Embryonic liver fodrin involved in hepatic stellate cell activation and formation of regenerative nodule in liver cirrhosis

Journal of Cellular and Molecular Medicine

Volumn 16, Issue 1, 2012, Pages 118-128

  Wang, Zhijun ^a,b   Liu, Fang ^a   Tu, Wei ^b   Chang, Ying ^b   Yao, Jinjian ^b   Wu, Wei ^b   Jiang, Xiang ^b   He, Xingxing ^b   Lin, Jusheng ^b   Song, Yuhu ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

B 2 Spectrin; Hepatic progenitor cell; Hepatic stellate cell; Liver cirrhosis

Indexed keywords

ACTIN BINDING PROTEIN; CARBON TETRACHLORIDE; CARRIER PROTEIN; FODRIN; SMAD3 PROTEIN; SMAD3 PROTEIN, MOUSE; SMAD4 PROTEIN; SMAD4 PROTEIN, MOUSE; SPECTRIN;

ANIMAL; ARTICLE; C57BL MOUSE; CELL PROLIFERATION; CHEMICALLY INDUCED DISORDER; CYTOLOGY; GENETICS; LIVER; LIVER CIRRHOSIS; LIVER REGENERATION; METABOLISM; MOUSE; PATHOLOGY; PHYSIOLOGY; PRENATAL DEVELOPMENT; SIGNAL TRANSDUCTION; STELLATE CELL; STEM CELL;

ANIMALS; CARBON TETRACHLORIDE; CARRIER PROTEINS; CELL PROLIFERATION; HEPATIC STELLATE CELLS; LIVER; LIVER CIRRHOSIS; LIVER REGENERATION; MICE; MICE, INBRED C57BL; MICROFILAMENT PROTEINS; SIGNAL TRANSDUCTION; SMAD3 PROTEIN; SMAD4 PROTEIN; SPECTRIN; STEM CELLS;

MUS;

EID: 84855162699     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1582-4934.2011.01290.x     Document Type: Article

References (45)

1. Derynck R, Zhang Y, Feng XH. Smads: transcriptional activators of TGF-beta responses. Cell. 1998; 95: 737-40.
2. Attisano L, Wrana JL. Signal transduction by the TGF-beta superfamily. Science. 2002; 296: 1646-7.
3. Mishra L, Shetty K, Tang Y, et al The role of TGF-beta and Wnt signaling in gastrointestinal stem cells and cancer. Oncogene. 2005; 24: 5775-89.
4. Mishra L, Banker T, Murray J, et al Liver stem cells and hepatocellular carcinoma. Hepatology. 2009; 49: 318-29.
5. Beck KA, Nelson WJ. The spectrin-based membrane skeleton as a membrane protein-sorting machine. Am J Physiol. 1996; 270: C1263-70.
6. Viel A. Alpha-actinin and spectrin structures: an unfolding family story. FEBS Lett. 1999; 460: 391-4.
7. Mishra B, Tang Y, Katuri V, et al Loss of cooperative function of transforming growth factor-beta signaling proteins, smad3 with embryonic liver fodrin, a beta-spectrin, in primary biliary cirrhosis. Liver Int. 2004; 24: 637-45.
8. Tang Y, Katuri V, Dillner A, et al Disruption of transforming growth factor-beta signaling in ELF beta-spectrin-deficient mice. Science. 2003; 299: 574-7.
9. Bataller R, Brenner DA. Liver fibrosis. J Clin Invest. 2005; 115: 209-18.
10. Friedman SL. Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury. J Biol Chem. 2000; 275: 2247-50.
11. Friedman SL. Mechanisms of hepatic fibrogenesis. Gastroenterology. 2008; 134: 1655-69.
12. Hellerbrand C, Stefanovic B, Giordano F, et al The role of TGFbeta1 in initiating hepatic stellate cell activationin vivo. J Hepatol. 1999; 30: 77-87.
13. Kanzler S, Lohse AW, Keil A, et al TGF-beta1 in liver fibrosis: an inducible transgenic mouse model to study liver fibrogenesis. Am J Physiol. 1999; 276: G1059-68.
14. Sanderson N, Factor V, Nagy P, et al Hepatic expression of mature transforming growth factor beta 1 in transgenic mice results in multiple tissue lesions. Proc Natl Acad Sci USA. 1995; 92: 2572-6.
15. Ueberham E, Low R, Ueberham U, et al Conditional tetracycline-regulated expression of TGF-beta1 in liver of transgenic mice leads to reversible intermediary fibrosis. Hepatology. 2003; 37: 1067-78.
16. Nakamura T, Sakata R, Ueno T, et al Inhibition of transforming growth factor beta prevents progression of liver fibrosis and enhances hepatocyte regeneration in dimethylnitrosamine-treated rats. Hepatology. 2000; 32: 247-55.
17. Qi Z, Atsuchi N, Ooshima A, et al Blockade of type beta transforming growth factor signaling prevents liver fibrosis and dysfunction in the rat. Proc Natl Acad Sci USA. 1999; 96: 2345-9.
18. Arias M, Lahme B, Van de Leur E, et al Adenoviral delivery of an antisense RNA complementary to the 3' coding sequence of transforming growth factor-beta1 inhibits fibrogenic activities of hepatic stellate cells. Cell Growth Differ. 2002; 13: 265-73.
19. Song YH, Chen XL, Kong XJ, et al Ribozymes against TGFbeta1 reverse character of activated hepatic stellate cellsin vitroand inhibit liver fibrosis in rats. J Gene Med. 2005; 7: 965-76.
20. Mishra L, Cai T, Yu P, et al Elf3 encodes a novel 200-kD beta-spectrin: role in liver development. Oncogene. 1999; 18: 353-64.
21. Radaeva S, Wang L, Radaev S, et al Retinoic acid signaling sensitizes hepatic stellate cells to NK cell killingviaupregulation of NK cell activating ligand RAE1. Am J Physiol Gastrointest Liver Physiol. 2007; 293: G809-16.
22. Kaimori A, Potter J, Kaimori JY, et al Transforming growth factor-beta1 induces an epithelial-to-mesenchymal transition state in mouse hepatocytesin vitro. J Biol Chem. 2007; 282: 22089-101.
23. Nguyen LN, Furuya MH, Wolfraim LA, et al Transforming growth factor-beta differentially regulates oval cell and hepatocyte proliferation. Hepatology. 2007; 45: 31-41.
24. Wu JC, Merlino G, Fausto N. Establishment and characterization of differentiated, nontransformed hepatocyte cell lines derived from mice transgenic for transforming growth factor alpha. Proc Natl Acad Sci USA. 1994; 91: 674-8.
25. Romero-Gallo J, Sozmen EG, Chytil A, et al Inactivation of TGF-beta signaling in hepatocytes results in an increased proliferative response after partial hepatectomy. Oncogene. 2005; 24: 3028-41.
26. Sanchez A, Alvarez AM, Benito M, et al Apoptosis induced by transforming growth factor-beta in fetal hepatocyte primary cultures: involvement of reactive oxygen intermediates. J Biol Chem. 1996; 271: 7416-22.
27. Kitisin K, Ganesan N, Tang Y, et al Disruption of transforming growth factor-beta signaling through beta-spectrin ELF leads to hepatocellular cancer through cyclin D1 activation. Oncogene. 2007; 26: 7103-10.
28. Moreno M, Gonzalo T, Kok RJ, et al Reduction of advanced liver fibrosis by short-term targeted delivery of an angiotensin receptor blocker to hepatic stellate cells in rats. Hepatology. 2010; 51: 942-52.
29. Beljaars L, Molema G, Weert B, et al Albumin modified with mannose 6-phosphate: a potential carrier for selective delivery of antifibrotic drugs to rat and human hepatic stellate cells. Hepatology. 1999; 29: 1486-93.
30. Beljaars L, Molema G, Schuppan D, et al Successful targeting to rat hepatic stellate cells using albumin modified with cyclic peptides that recognize the collagen type VI receptor. J Biol Chem. 2000; 275: 12743-51.
31. Pinzani M, Milani S, Herbst H, et al Expression of platelet-derived growth factor and its receptors in normal human liver and during active hepatic fibrogenesis. Am J Pathol. 1996; 148: 785-800.
32. Sato Y, Murase K, Kato J, et al Resolution of liver cirrhosis using vitamin A-coupled liposomes to deliver siRNA against a collagen-specific chaperone. Nat Biotechnol. 2008; 26: 431-42.
33. Son G, Hines IN, Lindquist J, et al Inhibition of phosphatidylinositol 3-kinase signaling in hepatic stellate cells blocks the progression of hepatic fibrosis. Hepatology. 2009; 50: 1512-23.
34. Falkowski O, An HJ, Ianus IA, et al Regeneration of hepatocyte 'buds' in cirrhosis from intrabiliary stem cells. J Hepatol. 2003; 39: 357-64.
35. Sun YL, Yin SY, Xie HY, et al Stem-like cells in hepatitis B virus-associated cirrhotic livers and adjacent tissue to hepatocellular carcinomas possess the capacity of tumorigenicity. J Gastroenterol Hepatol. 2008; 23: 1280-6.
36. Van Hul NK, Abarca-Quinones J, Sempoux C, et al Relation between liver progenitor cell expansion and extracellular matrix deposition in a CDE-induced murine model of chronic liver injury. Hepatology. 2009; 49: 1625-35.
37. Xiao JC, Jin XL, Ruck P, et al Hepatic progenitor cells in human liver cirrhosis: immunohistochemical, electron microscopic and immunofluorencence confocal microscopic findings. World J Gastroenterol. 2004; 10: 1208-11.
38. Greenbaum LE, Wells RG. The role of stem cells in liver repair and fibrosis. Int J Biochem Cell Biol. 2009; doi: .
39. He XC, Zhang J, Tong WG, et al BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt-beta-catenin signaling. Nat Genet. 2004; 36: 1117-21.
40. Watabe T, Miyazono K. Roles of TGF-beta family signaling in stem cell renewal and differentiation. Cell Res. 2009; 19: 103-15.
41. Zaret KS. Genetic programming of liver and pancreas progenitors: lessons for stem-cell differentiation. Nat Rev Genet. 2008; 9: 329-40.
42. Mishra L, Derynck R, Mishra B. Transforming growth factor-beta signaling in stem cells and cancer. Science. 2005; 310: 68-71.
43. Golestaneh N, Tang Y, Katuri V, et al Cell cycle deregulation and loss of stem cell phenotype in the subventricular zone of TGF-beta adaptor elf-/- mouse brain. Brain Res. 2006; 1108: 45-53.
44. Kim SS, Shetty K, Katuri V, et al TGF-beta signaling pathway inactivation and cell cycle deregulation in the development of gastric cancer: role of the beta-spectrin, ELF. Biochem Biophys Res Commun. 2006; 344: 1216-23.
45. Tang Y, Kitisin K, Jogunoori W, et al Progenitor/stem cells give rise to liver cancer due to aberrant TGF-beta and IL-6 signaling. Proc Natl Acad Sci USA. 2008; 105: 2445-50.