Hydrophobicity of protein determinants influences the recognition of substrates by EDEM1 and EDEM2 in human cells

BMC Cell Biology

Volumn 16, Issue 1, 2015, Pages

  Sokołowska, Iwona ^a   Piłka, Ewa S ^b   Sandvig, Kirsten ^c,d   Wȩgrzyn, Grzegorz ^a   Slomińska Wojewódzka, Monika ^a  

^a UNIVERSITY OF GDA SK   (Poland)

^b EVOTEC UK LTD   (United Kingdom)

^c UNIVERSITY OF OSLO   (Norway)

^d Centre for Cancer Biomedicine   (Norway)

Author keywords

BACE457; EDEM proteins; Endoplasmic reticulum; ERAD; Ricin

Indexed keywords

BETA SECRETASE; CHAPERONE; ER DEGRADATION ENHANCING ALPHA MANNOSIDASE I LIKE PROTEIN; ER DEGRADATION ENHANCING ALPHA MANNOSIDASE II LIKE PROTEIN; PROTEIN BACE457; RICIN; UNCLASSIFIED DRUG; ALPHA MANNOSIDASE; EDEM1 PROTEIN, HUMAN; EDEM2 PROTEIN, HUMAN; GLYCOPROTEIN; MEMBRANE PROTEIN; PROTEIN BINDING; SECRETASE;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL SURFACE; CONTROLLED STUDY; CYTOSOL; EMBRYO; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM ASSOCIATED DEGRADATION; GOLGI COMPLEX; HEK293 CELL LINE; HUMAN; HUMAN CELL; HYDROPHOBICITY; MOLECULAR RECOGNITION; MUTATIONAL ANALYSIS; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; SUBSTRATE RECOGNITION; AMINO ACID SEQUENCE; CHEMICAL PHENOMENA; CHEMISTRY; CIRCULAR DICHROISM; ENZYME SPECIFICITY; GENETICS; METABOLISM; MOLECULAR GENETICS; MUTAGENESIS; PROTEIN DENATURATION; PROTEIN STABILITY;

MAMMALIA;

ALPHA-MANNOSIDASE; AMINO ACID SEQUENCE; AMYLOID PRECURSOR PROTEIN SECRETASES; CIRCULAR DICHROISM; CYTOSOL; ENDOPLASMIC RETICULUM; GLYCOPROTEINS; GOLGI APPARATUS; HEK293 CELLS; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MEMBRANE PROTEINS; MOLECULAR SEQUENCE DATA; MUTAGENESIS; PROTEIN BINDING; PROTEIN DENATURATION; PROTEIN STABILITY; RICIN; SUBSTRATE SPECIFICITY;

EID: 84923922998     PISSN: None     EISSN: 14712121     Source Type: Journal    
DOI: 10.1186/s12860-015-0047-7     Document Type: Article

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