Double-blind placebo-controlled study of testosterone patch therapy on bone turnover in men with borderline hypogonadism

International Journal of Andrology

Volumn 29, Issue 3, 2006, Pages 381-391

  Merza, Z ^a   Blumsohn, A ^a   Mah, P M ^a   Meads, D M ^b   McKenna, S P ^b   Wylie, K ^c   Eastell, R ^a   Wu, F ^d   Ross, R J M ^a  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

^b GALEN RESEARCH   (United Kingdom)

^c ROYAL HALLAMSHIRE HOSPITAL   (United Kingdom)

^d UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Andropause; Body composition; Bone turnover; Erectile dysfunction; Testosterone

Indexed keywords

ANDROGEN; ESTRADIOL; FOLLITROPIN; LUTEINIZING HORMONE; PLACEBO; SEX HORMONE BINDING GLOBULIN; SILDENAFIL; TESTODERM TTS; TESTOSTERONE;

ADULT; AGED; ARTICLE; BODY FAT; BONE DENSITY; BONE DEVELOPMENT; BONE MINERAL; BONE TURNOVER; BORDERLINE HYPOGONADISM; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DETERIORATION; DOUBLE BLIND PROCEDURE; ERECTILE DYSFUNCTION; HEMOGLOBIN DETERMINATION; HORMONE SUBSTITUTION; HUMAN; HYPERHEMOGLOBINEMIA; HYPOGONADISM; LEAN BODY WEIGHT; MALE; OPEN STUDY; PRIORITY JOURNAL; PSYCHOLOGICAL ASPECT; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL; SEXUAL DYSFUNCTION; STATISTICAL SIGNIFICANCE; TESTOSTERONE BLOOD LEVEL;

ADIPOSE TISSUE; ADMINISTRATION, TOPICAL; AGED; ANDROGENS; BODY COMPOSITION; BONE DENSITY; BONE REMODELING; DOUBLE-BLIND METHOD; ESTRADIOL; FOLLICLE STIMULATING HORMONE; HUMANS; HYPOGONADISM; LUTEINIZING HORMONE; MALE; MIDDLE AGED; PATIENT DROPOUTS; PLACEBOS; QUALITY OF LIFE; SEVERITY OF ILLNESS INDEX; SEXUAL DYSFUNCTION, PHYSIOLOGICAL; TESTOSTERONE;

EID: 33646711687     PISSN: 01056263     EISSN: 13652605     Source Type: Journal    
DOI: 10.1111/j.1365-2605.2005.00612.x     Document Type: Article

References (39)

1. Amory J. K. Watts N. B. Easley K. A. Sutton P. R. Anawalt B. D. Matsumoto A. M. Bremner W. J. Tenover J. L. 2004 Exogenous testosterone or testosterone with finasteride increases bone mineral density in older men with low serum testosterone Journal of Clinical Endocrinology and Metabolism 89 503 510
2. Arver S. Dobs A. S. Meikle A. W. Allen R. P. Sanders S. W. Mazer N. A. 1996 Improvement of sexual function in testosterone deficient men treated for 1 year with a permeation enhanced testosterone transdermal system Journal of Urology 155 1604 1608
3. Behre H. M. Bohmeyer J. Nieschlag E. 1994 Prostate volume in testosterone-treated and untreated hypogonadal men in comparison to age-matched normal controls Clinical Endocrinology (Oxf) 40 341 349
4. Buena F. Swerdloff R. S. Steiner B. S. Lutchmansingh P. Peterson M. A. Pandian M. R. Galmarini M. Bhasin S. 1993 Sexual function does not change when serum testosterone levels are pharmacologically varied within the normal male range Fertility and Sterility 59 1118 1123
5. Colvard D. S. Eriksen E. F. Keeting P. E. Wilson E. M. Lubahn D. B. French F. S. Riggs B. L. Spelsberg T. C. 1989 Identification of androgen receptors in normal human osteoblast-like cells Proceedings of the National Academy of Sciences of the United States of America 86 854 857
6. Davidson J. M. Camargo C. A. Smith E. R. 1979 Effects of androgen on sexual behavior in hypogonadal men Journal of Clinical Endocrinology and Metabolism 48 955 958
7. Dupuy H. 1984 The Psychological General Well-Being Index In Assessment of Quality of Life in Clinical Trials of Cardiovascular Therapies eds N. Wenger M. Mattson C. Furberg J. Elinson pp 170 183 Le Jacq Publishing Company New York
8. Falahati-Nini A. Riggs B. L. Atkinson E. J. O'Fallon W. M. Eastell R. Khosla S. 2000 Relative contributions of testosterone and estrogen in regulating bone resorption and formation in normal elderly men Journal of Clinical Investigations 106 1553 1560
9. Finkelstein J. S. Klibanski A. Neer R. M. Doppelt S. H. Rosenthal D. I. Segre G. V. Crowley W. F. Jr 1989 Increases in bone density during treatment of men with idiopathic hypogonadotropic hypogonadism Journal of Clinical Endocrinology and Metabolism 69 776 783
10. Gooren L. 1988 Hypogonadotropic hypogonadal men respond less well to androgen substitution treatment than hypergonadotropic hypogonadal men Archives of Sexual Behaviour 17 265 270
11. Gray P. B. Singh A. B. Woodhouse L. J. Storer T. W. Casaburi R. Dzekov J. Dzekov C. Sinha-Hikim I. Bhasin S. 2005 Dose-dependent effects of testosterone on sexual function, mood, and visuospatial cognition in older men Journal of Clinical Endocrinology and Metabolism 90 3838 3846
12. Guo C. Y. Jones T. H. Eastell R. 1997 Treatment of isolated hypogonadotropic hypogonadism effect on bone mineral density and bone turnover Journal of Clinical Endocrinology and Metabolism 82 658 665
13. Hannon R. Blumsohn A. Naylor K. Eastell R. 1998 Response of biochemical markers of bone turnover to hormone replacement therapy: impact of biological variability Journal of Bone & Mineral Research 13 1124 1133
14. Katznelson L. Finkelstein J. S. Schoenfeld D. A. Rosenthal D. I. Anderson E. J. Klibanski A. 1996 Increase in bone density and lean body mass during testosterone administration in men with acquired hypogonadism Journal of Clinical Endocrinology and Metabolism 81 4358 4365
15. Kelleher S. Conway A. J. Handelsman D. J. 2004 Blood testosterone threshold for androgen deficiency symptoms Journal of Clinical Endocrinology and Metabolism 89 3813 3817
16. Kenny A. M. Prestwood K. M. Gruman C. A. Marcello K. M. Raisz L. G. 2001 Effects of transdermal testosterone on bone and muscle in older men with low bioavailable testosterone levels The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences 56 M266 M272
17. Khosla S. Melton L. J. III Atkinson E. J. O'Fallon W. M. Klee G. G. Riggs B. L. 1998 Relationship of serum sex steroid levels and bone turnover markers with bone mineral density in men and women: a key role for bioavailable estrogen. Journal of Clinical Endocrinology and Metabolism 83 2266 2274
18. Lands L. C. Hornby L. Hohenkerk J. M. Glorieux F. H. 1996 Accuracy of measurements of small changes in soft-tissue mass by dual-energy x-ray absorptiometry Clinical and Investigative Medicine 19 279 285
19. Morales A. Johnston B. Heaton J. P. Lundie M. 1997 Testosterone supplementation for hypogonadal impotence: assessment of biochemical measures and therapeutic outcomes Journal of Urology 157 849 854
20. Munzer T. Harman S. M. Hees P. Shapiro E. Christmas C. Bellantoni M. F. et al. 2001 Effects of GH and/or sex steroid administration on abdominal subcutaneous and visceral fat in healthy aged women and men Journal of Clinical Endocrinology and Metabolism 86 3604 3610
21. O'Carroll R. Bancroft J. 1984 Testosterone therapy for low sexual interest and erectile dysfunction in men: a controlled study British Journal of Psychiatry 145 146 151
22. O'Carroll R. Shapiro C. Bancroft J. 1985 Androgens, behaviour and nocturnal erection in hypogonadal men: the effects of varying the replacement dose Clinical Endocrinology 23 527 538
23. O'Connor D. B. Archer J. Hair W. M. Wu F. C. 2002 Exogenous testosterone, aggression, and mood in eugonadal and hypogonadal men Physiology & Behavior 75 557 566
24. Perry P. J. Lund B. C. Arndt S. Holman T. Bever-Stille K. A. Paulsen J. Demers L. M. 2001 Bioavailable testosterone as a correlate of cognition, psychological status, quality of life, and sexual function in aging males: implications for testosterone replacement therapy Annals of Clinical Psychiatry 13 75 80
25. Rhoden E. L. Morgentaler A. 2004 Risks of testosterone-replacement therapy and recommendations for monitoring New England Journal of Medicine 350 482 492
26. Salmimies P. Kockott G. Pirke K. M. Vogt H. J. Schill W. B. 1982 Effects of testosterone replacement on sexual behavior in hypogonadal men Archives of Sexual Behaviour 11 345 353
27. Schiavi R. C. White D. Mandeli J. Levine A. C. 1997 Effect of testosterone administration on sexual behavior and mood in men with erectile dysfunction Archives of Sexual Behaviour 26 231 241
28. Seidman S. N. Spatz E. Rizzo C. Roose S. P. 2001 Testosterone replacement therapy for hypogonadal men with major depressive disorder: a randomised, placebo-controlled clinical trial Journal of Clinical Psychiatry 62 406 412
29. Sih R. Morley J. E. Kaiser F. E. Perry H. M. III. Patrick P. Ross C. 1997 Testosterone replacement in older hypogonadal men: a 12-month randomised controlled trial Journal of Clinical Endocrinology and Metabolism 82 1661 1667
30. Snyder P. J. 2004 Hypogonadism in elderly men - what to do until the evidence comes New England Journal of Medicine 350 440 442
31. Snyder P. J. Peachey H. Hannoush P. Berlin J. A. Loh L. Holmes J. H. et al. 1999a Effect of testosterone treatment on bone mineral density in men over 65 years of age Journal of Clinical Endocrinology and Metabolism 84 1966 1972
32. Snyder P. J. Peachey H. Hannoush P. Berlin J. A. Loh L. Lenrow D. A. et al. 1999b Effect of testosterone treatment on body composition and muscle strength in men over 65 years of age Journal of Clinical Endocrinology and Metabolism 84 2647 2653
33. Steidle C. Schwartz S. Jacoby K. Sebree T. Smith T. Bachand R. 2003 AA2500 testosterone gel normalizes androgen levels in aging males with improvements in body composition and sexual function Journal of Clinical Endocrinology and Metabolism 88 2673 2681
34. Vanderschueren D. Vandenput L. Boonen S. Lindberg M. K. Bouillon R. Ohlsson C. 2004 Androgens and bone Endocrine Reviews 25 389 425
35. Wagner T. H. Patrick D. L. McKenna S. P. Froese M. A. 1996 Cross-cultural development of a quality of life measure for men with erection difficulties Quality of Life Research 5 443 449
36. Wang C. Eyre D. R. Clark R. Kleinberg D. Newman C. Iranmanesh A. et al. 1996 Sublingual testosterone replacement improves muscle mass and strength, decreases bone resorption, and increases bone formation markers in hypogonadal men - a clinical research center study Journal of Clinical Endocrinology and Metabolism 81 3654 3662
37. Wang C. Swedloff R. S. Iranmanesh A. Dobs A. Snyder P. J. Cunningham G. Matsumoto A. M. Weber T. Berman N. 2000 Transdermal testosterone gel improves sexual function, mood, muscle strength, and body composition parameters in hypogonadal men. Testosterone Gel Study Group Journal of Clinical Endocrinology and Metabolism 85 2839 2853
38. Wang C. Swerdloff R. S. Iranmanesh A. Dobs A. Snyder P. J. Cunningham G. Matsumoto A. M. Weber T. Berman N. 2001 Effects of transdermal testosterone gel on bone turnover markers and bone mineral density in hypogonadal men Clinical Endocrinology 54 739 750
39. Wang C. Cunningham G. Dobs A. Iranmanesh A. Matsumoto A. M. Snyder P. J. Weber T. Berman N. Hull L. Swerdloff R. S. 2004 Long-term testosterone gel (AndroGel) treatment maintains beneficial effects on sexual function and mood, lean and fat mass, and bone mineral density in hypogonadal men Journal of Clinical Endocrinology and Metabolism 89 2085 2098