab 81 1996 3578 3583
18. A. Vermeulen, L. Verdonck, J.M. Kaufman A critical evaluation of simple methods for the estimation of free testosterone in serum J Clin Endocrinol Metab 84 1999 3666 3672
19. A. Barton Pai, C. Chretien, A.H. Lau The effects of nandrolone decanoate on nutritional parameters in hemodialysis patients Clin Nephrol 58 2002 38 46
20. T. Marbury, E. Hamill, R. Bachand, T. Sebree, T. Smith Evaluation of the pharmacokinetic profiles of the new testosterone topical gel formulation, Testim, compared to AndroGel Biopharm Drug Dispos 24 2003 115 120
21. C.P. de Vries, L.J. Gooren, P.L. Oe Haemodialysis and testicular function Int J Androl 7 1984 97 103
22. M. Stewart-Bentley, D. Gans, R. Horton Regulation of gonadal function in uremia Metabolism 23 1974 1065 1072
23. M.S. Neff, J. Goldberg, R.F. Slifkin A comparison of androgens for anemia in patients on hemodialysis N Engl J Med 304 1981 871 875
24. K.L. Johansen, K. Mulligan, M. Schambelan Anabolic effects of nandrolone decanoate in patients receiving dialysis A randomized controlled trial JAMA 281 1999 1275 1281
25. C. Wang, D.R. Eyre, R. Clark Sublingual testosterone replacement improves muscle mass and strength, decreases bone resorption, and increases bone formation markers in hypogonadal men - A clinical research center study J Clin Endocrinol Metab 81 1996 3654 3662
26. R.T. Chopp, R. Mendez Sexual function and hormonal abnormalities in uremic men on chronic dialysis and after renal transplantation Fertil Steril 29 1978 661 666
27. K.L. Johansen Testosterone metabolism and replacement therapy in patients with end-stage renal disease Semin Dial 17 2004 202 208
28. J.E. Morley, E. Charlton, P. Patrick Validation of a screening questionnaire for androgen deficiency in aging males Metabolism 49 2000 1239 1242
29. J.L. Teruel, A. Aguilera, C. Avila, J. Ortuno Effects of androgen therapy on prostatic markers in hemodialyzed patients Scand J Urol Nephrol 30 1996 129 131
30. J.L. Teruel, M.A. Lasuncion, M. Rivera Nandrolone decanoate reduces serum lipoprotein(a) concentrations in hemodialysis patients Am J Kidney Dis 29 1997 569 575
31. S. Hulley, D. Grady, T. Bush Heart and Estrogen/progestin Replacement Study (HERS) Research Group Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women JAMA 280 1998 605 613
32. J.E. Rossouw, G.L. Anderson, R.L. Prentice Risks and benefits of estrogen plus progestin in healthy postmenopausal women Principal results from the Women's Health Initiative randomized controlled trial JAMA 288 2002 321 333
33. D.J. Handelsman, J.A. Spaliviero, J.R. Turtle Hypothalamic-pituitary function in experimental uremic hypogonadism Endocrinology 117 1985 1984 1995