메뉴 건너뛰기




Volumn 9, Issue 3, 2012, Pages 873-886

Concerns about serum androgens monitoring during testosterone replacement treatments in hypogonadal male athletes: A pilot study

Author keywords

Bioavailable Testosterone; DHT; Doping; Free Testosterone; Sport; Testosterone

Indexed keywords

ANDROGEN; ANDROSTANOLONE; ESTRADIOL; GLUCURONIDE; TESTOSTERONE; TESTOSTERONE ENANTATE;

EID: 84857646638     PISSN: 17436095     EISSN: 17436109     Source Type: Journal    
DOI: 10.1111/j.1743-6109.2011.02600.x     Document Type: Article
Times cited : (13)

References (50)
  • 1
    • 78650909514 scopus 로고    scopus 로고
    • Clinical review: Why is androgen replacement in males controversial?
    • Cunningham GR, Toma SM. Clinical review: Why is androgen replacement in males controversial? J Clin Endocrinol Metab 2011;96:38-52.
    • (2011) J Clin Endocrinol Metab , vol.96 , pp. 38-52
    • Cunningham, G.R.1    Toma, S.M.2
  • 2
    • 43549117911 scopus 로고    scopus 로고
    • Testosterone treatment of hypogonadal men participating in competitive sports
    • Gooren LJ, Behre HM. Testosterone treatment of hypogonadal men participating in competitive sports. Andrologia 2008;40:195-9.
    • (2008) Andrologia , vol.40 , pp. 195-199
    • Gooren, L.J.1    Behre, H.M.2
  • 3
    • 77955126164 scopus 로고    scopus 로고
    • Prevalence of undiagnosed testosterone deficiency in aging athletes: Does exercise training influence the symptoms of male hypogonadism?
    • Di Luigi L, Sgrò P, Fierro V, Bianchini S, Battistini G, Magini V, Jannini EA, Lenzi A. Prevalence of undiagnosed testosterone deficiency in aging athletes: Does exercise training influence the symptoms of male hypogonadism? J Sex Med 2010;7:2591-601.
    • (2010) J Sex Med , vol.7 , pp. 2591-2601
    • Di Luigi, L.1    Sgrò, P.2    Fierro, V.3    Bianchini, S.4    Battistini, G.5    Magini, V.6    Jannini, E.A.7    Lenzi, A.8
  • 4
    • 0346368461 scopus 로고    scopus 로고
    • Effects of androgen replacement on metabolism and physical performances in male hypogonadism
    • Zitzmann M, Nieschlag E. Effects of androgen replacement on metabolism and physical performances in male hypogonadism. J Endocrinol Invest 2003;26:886-92.
    • (2003) J Endocrinol Invest , vol.26 , pp. 886-892
    • Zitzmann, M.1    Nieschlag, E.2
  • 8
    • 78751610788 scopus 로고    scopus 로고
    • Two emerging concepts for elite athletes: The short-term effects of testosterone and cortisol on the neuromuscular system and the dose-response training role of these endogenous hormones
    • Crewther BT, Cook C, Cardinale M, Weatherby RP, Lowe T. Two emerging concepts for elite athletes: The short-term effects of testosterone and cortisol on the neuromuscular system and the dose-response training role of these endogenous hormones. Sports Med 2011;41:103-23.
    • (2011) Sports Med , vol.41 , pp. 103-123
    • Crewther, B.T.1    Cook, C.2    Cardinale, M.3    Weatherby, R.P.4    Lowe, T.5
  • 9
    • 31144445179 scopus 로고    scopus 로고
    • Male hypogonadism: An update on diagnosis and treatment
    • Darby E, Anawalt BD. Male hypogonadism: An update on diagnosis and treatment. Treat Endocrinol 2005;4:293-309.
    • (2005) Treat Endocrinol , vol.4 , pp. 293-309
    • Darby, E.1    Anawalt, B.D.2
  • 10
    • 33644780661 scopus 로고    scopus 로고
    • Male hypogonadism. Part I: Epidemiology of hypogonadism
    • Seftel AD. Male hypogonadism. Part I: Epidemiology of hypogonadism. Int J Impot Res 2006;18:115-20.
    • (2006) Int J Impot Res , vol.18 , pp. 115-120
    • Seftel, A.D.1
  • 12
    • 59849116257 scopus 로고    scopus 로고
    • Advances in testosterone replacement therapy
    • Gooren LJ. Advances in testosterone replacement therapy. Front Horm Res 2009;37:32-51.
    • (2009) Front Horm Res , vol.37 , pp. 32-51
    • Gooren, L.J.1
  • 13
    • 4544289803 scopus 로고    scopus 로고
    • Androgen replacement therapy: Present and future
    • Gooren LJ, Bunck MC. Androgen replacement therapy: Present and future. Drugs 2004;64:1861-91.
    • (2004) Drugs , vol.64 , pp. 1861-1891
    • Gooren, L.J.1    Bunck, M.C.2
  • 14
    • 33747356206 scopus 로고    scopus 로고
    • Testosterone treatment comes of age: New options for hypogonadal men
    • Nieschlag E. Testosterone treatment comes of age: New options for hypogonadal men. Clin Endocrinol 2006;65:275-81.
    • (2006) Clin Endocrinol , vol.65 , pp. 275-281
    • Nieschlag, E.1
  • 15
    • 33845926887 scopus 로고    scopus 로고
    • Testosterone replacement therapy: What we know is not yet enough
    • Isidori AM, Lenzi A. Testosterone replacement therapy: What we know is not yet enough. Mayo Clin Proc 2007;82:11-3.
    • (2007) Mayo Clin Proc , vol.82 , pp. 11-13
    • Isidori, A.M.1    Lenzi, A.2
  • 16
    • 23844481906 scopus 로고    scopus 로고
    • Androgenic-anabolic steroids abuse in males
    • Di Luigi L, Romanelli F, Lenzi A. Androgenic-anabolic steroids abuse in males. J Endocrinol Invest 2005;28(3 suppl):81-4.
    • (2005) J Endocrinol Invest , vol.28 , Issue.3 SUPPL. , pp. 81-84
    • Di Luigi, L.1    Romanelli, F.2    Lenzi, A.3
  • 17
    • 33745713621 scopus 로고    scopus 로고
    • The effect of anabolic steroids on the gastrointestinal system, kidneys, and adrenal glands
    • Modlinski R, Fields KB. The effect of anabolic steroids on the gastrointestinal system, kidneys, and adrenal glands. Curr Sports Med Rep 2006;5:104-9.
    • (2006) Curr Sports Med Rep , vol.5 , pp. 104-109
    • Modlinski, R.1    Fields, K.B.2
  • 18
    • 1642458222 scopus 로고    scopus 로고
    • Risks of testosterone-replacement therapy and recommendations for monitoring
    • Rhoden EL, Morgentaler A. Risks of testosterone-replacement therapy and recommendations for monitoring. N Engl J Med 2004;350:482-92.
    • (2004) N Engl J Med , vol.350 , pp. 482-492
    • Rhoden, E.L.1    Morgentaler, A.2
  • 19
    • 70350341475 scopus 로고    scopus 로고
    • Urinary and serum hormones profiles after testosterone enanthate administration in male hypogonadism: Concerns on the detection of doping with testosterone in treated hypogonadal athletes
    • Di Luigi L, Sgrò P, Romanelli F, Mazzarino M, Donati F, Braganò MC, Bianchini S, Fierro V, Casasco M, Botrè F, Lenzi A. Urinary and serum hormones profiles after testosterone enanthate administration in male hypogonadism: Concerns on the detection of doping with testosterone in treated hypogonadal athletes. J Endocrinol Invest 2009;32:445-53.
    • (2009) J Endocrinol Invest , vol.32 , pp. 445-453
    • Di Luigi, L.1    Sgrò, P.2    Romanelli, F.3    Mazzarino, M.4    Donati, F.5    Braganò, M.C.6    Bianchini, S.7    Fierro, V.8    Casasco, M.9    Botrè, F.10    Lenzi, A.11
  • 20
    • 2942541820 scopus 로고    scopus 로고
    • Effects of androgenic-anabolic steroids in athletes
    • Hartgens F, Kuipers H. Effects of androgenic-anabolic steroids in athletes. Sports Med 2004;34:513-54.
    • (2004) Sports Med , vol.34 , pp. 513-554
    • Hartgens, F.1    Kuipers, H.2
  • 21
    • 0033304555 scopus 로고    scopus 로고
    • Pharmacokinetics, efficacy, and safety of a permeation-enhanced testosterone transdermal system in comparison with bi-weekly injections of testosterone enanthate for the treatment of hypogonadal men
    • Dobs AS, Meikle AW, Arver S, Sanders SW, Caramelli KE, Mazer NA. Pharmacokinetics, efficacy, and safety of a permeation-enhanced testosterone transdermal system in comparison with bi-weekly injections of testosterone enanthate for the treatment of hypogonadal men. J Clin Endocrinol Metab 1999;84:3469-78.
    • (1999) J Clin Endocrinol Metab , vol.84 , pp. 3469-3478
    • Dobs, A.S.1    Meikle, A.W.2    Arver, S.3    Sanders, S.W.4    Caramelli, K.E.5    Mazer, N.A.6
  • 22
    • 0017096216 scopus 로고
    • Bioavailability and LH-suppressing effect of different testosterone preparations in normal and hypogonadal men
    • Nieschlag E, Cüppers HJ, Wiegelmann W, Wickings EJ. Bioavailability and LH-suppressing effect of different testosterone preparations in normal and hypogonadal men. Horm Res 1976;7:138-45.
    • (1976) Horm Res , vol.7 , pp. 138-145
    • Nieschlag, E.1    Cüppers, H.J.2    Wiegelmann, W.3    Wickings, E.J.4
  • 23
    • 0000915913 scopus 로고
    • Comparative pharmacokinetic of androgen preparations: Applications of computer analysis and simulation
    • Nieschlag E, Behre HM, eds. Berlin: Springer-Verlag
    • Behre HM, Nieschlag E. Comparative pharmacokinetic of androgen preparations: Applications of computer analysis and simulation. In: Nieschlag E, Behre HM, eds. Testosterone action, deficiency, substitution. Berlin: Springer-Verlag; 1990:115-35.
    • (1990) Testosterone action, deficiency, substitution , pp. 115-135
    • Behre, H.M.1    Nieschlag, E.2
  • 24
    • 0034453061 scopus 로고    scopus 로고
    • Pharmacokinetics of transdermal testosterone gel in hypogonadal men: Application of gel at one site versus four sites: A general clinical research center study
    • Wang C, Berman N, Longstreth JA, Chuapoco B, Hull L, Steiner B, Faulkner S, Dudley RE, Swerdloff RS. Pharmacokinetics of transdermal testosterone gel in hypogonadal men: Application of gel at one site versus four sites: A general clinical research center study. J Clin Endocrinol Metab 2000;85:964-9.
    • (2000) J Clin Endocrinol Metab , vol.85 , pp. 964-969
    • Wang, C.1    Berman, N.2    Longstreth, J.A.3    Chuapoco, B.4    Hull, L.5    Steiner, B.6    Faulkner, S.7    Dudley, R.E.8    Swerdloff, R.S.9
  • 25
    • 33646573358 scopus 로고    scopus 로고
    • Male hypogonadism. Part II: Etiology, pathophysiology, and diagnosis
    • Seftel A. Male hypogonadism. Part II: Etiology, pathophysiology, and diagnosis. Int J Impot Res 2006;18:223-8.
    • (2006) Int J Impot Res , vol.18 , pp. 223-228
    • Seftel, A.1
  • 28
    • 0020417830 scopus 로고
    • Calculation of free and bound fractions of testosterone and estradiol-17β to human plasma proteins at body temperature
    • Sodergard R, Backstrom T, Shanbhag V, Carstensen H. Calculation of free and bound fractions of testosterone and estradiol-17β to human plasma proteins at body temperature. J Steroid Biochem 1982;16:801-10.
    • (1982) J Steroid Biochem , vol.16 , pp. 801-810
    • Sodergard, R.1    Backstrom, T.2    Shanbhag, V.3    Carstensen, H.4
  • 29
    • 0033305020 scopus 로고    scopus 로고
    • A critical evaluation of simple methods for the estimation of free testosterone in serum
    • Vermeulen A, Verdonck L, Kaufman JM. A critical evaluation of simple methods for the estimation of free testosterone in serum. J Clin Endocrinol Metab 1999;84:3666-72.
    • (1999) J Clin Endocrinol Metab , vol.84 , pp. 3666-3672
    • Vermeulen, A.1    Verdonck, L.2    Kaufman, J.M.3
  • 30
    • 33751108255 scopus 로고    scopus 로고
    • A fast liquid chromatographic/mass spectrometric screening method for the simultaneous detection of synthetic glucocorticoids, some stimulants, anti-oestrogen drugs and synthetic anabolic steroids
    • Mazzarino M, Botrè F. A fast liquid chromatographic/mass spectrometric screening method for the simultaneous detection of synthetic glucocorticoids, some stimulants, anti-oestrogen drugs and synthetic anabolic steroids. Rapid Commun Mass Spectrom 2006;20:3465-76.
    • (2006) Rapid Commun Mass Spectrom , vol.20 , pp. 3465-3476
    • Mazzarino, M.1    Botrè, F.2
  • 31
    • 73249146256 scopus 로고    scopus 로고
    • Reference ranges for urinary concentrations and ratios of endogenous steroids, which can be used as markers for steroid misuse, in a Caucasian population of athletes
    • Van Renterghem P, Van Eenoo P, Geyer H, Schänzer W, Delbeke FT. Reference ranges for urinary concentrations and ratios of endogenous steroids, which can be used as markers for steroid misuse, in a Caucasian population of athletes. Steroids 2010;75:154-63.
    • (2010) Steroids , vol.75 , pp. 154-163
    • Van Renterghem, P.1    Van Eenoo, P.2    Geyer, H.3    Schänzer, W.4    Delbeke, F.T.5
  • 32
    • 58649099845 scopus 로고    scopus 로고
    • Effects of endurance exercise on the reproductive system of men: The "exercise-hypogonadal male condition"
    • Hackney AC. Effects of endurance exercise on the reproductive system of men: The "exercise-hypogonadal male condition". J Endocrinol Invest 2008;31:932-8.
    • (2008) J Endocrinol Invest , vol.31 , pp. 932-938
    • Hackney, A.C.1
  • 35
    • 0036099106 scopus 로고    scopus 로고
    • Pharmacokinetics of a new transdermal testosterone gel in gonadotrophin-suppressed normal men
    • Rolf C, Kemper S, Lemmnitz G, Eickenberg U, Nieschlag E. Pharmacokinetics of a new transdermal testosterone gel in gonadotrophin-suppressed normal men. Eur J Endocrinol 2002;146:673-9.
    • (2002) Eur J Endocrinol , vol.146 , pp. 673-679
    • Rolf, C.1    Kemper, S.2    Lemmnitz, G.3    Eickenberg, U.4    Nieschlag, E.5
  • 36
    • 33644912036 scopus 로고    scopus 로고
    • Pharmacokinetics of a new testosterone transdermal delivery system, TDS-testosterone in healthy males
    • Chik Z, Johnston A, Tucker AT, Chew SL, Michaels L, Alam CA. Pharmacokinetics of a new testosterone transdermal delivery system, TDS-testosterone in healthy males. Br J Clin Pharmacol 2006;61:275-9.
    • (2006) Br J Clin Pharmacol , vol.61 , pp. 275-279
    • Chik, Z.1    Johnston, A.2    Tucker, A.T.3    Chew, S.L.4    Michaels, L.5    Alam, C.A.6
  • 37
    • 0019159310 scopus 로고
    • Treatment of male hypogonadism with testosterone enanthate
    • Snyder PJ, Lawrence DA. Treatment of male hypogonadism with testosterone enanthate. J Clin Endocrinol Metab 1980;51:1335-9.
    • (1980) J Clin Endocrinol Metab , vol.51 , pp. 1335-1339
    • Snyder, P.J.1    Lawrence, D.A.2
  • 40
    • 0027401767 scopus 로고
    • Long-term administration of testosterone enanthate to normal men: Alterations of the urinary profile of androgen metabolites potentially useful for detection of testosterone misuse in sport
    • Dehennin L, Matsumoto AM. Long-term administration of testosterone enanthate to normal men: Alterations of the urinary profile of androgen metabolites potentially useful for detection of testosterone misuse in sport. J Steroid Biochem Mol Biol 1993;44:179-89.
    • (1993) J Steroid Biochem Mol Biol , vol.44 , pp. 179-189
    • Dehennin, L.1    Matsumoto, A.M.2
  • 43
    • 0036220738 scopus 로고    scopus 로고
    • Treatment of male hypogonadism with testosterone undecanoate injected at extended intervals of 12 weeks: A phase II study
    • von Eckardstein S, Nieschlag E. Treatment of male hypogonadism with testosterone undecanoate injected at extended intervals of 12 weeks: A phase II study. J Androl 2002;23:419-25.
    • (2002) J Androl , vol.23 , pp. 419-425
    • von Eckardstein, S.1    Nieschlag, E.2
  • 44
    • 77953760547 scopus 로고    scopus 로고
    • Randomized cross-over clinical trial of injectable vs. implantable depot testosterone for maintenance of testosterone replacement therapy in androgen deficient men
    • Fennell C, Sartorius G, Ly LP, Turner L, Liu PY, Conway AJ, Handelsman DJ. Randomized cross-over clinical trial of injectable vs. implantable depot testosterone for maintenance of testosterone replacement therapy in androgen deficient men. Clin Endocrinol (Oxf) 2010;73:102-9.
    • (2010) Clin Endocrinol (Oxf) , vol.73 , pp. 102-109
    • Fennell, C.1    Sartorius, G.2    Ly, L.P.3    Turner, L.4    Liu, P.Y.5    Conway, A.J.6    Handelsman, D.J.7
  • 45
    • 35348829162 scopus 로고    scopus 로고
    • Plasma levels of dihydrotestosterone remain in the normal range in men treated with long-acting parenteral testosterone undecanoate
    • Yassin AA, Saad F. Plasma levels of dihydrotestosterone remain in the normal range in men treated with long-acting parenteral testosterone undecanoate. Andrologia 2007;39:181-4.
    • (2007) Andrologia , vol.39 , pp. 181-184
    • Yassin, A.A.1    Saad, F.2
  • 47
    • 80054827093 scopus 로고    scopus 로고
    • Onset of effects of testosterone treatment and time span until maximum effects are achieved
    • Saad F, Aversa A, Isidori AM, Zafalon L, Zitzmann M, Gooren LJ. Onset of effects of testosterone treatment and time span until maximum effects are achieved. Eur J Endocrinol 2011;165:675-85.
    • (2011) Eur J Endocrinol , vol.165 , pp. 675-685
    • Saad, F.1    Aversa, A.2    Isidori, A.M.3    Zafalon, L.4    Zitzmann, M.5    Gooren, L.J.6
  • 48
    • 79958839781 scopus 로고    scopus 로고
    • A pilot study on subject-based comprehensive steroid profiling: Novel biomarkers to detect testosterone misuse in sports
    • Van Renterghem P, Van Eenoo P, Sottas PE, Saugy M, Delbeke F. A pilot study on subject-based comprehensive steroid profiling: Novel biomarkers to detect testosterone misuse in sports. Clin Endocrinol (Oxf) 2011;75:134-40.
    • (2011) Clin Endocrinol (Oxf) , vol.75 , pp. 134-140
    • Van Renterghem, P.1    Van Eenoo, P.2    Sottas, P.E.3    Saugy, M.4    Delbeke, F.5
  • 49
    • 74049162428 scopus 로고    scopus 로고
    • Endogenous steroid profiling in the athlete biological passport
    • Sottas PE, Saugy M, Saudan C. Endogenous steroid profiling in the athlete biological passport. Endocrinol Metab Clin North Am 2010;39:59-73.
    • (2010) Endocrinol Metab Clin North Am , vol.39 , pp. 59-73
    • Sottas, P.E.1    Saugy, M.2    Saudan, C.3
  • 50
    • 47549100005 scopus 로고    scopus 로고
    • Testosterone doping: Dealing with genetic differences in metabolism and excretion
    • Bowers LD. Testosterone doping: Dealing with genetic differences in metabolism and excretion. J Clin Endocrinol Metab 2008;93:2469-71.
    • (2008) J Clin Endocrinol Metab , vol.93 , pp. 2469-2471
    • Bowers, L.D.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.