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Volumn 11, Issue 1, 2015, Pages 1-21

GITR Intrinsically Sustains Early Type 1 and Late Follicular Helper CD4 T Cell Accumulation to Control a Chronic Viral Infection

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CXCR5; GAMMA INTERFERON; GLUCOCORTICOID INDUCED TUMOR NECROSIS FACTOR RECEPTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IMMUNOGLOBULIN G; INTERLEUKIN 2; PROTEIN S6; TETRAMER; TNFRSF18 PROTEIN, MOUSE;

EID: 84923849317     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1004517     Document Type: Article
Times cited : (38)

References (50)
  • 1
    • 84879120951 scopus 로고    scopus 로고
    • Networking at the level of host immunity: immune cell interactions during persistent viral infections
    • Ng CT, Snell LM, Brooks DG, Oldstone MB, (2013) Networking at the level of host immunity: immune cell interactions during persistent viral infections. Cell Host Microbe 13: 652–664. doi: 10.1016/j.chom.2013.05.014 23768490
    • (2013) Cell Host Microbe , vol.13 , pp. 652-664
    • Ng, C.T.1    Snell, L.M.2    Brooks, D.G.3    Oldstone, M.B.4
  • 2
    • 79956077563 scopus 로고    scopus 로고
    • T cell exhaustion
    • Wherry EJ, (2011) T cell exhaustion. Nature Immunology 131: 492–499. doi: 10.1038/ni.2035
    • (2011) Nature Immunology , vol.131 , pp. 492-499
    • Wherry, E.J.1
  • 3
    • 67649660551 scopus 로고    scopus 로고
    • Redefining chronic viral infection
    • Virgin HW, Wherry EJ, Ahmed R, (2009) Redefining chronic viral infection. Cell 138: 30–50. doi: 10.1016/j.cell.2009.06.036
    • (2009) Cell , vol.138 , pp. 30-50
    • Virgin, H.W.1    Wherry, E.J.2    Ahmed, R.3
  • 4
    • 32544459770 scopus 로고    scopus 로고
    • Restoring function in exhausted CD8 T cells during chronic viral infection
    • Barber DL, Wherry EJ, Masopust D, Zhu B, Allison JP, et al. (2006) Restoring function in exhausted CD8 T cells during chronic viral infection. Nature 439: 682–687. doi: 10.1038/nature04444 16382236
    • (2006) Nature , vol.439 , pp. 682-687
    • Barber, D.L.1    Wherry, E.J.2    Masopust, D.3    Zhu, B.4    Allison, J.P.5
  • 5
    • 77957059176 scopus 로고    scopus 로고
    • Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection
    • Jin HT, Anderson AC, Tan WG, West EE, Ha SJ, et al. (2010) Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection. Proc Natl Acad Sci U S A 107: 14733–14738. doi: 10.1073/pnas.1009731107 20679213
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 14733-14738
    • Jin, H.T.1    Anderson, A.C.2    Tan, W.G.3    West, E.E.4    Ha, S.J.5
  • 6
    • 58149277359 scopus 로고    scopus 로고
    • Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infection
    • Jones RB, Ndhlovu LC, Barbour JD, Sheth PM, Jha AR, et al. (2008) Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infection. J Exp Med 205: 2763–2779. doi: 10.1084/jem.20081398 19001139
    • (2008) J Exp Med , vol.205 , pp. 2763-2779
    • Jones, R.B.1    Ndhlovu, L.C.2    Barbour, J.D.3    Sheth, P.M.4    Jha, A.R.5
  • 7
    • 33750499311 scopus 로고    scopus 로고
    • Interleukin-10 determines viral clearance or persistence in vivo
    • Brooks DG, Trifilo MJ, Edelmann KH, Teyton L, McGavern DB, et al. (2006) Interleukin-10 determines viral clearance or persistence in vivo. Nat Med 12: 1301–1309. doi: 10.1038/nm1492 17041596
    • (2006) Nat Med , vol.12 , pp. 1301-1309
    • Brooks, D.G.1    Trifilo, M.J.2    Edelmann, K.H.3    Teyton, L.4    McGavern, D.B.5
  • 8
    • 84863116516 scopus 로고    scopus 로고
    • Loss of the signaling adaptor TRAF1 causes CD8+ T cell dysregulation during human and murine chronic infection
    • Wang C, McPherson AJ, Jones RB, Kawamura KS, Lin GH, et al. (2012) Loss of the signaling adaptor TRAF1 causes CD8+ T cell dysregulation during human and murine chronic infection. J Exp Med 209: 77–91. doi: 10.1084/jem.20110675 22184633
    • (2012) J Exp Med , vol.209 , pp. 77-91
    • Wang, C.1    McPherson, A.J.2    Jones, R.B.3    Kawamura, K.S.4    Lin, G.H.5
  • 9
    • 84866929046 scopus 로고    scopus 로고
    • OX40 facilitates control of a persistent virus infection
    • Boettler T, Moeckel F, Cheng Y, Heeg M, Salek-Ardakani S, et al. (2012) OX40 facilitates control of a persistent virus infection. PLoS Pathog 8: e1002913. doi: 10.1371/journal.ppat.1002913 22969431
    • (2012) PLoS Pathog , vol.8 , pp. e1002913
    • Boettler, T.1    Moeckel, F.2    Cheng, Y.3    Heeg, M.4    Salek-Ardakani, S.5
  • 10
    • 35349014587 scopus 로고    scopus 로고
    • Molecular signature of CD8+ T cell exhaustion during chronic viral infection
    • Wherry EJ, Ha SJ, Kaech SM, Haining WN, Sarkar S, et al. (2007) Molecular signature of CD8+ T cell exhaustion during chronic viral infection. Immunity 27: 670–684. doi: 10.1016/j.immuni.2007.09.006 17950003
    • (2007) Immunity , vol.27 , pp. 670-684
    • Wherry, E.J.1    Ha, S.J.2    Kaech, S.M.3    Haining, W.N.4    Sarkar, S.5
  • 11
    • 0027971622 scopus 로고
    • CD4+ T cells are required to sustain CD8+ cytotoxic T-cell responses during chronic viral infection
    • Matloubian M, Concepcion RJ, Ahmed R, (1994) CD4+ T cells are required to sustain CD8+ cytotoxic T-cell responses during chronic viral infection. J Virol 68: 8056–8063. 7966595
    • (1994) J Virol , vol.68 , pp. 8056-8063
    • Matloubian, M.1    Concepcion, R.J.2    Ahmed, R.3
  • 12
    • 0032416085 scopus 로고    scopus 로고
    • Viral immune evasion due to persistence of activated T cells without effector function
    • Zajac AJ, Blattman JN, Murali-Krishna K, Sourdive DJ, Suresh M, et al. (1998) Viral immune evasion due to persistence of activated T cells without effector function. J Exp Med 188: 2205–2213. doi: 10.1084/jem.188.12.2205 9858507
    • (1998) J Exp Med , vol.188 , pp. 2205-2213
    • Zajac, A.J.1    Blattman, J.N.2    Murali-Krishna, K.3    Sourdive, D.J.4    Suresh, M.5
  • 13
    • 0028298652 scopus 로고
    • Enhanced establishment of a virus carrier state in adult CD4+ T-cell-deficient mice
    • Battegay M, Moskophidis D, Rahemtulla A, Hengartner H, Mak TW, et al. (1994) Enhanced establishment of a virus carrier state in adult CD4+ T-cell-deficient mice. J Virol 68: 4700–4704. 7911534
    • (1994) J Virol , vol.68 , pp. 4700-4704
    • Battegay, M.1    Moskophidis, D.2    Rahemtulla, A.3    Hengartner, H.4    Mak, T.W.5
  • 14
    • 79751468870 scopus 로고    scopus 로고
    • Pathogenic mechanisms of HIV disease
    • Moir S, Chun TW, Fauci AS, (2011) Pathogenic mechanisms of HIV disease. Annu Rev Pathol 6: 223–248. doi: 10.1146/annurev-pathol-011110-130254 21034222
    • (2011) Annu Rev Pathol , vol.6 , pp. 223-248
    • Moir, S.1    Chun, T.W.2    Fauci, A.S.3
  • 15
    • 18244366653 scopus 로고    scopus 로고
    • Constitutive CD27/CD70 interaction induces expansion of effector-type T cells and results in IFNgamma-mediated B cell depletion
    • Arens R, Tesselaar K, Baars PA, van Schijndel GM, Hendriks J, et al. (2001) Constitutive CD27/CD70 interaction induces expansion of effector-type T cells and results in IFNgamma-mediated B cell depletion. Immunity 15: 801–812. doi: 10.1016/S1074-7613(01)00236-9 11728341
    • (2001) Immunity , vol.15 , pp. 801-812
    • Arens, R.1    Tesselaar, K.2    Baars, P.A.3    van Schijndel, G.M.4    Hendriks, J.5
  • 16
    • 0035947417 scopus 로고    scopus 로고
    • Loss of memory (CD27) B lymphocytes in HIV-1 infection
    • De Milito A, Morch C, Sonnerborg A, Chiodi F, (2001) Loss of memory (CD27) B lymphocytes in HIV-1 infection. AIDS 15: 957–964. doi: 10.1097/00002030-200105250-00003 11399977
    • (2001) AIDS , vol.15 , pp. 957-964
    • De Milito, A.1    Morch, C.2    Sonnerborg, A.3    Chiodi, F.4
  • 17
    • 33748462545 scopus 로고    scopus 로고
    • Elimination of chronic viral infection by blocking CD27 signaling
    • Matter M, Odermatt B, Yagita H, Nuoffer JM, Ochsenbein AF, (2006) Elimination of chronic viral infection by blocking CD27 signaling. J Exp Med 203: 2145–2155. doi: 10.1084/jem.20060651 16923852
    • (2006) J Exp Med , vol.203 , pp. 2145-2155
    • Matter, M.1    Odermatt, B.2    Yagita, H.3    Nuoffer, J.M.4    Ochsenbein, A.F.5
  • 18
    • 0037232212 scopus 로고    scopus 로고
    • Lethal T cell immunodeficiency induced by chronic costimulation via CD27-CD70 interactions
    • Tesselaar K, Arens R, van Schijndel GM, Baars PA, van der Valk MA, et al. (2003) Lethal T cell immunodeficiency induced by chronic costimulation via CD27-CD70 interactions. Nat Immunol 4: 49–54. doi: 10.1038/ni869 12469117
    • (2003) Nat Immunol , vol.4 , pp. 49-54
    • Tesselaar, K.1    Arens, R.2    van Schijndel, G.M.3    Baars, P.A.4    van der Valk, M.A.5
  • 19
    • 84899050190 scopus 로고    scopus 로고
    • Cell-specific and context-dependent effects of GITR in cancer, autoimmunity, and infection
    • Clouthier DL, Watts TH, (2014) Cell-specific and context-dependent effects of GITR in cancer, autoimmunity, and infection. Cytokine Growth Factor Rev 25: 91–106. doi: 10.1016/j.cytogfr.2013.12.003 24484736
    • (2014) Cytokine Growth Factor Rev , vol.25 , pp. 91-106
    • Clouthier, D.L.1    Watts, T.H.2
  • 20
    • 6344279933 scopus 로고    scopus 로고
    • Engagement of glucocorticoid-induced TNFR family-related receptor on effector T cells by its ligand mediates resistance to suppression by CD4+CD25+ T cells
    • Stephens GL, McHugh RS, Whitters MJ, Young DA, Luxenberg D, et al. (2004) Engagement of glucocorticoid-induced TNFR family-related receptor on effector T cells by its ligand mediates resistance to suppression by CD4+CD25+ T cells. J Immunol 173: 5008–5020. doi: 10.4049/jimmunol.173.8.5008 15470044
    • (2004) J Immunol , vol.173 , pp. 5008-5020
    • Stephens, G.L.1    McHugh, R.S.2    Whitters, M.J.3    Young, D.A.4    Luxenberg, D.5
  • 21
    • 67649198525 scopus 로고    scopus 로고
    • GITR triggering induces expansion of both effector and regulatory CD4+ T cells in vivo
    • van Olffen RW, Koning N, van Gisbergen KP, Wensveen FM, Hoek RM, et al. (2009) GITR triggering induces expansion of both effector and regulatory CD4+ T cells in vivo. J Immunol 182: 7490–7500. doi: 10.4049/jimmunol.0802751 19494272
    • (2009) J Immunol , vol.182 , pp. 7490-7500
    • van Olffen, R.W.1    Koning, N.2    van Gisbergen, K.P.3    Wensveen, F.M.4    Hoek, R.M.5
  • 22
    • 33746575650 scopus 로고    scopus 로고
    • The GITR-GITRL interaction: co-stimulation or contrasuppression of regulatory activity?
    • Shevach EM, Stephens GL, (2006) The GITR-GITRL interaction: co-stimulation or contrasuppression of regulatory activity? Nat Rev Immunol 6: 613–618. doi: 10.1038/nri1867 16868552
    • (2006) Nat Rev Immunol , vol.6 , pp. 613-618
    • Shevach, E.M.1    Stephens, G.L.2
  • 23
    • 84883505814 scopus 로고    scopus 로고
    • Modulation of Treg cells/T effector function by GITR signaling is context-dependent
    • Ephrem A, Epstein AL, Stephens GL, Thornton AM, Glass D, et al. (2013) Modulation of Treg cells/T effector function by GITR signaling is context-dependent. Eur J Immunol 43: 2421–2429. doi: 10.1002/eji.201343451 23722868
    • (2013) Eur J Immunol , vol.43 , pp. 2421-2429
    • Ephrem, A.1    Epstein, A.L.2    Stephens, G.L.3    Thornton, A.M.4    Glass, D.5
  • 24
    • 0036660176 scopus 로고    scopus 로고
    • Role of GITR in activation response of T lymphocytes
    • Ronchetti S, Nocentini G, Riccardi C, Pandolfi PP, (2002) Role of GITR in activation response of T lymphocytes. Blood 100: 350–352. doi: 10.1182/blood-2001-12-0276 12070049
    • (2002) Blood , vol.100 , pp. 350-352
    • Ronchetti, S.1    Nocentini, G.2    Riccardi, C.3    Pandolfi, P.P.4
  • 25
    • 0023908516 scopus 로고
    • Organ-specific selection of viral variants during chronic infection
    • Ahmed R, Oldstone MB, (1988) Organ-specific selection of viral variants during chronic infection. J Exp Med 167: 1719–1724. doi: 10.1084/jem.167.5.1719 3367096
    • (1988) J Exp Med , vol.167 , pp. 1719-1724
    • Ahmed, R.1    Oldstone, M.B.2
  • 26
    • 78650668092 scopus 로고    scopus 로고
    • CD8 T cell-intrinsic GITR is required for T cell clonal expansion and mouse survival following severe influenza infection
    • Snell LM, McPherson AJ, Lin GH, Sakaguchi S, Pandolfi PP, et al. (2010) CD8 T cell-intrinsic GITR is required for T cell clonal expansion and mouse survival following severe influenza infection. J Immunol 185: 7223–7234. doi: 10.4049/jimmunol.1001912 21076066
    • (2010) J Immunol , vol.185 , pp. 7223-7234
    • Snell, L.M.1    McPherson, A.J.2    Lin, G.H.3    Sakaguchi, S.4    Pandolfi, P.P.5
  • 27
    • 0024307348 scopus 로고
    • Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen
    • Pircher H, Burki K, Lang R, Hengartner H, Zinkernagel RM, (1989) Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen. Nature 342: 559–561. doi: 10.1038/342559a0 2573841
    • (1989) Nature , vol.342 , pp. 559-561
    • Pircher, H.1    Burki, K.2    Lang, R.3    Hengartner, H.4    Zinkernagel, R.M.5
  • 28
    • 0038025292 scopus 로고    scopus 로고
    • Therapeutic use of IL-2 to enhance antiviral T-cell responses in vivo
    • Blattman JN, Grayson JM, Wherry EJ, Kaech SM, Smith KA, et al. (2003) Therapeutic use of IL-2 to enhance antiviral T-cell responses in vivo. Nat Med 9: 540–547. doi: 10.1038/nm866 12692546
    • (2003) Nat Med , vol.9 , pp. 540-547
    • Blattman, J.N.1    Grayson, J.M.2    Wherry, E.J.3    Kaech, S.M.4    Smith, K.A.5
  • 29
    • 84878585947 scopus 로고    scopus 로고
    • PD-L1 blockade synergizes with IL-2 therapy in reinvigorating exhausted T cells
    • West EE, Jin HT, Rasheed AU, Penaloza-Macmaster P, Ha SJ, et al. (2013) PD-L1 blockade synergizes with IL-2 therapy in reinvigorating exhausted T cells. J Clin Invest 123: 2604–2615. doi: 10.1172/JCI67008 23676462
    • (2013) J Clin Invest , vol.123 , pp. 2604-2615
    • West, E.E.1    Jin, H.T.2    Rasheed, A.U.3    Penaloza-Macmaster, P.4    Ha, S.J.5
  • 30
    • 34250787647 scopus 로고    scopus 로고
    • Differential role of IL-2R signaling for CD8+ T cell responses in acute and chronic viral infections
    • Bachmann MF, Wolint P, Walton S, Schwarz K, Oxenius A, (2007) Differential role of IL-2R signaling for CD8+ T cell responses in acute and chronic viral infections. Eur J Immunol 37: 1502–1512. doi: 10.1002/eji.200637023 17492805
    • (2007) Eur J Immunol , vol.37 , pp. 1502-1512
    • Bachmann, M.F.1    Wolint, P.2    Walton, S.3    Schwarz, K.4    Oxenius, A.5
  • 31
    • 0037383592 scopus 로고    scopus 로고
    • Viral persistence alters CD8 T-cell immunodominance and tissue distribution and results in distinct stages of functional impairment
    • Wherry EJ, Blattman JN, Murali-Krishna K, van der Most R, Ahmed R, (2003) Viral persistence alters CD8 T-cell immunodominance and tissue distribution and results in distinct stages of functional impairment. J Virol 77: 4911–4927. doi: 10.1128/JVI.77.8.4911-4927.2003 12663797
    • (2003) J Virol , vol.77 , pp. 4911-4927
    • Wherry, E.J.1    Blattman, J.N.2    Murali-Krishna, K.3    van der Most, R.4    Ahmed, R.5
  • 32
    • 79956104027 scopus 로고    scopus 로고
    • Viral persistence redirects CD4 T cell differentiation toward T follicular helper cells
    • Fahey LM, Wilson EB, Elsaesser H, Fistonich CD, McGavern DB, et al. (2011) Viral persistence redirects CD4 T cell differentiation toward T follicular helper cells. J Exp Med 208: 987–999. doi: 10.1084/jem.20101773 21536743
    • (2011) J Exp Med , vol.208 , pp. 987-999
    • Fahey, L.M.1    Wilson, E.B.2    Elsaesser, H.3    Fistonich, C.D.4    McGavern, D.B.5
  • 33
    • 79952675131 scopus 로고    scopus 로고
    • Follicular helper CD4 T cells (TFH)
    • Crotty S, (2011) Follicular helper CD4 T cells (TFH). Annu Rev Immunol 29: 621–663. doi: 10.1146/annurev-immunol-031210-101400 21314428
    • (2011) Annu Rev Immunol , vol.29 , pp. 621-663
    • Crotty, S.1
  • 34
    • 0031975635 scopus 로고    scopus 로고
    • Virus-specific MHC-class II-restricted TCR-transgenic mice: effects on humoral and cellular immune responses after viral infection
    • Oxenius A, Bachmann MF, Zinkernagel RM, Hengartner H, (1998) Virus-specific MHC-class II-restricted TCR-transgenic mice: effects on humoral and cellular immune responses after viral infection. Eur J Immunol 28: 390–400. doi: 10.1002/(SICI)1521-4141(199801)28:01%3C390::AID-IMMU390%3E3.3.CO;2-F 9485218
    • (1998) Eur J Immunol , vol.28 , pp. 390-400
    • Oxenius, A.1    Bachmann, M.F.2    Zinkernagel, R.M.3    Hengartner, H.4
  • 35
    • 79961151137 scopus 로고    scopus 로고
    • Foxp3+ follicular regulatory T cells control the germinal center response
    • Linterman MA, Pierson W, Lee SK, Kallies A, Kawamoto S, et al. (2011) Foxp3+ follicular regulatory T cells control the germinal center response. Nat Med 17: 975–982. doi: 10.1038/nm.2425 21785433
    • (2011) Nat Med , vol.17 , pp. 975-982
    • Linterman, M.A.1    Pierson, W.2    Lee, S.K.3    Kallies, A.4    Kawamoto, S.5
  • 36
    • 79961158055 scopus 로고    scopus 로고
    • Follicular regulatory T cells expressing Foxp3 and Bcl-6 suppress germinal center reactions
    • Chung Y, Tanaka S, Chu F, Nurieva RI, Martinez GJ, et al. (2011) Follicular regulatory T cells expressing Foxp3 and Bcl-6 suppress germinal center reactions. Nat Med 17: 983–988. doi: 10.1038/nm.2426 21785430
    • (2011) Nat Med , vol.17 , pp. 983-988
    • Chung, Y.1    Tanaka, S.2    Chu, F.3    Nurieva, R.I.4    Martinez, G.J.5
  • 37
    • 84883768106 scopus 로고    scopus 로고
    • Regulation of PI-3-Kinase and Akt Signaling in T Lymphocytes and Other Cells by TNFR Family Molecules
    • So T, Croft M, (2013) Regulation of PI-3-Kinase and Akt Signaling in T Lymphocytes and Other Cells by TNFR Family Molecules. Front Immunol 4: 139. doi: 10.3389/fimmu.2013.00139 23760533
    • (2013) Front Immunol , vol.4 , pp. 139
    • So, T.1    Croft, M.2
  • 38
    • 84873631376 scopus 로고    scopus 로고
    • The Role of the PI3K Signaling Pathway in CD4(+) T Cell Differentiation and Function
    • Han JM, Patterson SJ, Levings MK, (2012) The Role of the PI3K Signaling Pathway in CD4(+) T Cell Differentiation and Function. Front Immunol 3: 245. doi: 10.3389/fimmu.2012.00245 22905034
    • (2012) Front Immunol , vol.3 , pp. 245
    • Han, J.M.1    Patterson, S.J.2    Levings, M.K.3
  • 39
    • 0033621956 scopus 로고    scopus 로고
    • The Rel/NF-kappaB family directly activates expression of the apoptosis inhibitor Bcl-x(L)
    • Chen C, Edelstein LC, Gelinas C, (2000) The Rel/NF-kappaB family directly activates expression of the apoptosis inhibitor Bcl-x(L). Mol Cell Biol 20: 2687–2695. doi: 10.1128/MCB.20.8.2687-2695.2000 10733571
    • (2000) Mol Cell Biol , vol.20 , pp. 2687-2695
    • Chen, C.1    Edelstein, L.C.2    Gelinas, C.3
  • 40
    • 84860237060 scopus 로고    scopus 로고
    • Regulation and function of mTOR signalling in T cell fate decisions
    • Chi H, (2012) Regulation and function of mTOR signalling in T cell fate decisions. Nat Rev Immunol 12: 325–338. doi: 10.1038/nri3198 22517423
    • (2012) Nat Rev Immunol , vol.12 , pp. 325-338
    • Chi, H.1
  • 41
    • 20444378564 scopus 로고    scopus 로고
    • Glucocorticoid-induced TNF receptor functions as a costimulatory receptor that promotes survival in early phases of T cell activation
    • Esparza EM, Arch RH, (2005) Glucocorticoid-induced TNF receptor functions as a costimulatory receptor that promotes survival in early phases of T cell activation. J Immunol 174: 7869–7874. doi: 10.4049/jimmunol.174.12.7869 15944292
    • (2005) J Immunol , vol.174 , pp. 7869-7874
    • Esparza, E.M.1    Arch, R.H.2
  • 42
    • 2942532501 scopus 로고    scopus 로고
    • Costimulation via glucocorticoid-induced TNF receptor in both conventional and CD25+ regulatory CD4+ T cells
    • Kanamaru F, Youngnak P, Hashiguchi M, Nishioka T, Takahashi T, et al. (2004) Costimulation via glucocorticoid-induced TNF receptor in both conventional and CD25+ regulatory CD4+ T cells. J Immunol 172: 7306–7314. doi: 10.4049/jimmunol.172.12.7306 15187106
    • (2004) J Immunol , vol.172 , pp. 7306-7314
    • Kanamaru, F.1    Youngnak, P.2    Hashiguchi, M.3    Nishioka, T.4    Takahashi, T.5
  • 43
    • 38449114329 scopus 로고    scopus 로고
    • Glucocorticoid-induced TNFR-related protein lowers the threshold of CD28 costimulation in CD8+ T cells
    • Ronchetti S, Nocentini G, Bianchini R, Krausz LT, Migliorati G, et al. (2007) Glucocorticoid-induced TNFR-related protein lowers the threshold of CD28 costimulation in CD8+ T cells. J Immunol 179: 5916–5926. doi: 10.4049/jimmunol.179.9.5916 17947665
    • (2007) J Immunol , vol.179 , pp. 5916-5926
    • Ronchetti, S.1    Nocentini, G.2    Bianchini, R.3    Krausz, L.T.4    Migliorati, G.5
  • 44
    • 79953185367 scopus 로고    scopus 로고
    • OX40 complexes with phosphoinositide 3-kinase and protein kinase B (PKB) to augment TCR-dependent PKB signaling
    • So T, Choi H, Croft M, (2011) OX40 complexes with phosphoinositide 3-kinase and protein kinase B (PKB) to augment TCR-dependent PKB signaling. J Immunol 186: 3547–3555. doi: 10.4049/jimmunol.1003156 21289304
    • (2011) J Immunol , vol.186 , pp. 3547-3555
    • So, T.1    Choi, H.2    Croft, M.3
  • 45
    • 84856226311 scopus 로고    scopus 로고
    • Expanding roles for CD4(+) T cells in immunity to viruses
    • Swain SL, McKinstry KK, Strutt TM, (2012) Expanding roles for CD4(+) T cells in immunity to viruses. Nat Rev Immunol 12: 136–148. doi: 10.1038/nri3152 22266691
    • (2012) Nat Rev Immunol , vol.12 , pp. 136-148
    • Swain, S.L.1    McKinstry, K.K.2    Strutt, T.M.3
  • 46
    • 84910119679 scopus 로고    scopus 로고
    • Anti-GITR agonist therapy intrinsically enhances CD8 T cell responses to chronic LCMV thereby circumventing LCMV-induced downregulation of co-stimulatory GITRL on APC
    • Clouthier DL, Zhou AC, Watts TH, (2014) Anti-GITR agonist therapy intrinsically enhances CD8 T cell responses to chronic LCMV thereby circumventing LCMV-induced downregulation of co-stimulatory GITRL on APC. J Immunol 193. doi: 10.4049/jimmunol.1401002 25281716
    • (2014) J Immunol , vol.193
    • Clouthier, D.L.1    Zhou, A.C.2    Watts, T.H.3
  • 47
    • 84855485734 scopus 로고    scopus 로고
    • Antigen-specific CD4 T-cell help rescues exhausted CD8 T cells during chronic viral infection
    • Aubert RD, Kamphorst AO, Sarkar S, Vezys V, Ha SJ, et al. (2011) Antigen-specific CD4 T-cell help rescues exhausted CD8 T cells during chronic viral infection. Proc Natl Acad Sci U S A 108: 21182–21187. doi: 10.1073/pnas.1118450109 22160724
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 21182-21187
    • Aubert, R.D.1    Kamphorst, A.O.2    Sarkar, S.3    Vezys, V.4    Ha, S.J.5
  • 48
    • 84856630465 scopus 로고    scopus 로고
    • Murine B cell development and antibody responses to model antigens are not impaired in the absence of the TNF receptor GITR
    • Teodorovic LS, Riccardi C, Torres RM, Pelanda R, (2012) Murine B cell development and antibody responses to model antigens are not impaired in the absence of the TNF receptor GITR. PLoS One 7: e31632. doi: 10.1371/journal.pone.0031632 22328941
    • (2012) PLoS One , vol.7 , pp. e31632
    • Teodorovic, L.S.1    Riccardi, C.2    Torres, R.M.3    Pelanda, R.4
  • 49
    • 33846423147 scopus 로고    scopus 로고
    • Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease
    • Lahl K, Loddenkemper C, Drouin C, Freyer J, Arnason J, et al. (2007) Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease. J Exp Med 204: 57–63. doi: 10.1084/jem.20061852 17200412
    • (2007) J Exp Med , vol.204 , pp. 57-63
    • Lahl, K.1    Loddenkemper, C.2    Drouin, C.3    Freyer, J.4    Arnason, J.5
  • 50
    • 45849128721 scopus 로고    scopus 로고
    • Animal models using lymphocytic choriomeningitis virus
    • von Herrath M, Whitton JL, (2001) Animal models using lymphocytic choriomeningitis virus. Curr Protoc Immunol Chapter 19: Unit 19 10. doi: 10.1002/0471142735.im1910s36
    • (2001) Curr Protoc Immunol , vol.19 , Issue.19 , pp. 10
    • von Herrath, M.1    Whitton, J.L.2


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