Mechanism of amorphous itraconazole stabilization in polymer solid dispersions: Role of molecular mobility

Molecular Pharmaceutics

Volumn 11, Issue 11, 2014, Pages 4228-4237

  Bhardwaj, Sunny P ^a   Arora, Kapildev K ^a,b   Kwong, Elizabeth ^b,c   Templeton, Allen ^a   Clas, Sophie Dorothee ^b,d   Suryanarayanan, Raj ^a,e  

^a UNIVERSITY OF MINNESOTA   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

^c PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

^d Kwong Eureka Solutions   (Canada)

^e PharmaSolv Consulting   (Canada)

Author keywords

Crystallization kinetics; Crystallization onset; Dielectric spectroscopy; HPMCAS; Itraconazole; Molecular mobility; PVP; Solid dispersion; Synchrotron radiation

Indexed keywords

HYDROXYPROPYLMETHYLCELLULOSE ACETATE SUCCINATE; ITRACONAZOLE; PLASTICIZER; POVIDONE; METHYLCELLULOSE;

ARTICLE; CRYSTALLIZATION; DISPERSION; DRUG MECHANISM; DRUG STABILITY; ELECTROCHEMICAL IMPEDANCE SPECTROSCOPY; GLASS TRANSITION TEMPERATURE; MOLECULAR DYNAMICS; PHYSICAL PARAMETERS; PRIORITY JOURNAL; RATE CONSTANT; RELAXATION TIME; SOLID DISPERSION; TEMPERATURE DEPENDENCE; ANALOGS AND DERIVATIVES; CHEMISTRY; KINETICS; SYNCHROTRON; TEMPERATURE; X RAY DIFFRACTION;

CRYSTALLIZATION; DRUG STABILITY; ITRACONAZOLE; KINETICS; METHYLCELLULOSE; POVIDONE; SYNCHROTRONS; TEMPERATURE; X-RAY DIFFRACTION;

EID: 84923373929     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp5004515     Document Type: Article

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