Molecular motions in sucrose-PVP and sucrose-sorbitol dispersions: I. Implications of global and local mobility on stability

Pharmaceutical Research

Volumn 28, Issue 9, 2011, Pages 2191-2203

  Bhattacharya, Sisir ^a,b   Suryanarayanan, Raj ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

^b FOREST RESEARCH INSTITUTE   (United States)

Author keywords

Amorphous; Dielectric spectroscopy; Global and local mobility; Solid dispersions; Sucrose

Indexed keywords

PLASTICIZER; POVIDONE; SORBITOL; SUCROSE;

ALPHA RELAXATION TIME; ARTICLE; BETA1 RELAXATION TIME; BETA2 RELAXATION TIME; CALORIMETRY; CRYSTALLIZATION; DIFFERENTIAL SCANNING CALORIMETRY; DISPERSION; ELECTROCHEMICAL IMPEDANCE SPECTROSCOPY; FREEZE DRYING; GLASS TRANSITION TEMPERATURE; JOHARI GOLDSTEIN RELAXATION; MOLECULAR DYNAMICS; MOLECULAR MOBILITY; PRIORITY JOURNAL; RELAXATION TIME; SOLID DISPERSION; SOLID STATE; TEMPERATURE DEPENDENCE;

EID: 85027919300     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-011-0447-0     Document Type: Article

References (59)

1. Pouton CW. Formulation of poorly water-soluble drugs for oral administration: physicochemical and physiological issues and the lipid formulation classification system. Eur J Pharm Sci. 2006;29:278-87. (Pubitemid 44740131)
2. Bhugra C, Rambhatla S, Bakri A, Duddu SP, Miller DP, Pikal MJ, et al. Prediction of the onset of crystallization of amorphous sucrose below the calorimetric glass transition temperature from correlations with mobility. J Pharm Sci. 2007;96:1258-69. (Pubitemid 46797490)
3. Bhugra C, Shmeis RA, Krill SL, Pikal MJ. Predictions of onset of crystallization from experimental relaxation times I-Correlation of molecular mobility from temperatures above the glass transition to temperatures below the glass transition. Pharm Res. 2006;23:2277-90. (Pubitemid 44511509)
4. Bhugra C, Shmeis RA, Krill SL, Pikal MJ. Prediction of onset of crystallization from experimental relaxation times. II. Comparison between predicted and experimental onset times. J Pharm Sci. 2008;97:455-72.
5. Shamblin SL, Hancock BC, Pikal MJ. Coupling between chemical reactivity and structural relaxation in pharmaceutical glasses. Pharm Res. 2006;23:2254-68. (Pubitemid 44515010)
6. Shamblin SL, Tang X, Chang L, Hancock BC, Pikal MJ. Characterization of the time scales of molecular motion in pharmaceutically important glasses. J Phys Chem B. 1999;103:4113-21. (Pubitemid 129702538)
7. Craig DQM, Royall PG, Kett VL, Hopton ML. The relevance of the amorphous state to pharmaceutical dosage forms: glassy drugs and freeze-dried systems. Int J Pharm. 1999;179:179-207. (Pubitemid 29131430)
8. Yu L. Amorphous pharmaceutical solids: preparation, characterization and stabilization. Adv Drug Deliv Rev. 2001;48:27-42. (Pubitemid 32454482)
9. Kerc J, Srcic S. Thermal analysis of glassy pharmaceuticals. Thermochim Acta. 1995;248:81-95.
10. Hilden LR, Morris KR. Physics of amorphous solids. J Pharm Sci. 2001;93:3-12. (Pubitemid 38087927)
11. Vyazovkin S, Dranca I. Effect of physical aging on nucleation of amorphous indomethacin. J Phys Chem B. 2007;111:7283-7. (Pubitemid 47152514)
12. Yoshioka S, Miyazaki T, Aso Y. β-relaxation of insulin molecule in lyophilized formulations containing trehalose or dextran as a determinant of chemical reactivity. Pharm Res. 2006;23:961-6. (Pubitemid 43781404)
13. Yoshioka S, Miyazaki T, Aso Y, Kawanishi T. Significance of local mobility in aggregation of β-galactosidase lyophilized with trehalose, sucrose or stachyose. Pharm Res. 2007;24:1660-7. (Pubitemid 47206617)
14. Alie J, Menegotto J, Cardon P, Duplaa H, Caron A, Lacabanne C, et al. Dielectric study of the molecular mobility and the isothermal crystallization kinetics of an amorphous pharmaceutical drug substance. J Pharm Sci. 2004;93:218-33. (Pubitemid 38087928)
15. Hikima T, Adachi Y, Hanaya M, Oguni M. Determination of potentially homogeneous-nucleation-based crystallization in oterphenyl and an interpretation of the nucleation-enhancement mechanism. Phys Rev B Condens Matter. 1995;52:3900-8.
16. Hikima T, Hanaya M, Oguni M. Discovery of a potentially homogeneous-nucleation-based crystallization around the glass transition temperature in salol. Solid State Commun. 1995;93:713-7.
17. Hikima T, Hanaya M, Oguni M. Microscopic observation of a peculiar crystallization in the glass transition region and β-process as potentially controlling the growth rate in triphenylethylene. J Mol Struct. 1999;479:245-50. (Pubitemid 29162257)
18. Hikima T, Okamoto N, Hanaya M, Oguni M. Calorimetric study of triphenylethene: observation of homogeneous-nucleation-based crystallization. J Chem Thermodyn. 1998;30:509-23. (Pubitemid 128398595)
19. Sixou B, Faivre A, David L, Vigier G. Intermolecular and intramolecular contributions to the relaxation process in sorbitol and maltitol. Mol Phys. 2001;99:1845-50. (Pubitemid 35236392)
20. Gusseme AD, Carpentier L, Willart JF, Descamps M. Molecular mobility in supercooled trehalose. J Phys Chem B. 2003;107:10879-86.
21. Johari GP. Intrinsic mobility of molecular glasses. J Chem Phys. 1973;58:1766-70.
22. Johari GP, Goldstein M. Viscous liquids and the glass transition. II. Secondary relaxations in glasses of rigid molecules. J Chem Phys. 1970:2372-2388.
23. Ngai KL. An extended coupling model description of the evolution of dynamics with time in supercooled liquids and ionic conductors. J Phys Condens Matter. 2003;15:S1107-25.
24. Hancock BC, Shamblin SL, Zografi G. Molecular mobility of amorphous pharmaceutical solids below their glass transition temperatures. Pharm Res. 1995;12:799-806.
25. Vyazovkin S, Dranca I. Probing beta relaxation in pharmaceutically relevant glasses by using DSC. Pharm Res. 2006;23:422-8. (Pubitemid 43237872)
26. Zeng XM, Martin GP, Marriott C. Effects of molecular weight of polyvinylpyrrolidone on the glass transition and crystallization of co-lyophilized sucrose. Int J Pharm. 2001;218:63-73. (Pubitemid 32406157)
27. Shamblin SL, Huang EY, Zografi G. The effects of co-lyophilized polymeric additives on the glass transition temperature and crystallization of amorphous sucrose. J Therm Anal. 1996;47:1567-79. (Pubitemid 126794510)
28. Shamblin SL, Zografi G. The effects of absrobed water on the properties of amorphous mixtures containing sucrose. Pharm Res. 1999;16:1119-24. (Pubitemid 29368163)
29. Johari GP, Kim S, Shanker RM. Dielectric studies of molecular motions in amorphous solid and ultraviscous acetaminophen. J Pharm Sci. 2005;94:2207-23. (Pubitemid 41670502)
30. Crowley KJ, Zografi G. The use of thermal methods for predicting glass-former fragility. Thermochim Acta. 2001;380:79-93. (Pubitemid 33100002)
31. Kremer F. Dielectric spectroscopy-yesterday, today and tomorrow. J Non-Cryst Solids. 2002;305:1-9.
32. Kremer F, Schonhals A, editors. Broadband dielectric spectroscopy. Berlin: Springer; 2003.
33. Craig DQM. Dielectric analysis of pharmaceutical systems. London: Taylor & Francis; 1995.
34. Hancock BC, Zografi G. Characteristics and significance of the amorphous state in pharmaceutical systems. J Pharm Sci. 1997;86:1-12.
35. Alig I, Braun D, Langendorf R, Voigt M, Wendorff JH. Simultaneous aging and crystallization processes within the glassy state of a low molecular weight substance. J Non-Cryst Solids. 1997;221:261-4. (Pubitemid 127433551)
36. Grzybowska K, Pawlus S, Mierzwa M, Paluch M, Ngai KL. Changes of relaxation dynamics of a hydrogen-bonded glass former after removal of the hydrogen bonds. J Chem Phys. 2006;125:144507/1-8.
37. Kaminski K, Kaminska E, Hensel-Bielowka E, Chelmecka E, Paluch M, Ziolo J, et al. Identification of the molecular motions responsible for the slower secondary (β) relaxation in sucrose. J Phys Chem B. 2008;112:7662-8.
38. Vanhal I, Blond G. Impact of melting conditions of sucrose on its glass transition temperature. J Agr Food Chem. 1999;47:4285-90. (Pubitemid 29506237)
39. Shamblin SL, Taylor LS, Zografi G. Mixing behavior of colyophilized binary systems. J Pharm Sci. 1998;87(6):694-701. (Pubitemid 28268567)
40. Ediger MD, Harrowell P, Yu L. Crystal growth kinetics exhibit a fragility-dependent decoupling from viscosity. J Chem Phys. 2008;128:034709/1-6.
41. Sun Y, Xi H, Ediger MD, Yu L. Diffusionless crystal growth from glass has precursor in equilibrium liquid. J Phys Chem B. 2008;112:661-4. (Pubitemid 351212499)
42. Kudlik A, Benkhof S, Blochowicz T, Tschirwitz C, Rossler E. The dielectric response of simple organic glass formers. J Mol Struct. 1999;479:201-18. (Pubitemid 29162253)
43. Ngai KL, Capaccioli S. Relation between the activation energy of the Johari-Goldstein β relaxation and Tg of glass formers. Phys Rev E. 2004;69:031501/1-5.
44. Kaminski K, Kaminska E, Paluch M, Ziolo J, Ngai KL. The true Johari-Goldstein β-relaxation of monosaccharides. J Phys Chem B. 2006;110:25045-9.
45. Noel TR, Ring SG, Whittam MA. Dielectric relaxations of small carbohydrate molecules in the liquid and glassy states. J Phys Chem. 1992;96:5662-7.
46. Noel TR, Parker R, Ring SG. Effect of molecular structure and water content on the dielectric relaxation behavior of amorphous low molecular weight carbohydrates above and below their glass transition. Carbohydr Res. 2000;329:839-45. (Pubitemid 32056155)
47. Surana R, Pyne A, Suryanarayanan R. Effect of preparation method on physical properties of amorphous trehalose. Pharm Res. 2004;21:1167-76. (Pubitemid 38960768)
48. Johari GP. Effect of annealing on the secondary relaxations in glasses. J Chem Phys. 1982;77:4619-26.
49. Ngai KL, Paluch M. Classification of secondary relaxation in glass-formers based on dynamic properties. J Chem Phys. 2004;120:857-73.
50. Cicerone MT, Soles CL. Fast dynamics and stabilization of proteins: binary glasses of trehalose and glycerol. Biophys J. 2004;86:3836-45. (Pubitemid 38780260)
51. Cicerone MT, Tellington A, Trost L, Sokolov A. Substantially improved stability of biological agents in dried form. BioProcess Int. 2003;1:36-47.
52. Duddu SP, Sokoloski TD. Dielectric analysis in the characterization of amorphous pharmaceutical solids. 1. Molecular mobility in poly (vinylpyrrolidone)-water systems in the glassy state. J Pharm Sci. 1995;84:773-6.
53. Nozaki R, Suzuki D, Ozawa S, Shiozaki Y. The α and the β relaxation processes in supercooled sorbitol. J Non-Cryst Solids. 1998;235-237:393-8.
54. Jain SK, Johari GP. Dielectric studies of molecular motions in the glassy states of pure and aqueous poly (vinylpyrrolidone). J Phys Chem. 1988;92:5851-4.
55. Taylor LS, Zografi G. Sugar-polymer hydrogen bond interactions in lyophilized amorphous mixtures. J Pharm Sci. 1998;87:1615-21. (Pubitemid 28559651)
56. Colmenero J, Arbe A, Alegria A. Crossover from Debye to non-Debye dynamical behavior of the α relaxation observed by quasielastic neutron scattering in a glass-forming polymer. Phys Rev Lett. 1993;71:2603-6.
57. Colmenero J, Arbe A, Alegria A. The dynamics of the α-and β-relaxations in glass-forming polymers studied by quasielastic neutron scattering and dielectric spectroscopy. J Non-Cryst Solids. 1994;172-174:126-37.
58. Ngai KL. Relation between some secondary relaxations and the α relaxations in glass-forming materials according to the coupling model. J Chem Phys. 1998;109:6982-94. (Pubitemid 128678329)
59. Alvarez F, Alegria A, Colmenero J. Relationship between the time-domain Kohlrausch-Williams-Watts and frequency-domain Havriliak-Negami relaxation functions. Phys Rev B Condens Matter. 1991;44:7306-12.