-
1
-
-
84918795323
-
Protein engineering for improved pharmacologic characteristics of established monoclonal antibody-based therapeutics
-
Meibohm B,. Protein engineering for improved pharmacologic characteristics of established monoclonal antibody-based therapeutics. Clin Pharmacokinet. 2014; 53 (10): 863-864.
-
(2014)
Clin Pharmacokinet
, vol.53
, Issue.10
, pp. 863-864
-
-
Meibohm, B.1
-
2
-
-
84892170718
-
What's fueling the biotech engine-2012 to 2013
-
Aggarwal RS,. What's fueling the biotech engine-2012 to 2013. Nat Biotechnol. 2014; 32 (1): 32-39.
-
(2014)
Nat Biotechnol
, vol.32
, Issue.1
, pp. 32-39
-
-
Aggarwal, R.S.1
-
3
-
-
79955666020
-
Introduction to current and future protein therapeutics: A protein engineering perspective
-
Carter PJ,. Introduction to current and future protein therapeutics: a protein engineering perspective. Exp Cell Res. 2011; 317 (9): 1261-1269.
-
(2011)
Exp Cell Res
, vol.317
, Issue.9
, pp. 1261-1269
-
-
Carter, P.J.1
-
4
-
-
77951529848
-
Therapeutic antibodies for autoimmunity and inflammation
-
Chan AC, Carter PJ,. Therapeutic antibodies for autoimmunity and inflammation. Nat. Rev Immunol. 2010; 10 (5): 301-316.
-
(2010)
Nat. Rev Immunol
, vol.10
, Issue.5
, pp. 301-316
-
-
Chan, A.C.1
Carter, P.J.2
-
5
-
-
60849128549
-
Monoclonal antibodies as innovative therapeutics
-
Reichert JM,. Monoclonal antibodies as innovative therapeutics. Curr Pharmaceut Biotechnol. 2008; 9 (6): 423-430.
-
(2008)
Curr Pharmaceut Biotechnol
, vol.9
, Issue.6
, pp. 423-430
-
-
Reichert, J.M.1
-
7
-
-
84860710411
-
Immunogenicity to therapeutic proteins: Impact on PK/PD and efficacy
-
Chirmule N, Jawa V, Meibohm B,. Immunogenicity to therapeutic proteins: impact on PK/PD and efficacy. AAPS J. 2012; 14 (2): 296-302.
-
(2012)
AAPS J
, vol.14
, Issue.2
, pp. 296-302
-
-
Chirmule, N.1
Jawa, V.2
Meibohm, B.3
-
8
-
-
27144550160
-
Arming antibodies: Prospects and challenges for immunoconjugates
-
Wu AM, Senter PD,. Arming antibodies: prospects and challenges for immunoconjugates. Nat Biotechnol. 2005; 23 (9): 1137-1146.
-
(2005)
Nat Biotechnol
, vol.23
, Issue.9
, pp. 1137-1146
-
-
Wu, A.M.1
Senter, P.D.2
-
9
-
-
84858257263
-
Dual targeting strategies with bispecific antibodies
-
Kontermann RE,. Dual targeting strategies with bispecific antibodies. mAbs. 2012; 4 (2): 182-197.
-
(2012)
MAbs
, vol.4
, Issue.2
, pp. 182-197
-
-
Kontermann, R.E.1
-
10
-
-
84866596013
-
Advances in bispecific biotherapeutics for the treatment of cancer
-
May C, Sapra P, Gerber HP,. Advances in bispecific biotherapeutics for the treatment of cancer. Biochem Pharmacol. 2012; 84 (9): 1105-1112.
-
(2012)
Biochem Pharmacol
, vol.84
, Issue.9
, pp. 1105-1112
-
-
May, C.1
Sapra, P.2
Gerber, H.P.3
-
11
-
-
77953364464
-
Bispecific antibodies for cancer therapy
-
Hollander N,. Bispecific antibodies for cancer therapy. Immunotherapy. 2009; 1 (2): 211-222.
-
(2009)
Immunotherapy
, vol.1
, Issue.2
, pp. 211-222
-
-
Hollander, N.1
-
12
-
-
84886099419
-
A tale of two specificities: Bispecific antibodies for therapeutic and diagnostic applications
-
Byrne H, Conroy PJ, Whisstock JC, O'Kennedy RJ,. A tale of two specificities: bispecific antibodies for therapeutic and diagnostic applications. Trends Biotechnol. 2013; 31 (11): 621-632.
-
(2013)
Trends Biotechnol
, vol.31
, Issue.11
, pp. 621-632
-
-
Byrne, H.1
Conroy, P.J.2
Whisstock, J.C.3
O'Kennedy, R.J.4
-
13
-
-
84855586532
-
Humoral response to catumaxomab correlates with clinical outcome: Results of the pivotal phase II/III study in patients with malignant ascites
-
Ott MG, Marme F, Moldenhauer G, et al. Humoral response to catumaxomab correlates with clinical outcome: results of the pivotal phase II/III study in patients with malignant ascites. Int J Cancer. 2012; 130 (9): 2195-2203.
-
(2012)
Int J Cancer
, vol.130
, Issue.9
, pp. 2195-2203
-
-
Ott, M.G.1
Marme, F.2
Moldenhauer, G.3
-
14
-
-
77954676136
-
The trifunctional antibody catumaxomab for the treatment of malignant ascites due to epithelial cancer: Results of a prospective randomized phase II/III trial
-
Heiss MM, Murawa P, Koralewski P, et al. The trifunctional antibody catumaxomab for the treatment of malignant ascites due to epithelial cancer: Results of a prospective randomized phase II/III trial. Int J Cancer. 2010; 127 (9): 2209-2221.
-
(2010)
Int J Cancer
, vol.127
, Issue.9
, pp. 2209-2221
-
-
Heiss, M.M.1
Murawa, P.2
Koralewski, P.3
-
15
-
-
84858249264
-
The Design and Engineering of IgG-Like Bispecific Antibodies
-
In. Berlin: Springer
-
Jin P, Zhu Z,. The Design and Engineering of IgG-Like Bispecific Antibodies. In Bispecific Antibodies. Berlin: Springer; 2011: 151-169.
-
(2011)
Bispecific Antibodies
, pp. 151-169
-
-
Jin, P.1
Zhu, Z.2
-
16
-
-
35948977323
-
Simultaneous targeting of multiple disease mediators by a dual-variable-domain immunoglobulin
-
Wu C, Ying H, Grinnell C, et al. Simultaneous targeting of multiple disease mediators by a dual-variable-domain immunoglobulin. Nat Biotechnol. 2007; 25 (11): 1290-1297.
-
(2007)
Nat Biotechnol
, vol.25
, Issue.11
, pp. 1290-1297
-
-
Wu, C.1
Ying, H.2
Grinnell, C.3
-
18
-
-
84876222876
-
Clinical and pharmacologic aspects of blinatumomab in the treatment of B-cell acute lymphoblastic leukemia
-
Portell CA, Wenzell CM, Advani AS,. Clinical and pharmacologic aspects of blinatumomab in the treatment of B-cell acute lymphoblastic leukemia. Clin Pharmacol. 2013; 5 (Suppl 1): 5-11.
-
(2013)
Clin Pharmacol
, vol.5
, pp. 5-11
-
-
Portell, C.A.1
Wenzell, C.M.2
Advani, A.S.3
-
19
-
-
84871546145
-
Antitumor activities of PSMAxCD3 diabodies by redirected T-cell lysis of prostate cancer cells
-
Baum V, Buhler P, Gierschner D, et al. Antitumor activities of PSMAxCD3 diabodies by redirected T-cell lysis of prostate cancer cells. Immunotherapy. 2013; 5 (1): 27-38.
-
(2013)
Immunotherapy
, vol.5
, Issue.1
, pp. 27-38
-
-
Baum, V.1
Buhler, P.2
Gierschner, D.3
-
20
-
-
11844273237
-
Recombinant bispecific antibodies for cancer therapy
-
Kontermann RE,. Recombinant bispecific antibodies for cancer therapy. Acta Pharmacol Sin. 2005; 26 (1): 1-9.
-
(2005)
Acta Pharmacol Sin
, vol.26
, Issue.1
, pp. 1-9
-
-
Kontermann, R.E.1
-
21
-
-
0036839077
-
Phase 1 trial of the novel bispecific molecule H22xKi-4 in patients with refractory Hodgkin lymphoma
-
Borchmann P, Schnell R, Fuss I, et al. Phase 1 trial of the novel bispecific molecule H22xKi-4 in patients with refractory Hodgkin lymphoma. Blood. 2002; 100 (9): 3101-3107.
-
(2002)
Blood
, vol.100
, Issue.9
, pp. 3101-3107
-
-
Borchmann, P.1
Schnell, R.2
Fuss, I.3
-
22
-
-
84923322716
-
Pharmacokinetics and pharmacodynamics of peptide and protein therapeutics
-
Crommelin D.J.A. Sindelar R.B. Meibohm B. eds. 4th ed. New York: Springer
-
Meibohm B,. Pharmacokinetics and pharmacodynamics of peptide and protein therapeutics. In:, Crommelin DJA, Sindelar RB, Meibohm B, eds. Pharmaceutical Biotechnology: Fundamentals and Applications. 4th ed. New York: Springer; 2013: 101-132.
-
(2013)
Pharmaceutical Biotechnology: Fundamentals and Applications
, pp. 101-132
-
-
Meibohm, B.1
-
23
-
-
4344634877
-
Pharmacokinetic aspects of biotechnology products
-
Tang L, Persky AM, Hochhaus G, Meibohm B,. Pharmacokinetic aspects of biotechnology products. J Pharmaceut Sci. 2004; 93 (9): 2184-2204.
-
(2004)
J Pharmaceut Sci
, vol.93
, Issue.9
, pp. 2184-2204
-
-
Tang, L.1
Persky, A.M.2
Hochhaus, G.3
Meibohm, B.4
-
24
-
-
84886160521
-
Pharmacokinetics and half-life of protein therapeutics
-
Kontermann R.E. ed. Weinheim: Wiley-VCH
-
Meibohm B,. Pharmacokinetics and half-life of protein therapeutics. In:, Kontermann RE, ed. Therapeutic Proteins: Strategies to Modulate their Plasma Half-Lives. Weinheim: Wiley-VCH; 2012: 23-38.
-
(2012)
Therapeutic Proteins: Strategies to Modulate Their Plasma Half-Lives
, pp. 23-38
-
-
Meibohm, B.1
-
25
-
-
0028147336
-
Transport of macromolecules across microvascular walls: The two-pore theory
-
Rippe B, Haraldsson B,. Transport of macromolecules across microvascular walls: the two-pore theory. Physiol Rev. 1994; 74 (1): 163-219.
-
(1994)
Physiol Rev
, vol.74
, Issue.1
, pp. 163-219
-
-
Rippe, B.1
Haraldsson, B.2
-
26
-
-
84875542050
-
Efficient generation of stable bispecific IgG1 by controlled Fab-arm exchange
-
Labrijn AF, Meesters JI, de Goeij BE, et al. Efficient generation of stable bispecific IgG1 by controlled Fab-arm exchange. Proc Natl Acad Sci USA. 2013; 110 (13): 5145-5150.
-
(2013)
Proc Natl Acad Sci USA
, vol.110
, Issue.13
, pp. 5145-5150
-
-
Labrijn, A.F.1
Meesters, J.I.2
De Goeij, B.E.3
-
27
-
-
62149129236
-
Therapeutic antibodies: Successes, limitations and hopes for the future
-
Chames P, Van Regenmortel M, Weiss E, Baty D,. Therapeutic antibodies: successes, limitations and hopes for the future. Br J Pharmacol. 2009; 157 (2): 220-233.
-
(2009)
Br J Pharmacol
, vol.157
, Issue.2
, pp. 220-233
-
-
Chames, P.1
Van Regenmortel, M.2
Weiss, E.3
Baty, D.4
-
28
-
-
0025376171
-
A modeling analysis of monoclonal antibody percolation through tumors: A binding-site barrier
-
Fujimori K, Covell DG, Fletcher JE, Weinstein JN,. A modeling analysis of monoclonal antibody percolation through tumors: a binding-site barrier. J Nucl Med. 1990; 31 (7): 1191-1198.
-
(1990)
J Nucl Med
, vol.31
, Issue.7
, pp. 1191-1198
-
-
Fujimori, K.1
Covell, D.G.2
Fletcher, J.E.3
Weinstein, J.N.4
-
29
-
-
27144432842
-
Engineered antibody fragments and the rise of single domains
-
Holliger P, Hudson PJ,. Engineered antibody fragments and the rise of single domains. Nat Biotechnol. 2005; 23 (9): 1126-1136.
-
(2005)
Nat Biotechnol
, vol.23
, Issue.9
, pp. 1126-1136
-
-
Holliger, P.1
Hudson, P.J.2
-
30
-
-
84869798378
-
Biodistribution studies with tumor-targeting bispecific antibodies reveal selective accumulation at the tumor site
-
List T, Neri D,. Biodistribution studies with tumor-targeting bispecific antibodies reveal selective accumulation at the tumor site. mAbs. 2012; 4 (6): 775-783.
-
(2012)
MAbs
, vol.4
, Issue.6
, pp. 775-783
-
-
List, T.1
Neri, D.2
-
32
-
-
32444438731
-
Elimination mechanisms of therapeutic monoclonal antibodies
-
Tabrizi MA, Tseng CM, Roskos LK,. Elimination mechanisms of therapeutic monoclonal antibodies. Drug Discov Today. 2006; 11 (1-2): 81-88.
-
(2006)
Drug Discov Today
, vol.11
, Issue.12
, pp. 81-88
-
-
Tabrizi, M.A.1
Tseng, C.M.2
Roskos, L.K.3
-
33
-
-
33646901012
-
Target-mediated drug disposition dynamics
-
Mager DE,. Target-mediated drug disposition dynamics. Biochem Pharmacol. 2006; 72 (1): 1-10.
-
(2006)
Biochem Pharmacol
, vol.72
, Issue.1
, pp. 1-10
-
-
Mager, D.E.1
-
34
-
-
34548229364
-
FcRn: The neonatal Fc receptor comes of age
-
Roopenian DC, Akilesh S,. FcRn: the neonatal Fc receptor comes of age. Nat Rev Immunol. 2007; 7 (9): 715-725.
-
(2007)
Nat Rev Immunol
, vol.7
, Issue.9
, pp. 715-725
-
-
Roopenian, D.C.1
Akilesh, S.2
-
35
-
-
84885229737
-
Pharmacokinetics and pharmacokinetic-pharmacodynamic correlations of therapeutic peptides
-
Diao L, Meibohm B,. Pharmacokinetics and pharmacokinetic-pharmacodynamic correlations of therapeutic peptides. Clin Pharmacokinet. 2013; 52 (10): 855-868.
-
(2013)
Clin Pharmacokinet
, vol.52
, Issue.10
, pp. 855-868
-
-
Diao, L.1
Meibohm, B.2
-
36
-
-
77956388219
-
Population pharmacokinetics of therapeutic monoclonal antibodies
-
Dirks NL, Meibohm B,. Population pharmacokinetics of therapeutic monoclonal antibodies. Clin Pharmacokinet. 2010; 49 (10): 633-659.
-
(2010)
Clin Pharmacokinet
, vol.49
, Issue.10
, pp. 633-659
-
-
Dirks, N.L.1
Meibohm, B.2
-
37
-
-
71749094615
-
Production of therapeutic antibodies with controlled fucosylation
-
Yamane-Ohnuki N, Satoh M,. Production of therapeutic antibodies with controlled fucosylation. mAbs. 2009; 1 (3): 230-236.
-
(2009)
MAbs
, vol.1
, Issue.3
, pp. 230-236
-
-
Yamane-Ohnuki, N.1
Satoh, M.2
-
38
-
-
84899741811
-
Quantitative cumulative biodistribution of antibodies in mice: Effect of modulating binding affinity to the neonatal Fc receptor
-
Yip V, Palma E, Tesar DB, et al. Quantitative cumulative biodistribution of antibodies in mice: Effect of modulating binding affinity to the neonatal Fc receptor. mAbs. 2014; 6 (3): 689-696.
-
(2014)
MAbs
, vol.6
, Issue.3
, pp. 689-696
-
-
Yip, V.1
Palma, E.2
Tesar, D.B.3
-
39
-
-
78650394814
-
Effects of charge on antibody tissue distribution and pharmacokinetics
-
Boswell CA, Tesar DB, Mukhyala K, Theil FP, Fielder PJ, Khawli LA,. Effects of charge on antibody tissue distribution and pharmacokinetics. Bioconjug Chem. 2010; 21 (12): 2153-2163.
-
(2010)
Bioconjug Chem
, vol.21
, Issue.12
, pp. 2153-2163
-
-
Boswell, C.A.1
Tesar, D.B.2
Mukhyala, K.3
Theil, F.P.4
Fielder, P.J.5
Khawli, L.A.6
-
40
-
-
84874562364
-
Identification and multidimensional optimization of an asymmetric bispecific IgG antibody mimicking the function of factor VIII cofactor activity
-
Sampei Z, Igawa T, Soeda T, et al. Identification and multidimensional optimization of an asymmetric bispecific IgG antibody mimicking the function of factor VIII cofactor activity. PloS One. 2013; 8 (2): e57479.
-
(2013)
PloS One
, vol.8
, Issue.2
, pp. e57479
-
-
Sampei, Z.1
Igawa, T.2
Soeda, T.3
-
41
-
-
84860324841
-
Characterizing the impact of renal impairment on the clinical pharmacology of biologics
-
Meibohm B, Zhou H,. Characterizing the impact of renal impairment on the clinical pharmacology of biologics. J Clin Pharmacol. 2012; 52 (1 Suppl): 54S-62S.
-
(2012)
J Clin Pharmacol
, vol.52
, pp. 54S-62S
-
-
Meibohm, B.1
Zhou, H.2
-
42
-
-
84859409756
-
Antitumor activity of a novel bispecific antibody that targets the ErbB2/ErbB3 oncogenic unit and inhibits heregulin-induced activation of ErbB3
-
McDonagh CF, Huhalov A, Harms BD, et al. Antitumor activity of a novel bispecific antibody that targets the ErbB2/ErbB3 oncogenic unit and inhibits heregulin-induced activation of ErbB3. Mol Cancer Therap. 2012; 11 (3): 582-593.
-
(2012)
Mol Cancer Therap
, vol.11
, Issue.3
, pp. 582-593
-
-
McDonagh, C.F.1
Huhalov, A.2
Harms, B.D.3
-
43
-
-
70350018276
-
Biodistribution of a bispecific single-chain diabody and its half-life extended derivatives
-
Stork R, Campigna E, Robert B, Muller D, Kontermann RE,. Biodistribution of a bispecific single-chain diabody and its half-life extended derivatives. J Biol Chem. 2009; 284 (38): 25612-25619.
-
(2009)
J Biol Chem
, vol.284
, Issue.38
, pp. 25612-25619
-
-
Stork, R.1
Campigna, E.2
Robert, B.3
Muller, D.4
Kontermann, R.E.5
-
44
-
-
43149096504
-
N-glycosylation as novel strategy to improve pharmacokinetic properties of bispecific single-chain diabodies
-
Stork R, Zettlitz KA, Muller D, Rether M, Hanisch FG, Kontermann RE,. N-glycosylation as novel strategy to improve pharmacokinetic properties of bispecific single-chain diabodies. J Biol Chem. 2008; 283 (12): 7804-7812.
-
(2008)
J Biol Chem
, vol.283
, Issue.12
, pp. 7804-7812
-
-
Stork, R.1
Zettlitz, K.A.2
Muller, D.3
Rether, M.4
Hanisch, F.G.5
Kontermann, R.E.6
-
45
-
-
35748956820
-
A bispecific diabody directed against prostate-specific membrane antigen,CD3 induces T-cell mediated lysis of prostate cancer cells
-
Buhler P, Wolf P, Gierschner D, et al. A bispecific diabody directed against prostate-specific membrane antigen,CD3 induces T-cell mediated lysis of prostate cancer cells. Cancer Immunol. 2008; 57 (1): 43-52.
-
(2008)
Cancer Immunol
, vol.57
, Issue.1
, pp. 43-52
-
-
Buhler, P.1
Wolf, P.2
Gierschner, D.3
-
46
-
-
77956344338
-
Development and approval of the trifunctional antibody catumaxomab (anti-EpCAM x anti-CD3) as a targeted cancer immunotherapy
-
Seimetz D, Lindhofer H, Bokemeyer C,. Development and approval of the trifunctional antibody catumaxomab (anti-EpCAM x anti-CD3) as a targeted cancer immunotherapy. Cancer Treatment Rev. 2010; 36 (6): 458-467.
-
(2010)
Cancer Treatment Rev
, vol.36
, Issue.6
, pp. 458-467
-
-
Seimetz, D.1
Lindhofer, H.2
Bokemeyer, C.3
-
47
-
-
77952078636
-
Pharmacokinetics, immunogenicity and bioactivity of the therapeutic antibody catumaxomab intraperitoneally administered to cancer patients
-
Ruf P, Kluge M, Jager M, et al. Pharmacokinetics, immunogenicity and bioactivity of the therapeutic antibody catumaxomab intraperitoneally administered to cancer patients. Br J Clin Pharmacol. 2010; 69 (6): 617-625.
-
(2010)
Br J Clin Pharmacol
, vol.69
, Issue.6
, pp. 617-625
-
-
Ruf, P.1
Kluge, M.2
Jager, M.3
-
48
-
-
0035210960
-
Differences in promiscuity for antibody-FcRn interactions across species: Implications for therapeutic antibodies
-
Ober RJ, Radu CG, Ghetie V, Ward ES,. Differences in promiscuity for antibody-FcRn interactions across species: implications for therapeutic antibodies. Int Immunol. 2001; 13 (12): 1551-1559.
-
(2001)
Int Immunol
, vol.13
, Issue.12
, pp. 1551-1559
-
-
Ober, R.J.1
Radu, C.G.2
Ghetie, V.3
Ward, E.S.4
-
49
-
-
79959312575
-
Targeted therapy with the T-cell-engaging antibody blinatumomab of chemotherapy-refractory minimal residual disease in B-lineage acute lymphoblastic leukemia patients results in high response rate and prolonged leukemia-free survival
-
Topp MS, Kufer P, Gokbuget N, et al. Targeted therapy with the T-cell-engaging antibody blinatumomab of chemotherapy-refractory minimal residual disease in B-lineage acute lymphoblastic leukemia patients results in high response rate and prolonged leukemia-free survival. J Clin Oncol. 2011; 29 (18): 2493-2498.
-
(2011)
J Clin Oncol
, vol.29
, Issue.18
, pp. 2493-2498
-
-
Topp, M.S.1
Kufer, P.2
Gokbuget, N.3
-
50
-
-
84908157861
-
Open-label phase 2 study of the bispecific T-cell engager (BiTE®) blinatumomab in patients with relapsed/refractory diffuse large B-cell lymphoma
-
Viardot A, Goebeler M, Pfreundschuh M, et al. Open-label phase 2 study of the bispecific T-cell engager (BiTE®) blinatumomab in patients with relapsed/refractory diffuse large B-cell lymphoma. Blood. 2013; 122 (21): 1811.
-
(2013)
Blood
, vol.122
, Issue.21
, pp. 1811
-
-
Viardot, A.1
Goebeler, M.2
Pfreundschuh, M.3
-
52
-
-
84863522243
-
Immunopharmacologic response of patients with B-lineage acute lymphoblastic leukemia to continuous infusion of T cell-engaging CD19/CD3-bispecific BiTE antibody blinatumomab
-
Klinger M, Brandl C, Zugmaier G, et al. Immunopharmacologic response of patients with B-lineage acute lymphoblastic leukemia to continuous infusion of T cell-engaging CD19/CD3-bispecific BiTE antibody blinatumomab. Blood. 2012; 119 (26): 6226-6233.
-
(2012)
Blood
, vol.119
, Issue.26
, pp. 6226-6233
-
-
Klinger, M.1
Brandl, C.2
Zugmaier, G.3
-
53
-
-
84867858547
-
Blinatumomab: A historical perspective
-
Nagorsen D, Kufer P, Baeuerle PA, Bargou R,. Blinatumomab: a historical perspective. Pharmacol Therap. 2012; 136 (3): 334-342.
-
(2012)
Pharmacol Therap
, vol.136
, Issue.3
, pp. 334-342
-
-
Nagorsen, D.1
Kufer, P.2
Baeuerle, P.A.3
Bargou, R.4
-
54
-
-
49649120397
-
Tumor regression in cancer patients by very low doses of a T cell-engaging antibody
-
Bargou R, Leo E, Zugmaier G, et al. Tumor regression in cancer patients by very low doses of a T cell-engaging antibody. Science. 2008; 321 (5891): 974-977.
-
(2008)
Science
, vol.321
, Issue.5891
, pp. 974-977
-
-
Bargou, R.1
Leo, E.2
Zugmaier, G.3
-
55
-
-
0028006565
-
Passage of intravenous immunoglobulin and interaction with the CNS
-
Wurster U, Haas J,. Passage of intravenous immunoglobulin and interaction with the CNS. J Neurol. 1994; 57: 21-25.
-
(1994)
J Neurol
, vol.57
, pp. 21-25
-
-
Wurster, U.1
Haas, J.2
-
56
-
-
79957452852
-
A therapeutic antibody targeting BACE1 inhibits amyloid-beta production in vivo
-
Atwal JK, Chen Y, Chiu C, et al. A therapeutic antibody targeting BACE1 inhibits amyloid-beta production in vivo. Sci Transl Med. 2011; 3 (84): 84ra43.
-
(2011)
Sci Transl Med
, vol.3
, Issue.84
, pp. 84ra43
-
-
Atwal, J.K.1
Chen, Y.2
Chiu, C.3
-
57
-
-
0031778715
-
Immunohistochemical localization of the murine transferrin receptor (TfR) on blood-tissue barriers using a novel anti-TfR monoclonal antibody
-
Kissel K, Hamm S, Schulz M, Vecchi A, Garlanda C, Engelhardt B,. Immunohistochemical localization of the murine transferrin receptor (TfR) on blood-tissue barriers using a novel anti-TfR monoclonal antibody. Histochem Cell Biol. 1998; 110 (1): 63-72.
-
(1998)
Histochem Cell Biol
, vol.110
, Issue.1
, pp. 63-72
-
-
Kissel, K.1
Hamm, S.2
Schulz, M.3
Vecchi, A.4
Garlanda, C.5
Engelhardt, B.6
-
58
-
-
34547642139
-
Blood-brain barrier transport of therapeutics via receptor-mediation
-
Jones AR, Shusta EV,. Blood-brain barrier transport of therapeutics via receptor-mediation. Pharmaceut Res. 2007; 24 (9): 1759-1771.
-
(2007)
Pharmaceut Res
, vol.24
, Issue.9
, pp. 1759-1771
-
-
Jones, A.R.1
Shusta, E.V.2
-
59
-
-
0023547088
-
Receptor-mediated transcytosis of transferrin across the blood-brain barrier
-
Fishman JB, Rubin JB, Handrahan JV, Connor JR, Fine RE,. Receptor-mediated transcytosis of transferrin across the blood-brain barrier. J Neurosci Res. 1987; 18 (2): 299-304.
-
(1987)
J Neurosci Res
, vol.18
, Issue.2
, pp. 299-304
-
-
Fishman, J.B.1
Rubin, J.B.2
Handrahan, J.V.3
Connor, J.R.4
Fine, R.E.5
-
60
-
-
79957439772
-
Boosting brain uptake of a therapeutic antibody by reducing its affinity for a transcytosis target
-
Yu YJ, Zhang Y, Kenrick M, et al. Boosting brain uptake of a therapeutic antibody by reducing its affinity for a transcytosis target. Sci Transl Med. 2011; 3 (84): 84ra44.
-
(2011)
Sci Transl Med
, vol.3
, Issue.84
, pp. 84ra44
-
-
Yu, Y.J.1
Zhang, Y.2
Kenrick, M.3
-
61
-
-
77953369554
-
A dual-targeting PDGFRbeta/VEGF-A molecule assembled from stable antibody fragments demonstrates anti-angiogenic activity in vitro and in vivo
-
Mabry R, Gilbertson DG, Frank A, et al. A dual-targeting PDGFRbeta/VEGF-A molecule assembled from stable antibody fragments demonstrates anti-angiogenic activity in vitro and in vivo. mAbs. 2010; 2 (1): 20-34.
-
(2010)
MAbs
, vol.2
, Issue.1
, pp. 20-34
-
-
Mabry, R.1
Gilbertson, D.G.2
Frank, A.3
-
62
-
-
84901263428
-
Bispecific therapeutics for ophthalmic indications: Target selection and the optimal molecular format
-
Le Couter J, Scheer JM,. Bispecific therapeutics for ophthalmic indications: target selection and the optimal molecular format. Exp Rev Ophthalmol. 2014; 9 (3): 217-225.
-
(2014)
Exp Rev Ophthalmol
, vol.9
, Issue.3
, pp. 217-225
-
-
Le Couter, J.1
Scheer, J.M.2
-
63
-
-
84923352053
-
-
Vol US20140017244 A1: US Patent and Trademark Office
-
Duerr H, Herting F, Klein C, Regula JT, Rueth M, Stubenrauch KG,. CNY Patent application: Bispecific Anti-VEGF/Anti-ANG-2 Antibodies and their use in the Treatment of Ocular Vascular Diseases. Vol US20140017244 A1: US Patent and Trademark Office. 2014.
-
(2014)
CNY Patent Application: Bispecific Anti-VEGF/Anti-ANG-2 Antibodies and Their Use in the Treatment of Ocular Vascular Diseases
-
-
Duerr, H.1
Herting, F.2
Klein, C.3
Regula, J.T.4
Rueth, M.5
Stubenrauch, K.G.6
-
64
-
-
77951586447
-
Strategies and challenges for the next generation of therapeutic antibodies
-
Beck A, Wurch T, Bailly C, Corvaia N,. Strategies and challenges for the next generation of therapeutic antibodies. Nat Rev Immunol. 2010; 10 (5): 345-352.
-
(2010)
Nat Rev Immunol
, vol.10
, Issue.5
, pp. 345-352
-
-
Beck, A.1
Wurch, T.2
Bailly, C.3
Corvaia, N.4
|