Metabolic modeling of muscle metabolism identifies key reactions linked to insulin resistance phenotypes

Molecular Metabolism

Volumn 4, Issue 3, 2015, Pages 151-163

  Nogiec, Christopher ^a   Burkart, Alison ^b   Dreyfuss, Jonathan M ^c   Lerin, Carles ^b,e   Kasif, Simon ^c,d   Patti, Mary Elizabeth ^b  

^a BOSTON UNIVERSITY   (United States)

^b JOSLIN DIABETES CENTER   (United States)

^c Boston University   (United States)

^d HARVARD MIT DIVISION OF HEALTH SCIENCES AND TECHNOLOGY   (United States)

^e HOSPITAL SANT JOAN DE DÉU   (Spain)

Author keywords

Computational modeling; Flux balance analysis; Muscle insulin resistance; Muscle metabolism

Indexed keywords

ADENOSINE TRIPHOSPHATE; CARNITINE PALMITOYLTRANSFERASE I; FATTY ACID TRANSPORTER; PYRUVATE DEHYDROGENASE; PYRUVATE DEHYDROGENASE KINASE 2; PYRUVATE DEHYDROGENASE KINASE 4;

ANIMAL CELL; ARTICLE; CARBOHYDRATE METABOLISM; CITRIC ACID CYCLE; CONTROLLED STUDY; DIET RESTRICTION; ENERGY TRANSFER; ENZYME INHIBITION; ENZYME SYNTHESIS; FATTY ACID OXIDATION; GLUCOSE TRANSPORT; GLYCOGEN METABOLISM; GLYCOLYSIS; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIPID OXIDATION; LIPID PEROXIDATION; MOUSE; MUSCLE METABOLISM; MYOBLAST; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; NUTRIENT AVAILABILITY; PENTOSE PHOSPHATE CYCLE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FUNCTION;

EID: 84924049258     PISSN: None     EISSN: 22128778     Source Type: Journal    
DOI: 10.1016/j.molmet.2014.12.012     Document Type: Article

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