Human antimicrobial peptide LL-37 induces glial-mediated neuroinflammation

Biochemical Pharmacology

Volumn 94, Issue 2, 2015, Pages 130-141

  Lee, Moonhee ^a   Shi, Xiaolei ^a   Barron, Annelise E ^b   McGeer, Edith ^a   McGeer, Patrick L ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b Stanford University   (United States)

Author keywords

Astrocytes; Cathelicidin; Chemokines; Inflammatory cytokines; Microglia

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; ANTIINFLAMMATORY AGENT; BAPTA AM; BISINDOLYLMALEIMIDE; CATHELICIDIN ANTIMICROBIAL PEPTIDE LL 37; GAMMA INTERFERON; HUMAN CATIONIC ANTIMICROBIAL PROTEIN 18; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; LIPOPOLYSACCHARIDE; MEK 1 INHIBITOR; MEK 2 INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE P38; PEPTIDE DERIVATIVE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN KINASE C INHIBITOR; SECONDARY LYMPHOID TISSUE CHEMOKINE; UNCLASSIFIED DRUG; WORTMANNIN; ANTIMICROBIAL CATIONIC PEPTIDE; CAP18 LIPOPOLYSACCHARIDE-BINDING PROTEIN; PRIMER DNA;

ADULT; AGED; ALZHEIMER DISEASE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASTROCYTE; CONTROLLED STUDY; CYTOKINE RELEASE; GLIA; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; MICROGLIA; MIDDLE AGED; MONOCYTE; NERVOUS SYSTEM INFLAMMATION; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN EXPRESSION; CELL LINE; CHEMICALLY INDUCED; DRUG EFFECTS; ENCEPHALITIS; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION;

ANTIMICROBIAL CATIONIC PEPTIDES; BASE SEQUENCE; CELL LINE; DNA PRIMERS; ENCEPHALITIS; HUMANS; NEUROGLIA; POLYMERASE CHAIN REACTION;

EID: 84923931299     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2015.02.003     Document Type: Article

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