A single point mutation in ricin A-chain increases toxin degradation and inhibits EDEM1-dependent ER retrotranslocation

Biochemical Journal

Volumn 436, Issue 2, 2011, Pages 371-385

  Sokołowska, Iwona ^a   Wälchli, Sébastien ^b   Wȩgrzyn, Grzegorz ^a   Sandvig, Kirsten ^b   Slominska Wojewodzka, Monika ^a  

^a UNIVERSITY OF GDA SK   (Poland)

^b OSLO UNIVERSITY HOSPITAL   (Norway)

Author keywords

Endoplasmic reticulum (ER); Endoplasmic reticulum degradation enhancing mannosidase I like protein 1 (EDEM1); Endosomal lysosomal degradation; P250A mutation; Retrotranslocation; Ricin A chain (RTA)

Indexed keywords

ALANINE; CHAPERONE; ENDOPLASMIC RETICULUM DEGRADATION ENHANCING ALPHA MANNOSIDASE I LIKE PROTEIN 1; MUTANT PROTEIN; PROLINE; RICIN A; UNCLASSIFIED DRUG;

ALPHA HELIX; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOSOL; CYTOTOXICITY; ENDOPLASMIC RETICULUM; ENDOSOME; HUMAN; HUMAN CELL; HYDROPHOBICITY; INTRACELLULAR TRANSPORT; LYSOSOME; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN MODIFICATION; PROTEIN SECONDARY STRUCTURE; PROTEIN TRANSPORT; WILD TYPE;

ANIMALS; CERCOPITHECUS AETHIOPS; ENDOPLASMIC RETICULUM; HEK293 CELLS; HUMANS; MEMBRANE PROTEINS; PLANTS, TOXIC; POINT MUTATION; PROTEIN FOLDING; PROTEIN TRANSPORT; RICIN; SUBSTRATE SPECIFICITY; TOXINS, BIOLOGICAL; VERO CELLS;

EID: 79956042755     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20101493     Document Type: Article

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