Partial correction of endogenous ΔF508 CFTR in human cystic fibrosis airway epithelia by spliceosome-mediated RNA trans-splicing

Nature Biotechnology

Volumn 20, Issue 1, 2002, Pages 47-52

  Liu, Xiaoming ^a   Jiang, Qinshi ^a   Mansfield, S Gary ^b   Puttaraju, M ^b   Zhang, Yulong ^a   Zhou, Weihong ^a   Cohn, Jonathan A ^c   Garcia Blanco, Mariano A ^b   Mitchell, Lloyd G ^b   Engelhardt, John F ^a  

^a UNIVERSITY OF IOWA   (United States)

^b INTRONN Inc   (United States)

^c DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MUTAGENESIS; PROTEINS; PULMONARY DISEASES; RESPIRATORY SYSTEM; RNA;

BRONCHIAL XENOGRAFTS;

BIOTECHNOLOGY;

CHLORIDE ION; CYCLIC AMP; MESSENGER RNA; TRANSMEMBRANE CONDUCTANCE REGULATOR;

ADENOVIRUS; ARTICLE; BRONCHUS MUCOSA; CHLORIDE CURRENT; CONTROLLED STUDY; CYSTIC FIBROSIS; DISEASE MODEL; GENE TARGETING; GENE THERAPY; HUMAN; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; INTRON; NONHUMAN; PRIORITY JOURNAL; RESPIRATORY EPITHELIUM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA SPLICING; SPLICEOSOME; TRANS SPLICING; VIRUS RECOMBINANT; WESTERN BLOTTING; XENOGRAFT;

ADENOVIRIDAE; ALLELES; BASE SEQUENCE; BLOTTING, SOUTHERN; BRONCHI; CYSTIC FIBROSIS; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; EPITHELIAL CELLS; HELA CELLS; HUMANS; IMMUNOBLOTTING; MODELS, GENETIC; MOLECULAR SEQUENCE DATA; MUTATION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA SPLICING; RNA, MESSENGER; SPLICEOSOMES;

ADENOVIRIDAE; BRONCHUS; DNA VIRUSES;

EID: 0036137663     PISSN: 10870156     EISSN: None     Source Type: Journal    
DOI: 10.1038/nbt0102-47     Document Type: Article

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