메뉴 건너뛰기




Volumn 5, Issue , 2015, Pages

Trans-splicing repair of mutant p53 suppresses the growth of hepatocellular carcinoma cells in vitro and in vivo

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CYCLINE; MESSENGER RNA; PROTEIN BAX; PROTEIN MDM2; PROTEIN P53;

EID: 84924105597     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep08705     Document Type: Article
Times cited : (29)

References (51)
  • 2
    • 28844480321 scopus 로고    scopus 로고
    • Management of hepatocellular carcinoma
    • Bruix, J.&Sherman, M. Management of hepatocellular carcinoma. Hepatology 42, 1208-1236 (2005).
    • (2005) Hepatology , vol.42 , pp. 1208-1236
    • Bruix, J.1    Sherman, M.2
  • 3
    • 75349084543 scopus 로고    scopus 로고
    • Risk of HCC: Genetic heterogeneity and complex genetics
    • Dragani, T. A. Risk of HCC: genetic heterogeneity and complex genetics. Journal of hepatology 52, 252-257 (2010).
    • (2010) Journal of Hepatology , vol.52 , pp. 252-257
    • Dragani, T.A.1
  • 5
    • 41849083418 scopus 로고    scopus 로고
    • Tumor suppressor and hepatocellular carcinoma
    • Martin, J. & Dufour, J. F. Tumor suppressor and hepatocellular carcinoma. World J Gastroenterol 14, 1720-1733 (2008).
    • (2008) World J Gastroenterol , vol.14 , pp. 1720-1733
    • Martin, J.1    Dufour, J.F.2
  • 6
  • 7
    • 37349114629 scopus 로고    scopus 로고
    • P53-master and commander
    • Foulkes, W. D. p53-master and commander. NEngl J Med 357, 2539-2541 (2007).
    • (2007) NEngl J Med , vol.357 , pp. 2539-2541
    • Foulkes, W.D.1
  • 8
    • 65549120715 scopus 로고    scopus 로고
    • Modes of p53 regulation
    • Kruse, J. P. & Gu, W. Modes of p53 regulation. Cell 137, 609-622 (2009).
    • (2009) Cell , vol.137 , pp. 609-622
    • Kruse, J.P.1    Gu, W.2
  • 11
    • 0345275881 scopus 로고    scopus 로고
    • Mouse models to study the interaction of risk factors for human liver cancer
    • Sell, S. Mouse models to study the interaction of risk factors for human liver cancer. Cancer Res 63, 7553-7562 (2003).
    • (2003) Cancer Res , vol.63 , pp. 7553-7562
    • Sell, S.1
  • 12
    • 58149376548 scopus 로고    scopus 로고
    • Molecular mechanisms of hepatocellular carcinoma
    • Aravalli, R. N., Steer, C. J. & Cressman, E. N. Molecular mechanisms of hepatocellular carcinoma. Hepatology 48, 2047-2063 (2008).
    • (2008) Hepatology , vol.48 , pp. 2047-2063
    • Aravalli, R.N.1    Steer, C.J.2    Cressman, E.N.3
  • 13
    • 84866740163 scopus 로고    scopus 로고
    • Alterations of TP53 are associated with a poor outcome for patients with hepatocellular carcinoma: Evidence from a systematic review and metaanalysis
    • Liu, J. et al. Alterations of TP53 are associated with a poor outcome for patients with hepatocellular carcinoma: evidence from a systematic review and metaanalysis. Eur J Cancer 48, 2328-2338 (2012).
    • (2012) Eur J Cancer , vol.48 , pp. 2328-2338
    • Liu, J.1
  • 14
    • 34047224955 scopus 로고    scopus 로고
    • Structure-function-rescue: The diverse nature of common p53 cancer mutants
    • Joerger, A. C. & Fersht, A. R. Structure-function-rescue: the diverse nature of common p53 cancer mutants. Oncogene 26, 2226-2242 (2007).
    • (2007) Oncogene , vol.26 , pp. 2226-2242
    • Joerger, A.C.1    Fersht, A.R.2
  • 15
    • 84862636275 scopus 로고    scopus 로고
    • Mutant p53: One name, many proteins
    • Freed-Pastor, W. A. & Prives, C.Mutant p53: one name, many proteins. Genes & development 26, 1268-1286 (2012).
    • (2012) Genes & Development , vol.26 , pp. 1268-1286
    • Freed-Pastor, W.A.1    Prives, C.2
  • 16
    • 33847366186 scopus 로고    scopus 로고
    • Restoration of wild-type p53 function in human cancer: Relevance for tumor therapy
    • Bossi, G. & Sacchi, A. Restoration of wild-type p53 function in human cancer: relevance for tumor therapy. Head Neck 29, 272-284 (2007).
    • (2007) Head Neck , vol.29 , pp. 272-284
    • Bossi, G.1    Sacchi, A.2
  • 17
    • 34047209861 scopus 로고    scopus 로고
    • Reactivation of mutant p53: Molecular mechanisms and therapeutic potential
    • Selivanova, G. & Wiman, K. G. Reactivation of mutant p53: molecular mechanisms and therapeutic potential. Oncogene 26, 2243-2254 (2007).
    • (2007) Oncogene , vol.26 , pp. 2243-2254
    • Selivanova, G.1    Wiman, K.G.2
  • 19
    • 33845638436 scopus 로고    scopus 로고
    • P53-based cancer therapies: Is defective p53 the Achilles heel of the tumor?
    • Levesque, A. A. & Eastman, A. p53-based cancer therapies: Is defective p53 the Achilles heel of the tumor? Carcinogenesis 28, 13-20 (2007).
    • (2007) Carcinogenesis , vol.28 , pp. 13-20
    • Levesque, A.A.1    Eastman, A.2
  • 20
    • 80052664208 scopus 로고    scopus 로고
    • Recent advances in p53 research and cancer treatment
    • Suzuki, K.&Matsubara, H. Recent advances in p53 research and cancer treatment. J Biomed Biotechnol 2011, 978312 (2011).
    • (2011) J Biomed Biotechnol , vol.2011 , pp. 978312
    • Suzuki, K.1    Matsubara, H.2
  • 21
    • 28444453994 scopus 로고    scopus 로고
    • Spliceosome-mediated RNA trans-splicing
    • Yang, Y. &Walsh, C. E. Spliceosome-mediated RNA trans-splicing. Mol Ther 12, 1006-1012 (2005).
    • (2005) Mol Ther , vol.12 , pp. 1006-1012
    • Yang, Y.1    Walsh, C.E.2
  • 22
    • 34347330301 scopus 로고    scopus 로고
    • Modulating the expression of disease genes with RNA-based therapy
    • Wood, M., Yin, H. & McClorey, G. Modulating the expression of disease genes with RNA-based therapy. PLoS Genet 3, e109 (2007).
    • (2007) PLoS Genet , vol.3 , pp. e109
    • Wood, M.1    Yin, H.2    McClorey, G.3
  • 23
    • 9244230654 scopus 로고    scopus 로고
    • Genetic medicine at the RNA level: Modifications of the genetic repertoire for therapeutic purposes by pre-mRNA trans-splicing
    • Pergolizzi, R. G. & Crystal, R. G. Genetic medicine at the RNA level: modifications of the genetic repertoire for therapeutic purposes by pre-mRNA trans-splicing. C R Biol 327, 695-709 (2004).
    • (2004) C R Biol , vol.327 , pp. 695-709
    • Pergolizzi, R.G.1    Crystal, R.G.2
  • 24
    • 33645127443 scopus 로고    scopus 로고
    • Genetic medicines: Treatment strategies for hereditary disorders
    • O'Connor, T. P. & Crystal, R. G. Genetic medicines: treatment strategies for hereditary disorders. Nat Rev Genet 7, 261-276 (2006).
    • (2006) Nat Rev Genet , vol.7 , pp. 261-276
    • O'connor, T.P.1    Crystal, R.G.2
  • 26
    • 69149089025 scopus 로고    scopus 로고
    • 30 years and a long way into p53 research
    • Hainaut, P. & Wiman, K. G. 30 years and a long way into p53 research. Lancet Oncol 10, 913-919 (2009).
    • (2009) Lancet Oncol , vol.10 , pp. 913-919
    • Hainaut, P.1    Wiman, K.G.2
  • 28
    • 9544244796 scopus 로고    scopus 로고
    • Retrovirus-mediated wild-type p53 gene transfer to tumors of patients with lung cancer
    • Roth, J. A. et al. Retrovirus-mediated wild-type p53 gene transfer to tumors of patients with lung cancer. Nat Med 2, 985-991 (1996).
    • (1996) Nat Med , vol.2 , pp. 985-991
    • Roth, J.A.1
  • 29
    • 33751562430 scopus 로고    scopus 로고
    • Chinese gene therapy. Splicing out the West?
    • Guo, J. & Xin, H. Chinese gene therapy. Splicing out the West? Science 314, 1232-1235 (2006).
    • (2006) Science , vol.314 , pp. 1232-1235
    • Guo, J.1    Xin, H.2
  • 30
    • 33744529601 scopus 로고    scopus 로고
    • Phase I/II adenoviral p53 gene therapy for chemoradiation resistant advanced esophageal squamous cell carcinoma
    • Shimada, H. et al. Phase I/II adenoviral p53 gene therapy for chemoradiation resistant advanced esophageal squamous cell carcinoma. Cancer science 97, 554-561 (2006).
    • (2006) Cancer Science , vol.97 , pp. 554-561
    • Shimada, H.1
  • 31
    • 30944435091 scopus 로고    scopus 로고
    • Unleashing the power of p53: Lessons from mice and men
    • Poyurovsky, M. V. & Prives, C. Unleashing the power of p53: lessons from mice and men. Genes & development 20, 125-131 (2006).
    • (2006) Genes & Development , vol.20 , pp. 125-131
    • Poyurovsky, M.V.1    Prives, C.2
  • 32
    • 70350567735 scopus 로고    scopus 로고
    • 20 years studying p53 functions in genetically engineered mice
    • Donehower, L. A. & Lozano, G. 20 years studying p53 functions in genetically engineered mice. Nature reviews. Cancer 9, 831-841 (2009).
    • (2009) Nature Reviews. Cancer , vol.9 , pp. 831-841
    • Donehower, L.A.1    Lozano, G.2
  • 33
    • 0037011958 scopus 로고    scopus 로고
    • P53 mutant mice that display early ageing-associated phenotypes
    • Tyner, S. D. et al. p53 mutant mice that display early ageing-associated phenotypes. Nature 415, 45-53 (2002).
    • (2002) Nature , vol.415 , pp. 45-53
    • Tyner, S.D.1
  • 34
    • 47249116180 scopus 로고    scopus 로고
    • Conditional RNA interference in vivo to study mutant p53 oncogenic gain of function on tumor malignancy
    • Bossi, G. et al. Conditional RNA interference in vivo to study mutant p53 oncogenic gain of function on tumor malignancy. Cell Cycle 7, 1870-1879 (2008).
    • (2008) Cell Cycle , vol.7 , pp. 1870-1879
    • Bossi, G.1
  • 35
    • 84872811756 scopus 로고    scopus 로고
    • Silencing of mutant p53 by siRNA induces cell cycle arrest and apoptosis in human bladder cancer cells
    • Zhu, H. B. et al. Silencing of mutant p53 by siRNA induces cell cycle arrest and apoptosis in human bladder cancer cells. World journal of surgical oncology 11, 22 (2013).
    • (2013) World Journal of Surgical Oncology , vol.11 , pp. 22
    • Zhu, H.B.1
  • 36
    • 30544452870 scopus 로고    scopus 로고
    • Mutant p53 gain of function: Reduction of tumor malignancy of human cancer cell lines through abrogation of mutant p53 expression
    • Bossi, G. et al. Mutant p53 gain of function: reduction of tumor malignancy of human cancer cell lines through abrogation of mutant p53 expression. Oncogene 25, 304-309 (2006).
    • (2006) Oncogene , vol.25 , pp. 304-309
    • Bossi, G.1
  • 37
    • 0034682505 scopus 로고    scopus 로고
    • Induction of wild-type p53 activity in human cancer cells by ribozymes that repair mutant p53 transcripts
    • Watanabe, T. & Sullenger, B. A. Induction of wild-type p53 activity in human cancer cells by ribozymes that repair mutant p53 transcripts. Proc Natl Acad Sci U S A 97, 8490-8494 (2000).
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 8490-8494
    • Watanabe, T.1    Sullenger, B.A.2
  • 38
    • 4344614627 scopus 로고    scopus 로고
    • Ribozyme-mediated induction of apoptosis in human cancer cells by targeted repair of mutant p53 RNA
    • Shin, K. S., Sullenger, B. A. & Lee, S. W. Ribozyme-mediated induction of apoptosis in human cancer cells by targeted repair of mutant p53 RNA. Mol Ther 10, 365-372 (2004).
    • (2004) Mol Ther , vol.10 , pp. 365-372
    • Shin, K.S.1    Sullenger, B.A.2    Lee, S.W.3
  • 39
    • 0033674357 scopus 로고    scopus 로고
    • Repair of CFTR mRNA by spliceosome-mediated RNA trans-splicing
    • Mansfield, S. G. et al. Repair of CFTR mRNA by spliceosome-mediated RNA trans-splicing. Gene Ther 7, 1885-1895 (2000).
    • (2000) Gene Ther , vol.7 , pp. 1885-1895
    • Mansfield, S.G.1
  • 40
    • 0036137663 scopus 로고    scopus 로고
    • Partial correction of endogenous DeltaF508 CFTR in human cystic fibrosis airway epithelia by spliceosome-mediated RNA trans-splicing
    • Liu, X. et al. Partial correction of endogenous DeltaF508 CFTR in human cystic fibrosis airway epithelia by spliceosome-mediated RNA trans-splicing. Nat Biotechnol 20, 47-52 (2002).
    • (2002) Nat Biotechnol , vol.20 , pp. 47-52
    • Liu, X.1
  • 41
    • 0042388694 scopus 로고    scopus 로고
    • Phenotype correction of hemophilia A mice by spliceosomemediated RNA trans-splicing
    • Chao, H. et al. Phenotype correction of hemophilia A mice by spliceosomemediated RNA trans-splicing. Nat Med 9, 1015-1019 (2003).
    • (2003) Nat Med , vol.9 , pp. 1015-1019
    • Chao, H.1
  • 42
    • 4043179784 scopus 로고    scopus 로고
    • Trans-splicing repair of CD40 ligand deficiency results in naturally regulated correction of a mouse model of hyper-IgM X-linked immunodeficiency
    • Tahara, M. et al. Trans-splicing repair of CD40 ligand deficiency results in naturally regulated correction of a mouse model of hyper-IgM X-linked immunodeficiency. Nat Med 10, 835-841 (2004).
    • (2004) Nat Med , vol.10 , pp. 835-841
    • Tahara, M.1
  • 43
    • 80053015725 scopus 로고    scopus 로고
    • P53 isoforms: An intracellular microprocessor?
    • Khoury, M. P. & Bourdon, J. C. p53 Isoforms: An Intracellular Microprocessor? Genes & cancer 2, 453-465 (2011).
    • (2011) Genes & Cancer , vol.2 , pp. 453-465
    • Khoury, M.P.1    Bourdon, J.C.2
  • 44
    • 0037112844 scopus 로고    scopus 로고
    • "Super p53" mice exhibit enhanced DNA damage response, are tumor resistant and age normally
    • Garcia-Cao, I. et al. "Super p53" mice exhibit enhanced DNA damage response, are tumor resistant and age normally. The EMBO journal 21, 6225-6235 (2002).
    • (2002) The EMBO Journal , vol.21 , pp. 6225-6235
    • Garcia-Cao, I.1
  • 45
    • 84897047751 scopus 로고    scopus 로고
    • ARF tumor suppression in the nucleolus
    • Maggi, L. B., Jr. et al. ARF tumor suppression in the nucleolus. Biochimica et biophysica acta 1842, 831-839 (2014).
    • (2014) Biochimica et Biophysica Acta , vol.1842 , pp. 831-839
    • Maggi, L.B.1
  • 46
    • 0034665749 scopus 로고    scopus 로고
    • P53-independent functions of the p19(ARF) tumor suppressor
    • Weber, J. D. et al. p53-independent functions of the p19(ARF) tumor suppressor. Genes & development 14, 2358-2365 (2000).
    • (2000) Genes & Development , vol.14 , pp. 2358-2365
    • Weber, J.D.1
  • 47
    • 2542423876 scopus 로고    scopus 로고
    • Alteration of the p14(ARF) gene and p53 status in human hepatocellular carcinomas
    • Ito, T. et al. Alteration of the p14(ARF) gene and p53 status in human hepatocellular carcinomas. Journal of gastroenterology 39, 355-361 (2004).
    • (2004) Journal of Gastroenterology , vol.39 , pp. 355-361
    • Ito, T.1
  • 48
    • 77957307009 scopus 로고    scopus 로고
    • Genetic and epigenetic characteristics of human multiple hepatocellular carcinoma
    • Taniguchi, K., Yamada, T., Sasaki, Y. & Kato, K. Genetic and epigenetic characteristics of human multiple hepatocellular carcinoma. BMC cancer 10, 530 (2010).
    • (2010) BMC Cancer , vol.10 , pp. 530
    • Taniguchi, K.1    Yamada, T.2    Sasaki, Y.3    Kato, K.4
  • 49
    • 84863804699 scopus 로고    scopus 로고
    • MicroRNA-375 targets AEG-1 in hepatocellular carcinoma and suppresses liver cancer cell growth in vitro and in vivo
    • He, X. X. et al. MicroRNA-375 targets AEG-1 in hepatocellular carcinoma and suppresses liver cancer cell growth in vitro and in vivo. Oncogene 31, 3357-3369 (2012).
    • (2012) Oncogene , vol.31 , pp. 3357-3369
    • He, X.X.1
  • 50
    • 84855162699 scopus 로고    scopus 로고
    • Embryonic liver fodrin involved in hepatic stellate cell activation and formation of regenerative nodule in liver cirrhosis
    • Wang, Z. et al. Embryonic liver fodrin involved in hepatic stellate cell activation and formation of regenerative nodule in liver cirrhosis. Journal of cellular and molecular medicine 16, 118-128 (2012).
    • (2012) Journal of Cellular and Molecular Medicine , vol.16 , pp. 118-128
    • Wang, Z.1
  • 51
    • 84863512851 scopus 로고    scopus 로고
    • Beta-2 spectrin is involved in hepatocyte proliferation through the interaction of TGFbeta/Smad and PI3K/AKT signalling
    • Wang, Z. et al. beta-2 spectrin is involved in hepatocyte proliferation through the interaction of TGFbeta/Smad and PI3K/AKT signalling. Liver international 32, 1103-1111 (2012).
    • (2012) Liver International , vol.32 , pp. 1103-1111
    • Wang, Z.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.